Paddle Speed

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Jean Paul Remon - One of the best experts on this subject based on the ideXlab platform.

  • Impact of blend properties on die filling during tableting.
    International Journal of Pharmaceutics, 2018
    Co-Authors: B. Van Snick, Jens Dhondt, Kenny Pandelaere, W. Grymonpré, Jean Paul Remon, T De Beer, Chris Vervaet, G. Di Pretoro, Valerie Vanhoorne
    Abstract:

    Abstract Based on characterization of a wide range of fillers and APIs, thirty divergent blends were composed and subsequently compressed on a rotary tablet press, varying Paddle Speed and turret Speed. The tablet weight variability was determined of 20 grab samples consisting of each 20 tablets. Additionally, the bulk residence time, ejection force, pre-compression displacement, main compression force, die fill fraction and feed frame fill fraction were determined during each run. Multivariate data analysis was applied to investigate the relation between the process parameters, blend characteristics, product and process responses. Blends with metoprolol tartrate as API showed high ejection forces. This behavior could be linked to the high wall friction value of metoprolol tartrate. The main responses related to the die filling could be predicted via a PLS model based on blend characteristics. Tablet weight variability was highly correlated with the variability on pre-compression displacement and main compression force. A good predictive model for tablet weight variability was obtained taking the porosity, wall friction angle, flowability, density, compressibility and permeability into account. Additionally, turret Speed and Paddle Speed were included in the calibration of the model. The applied approach can save resources (material, time) during early drug product development.

  • lubricant sensitivity in function of Paddle movement in the forced feeder of a high Speed tablet press
    Drug Development and Industrial Pharmacy, 2016
    Co-Authors: Elisabeth Peeters, Chris Vervaet, Valerie Vanhoorne, Jean Paul Remon
    Abstract:

    AbstractContext: The negative impact of magnesium stearate (MgSt) on the hardness of tablets is a well-known phenomenon, but the influence of Paddle movement in the forced feeder on the lubricant effect during tablet compression is often neglected.Objective: The purpose of this research was to investigate the influence of Paddle Speed in the forced feeder on tablet tensile strength (TS).Materials and methods: Mixtures of microcrystalline cellulose (MCC) and MgSt (0.5%) were blended using different methods (low & high shear). After blending, the formulations were compressed into tablets. All parameters of the tableting cycle were kept constant except the Speed of the Paddles in the forced feeder.Results and discussion: The blending technique affected the sensitivity of the formulation to the Paddle Speed. The TS of pure MCC tablets did not change in function of Paddle Speed, while tablets prepared by low shear mixing became softer at higher Paddle Speed. The TS of tablets manufactured using the high-shear ...

  • reduction of tablet weight variability by optimizing Paddle Speed in the forced feeder of a high Speed rotary tablet press
    Drug Development and Industrial Pharmacy, 2015
    Co-Authors: Elisabeth Peeters, Thomas Beer, Chris Vervaet, Jean Paul Remon
    Abstract:

    AbstractContext: Tableting is a complex process due to the large number of process parameters that can be varied. Knowledge and understanding of the influence of these parameters on the final product quality is of great importance for the industry, allowing economic efficiency and parametric release.Objective: The aim of this study was to investigate the influence of Paddle Speeds and fill depth at different tableting Speeds on the weight and weight variability of tablets.Materials and methods: Two excipients possessing different flow behavior, microcrystalline cellulose (MCC) and dibasic calcium phosphate dihydrate (DCP), were selected as model powders. Tablets were manufactured via a high-Speed rotary tablet press using design of experiments (DoE). During each experiment also the volume of powder in the forced feeder was measured.Results and discussion: Analysis of the DoE revealed that Paddle Speeds are of minor importance for tablet weight but significantly affect volume of powder inside the feeder in...

  • reduction of tablet weight variability by optimizing Paddle Speed in the forced feeder of a high Speed rotary tablet press
    Drug Development and Industrial Pharmacy, 2015
    Co-Authors: Elisabeth Peeters, Thomas Beer, Chris Vervaet, Jean Paul Remon
    Abstract:

    AbstractContext: Tableting is a complex process due to the large number of process parameters that can be varied. Knowledge and understanding of the influence of these parameters on the final product quality is of great importance for the industry, allowing economic efficiency and parametric release.Objective: The aim of this study was to investigate the influence of Paddle Speeds and fill depth at different tableting Speeds on the weight and weight variability of tablets.Materials and methods: Two excipients possessing different flow behavior, microcrystalline cellulose (MCC) and dibasic calcium phosphate dihydrate (DCP), were selected as model powders. Tablets were manufactured via a high-Speed rotary tablet press using design of experiments (DoE). During each experiment also the volume of powder in the forced feeder was measured.Results and discussion: Analysis of the DoE revealed that Paddle Speeds are of minor importance for tablet weight but significantly affect volume of powder inside the feeder in...

