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Patricia M. Kluding - One of the best experts on this subject based on the ideXlab platform.
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The Association of Diabetes with Knee Pain Severity and Distribution in People with Knee Osteoarthritis using Data from the Osteoarthritis Initiative.
Scientific reports, 2020Co-Authors: Aqeel M. Alenazi, Mohammed M. Alshehri, Shaima Alothman, Jason Rucker, Bader A. Alqahtani, Neena K. Sharma, Neil A. Segal, Saad M. Bindawas, Patricia M. KludingAbstract:Limited research has examined the association between diabetes mellitus (DM) and knee Pain in people with osteoarthritis (OA). Therefore, this study aimed at examining the association between DM and knee Pain Severity, and to explore the association between DM and knee Pain distribution (unilateral or bilateral versus no Pain) in subjects with knee OA. This is a cross-sectional analysis of the baseline visit of individuals who were enrolled in the Osteoarthritis Initiative. Data of participants with knee OA were used for this analysis (n = 1319), and grouped into subjects with both knee OA and DM (n = 148) or knee OA only without DM (n = 1171). Pain Severity was measured using a numeric rating scale from 0 to 10 over the past 7 and 30 days for each knee, and the more symptomatic knee with higher Pain Severity was chosen for analysis. DM was significantly associated with increased knee Pain Severity over 7 days (B 0.68; 95% CI 0.25–1.11) and over 30 days (B 0.59; 95% CI 0.17–1.01) after adjustments for all covariates, including age, gender, BMI, race, depression symptoms, composite OA score, use of Pain medications, and knee injections. Multinomial regression showed that participants with knee OA and DM had 2.45 (95% CI 1.07–5.61) to 2.55 (95% CI 1.12–5.79) times higher likelihood of having unilateral and bilateral knee Pain than those without DM and without knee Pain. This study found that DM was associated with higher Pain Severity and unilateral and bilateral knee Pain distribution.
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Type 2 Diabetes Affects Joint Pain Severity in People with Localized Osteoarthritis: A Retrospective Study.
Pain medicine (Malden Mass.), 2019Co-Authors: Aqeel M. Alenazi, Sakher M. Obaidat, Mohammed M. Alshehri, Shaima Alothman, Corey Gray, Jason Rucker, Lemuel R. Waitman, Patricia M. KludingAbstract:Objective To examine the association between type 2 diabetes (T2D) and Pain Severity in people with localized osteoarthritis (OA) and to explore the association between glycemic control, measured by hemoglobin A1c (HbA1c) level, and Pain Severity in people with localized OA and T2D. Design Retrospective study. Setting A tertiary medical center. Subjects Data from 819 patients (mean age = 65.08±9.77 years, 54.3% women) were used. Methods Patients were grouped to localized OA only (N = 671) and localized OA+T2D (N = 148) based on diagnosis codes. An index date was set as the first diagnosis date of localized OA and linked to Pain Severity, measured by numeric rating scale from 0 to 10. HbA1c values were obtained for patients with T2D within six months of the index date. Multiple linear regression was used. Results After controlling for age, gender, body mass index (BMI); diagnoses of depression, hypertension, dyslipidemia; OA locations; and medication list (+/- 90 days of the index date), T2D was significantly associated with increased Pain Severity (B = 1.07, 95% confidence interval [CI] = 0.25 to 1.88, P = 0.014). For patients with T2D and localized OA with available data for HbA1c (N = 87), the results showed that an increased HbA1c value was significantly associated with higher Pain Severity (B = 0.36, 95% CI = 0.036 to 0.67, P = 0.029) after controlling for age, gender, BMI, medications, and OA locations. Conclusion T2D was associated with higher Pain Severity in people with localized OA, and poor glycemic control was associated with higher Pain Severity in people with localized OA+T2D. Clinicians should emphasize that better HbA1c control might help with Pain management in people with T2D and OA.
