The Experts below are selected from a list of 12222 Experts worldwide ranked by ideXlab platform
Jacob Rajfer - One of the best experts on this subject based on the ideXlab platform.
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Paraneoplastic Syndromes in urologic malignancy: the many faces of renal cell carcinoma.
Reviews in urology, 2002Co-Authors: Ganesh S. Palapattu, Blaine Kristo, Jacob RajferAbstract:Renal cell carcinoma is unique among the genitourinary malignancies in that close to one third of affected patients show signs and symptoms of a Paraneoplastic Syndrome. The Paraneoplastic Syndromes associated with renal cell carcinoma range from those manifesting in constitutional symptoms (ie, fever, cachexia, and weight loss) to those that result in specific metabolic and biochemical abnormalities (ie, hypercalcemia, nonmetastatic hepatic dysfunction, amyloidosis, etc). The presence of a Paraneoplastic Syndrome in a patient with renal cell carcinoma is neither a marker of metastatic disease nor necessarily indicative of a poor prognosis. The importance of understanding the pathophysiology and biology behind the many Paraneoplastic Syndromes associated with renal cell carcinoma lies in the fact that the presence of these protean symptoms may be the initial presentation of either primary or recurrent disease. In this review, we will describe the proposed mechanisms of action of the many Paraneoplastic Syndromes associated with renal cell carcinoma as well as outline the clinical evaluation and treatment options currently available for these noteworthy disorders.
Ganesh S. Palapattu - One of the best experts on this subject based on the ideXlab platform.
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Paraneoplastic Syndromes in urologic malignancy: the many faces of renal cell carcinoma.
Reviews in urology, 2002Co-Authors: Ganesh S. Palapattu, Blaine Kristo, Jacob RajferAbstract:Renal cell carcinoma is unique among the genitourinary malignancies in that close to one third of affected patients show signs and symptoms of a Paraneoplastic Syndrome. The Paraneoplastic Syndromes associated with renal cell carcinoma range from those manifesting in constitutional symptoms (ie, fever, cachexia, and weight loss) to those that result in specific metabolic and biochemical abnormalities (ie, hypercalcemia, nonmetastatic hepatic dysfunction, amyloidosis, etc). The presence of a Paraneoplastic Syndrome in a patient with renal cell carcinoma is neither a marker of metastatic disease nor necessarily indicative of a poor prognosis. The importance of understanding the pathophysiology and biology behind the many Paraneoplastic Syndromes associated with renal cell carcinoma lies in the fact that the presence of these protean symptoms may be the initial presentation of either primary or recurrent disease. In this review, we will describe the proposed mechanisms of action of the many Paraneoplastic Syndromes associated with renal cell carcinoma as well as outline the clinical evaluation and treatment options currently available for these noteworthy disorders.
Roland C K Ng - One of the best experts on this subject based on the ideXlab platform.
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dual Paraneoplastic Syndromes small cell lung carcinoma related oncogenic osteomalacia and Syndrome of inappropriate antidiuretic hormone secretion report of a case and review of the literature
Hawaii medical journal, 2011Co-Authors: Ekamol Tantisattamo, Roland C K NgAbstract:Acquired isolated renal phosphate wasting associated with a tumor, known as oncogenic osteomalacia or tumor-induced osteomalacia, is a rare Paraneoplastic Syndrome caused by overproduction of fibroblast growth factor 23. Oncogenic osteomalacia is usually associated with benign mesenchymal tumors. Syndrome of inappropriate antidiuretic hormone secretion (SIADH), on the other hand, is a common Paraneoplastic Syndrome caused by small cell carcinoma (SCC). Concomitant oncogenic osteomalacia and SIADH associated with SCC is very rare with only 4 other cases reported in the literature. The authors report a case of small cell lung cancer (SCLC)-related renal wasting hypophosphatemia and concurrent SIADH, and review the literature reporting 9 other cases of SCC associated with oncogenic osteomalacia. Almost half of reported cases of renal phosphate wasting associated with SCC concomitantly presented with SIADH. These cases had initial serum phosphorus level lower and survival periods shorter than those without SIADH. This rare combination of a dual Paraneoplastic Syndrome and low serum phosphorus may be a poor prognostic sign. In addition, both renal phosphate wasting and SIADH usually occur in a short period of time before identification of SCC. Therefore, renal wasting hypophosphatemia with concomitant SIADH/hyponatremia should prompt a search for SCC rather than a benign mesenchymal tumor.
Qihua Yi - One of the best experts on this subject based on the ideXlab platform.
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A broad ligament solitary fibrous tumor with Doege–Potter Syndrome
Medicine, 2018Co-Authors: Sijing Chen, Ying Zheng, Lin Chen, Qihua YiAbstract:Introduction Solitary fibrous tumors (SFTs) are uncommon mesenchymal neoplasms and are particularly rare in the female genital tract. Doege–Potter Syndrome is a Paraneoplastic Syndrome involving SFT-associated hypoglycemia. We report, for the first time, on a broad ligament SFT with Doege–Potter Syndrome; additionally, we review 30 cases of women with SFTs reported in the literature.
Carter Van Waes - One of the best experts on this subject based on the ideXlab platform.
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dermatomyositis Paraneoplastic Syndrome before symptomatic tonsillar squamous cell carcinoma a case report
Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2015Co-Authors: Ahmad Adi, Hani J Alturkmani, Todd Spock, Patrice Williams Yohannes, Susannah Wargo, Eva Szabo, Silvio J Gutkind, Carter Van WaesAbstract:Background Paraneoplastic Syndromes are systemic or organ-related functional tumor-associated changes that arise distant to the tumor. Methods and Results We present a rare case of a 63-year-old man with dermatomyositis as a Paraneoplastic Syndrome developing more than a year before clinical manifestations of tonsillar squamous cell carcinoma (SCC). He subsequently developed stage T1N2bM0 IVA tonsillar SCC. He was treated on a research protocol with 3 weeks of neoadjuvant rapamycin therapy before right transoral lateral pharyngectomy and modified radical neck dissection with preservation of CN XI. His symptoms of dermatomyositis subsequently improved and he was weaned off immunosuppressive therapy. Conclusion To our knowledge, this is the first report of dermatomyositis as a Paraneoplastic Syndrome of tonsillar SCC in North America. We suggest that clinicians should monitor for signs of persistent or recurrent dermatomyositis symptoms as this may herald development or a return of the underlying malignancy. © 2014 Wiley Periodicals, Inc. Head Neck 37: E1–E3, 2015
