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Shaobo Zhang - One of the best experts on this subject based on the ideXlab platform.
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telomerase reverse transcriptase tert promoter mutation analysis of benign malignant and reactive urothelial lesions reveals a subpopulation of inverted Papilloma with immortalizing genetic change
Histopathology, 2016Co-Authors: Liang Cheng, Darrell D Davidson, Mingsheng Wang, Antonio Lopezbeltran, Rodolfo Montironi, Lisha Wang, Puay Hoon Tan, Gregory T Maclennan, Sean R Williamson, Shaobo ZhangAbstract:Aims To understand more clearly the genetic ontogeny of inverted Papilloma of urinary bladder, we analysed telomerase reverse transcriptase (TERT) promoter mutation status in a group of 26 inverted Papillomas in comparison with the mutation status of urothelial carcinoma with inverted growth (26 cases), conventional urothelial carcinoma (36 Ta non-invasive urothelial carcinoma, 35 T2 invasive urothelial carcinoma) and cystitis glandularis (25 cases). Methods and results TERT promoter mutations in inverted Papilloma, urothelial carcinoma with inverted growth, urothelial carcinoma and cystitis glandularis were found in 15% (four of 26), 58% (15 of 26), 63% (45 of 71) and 0% (none of 25), respectively. C228T mutations were the predominant mutations (97%) found in bladder tumours, while C250T aberrations occurred in approximately 3% of bladder tumours. In the inverted Papilloma group, TERT mutation occurred predominantly in female patients (P = 0.006). Among urothelial carcinomas, TERT promoter mutation status did not correlate with gender, histological grade or pathological stage. Conclusions TERT promoter mutations were found in 15% of inverted Papillomas. Our data suggest that there is a subpopulation of inverted Papilloma that shares a carcinogenetic pathway with urothelial carcinoma with inverted growth and conventional urothelial carcinomas. Caution is warranted in exploring TERT promoter mutation status as a screening or adjunct diagnostic test for bladder cancer.
Liang Cheng - One of the best experts on this subject based on the ideXlab platform.
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telomerase reverse transcriptase tert promoter mutation analysis of benign malignant and reactive urothelial lesions reveals a subpopulation of inverted Papilloma with immortalizing genetic change
Histopathology, 2016Co-Authors: Liang Cheng, Darrell D Davidson, Mingsheng Wang, Antonio Lopezbeltran, Rodolfo Montironi, Lisha Wang, Puay Hoon Tan, Gregory T Maclennan, Sean R Williamson, Shaobo ZhangAbstract:Aims To understand more clearly the genetic ontogeny of inverted Papilloma of urinary bladder, we analysed telomerase reverse transcriptase (TERT) promoter mutation status in a group of 26 inverted Papillomas in comparison with the mutation status of urothelial carcinoma with inverted growth (26 cases), conventional urothelial carcinoma (36 Ta non-invasive urothelial carcinoma, 35 T2 invasive urothelial carcinoma) and cystitis glandularis (25 cases). Methods and results TERT promoter mutations in inverted Papilloma, urothelial carcinoma with inverted growth, urothelial carcinoma and cystitis glandularis were found in 15% (four of 26), 58% (15 of 26), 63% (45 of 71) and 0% (none of 25), respectively. C228T mutations were the predominant mutations (97%) found in bladder tumours, while C250T aberrations occurred in approximately 3% of bladder tumours. In the inverted Papilloma group, TERT mutation occurred predominantly in female patients (P = 0.006). Among urothelial carcinomas, TERT promoter mutation status did not correlate with gender, histological grade or pathological stage. Conclusions TERT promoter mutations were found in 15% of inverted Papillomas. Our data suggest that there is a subpopulation of inverted Papilloma that shares a carcinogenetic pathway with urothelial carcinoma with inverted growth and conventional urothelial carcinomas. Caution is warranted in exploring TERT promoter mutation status as a screening or adjunct diagnostic test for bladder cancer.
Christian Von Buchwald - One of the best experts on this subject based on the ideXlab platform.