Elisabeth Peeters - One of the best experts on this subject based on the ideXlab platform.

  • lubricant sensitivity in function of Paddle movement in the forced feeder of a high Speed tablet press
    Drug Development and Industrial Pharmacy, 2016
    Co-Authors: Elisabeth Peeters, Chris Vervaet, Valerie Vanhoorne, Jean Paul Remon
    Abstract:

    AbstractContext: The negative impact of magnesium stearate (MgSt) on the hardness of tablets is a well-known phenomenon, but the influence of Paddle movement in the forced feeder on the lubricant effect during tablet compression is often neglected.Objective: The purpose of this research was to investigate the influence of Paddle Speed in the forced feeder on tablet tensile strength (TS).Materials and methods: Mixtures of microcrystalline cellulose (MCC) and MgSt (0.5%) were blended using different methods (low & high shear). After blending, the formulations were compressed into tablets. All parameters of the tableting cycle were kept constant except the Speed of the Paddles in the forced feeder.Results and discussion: The blending technique affected the sensitivity of the formulation to the Paddle Speed. The TS of pure MCC tablets did not change in function of Paddle Speed, while tablets prepared by low shear mixing became softer at higher Paddle Speed. The TS of tablets manufactured using the high-shear ...

  • reduction of tablet weight variability by optimizing Paddle Speed in the forced feeder of a high Speed rotary tablet press
    Drug Development and Industrial Pharmacy, 2015
    Co-Authors: Elisabeth Peeters, Thomas Beer, Chris Vervaet, Jean Paul Remon
    Abstract:

    AbstractContext: Tableting is a complex process due to the large number of process parameters that can be varied. Knowledge and understanding of the influence of these parameters on the final product quality is of great importance for the industry, allowing economic efficiency and parametric release.Objective: The aim of this study was to investigate the influence of Paddle Speeds and fill depth at different tableting Speeds on the weight and weight variability of tablets.Materials and methods: Two excipients possessing different flow behavior, microcrystalline cellulose (MCC) and dibasic calcium phosphate dihydrate (DCP), were selected as model powders. Tablets were manufactured via a high-Speed rotary tablet press using design of experiments (DoE). During each experiment also the volume of powder in the forced feeder was measured.Results and discussion: Analysis of the DoE revealed that Paddle Speeds are of minor importance for tablet weight but significantly affect volume of powder inside the feeder in...

  • reduction of tablet weight variability by optimizing Paddle Speed in the forced feeder of a high Speed rotary tablet press
    Drug Development and Industrial Pharmacy, 2015
    Co-Authors: Elisabeth Peeters, Thomas Beer, Chris Vervaet, Jean Paul Remon
    Abstract:

    AbstractContext: Tableting is a complex process due to the large number of process parameters that can be varied. Knowledge and understanding of the influence of these parameters on the final product quality is of great importance for the industry, allowing economic efficiency and parametric release.Objective: The aim of this study was to investigate the influence of Paddle Speeds and fill depth at different tableting Speeds on the weight and weight variability of tablets.Materials and methods: Two excipients possessing different flow behavior, microcrystalline cellulose (MCC) and dibasic calcium phosphate dihydrate (DCP), were selected as model powders. Tablets were manufactured via a high-Speed rotary tablet press using design of experiments (DoE). During each experiment also the volume of powder in the forced feeder was measured.Results and discussion: Analysis of the DoE revealed that Paddle Speeds are of minor importance for tablet weight but significantly affect volume of powder inside the feeder in...

Chris Vervaet - One of the best experts on this subject based on the ideXlab platform.

