The Experts below are selected from a list of 2316 Experts worldwide ranked by ideXlab platform
Karl F. Hoffmann - One of the best experts on this subject based on the ideXlab platform.
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Parasite Genomics and post-genomic activities: 21st century resources for the Parasite immunologist.
Parasite Immunology, 2012Co-Authors: K. Brehm, Jane M. Carlton, Karl F. HoffmannAbstract:Brehm, K., Carlton, J. M., Hoffmann, K. F. (2012). Editorial: Parasite Genomics and post-genomic activities: 21st century resources for the Parasite immunologist. Parasite Immunology Special Edition, 34 (2-3), 47-49. Special Issue: Parasite Genomics and post-genomic activities: 21st century resources for the Parasite immunologist
Rosenzvit, Mara Cecilia - One of the best experts on this subject based on the ideXlab platform.
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Genome-wide identification of microRNA targets in the neglected disease pathogens of the genus Echinococcus
'Elsevier BV', 2017Co-Authors: Macchiaroli Natalia, Maldonado Lucas, Zarowiecki Magdalena, Cucher, Marcela Alejandra, Gismondi, Maria Ines, Kamenetzky Laura, Rosenzvit, Mara CeciliaAbstract:MicroRNAs (miRNAs), a class of small non-coding RNAs, are key regulators of gene expression at posttranscriptional level and play essential roles in biological processes such as development. MiRNAs silence target mRNAs by binding to complementary sequences in the 3′untranslated regions (3′UTRs). The parasitic helminths of the genus Echinococcus are the causative agents of echinococcosis, a zoonotic neglected disease. In previous work, we performed a comprehensive identification and characterization of Echinococcus miRNAs. However, current knowledge about their targets is limited. Since target prediction algorithms rely on complementarity between 3′UTRs and miRNA sequences, a major limitation is the lack of accurate sequence information of 3′UTR for most species including parasitic helminths. We performed RNA-seq and developed a pipeline that integrates the transcriptomic data with available genomic data of this Parasite in order to identify 3′UTRs of Echinococcus canadensis. The high confidence set of 3′UTRs obtained allowed the prediction of miRNA targets in Echinococcus through a bioinformatic approach. We performed for the first time a comparative analysis of miRNA targets in Echinococcus and Taenia. We found that many evolutionarily conserved target sites in Echinococcus and Taenia may be functional and under selective pressure. Signaling pathways such as MAPK and Wnt were among the most represented pathways indicating miRNA roles in Parasite growth and development. Genome-wide identification and characterization of miRNA target genes in Echinococcus provide valuable information to guide experimental studies in order to understand miRNA functions in the Parasites biology. miRNAs involved in essential functions, especially those being absent in the host or showing sequence divergence with respect to host orthologs, might be considered as novel therapeutic targets for echinococcosis control.Inst. de BiotecnologíaFil: Macchiaroli, Natalia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Maldonado, Lucas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Zarowiecki, Magdalena. Wellcome Trust Sanger Institute. Parasite Genomics Group; Reino UnidoFil: Cucher, Marcela Alejandra. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médicas; ArgentinaFil: Gismondi, Maria Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; ArgentinaFil: Rosenzvit, Mara Cecilia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médicas; Argentin
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Genome-wide identification of microRNA targets in the neglected disease pathogens of the genus Echinococcus
'Elsevier BV', 2017Co-Authors: Macchiaroli Natalia, Zarowiecki Magdalena, Cucher, Marcela Alejandra, Gismondi, Maria Ines, Kamenetzky Laura, Maldonado, Lucas Luciano, Rosenzvit, Mara CeciliaAbstract:MicroRNAs (miRNAs), a class of small non-coding RNAs, are key regulators of gene expression at post-transcriptional level and play essential roles in biological processes such as development. MiRNAs silence target mRNAs by binding to complementary sequences in the 3´untranslated regions (3´UTRs). The parasitic helminths of the genus Echinococcus are the causative agents of echinococcosis, a zoonotic neglected disease. In previous work, we performed a comprehensive identification and characterization of Echinococcus miRNAs. However, current knowledge about their targets is limited. Since target prediction algorithms rely on complementarity between 3´UTRs and miRNA sequences, a major limitation is the lack of accurate sequence information of 3´UTR for most species including parasitic helminths. We performed RNA-seq and developed a pipeline that integrates the transcriptomic data with available genomic data of this Parasite in order to identify 3´UTRs of E. canadensis. The high confidence set of 3´UTRs obtained allowed the prediction of miRNA targets in Echinococcus through a bioinformatic approach. We performed for the first time a comparative analysis of miRNA targets in Echinococcus and Taenia. We found that many evolutionarily conserved target sites in Echinococcus and Taenia may be functional and under selective pressure. Signaling pathways such as MAPK and Wnt were among the most represented pathways indicating miRNA roles in Parasite growth and development. Genome-wide identification and characterization of miRNA target genes in Echinococcus provide valuable information to guide experimental studies in order to understand miRNA functions in the Parasites biology. miRNAs involved in essential functions, especially those being absent in the host or showing sequence divergence with respect to host orthologs, might be considered as novel therapeutic targets for echinococcosis control.Fil: Macchiaroli, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Maldonado, Lucas Luciano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Zarowiecki, Magdalena. Parasite Genomics Group; Reino UnidoFil: Cucher, Marcela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Gismondi, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas; ArgentinaFil: Kamenetzky, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Rosenzvit, Mara Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentin
Dinorah Gambino - One of the best experts on this subject based on the ideXlab platform.
