The Experts below are selected from a list of 288 Experts worldwide ranked by ideXlab platform
Billy S. Arant - One of the best experts on this subject based on the ideXlab platform.
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Morphological characteristics of segmental renal scarring in vesicoureteral reflux.
The Journal of Urology, 1992Co-Authors: Jay Bernstein, Billy S. ArantAbstract:AbstractWe examined 25 complete and partial nephrectomy specimens from 21 patients with advanced reflux nephropathy, all of which showed severe renal atrophy and loss of parenchyma. All specimens that included nonatrophic or partially atrophic renal tissue contained small medullary scars that involved only portions of the medullary pyramids. These sublobar medullary scars, which appeared linear and were typically discrete, extended from the inner medulla to the cortex. They obliterated collecting Ducts, vasa recta and recurrent loops. The cortical portions of the scars contained remnants of nephrons and variable infiltrates of chronic inflammatory cells with lymphoid follicles. Seven of the specimens also contained acute disruptive Ductal lesions with histopathological features characteristic of intrarenal reflux. We believe that the linear scars are the result of single Duct medullary disruptions, mediated perhaps through obstruction of the several thousand nephrons subtended by each Papillary Duct and p...
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Morphological characteristics of segmental renal scarring in vesicoureteral reflux.
The Journal of urology, 1992Co-Authors: Jay Bernstein, Billy S. ArantAbstract:We examined 25 complete and partial nephrectomy specimens from 21 patients with advanced reflux nephropathy, all of which showed severe renal atrophy and loss of parenchyma. All specimens that included nonatrophic or partially atrophic renal tissue contained small medullary scars that involved only portions of the medullary pyramids. These sublobar medullary scars, which appeared linear and were typically discrete, extended from the inner medulla to the cortex. They obliterated collecting Ducts, vasa recta and recurrent loops. The cortical portions of the scars contained remnants of nephrons and variable infiltrates of chronic inflammatory cells with lymphoid follicles. Seven of the specimens also contained acute disruptive Ductal lesions with histopathological features characteristic of intrarenal reflux. We believe that the linear scars are the result of single Duct medullary disruptions, mediated perhaps through obstruction of the several thousand nephrons subtended by each Papillary Duct and perhaps through localized disruption of the renal microvasculature. These sublobar scars accumulate as scarring progresses to end stage renal atrophy.
Jay Bernstein - One of the best experts on this subject based on the ideXlab platform.
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Morphological characteristics of segmental renal scarring in vesicoureteral reflux.
The Journal of Urology, 1992Co-Authors: Jay Bernstein, Billy S. ArantAbstract:AbstractWe examined 25 complete and partial nephrectomy specimens from 21 patients with advanced reflux nephropathy, all of which showed severe renal atrophy and loss of parenchyma. All specimens that included nonatrophic or partially atrophic renal tissue contained small medullary scars that involved only portions of the medullary pyramids. These sublobar medullary scars, which appeared linear and were typically discrete, extended from the inner medulla to the cortex. They obliterated collecting Ducts, vasa recta and recurrent loops. The cortical portions of the scars contained remnants of nephrons and variable infiltrates of chronic inflammatory cells with lymphoid follicles. Seven of the specimens also contained acute disruptive Ductal lesions with histopathological features characteristic of intrarenal reflux. We believe that the linear scars are the result of single Duct medullary disruptions, mediated perhaps through obstruction of the several thousand nephrons subtended by each Papillary Duct and p...
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Morphological characteristics of segmental renal scarring in vesicoureteral reflux.
The Journal of urology, 1992Co-Authors: Jay Bernstein, Billy S. ArantAbstract:We examined 25 complete and partial nephrectomy specimens from 21 patients with advanced reflux nephropathy, all of which showed severe renal atrophy and loss of parenchyma. All specimens that included nonatrophic or partially atrophic renal tissue contained small medullary scars that involved only portions of the medullary pyramids. These sublobar medullary scars, which appeared linear and were typically discrete, extended from the inner medulla to the cortex. They obliterated collecting Ducts, vasa recta and recurrent loops. The cortical portions of the scars contained remnants of nephrons and variable infiltrates of chronic inflammatory cells with lymphoid follicles. Seven of the specimens also contained acute disruptive Ductal lesions with histopathological features characteristic of intrarenal reflux. We believe that the linear scars are the result of single Duct medullary disruptions, mediated perhaps through obstruction of the several thousand nephrons subtended by each Papillary Duct and perhaps through localized disruption of the renal microvasculature. These sublobar scars accumulate as scarring progresses to end stage renal atrophy.
Ralph H Hruban - One of the best experts on this subject based on the ideXlab platform.