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1545-P: The Association between Type 2 Diabetes and Pain Severity in People with Localized Osteoarthritis: A Retrospective Study
Diabetes, 2019Co-Authors: Aqeel M. Alenazi, Sakher M. Obaidat, Mohammed M. Alshehri, Shaima Alothman, Corey Gray, Jason Rucker, Lemuel R. Waitman, Patricia M. KludingAbstract:Objective: Type 2 diabetes (T2D) has been associated with osteoarthritis (OA). However, research related to the impact of T2D on Pain Severity is limited. The purpose of this study was to examine the association between T2D and Pain Severity in people with localized OA (LOA) (e.g., OA restricted to only one or two joints), and to explore the association between glycosylated hemoglobin (A1c) level and Pain Severity in people with LOA and T2D. Methods: A retrospective review of data from a tertiary medical center was performed. Records were selected based on diagnoses codes for LOA using international classification of disease 9 th and 10 th revisions. Index date was set as the first diagnosis date. Pain Severity, measured by a 0 to 10 numeric rating scale, was obtained and linked to the index date. T2D was defined as having two diagnostic codes for T2D or using insulin. A1c was obtained for patients with T2D within six months of the index date. Covariates of age, sex, depression, hypertension, dyslipidemia, and medications (+/- 90 days of the index date) were included in linear regression analysis. Alpha level was 0.05. Results: Data from 819 patients (mean age = 65.08±9.77, 54.3% women) included 671 patients with LOA only (n=671) and 148 patients with LOA+T2D. T2D was significantly associated with increased Pain Severity (B=1.08, 95% CI 0.23 -1.93, p=0.013) after controlling for covariates. For patients with LOA+T2D with data for A1C (n=87), higher A1c was significantly associated with increased Pain Severity (B=0.33, 95% CI 0.01 -0.64, p=0.045) after controlling for medications. Conclusion: This study found that T2D was associated with higher Pain Severity in people with LOA, and that poorer glycemic control was associated with higher Pain Severity in people with LOA+T2D. Only T2D was associated with Pain that exceeded the clinically meaningful difference (>1 score). Clinicians should consider T2D as a factor in the management of Pain in people with LOA. Disclosure A.M. Alenazi: None. S.M. Obaidat: None. M. Alshehri: None. C.M. Gray: None. S. Alothman: None. J.L. Rucker: None. L.R. Waitman: None. P. Kluding: None.
Aqeel M. Alenazi - One of the best experts on this subject based on the ideXlab platform.
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The Association of Diabetes with Knee Pain Severity and Distribution in People with Knee Osteoarthritis using Data from the Osteoarthritis Initiative.
Scientific reports, 2020Co-Authors: Aqeel M. Alenazi, Mohammed M. Alshehri, Shaima Alothman, Jason Rucker, Bader A. Alqahtani, Neena K. Sharma, Neil A. Segal, Saad M. Bindawas, Patricia M. KludingAbstract:Limited research has examined the association between diabetes mellitus (DM) and knee Pain in people with osteoarthritis (OA). Therefore, this study aimed at examining the association between DM and knee Pain Severity, and to explore the association between DM and knee Pain distribution (unilateral or bilateral versus no Pain) in subjects with knee OA. This is a cross-sectional analysis of the baseline visit of individuals who were enrolled in the Osteoarthritis Initiative. Data of participants with knee OA were used for this analysis (n = 1319), and grouped into subjects with both knee OA and DM (n = 148) or knee OA only without DM (n = 1171). Pain Severity was measured using a numeric rating scale from 0 to 10 over the past 7 and 30 days for each knee, and the more symptomatic knee with higher Pain Severity was chosen for analysis. DM was significantly associated with increased knee Pain Severity over 7 days (B 0.68; 95% CI 0.25–1.11) and over 30 days (B 0.59; 95% CI 0.17–1.01) after adjustments for all covariates, including age, gender, BMI, race, depression symptoms, composite OA score, use of Pain medications, and knee injections. Multinomial regression showed that participants with knee OA and DM had 2.45 (95% CI 1.07–5.61) to 2.55 (95% CI 1.12–5.79) times higher likelihood of having unilateral and bilateral knee Pain than those without DM and without knee Pain. This study found that DM was associated with higher Pain Severity and unilateral and bilateral knee Pain distribution.
