The Experts below are selected from a list of 114 Experts worldwide ranked by ideXlab platform
J J Krintel - One of the best experts on this subject based on the ideXlab platform.
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residual neuromuscular block is a risk factor for postoperative pulmonary complications a prospective randomised and blinded study of postoperative pulmonary complications after atracurium vecuronium and Pancuronium
Acta Anaesthesiologica Scandinavica, 1997Co-Authors: H Berg, Jakob Engbæk, J Vibymogensen, J Roed, C R Mortensen, L T Skovgaard, J J KrintelAbstract:Background: After anaesthesia involving Pancuronium a high incidence of both residual neuromuscular block and postoperative pulmonary complications (POPC) has been reported. The aim of this study was to compare the incidence of POPC following the use of Pancuronium, atracurium, and vecuronium, and to examine the effect of residual neuromuscular block on the incidence of POPC. Methods: A total of 691 adult patients undergoing abdominal, gynaecological, or orthopaedic surgery under general anaesthesia were randomised to receive either Pancuronium, atracurium, or vecuronium. Perioperatively, the response to train-of-four (TOF) nerve stimulation was evaluated manually. Post-operatively, the TOF ratios were measured mechanomyograph-ically, and through a 6-day follow-up the patients were examined for pulmonary complications. Results: The incidence of residual block, defined as a TOF ratio <0.7, was significantly higher in the Pancuronium group (59/226: 26%) than in the atracurium/vecuronium groups (24/450: 5.3%). In the Pancuronium group, significantly more patients with residual block developed POPC (10/59: 16.9%) as compared to patients without residual block (8/167 4.8%). In the atracurium/vecuronium groups, the incidence of POPC was not significantly different in patients with (1/24: 4.2%) or without (23/426: 5.4%) residual block. Multiple regression analysis indicated that abdominal surgery, age, long-lasting surgery, and a TOF ratio<0.7 following the use of Pancuronium were potential risk factors for the development of POPC. Conclusion: Postoperative residual block caused by Pancuronium is a significant risk factor for development of POPC.
M. C. Tsai - One of the best experts on this subject based on the ideXlab platform.
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neuromuscular blockade of the fetus with Pancuronium or pipecuronium for intra uterine procedures
Anaesthesia, 1994Co-Authors: Shou-zen Fan, L. Susetlo, M. C. TsaiAbstract:Summary Fetal movement during intra-uterine fetal therapy makes these procedures technically more dificult and increases the likelihood of trauma to the fetus. Pancuronium or pipecuronium were used in a randomised study to temporarily arrest movement in 16 fetuses undergoing intra-uterine procedures. Under ultrasound guidance, Pancuronium or pipecuronium 0.2 mg.kg−1 was injected into the fetal gluteal region. Fetal movements ceased within 4.6 ± 2.3 min in the Pancuronium group and 4.5 ± 2.8 min in the pipecuronium group and returned by 115±26 min in the Pancuronium group and 121 ± 3 2 min in the pipecuronium group. No adverse effects of the relaxant were observed in the mothers. There bvas no evidence of soft tissue, nerve or muscle damage at the fetal injection site after delivery. Both muscle relaxants provided a safer method for diagnostic and therapeutic procedures. However, four cases in the Pancuronium group (50%) developed a fetal tachycardia, and two cases in the same group showed loss of beat-to-beat variability. Pipecuronium appeared to be more suitable for intra-uterine procedures.
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Neuromuscular blockade of the fetus with Pancuronium or pipecuronium for intra‐uterine procedures
Anaesthesia, 1994Co-Authors: Shou-zen Fan, L. Susetlo, M. C. TsaiAbstract:Fetal movement during intra-uterine fetal therapy makes these procedures technically more difficult and increases the likelihood of trauma to the fetus. Pancuronium or pipecuronium were used in a randomised study to temporarily arrest movement in 16 fetuses undergoing intra-uterine procedures. Under ultrasound guidance, Pancuronium or pipecuronium 0.2 mg.kg-1 was injected into the fetal gluteal region. Fetal movements ceased within 4.6 +/- 2.3 min in the Pancuronium group and 4.5 +/- 2.8 min in the pipecuronium group and returned by 115 +/- 26 min in the Pancuronium group and 121 +/- 32 min in the pipecuronium group. No adverse effects of the relaxant were observed in the mothers. There was no evidence of soft tissue, nerve or muscle damage at the fetal injection site after delivery. Both muscle relaxants provided a safer method for diagnostic and therapeutic procedures. However, four cases in the Pancuronium group (50%) developed a fetal tachycardia, and two cases in the same group showed loss of beat-to-beat variability. Pipecuronium appeared to be more suitable for intra-uterine procedures.
H Berg - One of the best experts on this subject based on the ideXlab platform.