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progression of pancreatic intraDuctal neoplasias to infiltrating adenocarcinoma of the pancreas
The American Journal of Surgical Pathology, 1998Co-Authors: Daniel J Brat, Keith D Lillemoe, Charles J Yeo, Paul B Warfield, Ralph H HrubanAbstract:Pancreata with cancer also frequently have intraDuctal proliferative lesions, suggesting an association between pancreatic cancer and these lesions. We present three cases in which atypical Papillary hyperplasia of the pancreas was documented 17 months to 10 years before the development of an infiltrating adenocarcinoma of the pancreas. The first patient was a 70-year-old woman who underwent pancreaticoduodenectomy for adenocarcinoma of the pancreas. Atypical Papillary Duct hyperplasia extended to the pancreatic neck margin of resection, but the margin was negative for infiltrating carcinoma. Nine years later, an infiltrating adenocarcinoma developed in the remaining pancreas. The second patient was a 58-year-old man who underwent distal pancreatectomy for chronic pancreatitis with pseudocyst. Histologic examination showed chronic pancreatitis and multiple foci of atypical Papillary Duct hyperplasia. Ten years later, the patient underwent a Whipple procedure for infiltrating adenocarcinoma of the pancreas. The third patient was a 46-year-old woman with recurrent pancreatitis who underwent a Whipple procedure. Histologic examination showed atypical Papillary Duct hyperplasia and chronic pancreatitis but no infiltrating carcinoma. At the time of surgery, the tail of the pancreas was grossly and radiographically normal. Seventeen months later, a malignant pleural effusion developed, and postmortem examination showed infiltrating adenocarcinoma in the tail of the pancreas. In the cases presented, atypical Papillary hyperplasia was documented 17 months, 9 years, and 10 years before the development of infiltrating adenocarcinoma of the pancreas, supporting the concept that there is a progression from intraDuctal hyperplasia to infiltrating carcinoma of the pancreas, just as there is a progression from adenoma to infiltrating carcinoma in the colorectum. Based on evidence that these intraDuctal lesions are precursor lesions to infiltrating adenocarcinoma of the pancreas, we suggest that the term "hyperplasia" be replaced by the more specific term "pancreatic intraepithelial neoplasia."
Daniel J Brat - One of the best experts on this subject based on the ideXlab platform.
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progression of pancreatic intraDuctal neoplasias to infiltrating adenocarcinoma of the pancreas
The American Journal of Surgical Pathology, 1998Co-Authors: Daniel J Brat, Keith D Lillemoe, Charles J Yeo, Paul B Warfield, Ralph H HrubanAbstract:Pancreata with cancer also frequently have intraDuctal proliferative lesions, suggesting an association between pancreatic cancer and these lesions. We present three cases in which atypical Papillary hyperplasia of the pancreas was documented 17 months to 10 years before the development of an infiltrating adenocarcinoma of the pancreas. The first patient was a 70-year-old woman who underwent pancreaticoduodenectomy for adenocarcinoma of the pancreas. Atypical Papillary Duct hyperplasia extended to the pancreatic neck margin of resection, but the margin was negative for infiltrating carcinoma. Nine years later, an infiltrating adenocarcinoma developed in the remaining pancreas. The second patient was a 58-year-old man who underwent distal pancreatectomy for chronic pancreatitis with pseudocyst. Histologic examination showed chronic pancreatitis and multiple foci of atypical Papillary Duct hyperplasia. Ten years later, the patient underwent a Whipple procedure for infiltrating adenocarcinoma of the pancreas. The third patient was a 46-year-old woman with recurrent pancreatitis who underwent a Whipple procedure. Histologic examination showed atypical Papillary Duct hyperplasia and chronic pancreatitis but no infiltrating carcinoma. At the time of surgery, the tail of the pancreas was grossly and radiographically normal. Seventeen months later, a malignant pleural effusion developed, and postmortem examination showed infiltrating adenocarcinoma in the tail of the pancreas. In the cases presented, atypical Papillary hyperplasia was documented 17 months, 9 years, and 10 years before the development of infiltrating adenocarcinoma of the pancreas, supporting the concept that there is a progression from intraDuctal hyperplasia to infiltrating carcinoma of the pancreas, just as there is a progression from adenoma to infiltrating carcinoma in the colorectum. Based on evidence that these intraDuctal lesions are precursor lesions to infiltrating adenocarcinoma of the pancreas, we suggest that the term "hyperplasia" be replaced by the more specific term "pancreatic intraepithelial neoplasia."
Paola D'ippolito - One of the best experts on this subject based on the ideXlab platform.
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Obstructive renal cyst in a dog: Ultrasonography-guided treatment using puncture aspiration and injection with 95% ethanol
Journal of veterinary internal medicine, 2005Co-Authors: Andrea Zatelli, Ugo Bonfanti, Paola D'ippolitoAbstract:A 12-year-old, intact male, mixed-breed dog was evaluated after surgical removal of a mast cell tumor from the shoulder. Results of laboratory tests were within the reference ranges, but examination of urinary sediment identified epithelial cells of the upper urinary tract and microscopic hematuria. Abdominal ultrasound examination performed after a 12-hour fast identified a simple cyst in the left kidney. The cyst was approximately 26 mm in diameter, was anechoic, and had a thin, slightly hyperechoic wall with distal acoustic enhancement accompanied by dilatation of the caudal Papillary Duct and renal pelvis (Fig 1). Excretory urography with iopamidola contrast (800 mg/kg IV) confirmed the presence of dilatation of the left renal pelvis and collecting system (Fig 2).