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Type 2 Diabetes Affects Joint Pain Severity in People with Localized Osteoarthritis: A Retrospective Study.
Pain medicine (Malden Mass.), 2019Co-Authors: Aqeel M. Alenazi, Sakher M. Obaidat, Mohammed M. Alshehri, Shaima Alothman, Corey Gray, Jason Rucker, Lemuel R. Waitman, Patricia M. KludingAbstract:Objective To examine the association between type 2 diabetes (T2D) and Pain Severity in people with localized osteoarthritis (OA) and to explore the association between glycemic control, measured by hemoglobin A1c (HbA1c) level, and Pain Severity in people with localized OA and T2D. Design Retrospective study. Setting A tertiary medical center. Subjects Data from 819 patients (mean age = 65.08±9.77 years, 54.3% women) were used. Methods Patients were grouped to localized OA only (N = 671) and localized OA+T2D (N = 148) based on diagnosis codes. An index date was set as the first diagnosis date of localized OA and linked to Pain Severity, measured by numeric rating scale from 0 to 10. HbA1c values were obtained for patients with T2D within six months of the index date. Multiple linear regression was used. Results After controlling for age, gender, body mass index (BMI); diagnoses of depression, hypertension, dyslipidemia; OA locations; and medication list (+/- 90 days of the index date), T2D was significantly associated with increased Pain Severity (B = 1.07, 95% confidence interval [CI] = 0.25 to 1.88, P = 0.014). For patients with T2D and localized OA with available data for HbA1c (N = 87), the results showed that an increased HbA1c value was significantly associated with higher Pain Severity (B = 0.36, 95% CI = 0.036 to 0.67, P = 0.029) after controlling for age, gender, BMI, medications, and OA locations. Conclusion T2D was associated with higher Pain Severity in people with localized OA, and poor glycemic control was associated with higher Pain Severity in people with localized OA+T2D. Clinicians should emphasize that better HbA1c control might help with Pain management in people with T2D and OA.
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1545-P: The Association between Type 2 Diabetes and Pain Severity in People with Localized Osteoarthritis: A Retrospective Study
Diabetes, 2019Co-Authors: Aqeel M. Alenazi, Sakher M. Obaidat, Mohammed M. Alshehri, Shaima Alothman, Corey Gray, Jason Rucker, Lemuel R. Waitman, Patricia M. KludingAbstract:Objective: Type 2 diabetes (T2D) has been associated with osteoarthritis (OA). However, research related to the impact of T2D on Pain Severity is limited. The purpose of this study was to examine the association between T2D and Pain Severity in people with localized OA (LOA) (e.g., OA restricted to only one or two joints), and to explore the association between glycosylated hemoglobin (A1c) level and Pain Severity in people with LOA and T2D. Methods: A retrospective review of data from a tertiary medical center was performed. Records were selected based on diagnoses codes for LOA using international classification of disease 9 th and 10 th revisions. Index date was set as the first diagnosis date. Pain Severity, measured by a 0 to 10 numeric rating scale, was obtained and linked to the index date. T2D was defined as having two diagnostic codes for T2D or using insulin. A1c was obtained for patients with T2D within six months of the index date. Covariates of age, sex, depression, hypertension, dyslipidemia, and medications (+/- 90 days of the index date) were included in linear regression analysis. Alpha level was 0.05. Results: Data from 819 patients (mean age = 65.08±9.77, 54.3% women) included 671 patients with LOA only (n=671) and 148 patients with LOA+T2D. T2D was significantly associated with increased Pain Severity (B=1.08, 95% CI 0.23 -1.93, p=0.013) after controlling for covariates. For patients with LOA+T2D with data for A1C (n=87), higher A1c was significantly associated with increased Pain Severity (B=0.33, 95% CI 0.01 -0.64, p=0.045) after controlling for medications. Conclusion: This study found that T2D was associated with higher Pain Severity in people with LOA, and that poorer glycemic control was associated with higher Pain Severity in people with LOA+T2D. Only T2D was associated with Pain that exceeded the clinically meaningful difference (>1 score). Clinicians should consider T2D as a factor in the management of Pain in people with LOA. Disclosure A.M. Alenazi: None. S.M. Obaidat: None. M. Alshehri: None. C.M. Gray: None. S. Alothman: None. J.L. Rucker: None. L.R. Waitman: None. P. Kluding: None.
