The Experts below are selected from a list of 5739 Experts worldwide ranked by ideXlab platform
Francois Vandenesch - One of the best experts on this subject based on the ideXlab platform.
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The Staphylococcal Toxin Panton-Valentine Leukocidin Targets Human C5a Receptors
Cell host & microbe, 2013Co-Authors: András N. Spaan, Cédric Badiou, Thomas Henry, Willemien J. M. Van Rooijen, Magali Perret, Piet C. Aerts, Johan Kemmink, Carla J. C. De Haas, Kok P. M. Van Kessel, Francois VandeneschAbstract:Panton-Valentine Leukocidin (PVL) is a staphylococcal bicomponent pore-forming toxin linked to severe invasive infections. Target-cell and species specificity of PVL are poorly understood, and the mechanism of action of this toxin in Staphylococcus aureus virulence is controversial. Here, we identify the human complement receptors C5aR and C5L2 as host targets of PVL, mediating both toxin binding and cytotoxicity. Expression and interspecies variations of the C5aR determine cell and species specificity of PVL. The C5aR binding PVL component, LukS-PV, is a potent inhibitor of C5a-induced immune cell activation. These findings provide insight into Leukocidin function and staphylococcal virulence and offer directions for future investigations into individual susceptibility to severe staphylococcal disease.
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Pragmatic management of Panton-Valentine Leukocidin-associated staphylococcal diseases.
International journal of antimicrobial agents, 2011Co-Authors: Y. Gillet, Jerome Etienne, Francois Vandenesch, Anne Tristan, Oana Dumitrescu, O. Dauwalder, E. Javouhey, D. Floret, Gerard LinaAbstract:Panton-Valentine Leukocidin (PVL)-producing Staphylococcus aureus is associated with a broad spectrum of diseases, ranging from common uncomplicated soft tissue infections to severe diseases such as complicated soft tissue infections, extensive bone and joint infections, and necrotising pneumonia. Specialised management of infection based on the presence of PVL may not be required for mild infections, whereas it could be lifesaving in other settings. Moreover, most severe PVL diseases are recently identified entities and a 'gold standard' treatment from comparatives studies of different therapeutic options is lacking. Thus, recommendations are based on expert opinions, which are elaborated based on theory, in vitro data and analogies with other toxin-mediated diseases. In this review, we consider the potential need for specialised PVL-based management and, if required, which tools should be used to achieve optimal management.
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Panton-Valentine Leukocidin-positive Staphylococcus aureus strains are associated with follicular skin infections.
Dermatology (Basel Switzerland), 2011Co-Authors: Pascal Del Giudice, Gerard Lina, Michele Bes, Francois Vandenesch, Thomas Hubiche, Véronique Blanc, Laurent Roudière, Jerome EtienneAbstract:Background/Aims: Panton-Valentine Leukocidin (PVL)-positive Staphylococcus aureus have been associated with suppurative infections; however, their precise role in
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Primary Skin Abscesses Are Mainly Caused by Panton-Valentine Leukocidin-Positive Staphylococcus aureus Strains
Dermatology (Basel Switzerland), 2009Co-Authors: Pascal Del Giudice, Gerard Lina, Michele Bes, Francois Vandenesch, Thomas Hubiche, Véronique Blanc, Laurent Roudière, Alexis De Rougemont, Jerome EtienneAbstract:Background: The role of Panton-Valentine Leukocidin (PVL) in skin and soft-tissue infections is not clear. Objective: Our purpose was to determine the prevalence
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Panton-Valentine Leukocidin is expressed at toxic levels in human skin abscesses.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2008Co-Authors: Cédric Badiou, Jerome Etienne, Yves Gillet, Francois Vandenesch, Oana Dumitrescu, M. Croze, Bruno Dohin, D.h. Slayman, Bernard Allaouchiche, Gerard LinaAbstract:Pus samples were prospectively collected from patients with Staphylococcus aureus skin infections and tested for Panton-Valentine Leukocidin (PVL). PVL was detected at concentrations that were toxic for rabbit skin in all specimens from patients infected with strains harbouring PVL genes.
Gerard Lina - One of the best experts on this subject based on the ideXlab platform.
