The Experts below are selected from a list of 90 Experts worldwide ranked by ideXlab platform
Xiaojia Wang - One of the best experts on this subject based on the ideXlab platform.
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a preliminary study of Pamidronic Acid downregulation of angiogenic factors igf 1 pecam 1 expression in circulating level in bone metastatic breast cancer patients
2016Co-Authors: Zeng Wang, Lei Lei, Xinjun Cai, Ling Ya Chen, Meiqin Yuan, Guonong Yang, Ping Huang, Xiaojia WangAbstract:Objective To evaluate the expressions of circulating angiogenic factors affected by Pamidronic Acid (PA) intravenous infusion in bone metastatic breast cancer patients and the impact on their prognosis. Methods Peripheral blood of ten bone metastatic breast cancer patients was collected for serum insulin-like growth factor-1 (IGF-1) and platelet endothelial cell adhesion molecule-1 expression detection just before and 2 days after PA infusion. Results Both IGF-1 and platelet endothelial cell adhesion molecule-1 concentrations decreased after PA treatment for 48 hours (P 20% decrease recorded 2 days after PA administration. The decrease of IGF-1 was more significant in breast cancer patients who had received previous hormonotherapy. Moreover, the progression-free survival of first-line chemotherapy treatment of IGF-1 modified patients was longer than that of IGF-1 unmodified patients (P=0.009). Conclusion PA treatment could suppress circulating serum IGF-1 and platelet endothelial cell adhesion molecule-1 concentrations; moreover, the prognosis of patients in IGF-1 unmodified group was relatively poor.
Inn-kyu Kang - One of the best experts on this subject based on the ideXlab platform.
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Pamidronic Acid grafted nha plga hybrid nanofiber scaffolds suppress osteoclastic cell viability and enhance osteoblastic cell activity
2016Co-Authors: Adnan Haider, Davylouis Versace, K C Gupta, Inn-kyu KangAbstract:Osteoclasts have the capability to resorb bone. When osteoclastic activity is excessively high, bones generally become weakened and more prone to fracture. In order to treat excessive osteoclastic cell activity, maintain the balance between bone formation and resorption, and enhance osseointegration, Pamidronic Acid-grafted nanorod hydroxyapatite/poly(lactide-co-glycolide) (P-g-nHA/PLGA) scaffolds were fabricated via an electrospinning technique. Various spectroscopic techniques were used for the structural and morphological characterization of pristine PLGA, nHA/PLGA, and P-g-nHA/PLGA hybrid nanofiber scaffolds. The potential of the P-g-nHA/PLGA hybrid nanofiber scaffold as an implantable material was assessed through in vitro studies. The results showed that the viability of osteoclastic cells on the P-g-nHA/PLGA nanofiber scaffold was significantly suppressed due to the presence of Pamidronic Acid. Osteoblastic cells adhered and proliferated on all scaffolds tested; however, increased osteoblastic cell proliferation was observed on the P-g-nHA/PLGA hybrid and nHA/PLGA nanofiber scaffolds compared to the pristine PLGA nanofiber scaffolds. Therefore, these types of dual function P-g-nHA/PLGA hybrid nanofiber scaffolds could certainly be used in therapeutic bone implantation.
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Fabrication of Pamidronic Acid-immobilized TiO 2 /hydroxyapatite composite nanofiber mats for biomedical applications
2013Co-Authors: Yong-suk Shin, Jyoti S. Borah, Adnan Haider, Sukyoung Kim, Man-woo Huh, Inn-kyu KangAbstract:TiO2/hydroxyapatite (TiO2/HA) composite nanofiber mats were fabricated using an electrospinning technique. Subsequently, Pamidronic Acid (PDA) was immobilized on the surface of the TiO2/HA nanofiber mat to improve osseointegration. X-ray photoelectron microscopy and scanning electron microscopy (SEM) were used to characterize the structure and morphology of the PDA-immobilized TiO2/HA composite nanofiber mat (TiO2/HA-P). The potential of TiO2/HA-P as a bone scaffold was assessed by examining the cell adhesion and proliferation of osteoblasts and osteoclasts. The adhesion and proliferation of osteoblasts on the TiO2/HA-P composite nanofiber mat were slightly higher than those on the TiO2/HA composite nanofiber mat, whereas the viability of osteoclasts on the TiO2/HA-P nanofiber mat was significantly suppressed. These results suggest that the TiO2/HAP nanofiber mat has the potential for use as a therapeutic bone implant.
