The Experts below are selected from a list of 54 Experts worldwide ranked by ideXlab platform

Yin Linliang - One of the best experts on this subject based on the ideXlab platform.

Bernard J Costello - One of the best experts on this subject based on the ideXlab platform.

  • surgical correction of midface deficiency in cleft lip and Palate Malformation
    Oral and Maxillofacial Surgery Clinics of North America, 2002
    Co-Authors: Timothy A Turvey, Ramon L Ruiz, Bernard J Costello
    Abstract:

    Timothy A. Turvey, DDS*, Ramon L. Ruiz, DMD, MD, Bernard J. Costello, DMD, MD Department of Oral and Maxillofacial Surgery, University of North Carolina at Chapel Hill, Brauer Hall, CB #7450, Chapel Hill, NC 27599-7450, USA Department of Pediatrics, University of North Carolina at Chapel Hill, Brauer Hall, CB #7450, Chapel Hill, NC 27599-7450, USA Children’s Hospital of North Carolina, Chapel Hill, NC, USA University of North Carolina Craniofacial Center, Chapel Hill, NC, USA Departments of Oral and Maxillofacial Surgery, Pediatric Dentistry, and Pediatric Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA Magee-Women’s Hospital, Pittsburgh, PA, USA Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA

Ren Huan-zhon - One of the best experts on this subject based on the ideXlab platform.

  • Review of Prenatal Ultrasonic Diagnosis in Fetal Cleft Lip and Palate
    Medical Recapitulate, 2020
    Co-Authors: Ren Huan-zhon
    Abstract:

    Fetal cleft lip and Palate is the most frequent facial Malformation,Ultrasonography is the most common method to detect it.This article reviewed two-dimensional ultrasound imaging for cleft lip and Palate Malformation in fetus,evaluation of the diagnosis of fetal cleft lip and Palate with three-dimensional ultrasonography etc.Recent study suggested that three-dimensional ultrasonography is more precise and more clearly visible in the diagnosis of cleft lip and Palate and is as the complement of two-dimensional space information.Combination of the two methods will improve the diagnostic rate of the congenital Malformation,and three-dimensional ultrasonography is also an efficient method to detect fetal cleft lip and Palate prenatally.

Xiaojun Ma - One of the best experts on this subject based on the ideXlab platform.

  • Study on the correlation between congenital microtia and HOXA2 and SIX2 gene mutation
    2017
    Co-Authors: Xiaojun Ma
    Abstract:

    Objective Congenital microtia is the most common deformity of the facial region after cleft lip and Palate Malformation, but its etiology is not clear yet. In this study, through sequencing the HOXA2 gene and SIX2 gene in patients with congenital microtia, we investigated whether there are mutations in the HOXA2 gene and SIX2 gene in patients with congenital microtia, and if there exist familial genetic characteristics of mutations. Methods 20 patients with congenital microtia were enrolled in this study; sequencing was performed in their family members with and without congenital microtia, and site mutation was detected with genetic mapping to provide genetic evidence. Mutations in HOXA2 and SIX2 genes were detected by PCR and direct sequencing. Results In the 20 cases of congenital microtia patients, no change in HOXA2 gene was found. Mutations were present in three loci of SIX2 gene, including 1650 (A>G), 1717 (A>C), 1792 (C>A) three base sites, which were heterozygous mutations and are likely correlated with the occurrence of the microtia. However, this correlation requires further investigation with large sample. There is correlative relationship with genetic characteristics in 1792 (C>A) in familial study. Conclusion The congenital microtia and HOXA2 Malformation loci have not been detected in this study. The change in SIX2.1792 (C>A) may be related to the occurrence of congenital microtia. Key words: congenital microtia; HOXA2; SIX2

Shelja Vashisth - One of the best experts on this subject based on the ideXlab platform.

  • Genetics of Cleft Lip and Palate - Is it still patchy?
    2020
    Co-Authors: Manav Lakhanpal, Nidhi Gupta, Shelja Vashisth
    Abstract:

    Clefts of the lip and/or Palate (CL/P) are immediately recognizable disruptions of normal facial structure. Approximately 1 in 700 children born have a cleft lip or a cleft Palate or both with a lifetime cost of treatment estimated at $200,000. CLP and CP individuals may experience difficulties in feeding, speaking, hearing and social integration. Recent successes in genome-wide linkage and association studies have identified novel loci that are significantly associated with CLP. In larger cohorts of people with CL/P, approximately 20% have other relatives with CL/P, and an increased prevalence is observed among first and second degree relatives. Many syndromes with phenotypes that include CL/P are now known. In some of the CL/P syndromes, the genes involved have been identified and the list is constantly increasing, primarily due to improved sequencing facilities. Genetics of NSCLP has been investigated by various studies such as Familial and Segregational Analysis, Twin Studies, Linkage Analysis, Association studies. There is overlapping of genes determining syndromic and non¬syndromic forms of CL /P. Greater efforts are necessary in order to have a complete picture of the main factors involved in lip and Palate Malformation.