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Outbreak of Panton-Valentine Leukocidin-Associated Methicillin-Susceptible Staphylococcus Aureus Infection in a Rugby Team, France, 2010-2011
Emerging infectious diseases, 2016Co-Authors: Elodie Couvé-deacon, Gerard Lina, Anne Tristan, N. Pestourie, Christian Faure, Valérie Doffoel-hantz, Fabien Garnier, Frédéric Laurent, Marie-cécile PloyAbstract:Staphylococcus aureus strains that produce Panton-Valentine Leukocidin are known to cause community infections. We describe an outbreak of skin abscesses caused by Panton-Valentine Leukocidin-producing methicillin-susceptible S. aureus (clonal complex 121) in a professional rugby team in France during July 2010-February 2011. Eight team members were carriers; 7 had skin abscesses.
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Pragmatic management of Panton-Valentine Leukocidin-associated staphylococcal diseases.
International journal of antimicrobial agents, 2011Co-Authors: Y. Gillet, Jerome Etienne, Francois Vandenesch, Anne Tristan, Oana Dumitrescu, O. Dauwalder, E. Javouhey, D. Floret, Gerard LinaAbstract:Panton-Valentine Leukocidin (PVL)-producing Staphylococcus aureus is associated with a broad spectrum of diseases, ranging from common uncomplicated soft tissue infections to severe diseases such as complicated soft tissue infections, extensive bone and joint infections, and necrotising pneumonia. Specialised management of infection based on the presence of PVL may not be required for mild infections, whereas it could be lifesaving in other settings. Moreover, most severe PVL diseases are recently identified entities and a 'gold standard' treatment from comparatives studies of different therapeutic options is lacking. Thus, recommendations are based on expert opinions, which are elaborated based on theory, in vitro data and analogies with other toxin-mediated diseases. In this review, we consider the potential need for specialised PVL-based management and, if required, which tools should be used to achieve optimal management.
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Panton-Valentine Leukocidin-positive Staphylococcus aureus strains are associated with follicular skin infections.
Dermatology (Basel Switzerland), 2011Co-Authors: Pascal Del Giudice, Gerard Lina, Michele Bes, Francois Vandenesch, Thomas Hubiche, Véronique Blanc, Laurent Roudière, Jerome EtienneAbstract:Background/Aims: Panton-Valentine Leukocidin (PVL)-positive Staphylococcus aureus have been associated with suppurative infections; however, their precise role in
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prompt and successful toxin targeting treatment of three patients with necrotizing pneumonia due to staphylococcus aureus strains carrying the Panton Valentine Leukocidin genes
Journal of Clinical Microbiology, 2010Co-Authors: Nicolas Rouzic, Gerard Lina, E. Javouhey, Frederic Janvier, N Libert, Jacquesyves Nizou, Pierre Pasquier, Didier Stamm, Louis Brinquin, Christophe PelletierAbstract:Three patients with extensive necrotizing pneumonia due to Panton-Valentine Leukocidin-positive Staphylococcus aureus strains and with aggravating factors (leukopenia count of less than 3 × 109/liter in all three cases and hemoptysis in two cases) were successfully treated with toxin-suppressing agents introduced rapidly after hospital admission.
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Primary Skin Abscesses Are Mainly Caused by Panton-Valentine Leukocidin-Positive Staphylococcus aureus Strains
Dermatology (Basel Switzerland), 2009Co-Authors: Pascal Del Giudice, Gerard Lina, Michele Bes, Francois Vandenesch, Thomas Hubiche, Véronique Blanc, Laurent Roudière, Alexis De Rougemont, Jerome EtienneAbstract:Background: The role of Panton-Valentine Leukocidin (PVL) in skin and soft-tissue infections is not clear. Objective: Our purpose was to determine the prevalence
Jerome Etienne - One of the best experts on this subject based on the ideXlab platform.
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Pragmatic management of Panton-Valentine Leukocidin-associated staphylococcal diseases.
International journal of antimicrobial agents, 2011Co-Authors: Y. Gillet, Jerome Etienne, Francois Vandenesch, Anne Tristan, Oana Dumitrescu, O. Dauwalder, E. Javouhey, D. Floret, Gerard LinaAbstract:Panton-Valentine Leukocidin (PVL)-producing Staphylococcus aureus is associated with a broad spectrum of diseases, ranging from common uncomplicated soft tissue infections to severe diseases such as complicated soft tissue infections, extensive bone and joint infections, and necrotising pneumonia. Specialised management of infection based on the presence of PVL may not be required for mild infections, whereas it could be lifesaving in other settings. Moreover, most severe PVL diseases are recently identified entities and a 'gold standard' treatment from comparatives studies of different therapeutic options is lacking. Thus, recommendations are based on expert opinions, which are elaborated based on theory, in vitro data and analogies with other toxin-mediated diseases. In this review, we consider the potential need for specialised PVL-based management and, if required, which tools should be used to achieve optimal management.