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Fabrication of Pamidronic Acid-Immobilized TiO2/Hydroxyapatite Composite Nanofiber Mats for Biomedical Applications
2013Co-Authors: Yong-suk Shin, Jyoti S. Borah, Adnan Haider, Sukyoung Kim, Man-woo Huh, Inn-kyu KangAbstract:TiO2/hydroxyapatite (TiO2/HA) composite nanofiber mats were fabricated using an electrospinning technique. Subsequently, Pamidronic Acid (PDA) was immobilized on the surface of the TiO2/HA nanofiber mat to improve osseointegration. X-ray photoelectron microscopy and scanning electron microscopy (SEM) were used to characterize the structure and morphology of the PDA-immobilized TiO2/HA composite nanofiber mat (TiO2/HA-P). The potential of TiO2/HA-P as a bone scaffold was assessed by examining the cell adhesion and proliferation of osteoblasts and osteoclasts. The adhesion and proliferation of osteoblasts on the TiO2/HA-P composite nanofiber mat were slightly higher than those on the TiO2/HA composite nanofiber mat, whereas the viability of osteoclasts on the TiO2/HA-P nanofiber mat was significantly suppressed. These results suggest that the TiO2/HA-P nanofiber mat has the potential for use as a therapeutic bone implant
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fabrication of Pamidronic Acid immobilized tio 2 hydroxyapatite composite nanofiber mats for biomedical applications
2013Co-Authors: Yong-suk Shin, Jyoti S. Borah, Adnan Haider, Sukyoung Kim, Man-woo Huh, Inn-kyu KangAbstract:TiO2/hydroxyapatite (TiO2/HA) composite nanofiber mats were fabricated using an electrospinning technique. Subsequently, Pamidronic Acid (PDA) was immobilized on the surface of the TiO2/HA nanofiber mat to improve osseointegration. X-ray photoelectron microscopy and scanning electron microscopy (SEM) were used to characterize the structure and morphology of the PDA-immobilized TiO2/HA composite nanofiber mat (TiO2/HA-P). The potential of TiO2/HA-P as a bone scaffold was assessed by examining the cell adhesion and proliferation of osteoblasts and osteoclasts. The adhesion and proliferation of osteoblasts on the TiO2/HA-P composite nanofiber mat were slightly higher than those on the TiO2/HA composite nanofiber mat, whereas the viability of osteoclasts on the TiO2/HA-P nanofiber mat was significantly suppressed. These results suggest that the TiO2/HAP nanofiber mat has the potential for use as a therapeutic bone implant.
Zeng Wang - One of the best experts on this subject based on the ideXlab platform.
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a preliminary study of Pamidronic Acid downregulation of angiogenic factors igf 1 pecam 1 expression in circulating level in bone metastatic breast cancer patients
2016Co-Authors: Zeng Wang, Lei Lei, Xinjun Cai, Ling Ya Chen, Meiqin Yuan, Guonong Yang, Ping Huang, Xiaojia WangAbstract:Objective To evaluate the expressions of circulating angiogenic factors affected by Pamidronic Acid (PA) intravenous infusion in bone metastatic breast cancer patients and the impact on their prognosis. Methods Peripheral blood of ten bone metastatic breast cancer patients was collected for serum insulin-like growth factor-1 (IGF-1) and platelet endothelial cell adhesion molecule-1 expression detection just before and 2 days after PA infusion. Results Both IGF-1 and platelet endothelial cell adhesion molecule-1 concentrations decreased after PA treatment for 48 hours (P 20% decrease recorded 2 days after PA administration. The decrease of IGF-1 was more significant in breast cancer patients who had received previous hormonotherapy. Moreover, the progression-free survival of first-line chemotherapy treatment of IGF-1 modified patients was longer than that of IGF-1 unmodified patients (P=0.009). Conclusion PA treatment could suppress circulating serum IGF-1 and platelet endothelial cell adhesion molecule-1 concentrations; moreover, the prognosis of patients in IGF-1 unmodified group was relatively poor.
Adnan Haider - One of the best experts on this subject based on the ideXlab platform.
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Pamidronic Acid grafted nha plga hybrid nanofiber scaffolds suppress osteoclastic cell viability and enhance osteoblastic cell activity
2016Co-Authors: Adnan Haider, Davylouis Versace, K C Gupta, Inn-kyu KangAbstract:Osteoclasts have the capability to resorb bone. When osteoclastic activity is excessively high, bones generally become weakened and more prone to fracture. In order to treat excessive osteoclastic cell activity, maintain the balance between bone formation and resorption, and enhance osseointegration, Pamidronic Acid-grafted nanorod hydroxyapatite/poly(lactide-co-glycolide) (P-g-nHA/PLGA) scaffolds were fabricated via an electrospinning technique. Various spectroscopic techniques were used for the structural and morphological characterization of pristine PLGA, nHA/PLGA, and P-g-nHA/PLGA hybrid nanofiber scaffolds. The potential of the P-g-nHA/PLGA hybrid nanofiber scaffold as an implantable material was assessed through in vitro studies. The results showed that the viability of osteoclastic cells on the P-g-nHA/PLGA nanofiber scaffold was significantly suppressed due to the presence of Pamidronic Acid. Osteoblastic cells adhered and proliferated on all scaffolds tested; however, increased osteoblastic cell proliferation was observed on the P-g-nHA/PLGA hybrid and nHA/PLGA nanofiber scaffolds compared to the pristine PLGA nanofiber scaffolds. Therefore, these types of dual function P-g-nHA/PLGA hybrid nanofiber scaffolds could certainly be used in therapeutic bone implantation.