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Human Papillomavirus in normal conjunctival tissue and in conjunctival Papilloma: types and frequencies in a large series
British Journal of Ophthalmology, 2007Co-Authors: Nicolai Christian Sjö, Jan Ulrik Prause, Christian Von Buchwald, Patricia Cassonnet, Bodil Norrild, Troels Vinding, Steffen HeegaardAbstract:Aim: To examine conjunctival Papilloma and normal conjunctival tissue for the presence of human Papillomavirus (HPV). Methods: Archival paraffin wax-embedded tissue from 165 conjunctival Papillomas and from 20 histological normal conjunctival biopsy specimens was analysed for the presence of HPV by PCR. Specimens considered HPV positive using consensus primers, but with a negative or uncertain PCR result using type-specific HPV probes, were analysed with DNA sequencing. Results: HPV was present in 86 of 106 (81%) β-globin-positive Papillomas. HPV type 6 was positive in 80 cases, HPV type 11 was identified in 5 cases and HPV type 45 was present in a single Papilloma. All the 20 normal conjunctival biopsy specimens were β-globin positive and HPV negative. Conclusion: There is a strong association between HPV and conjunctival Papilloma. The study presents the largest material of conjunctival Papilloma investigated for HPV and the first investigation of HPV in normal conjunctival tissue. HPV types 6 and 11 are the most common HPV types in conjunctival Papilloma. This also is the first report of HPV type 45 in conjunctival Papilloma.
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Human Papillomavirus in conjunctival Papilloma
The British journal of ophthalmology, 2001Co-Authors: Nicolai Christian Sjö, Steffen Heegaard, Jan Ulrik Prause, Christian Von Buchwald, Henning LindebergAbstract:AIM—To examine conjunctival Papillomas for the presence of human Papillomavirus (HPV) and koilocytosis. METHODS—Archival paraffin embedded tissue from 55 conjunctival Papillomas was analysed for the presence of HPV by polymerase chain reaction and subsequent filter hybridisation. Histological sections of the 55 Papillomas were evaluated for the presence of koilocytosis. RESULTS—HPV was present in 48 of 52 (92%) β globin positive Papillomas. HPV type 6/11 were found in 40 of 47 investigated Papillomas and a double infection with HPV 6/11 and 16 was identified in a single Papilloma. In six Papillomas the HPV type could not be identified. Koilocytosis was present in 22 of 55 Papillomas (40%). CONCLUSION—There is a strong association between HPV and conjunctival Papillomas. HPV type 6/11 is the most common HPV type in conjunctival Papilloma. The sensitivity of koilocytosis as an indicator of HPV in conjunctival Papilloma is low.
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Carcinomas occurring in Papillomas of the nasal septum associated with human Papilloma virus (HPV).
Rhinology, 1997Co-Authors: Christian Von Buchwald, Maria-benedicte Franzmann, Grete Krag Jacobsen, Birgitte Ravn Juhl, Henning LindebergAbstract:Carcinomas arising in pre-existing sinonasal Papillomas of the nasal septum are rare. To our knowledge only one case has been reported. We report two cases of carcinomas occurring in septal Papillomas. In the first case a carcinoma developed in an exophytic Papilloma 16 years after the first operation for a Papilloma. In the second case a carcinoma was present at the first presentation within an inverted Papilloma, and a metastasis had also developed. In the first case HPV type 6/11 was demonstrated by in-situ hybridisation and PCR in the original Papilloma as well as in the recurrent Papilloma and in the carcinoma. In the second case HPV type 18 was found in the nasal lesion as well as in the metastasis. All samples were examined for Epstein-Barr virus (EBV) by PCR, but with negative results. We believe that case one is the first reported case of carcinomatous transformation within an exophytic septal Papilloma.
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An expansive Papilloma of the nasolachrymal drainage system harbouring human Papilloma virus.
Rhinology, 1996Co-Authors: Christian Von Buchwald, V. Skoedt, Mirko TosAbstract:We report a case of an expansive tumour extending from the lachrymal sac into the adjacent maxillary sinus. Histology showed a benign exophytic Papilloma. By means of the in situ (DNA) hybridization technique, human Papilloma virus (HPV) 6/11 were demonstrated, indicating a viral aetiology, similar to exophytic Papillomas of the nose and larynx.
