The Experts below are selected from a list of 690 Experts worldwide ranked by ideXlab platform
Biagio Guarneri - One of the best experts on this subject based on the ideXlab platform.
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subcorneal pustular dermatosis and iga myeloma a uncommon association but probably not coincidental
European Journal of Dermatology, 1999Co-Authors: Mario Vaccaro, Serafinella P. Cannavò, Biagio GuarneriAbstract:Subcorneal pustular dermatosis (SCPD) is a rare chronic neutrophilic dermatosis, sometimes associated with benign or malignant IgA Paraproteinemia, usually seen in middle-aged females [1-3]. It appears as superficial pustules, that may coalesce to form circinate or polycyclic patterns, mainly located on the trunk and in intertriginous areas. Histologically it is characterised by a subcorneal accumulation of neutrophilic polymorphonuclear [...]
Clive B. Archer - One of the best experts on this subject based on the ideXlab platform.
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Erythema elevatum diutinum associated with Wegener's granulomatosis and IgA Paraproteinemia
Journal of the American Academy of Dermatology, 1993Co-Authors: Gina M. Kavanagh, C. Bernard Colaco, John W. Bradfield, Clive B. ArcherAbstract:A 69-year-old man had erythema elevatum diutinum for several years before he developed IgA Paraproteinemia and a limited form of Wegener's granulomatosis. This is the first report of an association between erythema elevatum diutinum and Wegener's granulomatosis. IgA Paraproteinemia has been reported in association with erythema elevatum diutinum but not with Wegener's granulomatosis.
Keiya Ozawa - One of the best experts on this subject based on the ideXlab platform.
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Paraproteinemia after hematopoietic stem cell transplantation
Leukemia & Lymphoma, 2004Co-Authors: Takahiro Nagashima, Kazuo Muroi, Chizuru Kawanoyamamoto, Norio Komatsu, Keiya OzawaAbstract:The frequency and clinical significance of Paraproteinemia in patients receiving hematopoietic stem cell (HSC) transplants were assessed. Of 66 patients with hematologic malignancies, excluding multiple myeloma who received an allogeneic or autologous HSC transplant, paraproteins were detected in 12 patients using immunoelectrophoresis. None of the patients showed Paraproteinemia before HSC transplantation. The class of paraproteins most commonly seen was IgG. In 9 of these 12 patients (75%), a paraprotein was detected continuously after HSC transplantation for an average duration of 464 days, while others demonstrated a transient appearance of the protein. Paraproteinemia after HSC transplantation was not related to the stem cell source, (allograft vs. autograft), age, gender, viral infection and graft-vs.-host disease (GVHD). None of the patients developed plasma cell dyscrasia after the appearance of the paraprotein, while 1 patient developed secondary acute lymphoblastic leukemia. These findings indicate that Paraproteinemia after HSC transplantation may be caused by an aberrant immune reconstitution after both allogeneic and autologous HSC transplantation. A long-term follow-up of patients with Paraproteinemia after HSC transplantation is needed to confirm this finding in a larger series of patients.
R. C. Ongley - One of the best experts on this subject based on the ideXlab platform.
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Erythema elevatum diutinum associated with IgA Paraproteinemia successfully controlled with intermittent plasma exchange
Archives of dermatology, 1996Co-Authors: R. K. P. Chow, W. B. Benny, R. L. Coupe, W. A. Dodd, R. C. OngleyAbstract:Background: We review the literature and report a case of refractory erythema elevatum diutinum associated with IgA Paraproteinemia that was successfully controlled with intermittent plasma exchange (PLEX). Observations: Typical lesions of erythema elevatum diutinum developed in a 72-year-old patient with IgA Paraproteinemia; the condition predictably flared whenever IgA levels reached a threshold of 8 g/L. After 8 years of unsuccessful treatment with various agents, we instituted a trial of PLEX during an acute flare. Following 6 exchanges over a period of 2 weeks, the IgA level decreased from 8 to 2 g/L and the skin lesions cleared. Three weeks later, new skin lesions developed and the IgA level had rebounded from 2 to just over 8 g/L. A second course of PLEX was administered, with excellent results, and a 3-month course of oral chlorambucil (2 mg/d) was initiated. The patient's condition remained in clinical remission for 10 months. Over the ensuing 9 years, she suffered 11 further flares, each of which was associated with IgA levels of 8 to 10 g/L and each responding dramatically to 3 to 5 PLEXs followed by a consolidative dose of intravenous cyclophosphamide (250-500 mg). Conclusion: We believe that PLEX may have an important role in the management of severe erythema elevatum diutinum associated with monoclonal Paraproteinemia refractory to other therapy. Arch Dermatol. 1996;132:1360-1364
Mario Vaccaro - One of the best experts on this subject based on the ideXlab platform.
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subcorneal pustular dermatosis and iga myeloma a uncommon association but probably not coincidental
European Journal of Dermatology, 1999Co-Authors: Mario Vaccaro, Serafinella P. Cannavò, Biagio GuarneriAbstract:Subcorneal pustular dermatosis (SCPD) is a rare chronic neutrophilic dermatosis, sometimes associated with benign or malignant IgA Paraproteinemia, usually seen in middle-aged females [1-3]. It appears as superficial pustules, that may coalesce to form circinate or polycyclic patterns, mainly located on the trunk and in intertriginous areas. Histologically it is characterised by a subcorneal accumulation of neutrophilic polymorphonuclear [...]