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Panton-Valentine Leukocidin-positive Staphylococcus aureus strains are associated with follicular skin infections.
Dermatology (Basel Switzerland), 2011Co-Authors: Pascal Del Giudice, Gerard Lina, Michele Bes, Francois Vandenesch, Thomas Hubiche, Véronique Blanc, Laurent Roudière, Jerome EtienneAbstract:Background/Aims: Panton-Valentine Leukocidin (PVL)-positive Staphylococcus aureus have been associated with suppurative infections; however, their precise role in
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Molecular Epidemiology of Panton-Valentine Leukocidin-Positive Staphylococcus aureus in Spain: Emergence of the USA300 Clone in an Autochthonous Population
Journal of clinical microbiology, 2010Co-Authors: Raquel Blanco, Jerome Etienne, Michele Bes, Anne Tristan, Guillermo Ezpeleta, Anders Rhod Larsen, Ramón Cisterna, Frédéric LaurentAbstract:We characterized all of the Panton-Valentine Leukocidin (PVL)-positive Staphylococcus aureus isolates collected between 2005 and 2008 in the Bilbao, Spain, area. For the first time, the USA300 clone is reported as predominant among PVL-positive clones in a European autochthonous population, requiring active monitoring of the incidence of USA300 in Spain and throughout Europe.
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Sudden death caused by Staphylococcus aureus carrying Panton-Valentine Leukocidin gene in a young girl.
BMJ case reports, 2009Co-Authors: Thanh-van Trieu, Jerome Etienne, Joel Gaudelus, Sophie Lefevre, Anne Marie Teychene, Isabelle Poilane, Anne Colignon, Loïc De PontualAbstract:Staphylococcus aureus carrying the Panton–Valentine Leukocidin (PVL) gene could be the source of both recurrent furunculosis or abscesses and severe infections, mainly necrotising pneumonia. We present the case of a young girl from consanguineous parents who died suddenly. The postmortem examination revealed necrotising pneumonia due to a PVL producing Staphylococcus aureus strain, raising the question of the role of the host’s immune status in this infection.
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Primary Skin Abscesses Are Mainly Caused by Panton-Valentine Leukocidin-Positive Staphylococcus aureus Strains
Dermatology (Basel Switzerland), 2009Co-Authors: Pascal Del Giudice, Gerard Lina, Michele Bes, Francois Vandenesch, Thomas Hubiche, Véronique Blanc, Laurent Roudière, Alexis De Rougemont, Jerome EtienneAbstract:Background: The role of Panton-Valentine Leukocidin (PVL) in skin and soft-tissue infections is not clear. Objective: Our purpose was to determine the prevalence
Michele Bes - One of the best experts on this subject based on the ideXlab platform.
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Panton-Valentine Leukocidin-positive Staphylococcus aureus strains are associated with follicular skin infections.
Dermatology (Basel Switzerland), 2011Co-Authors: Pascal Del Giudice, Gerard Lina, Michele Bes, Francois Vandenesch, Thomas Hubiche, Véronique Blanc, Laurent Roudière, Jerome EtienneAbstract:Background/Aims: Panton-Valentine Leukocidin (PVL)-positive Staphylococcus aureus have been associated with suppurative infections; however, their precise role in
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Molecular Epidemiology of Panton-Valentine Leukocidin-Positive Staphylococcus aureus in Spain: Emergence of the USA300 Clone in an Autochthonous Population
Journal of clinical microbiology, 2010Co-Authors: Raquel Blanco, Jerome Etienne, Michele Bes, Anne Tristan, Guillermo Ezpeleta, Anders Rhod Larsen, Ramón Cisterna, Frédéric LaurentAbstract:We characterized all of the Panton-Valentine Leukocidin (PVL)-positive Staphylococcus aureus isolates collected between 2005 and 2008 in the Bilbao, Spain, area. For the first time, the USA300 clone is reported as predominant among PVL-positive clones in a European autochthonous population, requiring active monitoring of the incidence of USA300 in Spain and throughout Europe.