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residual neuromuscular block is a risk factor for postoperative pulmonary complications a prospective randomised and blinded study of postoperative pulmonary complications after atracurium vecuronium and Pancuronium
Acta Anaesthesiologica Scandinavica, 1997Co-Authors: H Berg, Jakob Engbæk, J Vibymogensen, J Roed, C R Mortensen, L T Skovgaard, J J KrintelAbstract:Background: After anaesthesia involving Pancuronium a high incidence of both residual neuromuscular block and postoperative pulmonary complications (POPC) has been reported. The aim of this study was to compare the incidence of POPC following the use of Pancuronium, atracurium, and vecuronium, and to examine the effect of residual neuromuscular block on the incidence of POPC. Methods: A total of 691 adult patients undergoing abdominal, gynaecological, or orthopaedic surgery under general anaesthesia were randomised to receive either Pancuronium, atracurium, or vecuronium. Perioperatively, the response to train-of-four (TOF) nerve stimulation was evaluated manually. Post-operatively, the TOF ratios were measured mechanomyograph-ically, and through a 6-day follow-up the patients were examined for pulmonary complications. Results: The incidence of residual block, defined as a TOF ratio <0.7, was significantly higher in the Pancuronium group (59/226: 26%) than in the atracurium/vecuronium groups (24/450: 5.3%). In the Pancuronium group, significantly more patients with residual block developed POPC (10/59: 16.9%) as compared to patients without residual block (8/167 4.8%). In the atracurium/vecuronium groups, the incidence of POPC was not significantly different in patients with (1/24: 4.2%) or without (23/426: 5.4%) residual block. Multiple regression analysis indicated that abdominal surgery, age, long-lasting surgery, and a TOF ratio<0.7 following the use of Pancuronium were potential risk factors for the development of POPC. Conclusion: Postoperative residual block caused by Pancuronium is a significant risk factor for development of POPC.
J Roed - One of the best experts on this subject based on the ideXlab platform.
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residual neuromuscular block is a risk factor for postoperative pulmonary complications a prospective randomised and blinded study of postoperative pulmonary complications after atracurium vecuronium and Pancuronium
Acta Anaesthesiologica Scandinavica, 1997Co-Authors: H Berg, Jakob Engbæk, J Vibymogensen, J Roed, C R Mortensen, L T Skovgaard, J J KrintelAbstract:Background: After anaesthesia involving Pancuronium a high incidence of both residual neuromuscular block and postoperative pulmonary complications (POPC) has been reported. The aim of this study was to compare the incidence of POPC following the use of Pancuronium, atracurium, and vecuronium, and to examine the effect of residual neuromuscular block on the incidence of POPC. Methods: A total of 691 adult patients undergoing abdominal, gynaecological, or orthopaedic surgery under general anaesthesia were randomised to receive either Pancuronium, atracurium, or vecuronium. Perioperatively, the response to train-of-four (TOF) nerve stimulation was evaluated manually. Post-operatively, the TOF ratios were measured mechanomyograph-ically, and through a 6-day follow-up the patients were examined for pulmonary complications. Results: The incidence of residual block, defined as a TOF ratio <0.7, was significantly higher in the Pancuronium group (59/226: 26%) than in the atracurium/vecuronium groups (24/450: 5.3%). In the Pancuronium group, significantly more patients with residual block developed POPC (10/59: 16.9%) as compared to patients without residual block (8/167 4.8%). In the atracurium/vecuronium groups, the incidence of POPC was not significantly different in patients with (1/24: 4.2%) or without (23/426: 5.4%) residual block. Multiple regression analysis indicated that abdominal surgery, age, long-lasting surgery, and a TOF ratio<0.7 following the use of Pancuronium were potential risk factors for the development of POPC. Conclusion: Postoperative residual block caused by Pancuronium is a significant risk factor for development of POPC.
C R Mortensen - One of the best experts on this subject based on the ideXlab platform.
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residual neuromuscular block is a risk factor for postoperative pulmonary complications a prospective randomised and blinded study of postoperative pulmonary complications after atracurium vecuronium and Pancuronium
Acta Anaesthesiologica Scandinavica, 1997Co-Authors: H Berg, Jakob Engbæk, J Vibymogensen, J Roed, C R Mortensen, L T Skovgaard, J J KrintelAbstract:Background: After anaesthesia involving Pancuronium a high incidence of both residual neuromuscular block and postoperative pulmonary complications (POPC) has been reported. The aim of this study was to compare the incidence of POPC following the use of Pancuronium, atracurium, and vecuronium, and to examine the effect of residual neuromuscular block on the incidence of POPC. Methods: A total of 691 adult patients undergoing abdominal, gynaecological, or orthopaedic surgery under general anaesthesia were randomised to receive either Pancuronium, atracurium, or vecuronium. Perioperatively, the response to train-of-four (TOF) nerve stimulation was evaluated manually. Post-operatively, the TOF ratios were measured mechanomyograph-ically, and through a 6-day follow-up the patients were examined for pulmonary complications. Results: The incidence of residual block, defined as a TOF ratio <0.7, was significantly higher in the Pancuronium group (59/226: 26%) than in the atracurium/vecuronium groups (24/450: 5.3%). In the Pancuronium group, significantly more patients with residual block developed POPC (10/59: 16.9%) as compared to patients without residual block (8/167 4.8%). In the atracurium/vecuronium groups, the incidence of POPC was not significantly different in patients with (1/24: 4.2%) or without (23/426: 5.4%) residual block. Multiple regression analysis indicated that abdominal surgery, age, long-lasting surgery, and a TOF ratio<0.7 following the use of Pancuronium were potential risk factors for the development of POPC. Conclusion: Postoperative residual block caused by Pancuronium is a significant risk factor for development of POPC.