Richard L. Kravitz - One of the best experts on this subject based on the ideXlab platform.
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Tendency to adhere to provider-recommended treatments and subsequent Pain Severity among individuals with cancer.
Patient preference and adherence, 2011Co-Authors: Anthony F Jerant, Peter Franks, Daniel J. Tancredi, Naomi Saito, Richard L. KravitzAbstract:Background: Patients’ general tendency to adhere to health care provider-recommended treatments is associated with a number of health outcomes, but whether it influences Pain Severity over time among individuals with cancer is unclear. We explored the relationship between adherence tendency and subsequent Pain Severity among cancer patients participating in a randomized controlled trial of coaching to enhance communication with physicians and reduce Pain Severity. Methods: Associations between baseline Medical Outcomes Study general adherence measure score and Pain Severity over 12 weeks were examined with repeated-measures regression models. Model 1 included sociodemographics, study group and site, follow-up point, and baseline Pain; Model 2 included these variables plus partner status, physical and mental health status (12-item Short Form Health Survey [SF-12 ® ]), and Pain control self-efficacy. Results: Of 307 patients randomized, 224 (73%) had at least one follow-up Pain Severity assessment plus complete data for other model variables and were included in the analyses. In Model 1, adherence tendency was associated with less subsequent Pain Severity: a one standard deviation increase in adherence tendency was associated with a 0.22-point adjusted mean decrease in Pain Severity on a 0–10 scale (95% confidence interval 0.40, 0.03). The association was diminished and not statistically significant in Model 2, primarily due to adjustment for the SF-12. Conclusion: Tendency to adhere to provider-recommended treatments was associated with subsequent Pain Severity among individuals with cancer, suggesting a potential way of predicting and intervening to improve cancer Pain control. However, the association was attenuated after adjusting for health status, suggesting mediation or confounding of the relationship by health status.
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Associations between Pain control self-efficacy, self-efficacy for communicating with physicians, and subsequent Pain Severity among cancer patients
Patient education and counseling, 2010Co-Authors: Anthony F Jerant, Peter Franks, Richard L. KravitzAbstract:Abstract Objective Coaching patients to be more active in health encounters may improve communication with physicians but does not necessarily improve health outcomes. We explored this discrepancy by examining relationships between self-efficacy for communicating with physicians and Pain control self-efficacy and subsequent Pain Severity among cancer patients participating in a coaching trial. Methods We analyzed data from 244 English-speaking adults with various cancer types reporting significant Pain, recruited from 49 oncology physicians’ offices. Mixed model linear regression examined relationships between post-intervention communication self-efficacy and Pain control self-efficacy and subsequent Pain Severity over 12 weeks. Results Post-intervention Pain control self-efficacy (but not communication self-efficacy) was significantly related to subsequent Pain Severity: a one standard deviation increase was associated with a 0.19 point decrease (95% confidence interval = −0.33, −0.04; p = 0.01) in Pain Severity over time, approximately 25% of the effect size of the influence of post-intervention Pain on subsequent Pain. Conclusion Among cancer patients enrolled in a coaching trial, post-intervention Pain control self-efficacy, but not communication self-efficacy, was significantly related to subsequent Pain Severity. Practice implications Identifying behavioral mediators of cancer Pain Severity may lead to coaching interventions that are more effective in improving cancer Pain control.
Shaima Alothman - One of the best experts on this subject based on the ideXlab platform.
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The Association of Diabetes with Knee Pain Severity and Distribution in People with Knee Osteoarthritis using Data from the Osteoarthritis Initiative.