Darrell D Davidson - One of the best experts on this subject based on the ideXlab platform.
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telomerase reverse transcriptase tert promoter mutation analysis of benign malignant and reactive urothelial lesions reveals a subpopulation of inverted Papilloma with immortalizing genetic change
Histopathology, 2016Co-Authors: Liang Cheng, Darrell D Davidson, Mingsheng Wang, Antonio Lopezbeltran, Rodolfo Montironi, Lisha Wang, Puay Hoon Tan, Gregory T Maclennan, Sean R Williamson, Shaobo ZhangAbstract:Aims To understand more clearly the genetic ontogeny of inverted Papilloma of urinary bladder, we analysed telomerase reverse transcriptase (TERT) promoter mutation status in a group of 26 inverted Papillomas in comparison with the mutation status of urothelial carcinoma with inverted growth (26 cases), conventional urothelial carcinoma (36 Ta non-invasive urothelial carcinoma, 35 T2 invasive urothelial carcinoma) and cystitis glandularis (25 cases). Methods and results TERT promoter mutations in inverted Papilloma, urothelial carcinoma with inverted growth, urothelial carcinoma and cystitis glandularis were found in 15% (four of 26), 58% (15 of 26), 63% (45 of 71) and 0% (none of 25), respectively. C228T mutations were the predominant mutations (97%) found in bladder tumours, while C250T aberrations occurred in approximately 3% of bladder tumours. In the inverted Papilloma group, TERT mutation occurred predominantly in female patients (P = 0.006). Among urothelial carcinomas, TERT promoter mutation status did not correlate with gender, histological grade or pathological stage. Conclusions TERT promoter mutations were found in 15% of inverted Papillomas. Our data suggest that there is a subpopulation of inverted Papilloma that shares a carcinogenetic pathway with urothelial carcinoma with inverted growth and conventional urothelial carcinomas. Caution is warranted in exploring TERT promoter mutation status as a screening or adjunct diagnostic test for bladder cancer.
Puay Hoon Tan - One of the best experts on this subject based on the ideXlab platform.
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telomerase reverse transcriptase tert promoter mutation analysis of benign malignant and reactive urothelial lesions reveals a subpopulation of inverted Papilloma with immortalizing genetic change
Histopathology, 2016Co-Authors: Liang Cheng, Darrell D Davidson, Mingsheng Wang, Antonio Lopezbeltran, Rodolfo Montironi, Lisha Wang, Puay Hoon Tan, Gregory T Maclennan, Sean R Williamson, Shaobo ZhangAbstract:Aims To understand more clearly the genetic ontogeny of inverted Papilloma of urinary bladder, we analysed telomerase reverse transcriptase (TERT) promoter mutation status in a group of 26 inverted Papillomas in comparison with the mutation status of urothelial carcinoma with inverted growth (26 cases), conventional urothelial carcinoma (36 Ta non-invasive urothelial carcinoma, 35 T2 invasive urothelial carcinoma) and cystitis glandularis (25 cases). Methods and results TERT promoter mutations in inverted Papilloma, urothelial carcinoma with inverted growth, urothelial carcinoma and cystitis glandularis were found in 15% (four of 26), 58% (15 of 26), 63% (45 of 71) and 0% (none of 25), respectively. C228T mutations were the predominant mutations (97%) found in bladder tumours, while C250T aberrations occurred in approximately 3% of bladder tumours. In the inverted Papilloma group, TERT mutation occurred predominantly in female patients (P = 0.006). Among urothelial carcinomas, TERT promoter mutation status did not correlate with gender, histological grade or pathological stage. Conclusions TERT promoter mutations were found in 15% of inverted Papillomas. Our data suggest that there is a subpopulation of inverted Papilloma that shares a carcinogenetic pathway with urothelial carcinoma with inverted growth and conventional urothelial carcinomas. Caution is warranted in exploring TERT promoter mutation status as a screening or adjunct diagnostic test for bladder cancer.