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Primary Skin Abscesses Are Mainly Caused by Panton-Valentine Leukocidin-Positive Staphylococcus aureus Strains
Dermatology (Basel Switzerland), 2009Co-Authors: Pascal Del Giudice, Gerard Lina, Michele Bes, Francois Vandenesch, Thomas Hubiche, Véronique Blanc, Laurent Roudière, Alexis De Rougemont, Jerome EtienneAbstract:Background: The role of Panton-Valentine Leukocidin (PVL) in skin and soft-tissue infections is not clear. Objective: Our purpose was to determine the prevalence
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factors predicting mortality in necrotizing community acquired pneumonia caused by staphylococcus aureus containing Panton Valentine Leukocidin
Clinical Infectious Diseases, 2007Co-Authors: Philippe Vanhems, Yves Gillet, Gerard Lina, Michele Bes, Francois VandeneschAbstract:Background. Necrotizing pneumonia due to Panton-Valentine Leukocidin-producing strains of Staphylococcus aureus is associated with a high mortality rate. We sought factors associated with vital outcome in 50 cases occurring from 1986 through 2005. Methods. We compared the clinical and biological characteristics of 50 patients according to their vital outcome and examined the characteristics of the corresponding S. aureus isolates. Results. The overall mortality rate was 56%, and the median survival time was 10 days. All of the deaths were attributed to S. aureus infection and were secondary to refractory shock and/or respiratory failure. Fatal outcome was associated with classical severity factors, such as the need for mechanical ventilation or inotrope support, and with onset of the acute respiratory distress syndrome. Airway bleeding was strongly associated with fatal outcome (P = .002). Patients who had focal staphylococcal infection before the onset of pneumonia had a significantly lower mortality rate (P = .002). The main biological feature associated with death was leukopenia (P<.001). In multivariate analysis, leukopenia and erythroderma occurring within the first 24 h after admission to the hospital were independently associated with fatal outcome. Erythroderma was not associated with toxic shock syndrome toxin. Conclusions. Airway bleeding, erythroderma, and leukopenia are associated with fatal outcome from Panton-Valentine Leukocidin-positive S. aureus necrotizing pneumonia. More work is needed to develop more efficacious therapy against this highly lethal disease.
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Effect of Antibiotics on Staphylococcus aureus Producing Panton-Valentine Leukocidin
Antimicrobial agents and chemotherapy, 2007Co-Authors: Oana Dumitrescu, Jerome Etienne, Sandrine Boisset, Yvonne Benito, Michele Bes, Francois Vandenesch, Cédric Badiou, Marie-elisabeth Reverdy, Gerard LinaAbstract:We examined the capacity of Staphylococcus aureus strains to release Panton-Valentine Leukocidin (PVL) in the presence of antibiotics. No PVL was detected when S. aureus was incubated at inhibitory concentrations, while subinhibitory concentrations of oxacillin enhanced the PVL level; clindamycin, linezolid, and fusidic acid were inhibitory; and vancomycin had roughly no effect.
Frédéric Wallet - One of the best experts on this subject based on the ideXlab platform.
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Panton-Valentine Leukocidin–Secreting Staphylococcus aureus Pneumonia Complicating COVID-19
Emerging Infectious Diseases, 2020Co-Authors: Claire Duployez, Rémi Le Guern, Claire Tinez, Anne-laure Lejeune, Laurent Robriquet, Sophie Six, Caroline Loiez, Frédéric WalletAbstract:Necrotizing pneumonia induced by Panton-Valentine Leukocidin–secreting Staphylococcus aureus is a rare but life-threatening infection that has been described in patients after they had influenza. We report a fatal case of this superinfection in a young adult who had coronavirus disease.
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Panton-Valentine Leukocidin-Secreting Staphylococcus aureus Pneumonia Complicating COVID-19.
Emerging infectious diseases, 2020Co-Authors: Claire Duployez, Rémi Le Guern, Claire Tinez, Anne-laure Lejeune, Laurent Robriquet, Sophie Six, Caroline Loiez, Frédéric WalletAbstract:Necrotizing pneumonia induced by Panton-Valentine Leukocidin-secreting Staphylococcus aureus is a rare but life-threatening infection that has been described in patients after they had influenza. We report a fatal case of this superinfection in a young adult who had coronavirus disease.