Scientific reports, 2020Co-Authors: Aqeel M. Alenazi, Mohammed M. Alshehri, Shaima Alothman, Jason Rucker, Bader A. Alqahtani, Neena K. Sharma, Neil A. Segal, Saad M. Bindawas, Patricia M. KludingAbstract:Limited research has examined the association between diabetes mellitus (DM) and knee Pain in people with osteoarthritis (OA). Therefore, this study aimed at examining the association between DM and knee Pain Severity, and to explore the association between DM and knee Pain distribution (unilateral or bilateral versus no Pain) in subjects with knee OA. This is a cross-sectional analysis of the baseline visit of individuals who were enrolled in the Osteoarthritis Initiative. Data of participants with knee OA were used for this analysis (n = 1319), and grouped into subjects with both knee OA and DM (n = 148) or knee OA only without DM (n = 1171). Pain Severity was measured using a numeric rating scale from 0 to 10 over the past 7 and 30 days for each knee, and the more symptomatic knee with higher Pain Severity was chosen for analysis. DM was significantly associated with increased knee Pain Severity over 7 days (B 0.68; 95% CI 0.25–1.11) and over 30 days (B 0.59; 95% CI 0.17–1.01) after adjustments for all covariates, including age, gender, BMI, race, depression symptoms, composite OA score, use of Pain medications, and knee injections. Multinomial regression showed that participants with knee OA and DM had 2.45 (95% CI 1.07–5.61) to 2.55 (95% CI 1.12–5.79) times higher likelihood of having unilateral and bilateral knee Pain than those without DM and without knee Pain. This study found that DM was associated with higher Pain Severity and unilateral and bilateral knee Pain distribution.
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Type 2 Diabetes Affects Joint Pain Severity in People with Localized Osteoarthritis: A Retrospective Study.
Pain medicine (Malden Mass.), 2019Co-Authors: Aqeel M. Alenazi, Sakher M. Obaidat, Mohammed M. Alshehri, Shaima Alothman, Corey Gray, Jason Rucker, Lemuel R. Waitman, Patricia M. KludingAbstract:Objective To examine the association between type 2 diabetes (T2D) and Pain Severity in people with localized osteoarthritis (OA) and to explore the association between glycemic control, measured by hemoglobin A1c (HbA1c) level, and Pain Severity in people with localized OA and T2D. Design Retrospective study. Setting A tertiary medical center. Subjects Data from 819 patients (mean age = 65.08±9.77 years, 54.3% women) were used. Methods Patients were grouped to localized OA only (N = 671) and localized OA+T2D (N = 148) based on diagnosis codes. An index date was set as the first diagnosis date of localized OA and linked to Pain Severity, measured by numeric rating scale from 0 to 10. HbA1c values were obtained for patients with T2D within six months of the index date. Multiple linear regression was used. Results After controlling for age, gender, body mass index (BMI); diagnoses of depression, hypertension, dyslipidemia; OA locations; and medication list (+/- 90 days of the index date), T2D was significantly associated with increased Pain Severity (B = 1.07, 95% confidence interval [CI] = 0.25 to 1.88, P = 0.014). For patients with T2D and localized OA with available data for HbA1c (N = 87), the results showed that an increased HbA1c value was significantly associated with higher Pain Severity (B = 0.36, 95% CI = 0.036 to 0.67, P = 0.029) after controlling for age, gender, BMI, medications, and OA locations. Conclusion T2D was associated with higher Pain Severity in people with localized OA, and poor glycemic control was associated with higher Pain Severity in people with localized OA+T2D. Clinicians should emphasize that better HbA1c control might help with Pain management in people with T2D and OA.