  • Impact of blend properties on die filling during tableting.
    International Journal of Pharmaceutics, 2018
    Co-Authors: B. Van Snick, Jens Dhondt, Kenny Pandelaere, W. Grymonpré, Jean Paul Remon, T De Beer, Chris Vervaet, G. Di Pretoro, Valerie Vanhoorne
    Abstract:

    Abstract Based on characterization of a wide range of fillers and APIs, thirty divergent blends were composed and subsequently compressed on a rotary tablet press, varying Paddle Speed and turret Speed. The tablet weight variability was determined of 20 grab samples consisting of each 20 tablets. Additionally, the bulk residence time, ejection force, pre-compression displacement, main compression force, die fill fraction and feed frame fill fraction were determined during each run. Multivariate data analysis was applied to investigate the relation between the process parameters, blend characteristics, product and process responses. Blends with metoprolol tartrate as API showed high ejection forces. This behavior could be linked to the high wall friction value of metoprolol tartrate. The main responses related to the die filling could be predicted via a PLS model based on blend characteristics. Tablet weight variability was highly correlated with the variability on pre-compression displacement and main compression force. A good predictive model for tablet weight variability was obtained taking the porosity, wall friction angle, flowability, density, compressibility and permeability into account. Additionally, turret Speed and Paddle Speed were included in the calibration of the model. The applied approach can save resources (material, time) during early drug product development.

  • lubricant sensitivity in function of Paddle movement in the forced feeder of a high Speed tablet press
    Drug Development and Industrial Pharmacy, 2016
    Co-Authors: Elisabeth Peeters, Chris Vervaet, Valerie Vanhoorne, Jean Paul Remon
    Abstract:

    AbstractContext: The negative impact of magnesium stearate (MgSt) on the hardness of tablets is a well-known phenomenon, but the influence of Paddle movement in the forced feeder on the lubricant effect during tablet compression is often neglected.Objective: The purpose of this research was to investigate the influence of Paddle Speed in the forced feeder on tablet tensile strength (TS).Materials and methods: Mixtures of microcrystalline cellulose (MCC) and MgSt (0.5%) were blended using different methods (low & high shear). After blending, the formulations were compressed into tablets. All parameters of the tableting cycle were kept constant except the Speed of the Paddles in the forced feeder.Results and discussion: The blending technique affected the sensitivity of the formulation to the Paddle Speed. The TS of pure MCC tablets did not change in function of Paddle Speed, while tablets prepared by low shear mixing became softer at higher Paddle Speed. The TS of tablets manufactured using the high-shear ...

  • reduction of tablet weight variability by optimizing Paddle Speed in the forced feeder of a high Speed rotary tablet press
    Drug Development and Industrial Pharmacy, 2015
    Co-Authors: Elisabeth Peeters, Thomas Beer, Chris Vervaet, Jean Paul Remon
    Abstract:

    AbstractContext: Tableting is a complex process due to the large number of process parameters that can be varied. Knowledge and understanding of the influence of these parameters on the final product quality is of great importance for the industry, allowing economic efficiency and parametric release.Objective: The aim of this study was to investigate the influence of Paddle Speeds and fill depth at different tableting Speeds on the weight and weight variability of tablets.Materials and methods: Two excipients possessing different flow behavior, microcrystalline cellulose (MCC) and dibasic calcium phosphate dihydrate (DCP), were selected as model powders. Tablets were manufactured via a high-Speed rotary tablet press using design of experiments (DoE). During each experiment also the volume of powder in the forced feeder was measured.Results and discussion: Analysis of the DoE revealed that Paddle Speeds are of minor importance for tablet weight but significantly affect volume of powder inside the feeder in...

  • reduction of tablet weight variability by optimizing Paddle Speed in the forced feeder of a high Speed rotary tablet press
    Drug Development and Industrial Pharmacy, 2015
    Co-Authors: Elisabeth Peeters, Thomas Beer, Chris Vervaet, Jean Paul Remon
    Abstract:

    AbstractContext: Tableting is a complex process due to the large number of process parameters that can be varied. Knowledge and understanding of the influence of these parameters on the final product quality is of great importance for the industry, allowing economic efficiency and parametric release.Objective: The aim of this study was to investigate the influence of Paddle Speeds and fill depth at different tableting Speeds on the weight and weight variability of tablets.Materials and methods: Two excipients possessing different flow behavior, microcrystalline cellulose (MCC) and dibasic calcium phosphate dihydrate (DCP), were selected as model powders. Tablets were manufactured via a high-Speed rotary tablet press using design of experiments (DoE). During each experiment also the volume of powder in the forced feeder was measured.Results and discussion: Analysis of the DoE revealed that Paddle Speeds are of minor importance for tablet weight but significantly affect volume of powder inside the feeder in...

Thomas Beer - One of the best experts on this subject based on the ideXlab platform.