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Fabrication of Pamidronic Acid-immobilized TiO 2 /hydroxyapatite composite nanofiber mats for biomedical applications
2013Co-Authors: Yong-suk Shin, Jyoti S. Borah, Adnan Haider, Sukyoung Kim, Man-woo Huh, Inn-kyu KangAbstract:TiO2/hydroxyapatite (TiO2/HA) composite nanofiber mats were fabricated using an electrospinning technique. Subsequently, Pamidronic Acid (PDA) was immobilized on the surface of the TiO2/HA nanofiber mat to improve osseointegration. X-ray photoelectron microscopy and scanning electron microscopy (SEM) were used to characterize the structure and morphology of the PDA-immobilized TiO2/HA composite nanofiber mat (TiO2/HA-P). The potential of TiO2/HA-P as a bone scaffold was assessed by examining the cell adhesion and proliferation of osteoblasts and osteoclasts. The adhesion and proliferation of osteoblasts on the TiO2/HA-P composite nanofiber mat were slightly higher than those on the TiO2/HA composite nanofiber mat, whereas the viability of osteoclasts on the TiO2/HA-P nanofiber mat was significantly suppressed. These results suggest that the TiO2/HAP nanofiber mat has the potential for use as a therapeutic bone implant.
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Fabrication of Pamidronic Acid-Immobilized TiO2/Hydroxyapatite Composite Nanofiber Mats for Biomedical Applications
2013Co-Authors: Yong-suk Shin, Jyoti S. Borah, Adnan Haider, Sukyoung Kim, Man-woo Huh, Inn-kyu KangAbstract:TiO2/hydroxyapatite (TiO2/HA) composite nanofiber mats were fabricated using an electrospinning technique. Subsequently, Pamidronic Acid (PDA) was immobilized on the surface of the TiO2/HA nanofiber mat to improve osseointegration. X-ray photoelectron microscopy and scanning electron microscopy (SEM) were used to characterize the structure and morphology of the PDA-immobilized TiO2/HA composite nanofiber mat (TiO2/HA-P). The potential of TiO2/HA-P as a bone scaffold was assessed by examining the cell adhesion and proliferation of osteoblasts and osteoclasts. The adhesion and proliferation of osteoblasts on the TiO2/HA-P composite nanofiber mat were slightly higher than those on the TiO2/HA composite nanofiber mat, whereas the viability of osteoclasts on the TiO2/HA-P nanofiber mat was significantly suppressed. These results suggest that the TiO2/HA-P nanofiber mat has the potential for use as a therapeutic bone implant
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fabrication of Pamidronic Acid immobilized tio 2 hydroxyapatite composite nanofiber mats for biomedical applications
2013Co-Authors: Yong-suk Shin, Jyoti S. Borah, Adnan Haider, Sukyoung Kim, Man-woo Huh, Inn-kyu KangAbstract:TiO2/hydroxyapatite (TiO2/HA) composite nanofiber mats were fabricated using an electrospinning technique. Subsequently, Pamidronic Acid (PDA) was immobilized on the surface of the TiO2/HA nanofiber mat to improve osseointegration. X-ray photoelectron microscopy and scanning electron microscopy (SEM) were used to characterize the structure and morphology of the PDA-immobilized TiO2/HA composite nanofiber mat (TiO2/HA-P). The potential of TiO2/HA-P as a bone scaffold was assessed by examining the cell adhesion and proliferation of osteoblasts and osteoclasts. The adhesion and proliferation of osteoblasts on the TiO2/HA-P composite nanofiber mat were slightly higher than those on the TiO2/HA composite nanofiber mat, whereas the viability of osteoclasts on the TiO2/HA-P nanofiber mat was significantly suppressed. These results suggest that the TiO2/HAP nanofiber mat has the potential for use as a therapeutic bone implant.
Lei Lei - One of the best experts on this subject based on the ideXlab platform.
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a preliminary study of Pamidronic Acid downregulation of angiogenic factors igf 1 pecam 1 expression in circulating level in bone metastatic breast cancer patients
2016Co-Authors: Zeng Wang, Lei Lei, Xinjun Cai, Ling Ya Chen, Meiqin Yuan, Guonong Yang, Ping Huang, Xiaojia WangAbstract:Objective To evaluate the expressions of circulating angiogenic factors affected by Pamidronic Acid (PA) intravenous infusion in bone metastatic breast cancer patients and the impact on their prognosis. Methods Peripheral blood of ten bone metastatic breast cancer patients was collected for serum insulin-like growth factor-1 (IGF-1) and platelet endothelial cell adhesion molecule-1 expression detection just before and 2 days after PA infusion. Results Both IGF-1 and platelet endothelial cell adhesion molecule-1 concentrations decreased after PA treatment for 48 hours (P 20% decrease recorded 2 days after PA administration. The decrease of IGF-1 was more significant in breast cancer patients who had received previous hormonotherapy. Moreover, the progression-free survival of first-line chemotherapy treatment of IGF-1 modified patients was longer than that of IGF-1 unmodified patients (P=0.009). Conclusion PA treatment could suppress circulating serum IGF-1 and platelet endothelial cell adhesion molecule-1 concentrations; moreover, the prognosis of patients in IGF-1 unmodified group was relatively poor.