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1545-P: The Association between Type 2 Diabetes and Pain Severity in People with Localized Osteoarthritis: A Retrospective Study
Diabetes, 2019Co-Authors: Aqeel M. Alenazi, Sakher M. Obaidat, Mohammed M. Alshehri, Shaima Alothman, Corey Gray, Jason Rucker, Lemuel R. Waitman, Patricia M. KludingAbstract:Objective: Type 2 diabetes (T2D) has been associated with osteoarthritis (OA). However, research related to the impact of T2D on Pain Severity is limited. The purpose of this study was to examine the association between T2D and Pain Severity in people with localized OA (LOA) (e.g., OA restricted to only one or two joints), and to explore the association between glycosylated hemoglobin (A1c) level and Pain Severity in people with LOA and T2D. Methods: A retrospective review of data from a tertiary medical center was performed. Records were selected based on diagnoses codes for LOA using international classification of disease 9 th and 10 th revisions. Index date was set as the first diagnosis date. Pain Severity, measured by a 0 to 10 numeric rating scale, was obtained and linked to the index date. T2D was defined as having two diagnostic codes for T2D or using insulin. A1c was obtained for patients with T2D within six months of the index date. Covariates of age, sex, depression, hypertension, dyslipidemia, and medications (+/- 90 days of the index date) were included in linear regression analysis. Alpha level was 0.05. Results: Data from 819 patients (mean age = 65.08±9.77, 54.3% women) included 671 patients with LOA only (n=671) and 148 patients with LOA+T2D. T2D was significantly associated with increased Pain Severity (B=1.08, 95% CI 0.23 -1.93, p=0.013) after controlling for covariates. For patients with LOA+T2D with data for A1C (n=87), higher A1c was significantly associated with increased Pain Severity (B=0.33, 95% CI 0.01 -0.64, p=0.045) after controlling for medications. Conclusion: This study found that T2D was associated with higher Pain Severity in people with LOA, and that poorer glycemic control was associated with higher Pain Severity in people with LOA+T2D. Only T2D was associated with Pain that exceeded the clinically meaningful difference (>1 score). Clinicians should consider T2D as a factor in the management of Pain in people with LOA. Disclosure A.M. Alenazi: None. S.M. Obaidat: None. M. Alshehri: None. C.M. Gray: None. S. Alothman: None. J.L. Rucker: None. L.R. Waitman: None. P. Kluding: None.
Mohammed M. Alshehri - One of the best experts on this subject based on the ideXlab platform.
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The Association of Diabetes with Knee Pain Severity and Distribution in People with Knee Osteoarthritis using Data from the Osteoarthritis Initiative.
Scientific reports, 2020Co-Authors: Aqeel M. Alenazi, Mohammed M. Alshehri, Shaima Alothman, Jason Rucker, Bader A. Alqahtani, Neena K. Sharma, Neil A. Segal, Saad M. Bindawas, Patricia M. KludingAbstract:Limited research has examined the association between diabetes mellitus (DM) and knee Pain in people with osteoarthritis (OA). Therefore, this study aimed at examining the association between DM and knee Pain Severity, and to explore the association between DM and knee Pain distribution (unilateral or bilateral versus no Pain) in subjects with knee OA. This is a cross-sectional analysis of the baseline visit of individuals who were enrolled in the Osteoarthritis Initiative. Data of participants with knee OA were used for this analysis (n = 1319), and grouped into subjects with both knee OA and DM (n = 148) or knee OA only without DM (n = 1171). Pain Severity was measured using a numeric rating scale from 0 to 10 over the past 7 and 30 days for each knee, and the more symptomatic knee with higher Pain Severity was chosen for analysis. DM was significantly associated with increased knee Pain Severity over 7 days (B 0.68; 95% CI 0.25–1.11) and over 30 days (B 0.59; 95% CI 0.17–1.01) after adjustments for all covariates, including age, gender, BMI, race, depression symptoms, composite OA score, use of Pain medications, and knee injections. Multinomial regression showed that participants with knee OA and DM had 2.45 (95% CI 1.07–5.61) to 2.55 (95% CI 1.12–5.79) times higher likelihood of having unilateral and bilateral knee Pain than those without DM and without knee Pain. This study found that DM was associated with higher Pain Severity and unilateral and bilateral knee Pain distribution.
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Type 2 Diabetes Affects Joint Pain Severity in People with Localized Osteoarthritis: A Retrospective Study.