  • reduction of tablet weight variability by optimizing Paddle Speed in the forced feeder of a high Speed rotary tablet press
    Drug Development and Industrial Pharmacy, 2015
    Co-Authors: Elisabeth Peeters, Thomas Beer, Chris Vervaet, Jean Paul Remon
    Abstract:

    AbstractContext: Tableting is a complex process due to the large number of process parameters that can be varied. Knowledge and understanding of the influence of these parameters on the final product quality is of great importance for the industry, allowing economic efficiency and parametric release.Objective: The aim of this study was to investigate the influence of Paddle Speeds and fill depth at different tableting Speeds on the weight and weight variability of tablets.Materials and methods: Two excipients possessing different flow behavior, microcrystalline cellulose (MCC) and dibasic calcium phosphate dihydrate (DCP), were selected as model powders. Tablets were manufactured via a high-Speed rotary tablet press using design of experiments (DoE). During each experiment also the volume of powder in the forced feeder was measured.Results and discussion: Analysis of the DoE revealed that Paddle Speeds are of minor importance for tablet weight but significantly affect volume of powder inside the feeder in...

  • reduction of tablet weight variability by optimizing Paddle Speed in the forced feeder of a high Speed rotary tablet press
    Drug Development and Industrial Pharmacy, 2015
    Co-Authors: Elisabeth Peeters, Thomas Beer, Chris Vervaet, Jean Paul Remon
    Abstract:

    AbstractContext: Tableting is a complex process due to the large number of process parameters that can be varied. Knowledge and understanding of the influence of these parameters on the final product quality is of great importance for the industry, allowing economic efficiency and parametric release.Objective: The aim of this study was to investigate the influence of Paddle Speeds and fill depth at different tableting Speeds on the weight and weight variability of tablets.Materials and methods: Two excipients possessing different flow behavior, microcrystalline cellulose (MCC) and dibasic calcium phosphate dihydrate (DCP), were selected as model powders. Tablets were manufactured via a high-Speed rotary tablet press using design of experiments (DoE). During each experiment also the volume of powder in the forced feeder was measured.Results and discussion: Analysis of the DoE revealed that Paddle Speeds are of minor importance for tablet weight but significantly affect volume of powder inside the feeder in...

Remon, Jean Paul - One of the best experts on this subject based on the ideXlab platform.

  • Downscaling of the tableting process : feasibility of miniaturized forced feeders on a high-Speed rotary tablet press
    'Elsevier BV', 2018
    Co-Authors: Grymonpré Wouter, De Beer Thomas, Remon, Jean Paul, Vanhoorne Valérie, Blahova Prudilova Barbora, Van Snick Bernd, Detobel Frederik, Vervaet Chris
    Abstract:

    With the current transformation of the pharmaceutical industry towards continuous manufacturing, there is an inherent need to embrace this concept already during the early stages of drug formulation. Therefore, this research paper investigated the feasibility of using miniaturized forced feeders on a high-Speed rotary tablet press with the intention of downscaling the tableting process. Forced feeders with a reduced volume (up to 46% compared to the conventional two-compartment forced feeder) were designed by either sealing one compartment (i.e. R&D1) or lowering of the compartment height (i.e. R&D2). These feed frame designs were thoroughly analysed in combination with two Paddle types over a wide range of process-settings (i.e. tableting Speed, Paddle Speed, direction of Paddle rotation, overfill-level). A poorly flowing model powder (i.e. MCC 101) was deliberately selected as challenging formulation. Empirical modelling of feed frame R&D1 revealed a positive impact on the die-filling variability when the radial curved cuboid Paddles rotated in counterclockwise direction at high Paddle Speed. Moreover, a strong resemblance between the R&D2 feed frame and the conventional forced feeder was observed during multivariate data analysis, indicating that this miniaturized type could be used during downscaling studies of the conventional tableting process. The potential of this forced feeder was acknowledged by the similar trends in die-filling variability with respect to varying process settings, when a design-of-experiments (DOE) was performing including feed frame type as a qualitative factor. Overall, it was concluded that both types of miniaturized forced feeders can be used on a high-Speed rotary tablet press when lower material consumption rates are desired while the R&D2 feed frame bears the highest predictability regarding the diefilling uniformity in the conventional larger two-compartment forced feeder

  • Optimizing feed frame design and tableting process parameters to increase die-filling uniformity on a high-Speed rotary tablet press
    'Elsevier BV', 2018
    Co-Authors: Grymonpré Wouter, De Beer Thomas, Remon, Jean Paul, Vanhoorne Valérie, Blahova Prudilova Barbora, Van Snick Bernd, Detobel Frederik, Vervaet Chris
    Abstract:

    Despite the high quantities of tablets produced daily, many tableting processes are still operated at sub-optimal settings and hence lack the necessary flexibility to mitigate for possible process deviations. However, to ensure this flexibility on tableting throughput it is important to select the most robust feed frame design and settings regarding die-filling. In this research study, four Paddle designs for a two-compartment forced feeder (equipped with a metering and a feeding Paddle wheel) were evaluated at a wide range of process-settings (i.e. tableting Speed, Paddle Speed, overfill level) and feed frame features (i.e. deaeration) for their impact on the die-filling step of a poorly flowing model formulation (i.e. MCC 101) using a quality-by-design approach. No benefit on diefilling was observed when using higher Speeds of the metering Paddle wheel compared to the feeding Paddle wheel, and no convincing arguments were obtained to use the feed frame deaeration opening. Some combinations of Paddle design and process-settings significantly increased the risk for inconsistent die-filling (i.e. high tablet weight variability) which can therefore limit the efficiency of the tableting process. The approach used in this study enabled to compare the Paddle designs for their die-filling performance in function of varying tableting Speeds, eventually resulting in the selection of a feed frame design that is most robust and therefore will provide a uniform die-filling over a wide range of throughputs. Selection of the most robust parameters is an important prerequisite for the ability of using the rotary tablet press as an agile unit-operation

  • Lubricant sensitivity in function of Paddle movement in the forced feeder of a high-Speed tablet press
    'Informa UK Limited', 2016
    Co-Authors: Peeters Elisabeth, Vervaet Chris, Vanhoorne Valérie, Remon, Jean Paul
    Abstract:

    Context: The negative impact of magnesium stearate (MgSt) on the hardness of tablets is a well-known phenomenon, but the influence of Paddle movement in the forced feeder on the lubricant effect during tablet compression is often neglected. Objective: The purpose of this research was to investigate the influence of Paddle Speed in the forced feeder on tablet tensile strength (TS).Materials and methods: Mixtures of microcrystalline cellulose (MCC) and MgSt (0.5%) were blended using different methods (low & high shear). After blending, the formulations were compressed into tablets. All parameters of the tableting cycle were kept constant except the Speed of the Paddles in the forced feeder. Results and discussion: The blending technique affected the sensitivity of the formulation to the Paddle Speed. The TS of pure MCC tablets did not change in function of Paddle Speed, while tablets prepared by low shear mixing became softer at higher Paddle Speed. The TS of tablets manufactured using the high-shear mixed blend was low and did not vary in function of Paddle Speed, suggesting that overlubrication already occurred during the initial blending step. Furthermore, analysis of the machine parameters allowed evaluation of the influence of the Paddles on the flowability, initial packing, and compactability of the powder mixtures. Conclusion: The results elucidated that during manufacturing of tablets using MgSt-containing blends care should not only be taken during the blending step prior to tableting, but also during the tableting process itself, as Paddle Speed can affect tablet TS, a critical quality attribute

  • Reduction of tablet weight variability by optimizing Paddle Speed in the forced feeder of a high-Speed rotary tablet press
    'Informa UK Limited', 2015
    Co-Authors: Peeters Elisabeth, De Beer Thomas, Vervaet Chris, Remon, Jean Paul
    Abstract:

    Context: Tableting is a complex process due to the large number of process parameters that can be varied. Knowledge and understanding of the influence of these parameters on the final product quality is of great importance for the industry, allowing economic efficiency and parametric release. Objective: The aim of this study was to investigate the influence of Paddle Speeds and fill depth at different tableting Speeds on the weight and weight variability of tablets. Materials and methods: Two excipients possessing different flow behavior, microcrystalline cellulose (MCC) and dibasic calcium phosphate dihydrate (DCP), were selected as model powders. Tablets were manufactured via a high-Speed rotary tablet press using design of experiments (DoE). During each experiment also the volume of powder in the forced feeder was measured. Results and discussion: Analysis of the DoE revealed that Paddle Speeds are of minor importance for tablet weight but significantly affect volume of powder inside the feeder in case of powders with excellent flowability (DCP). The opposite effect of Paddle Speed was observed for fairly flowing powders (MCC). Tableting Speed played a role in weight and weight variability, whereas changing fill depth exclusively influenced tablet weight. Conclusion: The DoE approach allowed predicting the optimum combination of process parameters leading to minimum tablet weight variability. Monte Carlo simulations allowed assessing the probability to exceed the acceptable response limits if factor settings were varied around their optimum. This multi-dimensional combination and interaction of input variables leading to response criteria with acceptable probability reflected the design space

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