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Si Yeol Song - One of the best experts on this subject based on the ideXlab platform.

  • A dosimetric comparison of volumetric modulated arc therapy (VMAT) and non-coplanar intensity modulated radiotherapy (IMRT) for nasal cavity and Paranasal Sinus Cancer.
    Radiation Oncology, 2014
    Co-Authors: Yuri Jeong, Jungwon Kwak, Sang Min Yoon, Jin-hong Park, Eun Kyung Choi, Si Yeol Song
    Abstract:

    Background To compare dosimetric parameters of volumetric modulated arc therapy (VMAT) and non-coplanar intensity modulated radiotherapy (IMRT) for nasal cavity and Paranasal Sinus Cancer with regard to the coverage of planning target volume (PTV) and the sparing of organs at risk (OAR).

  • a dosimetric comparison of volumetric modulated arc therapy vmat and non coplanar intensity modulated radiotherapy imrt for nasal cavity and Paranasal Sinus Cancer
    Radiation Oncology, 2014
    Co-Authors: Yuri Jeong, Jungwon Kwak, Sang Min Yoon, Jin-hong Park, Eun Kyung Choi, Si Yeol Song
    Abstract:

    To compare dosimetric parameters of volumetric modulated arc therapy (VMAT) and non-coplanar intensity modulated radiotherapy (IMRT) for nasal cavity and Paranasal Sinus Cancer with regard to the coverage of planning target volume (PTV) and the sparing of organs at risk (OAR). Ten patients with nasal cavity or Paranasal Sinus Cancer were re-planned by VMAT (two-arc) plan and non-coplanar IMRT (7-, 11-, and 15-beam) plans. Planning objectives were to deliver 60 Gy in 30 fractions to 95% of PTV, with maximum doses (Dmax) of <50 Gy to the optic nerves, optic chiasm, and brainstem, <40 Gy to the eyes and <10 Gy to the lenses. The target mean dose (Dmean) to the parotid glands was <25 Gy, and no constraints were applied to the lacrimal glands. Planning was optimized to minimized doses to OAR without compromising coverage of the PTV. VMAT and three non-coplanar IMRT (7-, 11-, and 15-beam) plans were compared using the heterogeneity and conformity indices (HI and CI) of the PTV, Dmax and Dmean of the OAR, treatment delivery time, and monitor units (MUs). The HI and CI of VMAT plan were superior to those of the 7-, 11-, and 15-beam non-coplanar IMRT. VMAT and non-coplanar IMRT (7-, 11-, and 15-beam) showed equivalent sparing effects for the optic nerves, optic chiasm, brainstem, and parotid glands. For the eyes and lenses, VMAT achieved equivalent or better sparing effects when compared with the non-coplanar IMRT plans. VMAT showed lower MUs and reduced treatment delivery time when compared with non-coplanar IMRT. In 10 patients with nasal cavity or Paranasal Sinus Cancer, a VMAT plan provided better homogeneity and conformity for PTV than non-coplanar IMRT plans, with a shorter treatment delivery time, while achieving equal or better OAR-sparing effects and using fewer MUs.

Paolo Castelnuovo - One of the best experts on this subject based on the ideXlab platform.

  • prognostic value of pretreatment peripheral blood markers in Paranasal Sinus Cancer neutrophil to lymphocyte and platelet to lymphocyte ratio
    Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2017
    Co-Authors: Mario Turrizanoni, Giovanni Salzano, Alessia Lambertoni, Marta Giovannardi, Apostolos Karligkiotis, Paolo Battaglia, Paolo Castelnuovo
    Abstract:

    Background Pretreatment hematological markers have emerged as prognostic factors for several Cancers. The purpose of this study was to present our investigation of the value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting recurrence and mortality for patients with primary sinonasal Cancers (SNCs). Methods We carried out a retrospective review of patients with SNC who had been treated using endoscopic approaches from 2002 to 2014 at a single institute. The endpoints analyzed were overall survival (OS) and disease-free survival (DFS). Results Of 365 patients treated, 215 fulfilled the inclusion criteria. Analysis of epithelial tumors (adenocarcinoma and carcinoma) and advanced-stage Cancers (pT3–T4) showed shorter OS and DFS in those patients with higher NLR and PLR. Furthermore, the NLR and PLR were revealed as independent prognostic factors for DFS, with a reduced risk of recurrence in patients with NLR <2.6 (hazard ratio [HR], 0.39; p = .02) and PLR <156.9 (HR, 0.34; p = .001). Conclusion High pretreatment NLR and PLR are associated with poor prognosis in patients affected by epithelial advanced-stage SNC. © 2016 Wiley Periodicals, Inc. Head Neck, 2016

  • Prognostic value of pretreatment peripheral blood markers in Paranasal Sinus Cancer: Neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratio
    Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2016
    Co-Authors: Mario Turri-zanoni, Giovanni Salzano, Alessia Lambertoni, Marta Giovannardi, Apostolos Karligkiotis, Paolo Battaglia, Paolo Castelnuovo
    Abstract:

    Background Pretreatment hematological markers have emerged as prognostic factors for several Cancers. The purpose of this study was to present our investigation of the value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting recurrence and mortality for patients with primary sinonasal Cancers (SNCs). Methods We carried out a retrospective review of patients with SNC who had been treated using endoscopic approaches from 2002 to 2014 at a single institute. The endpoints analyzed were overall survival (OS) and disease-free survival (DFS). Results Of 365 patients treated, 215 fulfilled the inclusion criteria. Analysis of epithelial tumors (adenocarcinoma and carcinoma) and advanced-stage Cancers (pT3–T4) showed shorter OS and DFS in those patients with higher NLR and PLR. Furthermore, the NLR and PLR were revealed as independent prognostic factors for DFS, with a reduced risk of recurrence in patients with NLR

Yuri Jeong - One of the best experts on this subject based on the ideXlab platform.

  • A dosimetric comparison of volumetric modulated arc therapy (VMAT) and non-coplanar intensity modulated radiotherapy (IMRT) for nasal cavity and Paranasal Sinus Cancer.
    Radiation Oncology, 2014
    Co-Authors: Yuri Jeong, Jungwon Kwak, Sang Min Yoon, Jin-hong Park, Eun Kyung Choi, Si Yeol Song
    Abstract:

    Background To compare dosimetric parameters of volumetric modulated arc therapy (VMAT) and non-coplanar intensity modulated radiotherapy (IMRT) for nasal cavity and Paranasal Sinus Cancer with regard to the coverage of planning target volume (PTV) and the sparing of organs at risk (OAR).

  • a dosimetric comparison of volumetric modulated arc therapy vmat and non coplanar intensity modulated radiotherapy imrt for nasal cavity and Paranasal Sinus Cancer
    Radiation Oncology, 2014
    Co-Authors: Yuri Jeong, Jungwon Kwak, Sang Min Yoon, Jin-hong Park, Eun Kyung Choi, Si Yeol Song
    Abstract:

    To compare dosimetric parameters of volumetric modulated arc therapy (VMAT) and non-coplanar intensity modulated radiotherapy (IMRT) for nasal cavity and Paranasal Sinus Cancer with regard to the coverage of planning target volume (PTV) and the sparing of organs at risk (OAR). Ten patients with nasal cavity or Paranasal Sinus Cancer were re-planned by VMAT (two-arc) plan and non-coplanar IMRT (7-, 11-, and 15-beam) plans. Planning objectives were to deliver 60 Gy in 30 fractions to 95% of PTV, with maximum doses (Dmax) of <50 Gy to the optic nerves, optic chiasm, and brainstem, <40 Gy to the eyes and <10 Gy to the lenses. The target mean dose (Dmean) to the parotid glands was <25 Gy, and no constraints were applied to the lacrimal glands. Planning was optimized to minimized doses to OAR without compromising coverage of the PTV. VMAT and three non-coplanar IMRT (7-, 11-, and 15-beam) plans were compared using the heterogeneity and conformity indices (HI and CI) of the PTV, Dmax and Dmean of the OAR, treatment delivery time, and monitor units (MUs). The HI and CI of VMAT plan were superior to those of the 7-, 11-, and 15-beam non-coplanar IMRT. VMAT and non-coplanar IMRT (7-, 11-, and 15-beam) showed equivalent sparing effects for the optic nerves, optic chiasm, brainstem, and parotid glands. For the eyes and lenses, VMAT achieved equivalent or better sparing effects when compared with the non-coplanar IMRT plans. VMAT showed lower MUs and reduced treatment delivery time when compared with non-coplanar IMRT. In 10 patients with nasal cavity or Paranasal Sinus Cancer, a VMAT plan provided better homogeneity and conformity for PTV than non-coplanar IMRT plans, with a shorter treatment delivery time, while achieving equal or better OAR-sparing effects and using fewer MUs.

Allan F Thornton - One of the best experts on this subject based on the ideXlab platform.

  • acute ocular toxicity and long term visual outcome of primary and adjuvant hyperfractionated accelerated radiation therapy of advanced Paranasal Sinus Cancer employing proton irradiation
    International Journal of Radiation Oncology Biology Physics, 2002
    Co-Authors: Damien C Weber, J F Mcintyre, Simmons Lessell, Saveli Goldberg, Marc R Bussiere, Allan F Thornton
    Abstract:

    Materials/Methods: Between 1991 and 2001, HART (4 MeV photons and 160 MeV protons) was used to treat 35 pts with advanced stage primary (n 32) or recurrent (n 3) malignant tumors of the Paranasal Sinuses for whom full neuroophtalmologic follow-up was obtained. Median age was 52 years (range, 18.5-74.4). Ten (29%) unresectable patients were treated with primary and 25 (71%) with adjuvant radiation therapy, respectively. Chemotherapy (CT) was administered to 13 (37%) patients, however, none received concurrent CT. Prospectively specified neuro-ophtalmologic follow-up consisted of pupillary examination, exophtalmometry, color vision and ocular pressure measurements, motility testing, as well as dilated fundus exam and Goldmann visual field. The median dose to the macroscopic gross tumor volume (GTV) was 69.6 CGE (range, 60-76.6 CGE, CGE proton Gy 1.1 RBE). Optical apparatus dose constraint was 2 CGE/day and 56 CGE total dose, respectively. If clinically indicated, the treating physician had the option to relax the optical dose constraints. Median GTV and clinical tumor volume were 90 cc (range, 5.4-318) and 251 cc (range, 40.9-636), respectively. Lens and retinal late complications were graded according to objective portion of the SOMA scale of the Late Effects of Normal Tissue (LENT) Scoring system. Other late ocular/visual symptoms were classified according to the NCI Common Toxicity Criteria (CTC) grading system. Disease-free Survival (DFS) and visual complication free survival (CFS) rate were calculated using KaplanMeier method. The studied risk factors for late visual complications included dose, gender, age, acute ocular toxicity, GTV volume, adjuvant chemotherapy and follow-up length. Statistical analysis was performed on SAS 8.1 software, using adequate methods including Student T-test and Log rank analysis. The median follow-up was 37.6 months (range, 4.4-122.8).

  • Acute ocular toxicity and long-term visual outcome of primary and adjuvant hyperfractionated/accelerated radiation therapy of advanced Paranasal Sinus Cancer employing proton irradiation
    International Journal of Radiation Oncology Biology Physics, 2002
    Co-Authors: Damien C Weber, J F Mcintyre, Simmons Lessell, Saveli Goldberg, Marc R Bussiere, Allan F Thornton
    Abstract:

    Materials/Methods: Between 1991 and 2001, HART (4 MeV photons and 160 MeV protons) was used to treat 35 pts with advanced stage primary (n 32) or recurrent (n 3) malignant tumors of the Paranasal Sinuses for whom full neuroophtalmologic follow-up was obtained. Median age was 52 years (range, 18.5-74.4). Ten (29%) unresectable patients were treated with primary and 25 (71%) with adjuvant radiation therapy, respectively. Chemotherapy (CT) was administered to 13 (37%) patients, however, none received concurrent CT. Prospectively specified neuro-ophtalmologic follow-up consisted of pupillary examination, exophtalmometry, color vision and ocular pressure measurements, motility testing, as well as dilated fundus exam and Goldmann visual field. The median dose to the macroscopic gross tumor volume (GTV) was 69.6 CGE (range, 60-76.6 CGE, CGE proton Gy 1.1 RBE). Optical apparatus dose constraint was 2 CGE/day and 56 CGE total dose, respectively. If clinically indicated, the treating physician had the option to relax the optical dose constraints. Median GTV and clinical tumor volume were 90 cc (range, 5.4-318) and 251 cc (range, 40.9-636), respectively. Lens and retinal late complications were graded according to objective portion of the SOMA scale of the Late Effects of Normal Tissue (LENT) Scoring system. Other late ocular/visual symptoms were classified according to the NCI Common Toxicity Criteria (CTC) grading system. Disease-free Survival (DFS) and visual complication free survival (CFS) rate were calculated using KaplanMeier method. The studied risk factors for late visual complications included dose, gender, age, acute ocular toxicity, GTV volume, adjuvant chemotherapy and follow-up length. Statistical analysis was performed on SAS 8.1 software, using adequate methods including Student T-test and Log rank analysis. The median follow-up was 37.6 months (range, 4.4-122.8).

Mario Turrizanoni - One of the best experts on this subject based on the ideXlab platform.

  • prognostic value of pretreatment peripheral blood markers in Paranasal Sinus Cancer neutrophil to lymphocyte and platelet to lymphocyte ratio
    Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2017
    Co-Authors: Mario Turrizanoni, Giovanni Salzano, Alessia Lambertoni, Marta Giovannardi, Apostolos Karligkiotis, Paolo Battaglia, Paolo Castelnuovo
    Abstract:

    Background Pretreatment hematological markers have emerged as prognostic factors for several Cancers. The purpose of this study was to present our investigation of the value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting recurrence and mortality for patients with primary sinonasal Cancers (SNCs). Methods We carried out a retrospective review of patients with SNC who had been treated using endoscopic approaches from 2002 to 2014 at a single institute. The endpoints analyzed were overall survival (OS) and disease-free survival (DFS). Results Of 365 patients treated, 215 fulfilled the inclusion criteria. Analysis of epithelial tumors (adenocarcinoma and carcinoma) and advanced-stage Cancers (pT3–T4) showed shorter OS and DFS in those patients with higher NLR and PLR. Furthermore, the NLR and PLR were revealed as independent prognostic factors for DFS, with a reduced risk of recurrence in patients with NLR <2.6 (hazard ratio [HR], 0.39; p = .02) and PLR <156.9 (HR, 0.34; p = .001). Conclusion High pretreatment NLR and PLR are associated with poor prognosis in patients affected by epithelial advanced-stage SNC. © 2016 Wiley Periodicals, Inc. Head Neck, 2016