Pain medicine (Malden Mass.), 2019Co-Authors: Aqeel M. Alenazi, Sakher M. Obaidat, Mohammed M. Alshehri, Shaima Alothman, Corey Gray, Jason Rucker, Lemuel R. Waitman, Patricia M. KludingAbstract:Objective To examine the association between type 2 diabetes (T2D) and Pain Severity in people with localized osteoarthritis (OA) and to explore the association between glycemic control, measured by hemoglobin A1c (HbA1c) level, and Pain Severity in people with localized OA and T2D. Design Retrospective study. Setting A tertiary medical center. Subjects Data from 819 patients (mean age = 65.08±9.77 years, 54.3% women) were used. Methods Patients were grouped to localized OA only (N = 671) and localized OA+T2D (N = 148) based on diagnosis codes. An index date was set as the first diagnosis date of localized OA and linked to Pain Severity, measured by numeric rating scale from 0 to 10. HbA1c values were obtained for patients with T2D within six months of the index date. Multiple linear regression was used. Results After controlling for age, gender, body mass index (BMI); diagnoses of depression, hypertension, dyslipidemia; OA locations; and medication list (+/- 90 days of the index date), T2D was significantly associated with increased Pain Severity (B = 1.07, 95% confidence interval [CI] = 0.25 to 1.88, P = 0.014). For patients with T2D and localized OA with available data for HbA1c (N = 87), the results showed that an increased HbA1c value was significantly associated with higher Pain Severity (B = 0.36, 95% CI = 0.036 to 0.67, P = 0.029) after controlling for age, gender, BMI, medications, and OA locations. Conclusion T2D was associated with higher Pain Severity in people with localized OA, and poor glycemic control was associated with higher Pain Severity in people with localized OA+T2D. Clinicians should emphasize that better HbA1c control might help with Pain management in people with T2D and OA.
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1545-P: The Association between Type 2 Diabetes and Pain Severity in People with Localized Osteoarthritis: A Retrospective Study
Diabetes, 2019Co-Authors: Aqeel M. Alenazi, Sakher M. Obaidat, Mohammed M. Alshehri, Shaima Alothman, Corey Gray, Jason Rucker, Lemuel R. Waitman, Patricia M. KludingAbstract:Objective: Type 2 diabetes (T2D) has been associated with osteoarthritis (OA). However, research related to the impact of T2D on Pain Severity is limited. The purpose of this study was to examine the association between T2D and Pain Severity in people with localized OA (LOA) (e.g., OA restricted to only one or two joints), and to explore the association between glycosylated hemoglobin (A1c) level and Pain Severity in people with LOA and T2D. Methods: A retrospective review of data from a tertiary medical center was performed. Records were selected based on diagnoses codes for LOA using international classification of disease 9 th and 10 th revisions. Index date was set as the first diagnosis date. Pain Severity, measured by a 0 to 10 numeric rating scale, was obtained and linked to the index date. T2D was defined as having two diagnostic codes for T2D or using insulin. A1c was obtained for patients with T2D within six months of the index date. Covariates of age, sex, depression, hypertension, dyslipidemia, and medications (+/- 90 days of the index date) were included in linear regression analysis. Alpha level was 0.05. Results: Data from 819 patients (mean age = 65.08±9.77, 54.3% women) included 671 patients with LOA only (n=671) and 148 patients with LOA+T2D. T2D was significantly associated with increased Pain Severity (B=1.08, 95% CI 0.23 -1.93, p=0.013) after controlling for covariates. For patients with LOA+T2D with data for A1C (n=87), higher A1c was significantly associated with increased Pain Severity (B=0.33, 95% CI 0.01 -0.64, p=0.045) after controlling for medications. Conclusion: This study found that T2D was associated with higher Pain Severity in people with LOA, and that poorer glycemic control was associated with higher Pain Severity in people with LOA+T2D. Only T2D was associated with Pain that exceeded the clinically meaningful difference (>1 score). Clinicians should consider T2D as a factor in the management of Pain in people with LOA. Disclosure A.M. Alenazi: None. S.M. Obaidat: None. M. Alshehri: None. C.M. Gray: None. S. Alothman: None. J.L. Rucker: None. L.R. Waitman: None. P. Kluding: None.