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metal based drugs for malaria trypanosomiasis and leishmaniasis recent achievements and perspectives
Drug Discovery Today, 2010Co-Authors: Maribel Navarro, Chiara Gabbiani, Luigi Messori, Dinorah GambinoAbstract:Tropical diseases today constitute a major health problem and a big challenge for drug discovery. Because of the limited arsenal of effective antiparasitic agents and the frequent appearance of chemoresistance, there is an urgent and continuous need to develop new drugs against these ailments. Metal compounds still offer excellent opportunities to find new 'leads' against the major protozoan diseases such as malaria, leishmaniasis and trypanosomiasis. A few metal-based drugs are already available in this therapeutic area, and others are currently being developed. Recent progress in Parasite Genomics and the identification of a few biomolecular targets hold great promise for the discovery of new 'mechanism-based' antiparasitic metallodrugs. The trends and perspectives for this exciting research field are outlined here.
K. Brehm - One of the best experts on this subject based on the ideXlab platform.
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Parasite Genomics and post-genomic activities: 21st century resources for the Parasite immunologist.
Parasite Immunology, 2012Co-Authors: K. Brehm, Jane M. Carlton, Karl F. HoffmannAbstract:Brehm, K., Carlton, J. M., Hoffmann, K. F. (2012). Editorial: Parasite Genomics and post-genomic activities: 21st century resources for the Parasite immunologist. Parasite Immunology Special Edition, 34 (2-3), 47-49. Special Issue: Parasite Genomics and post-genomic activities: 21st century resources for the Parasite immunologist
Macchiaroli Natalia - One of the best experts on this subject based on the ideXlab platform.
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Genome-wide identification of microRNA targets in the neglected disease pathogens of the genus Echinococcus
'Elsevier BV', 2017Co-Authors: Macchiaroli Natalia, Maldonado Lucas, Zarowiecki Magdalena, Cucher, Marcela Alejandra, Gismondi, Maria Ines, Kamenetzky Laura, Rosenzvit, Mara CeciliaAbstract:MicroRNAs (miRNAs), a class of small non-coding RNAs, are key regulators of gene expression at posttranscriptional level and play essential roles in biological processes such as development. MiRNAs silence target mRNAs by binding to complementary sequences in the 3′untranslated regions (3′UTRs). The parasitic helminths of the genus Echinococcus are the causative agents of echinococcosis, a zoonotic neglected disease. In previous work, we performed a comprehensive identification and characterization of Echinococcus miRNAs. However, current knowledge about their targets is limited. Since target prediction algorithms rely on complementarity between 3′UTRs and miRNA sequences, a major limitation is the lack of accurate sequence information of 3′UTR for most species including parasitic helminths. We performed RNA-seq and developed a pipeline that integrates the transcriptomic data with available genomic data of this Parasite in order to identify 3′UTRs of Echinococcus canadensis. The high confidence set of 3′UTRs obtained allowed the prediction of miRNA targets in Echinococcus through a bioinformatic approach. We performed for the first time a comparative analysis of miRNA targets in Echinococcus and Taenia. We found that many evolutionarily conserved target sites in Echinococcus and Taenia may be functional and under selective pressure. Signaling pathways such as MAPK and Wnt were among the most represented pathways indicating miRNA roles in Parasite growth and development. Genome-wide identification and characterization of miRNA target genes in Echinococcus provide valuable information to guide experimental studies in order to understand miRNA functions in the Parasites biology. miRNAs involved in essential functions, especially those being absent in the host or showing sequence divergence with respect to host orthologs, might be considered as novel therapeutic targets for echinococcosis control.Inst. de BiotecnologíaFil: Macchiaroli, Natalia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Maldonado, Lucas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Zarowiecki, Magdalena. Wellcome Trust Sanger Institute. Parasite Genomics Group; Reino UnidoFil: Cucher, Marcela Alejandra. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médicas; ArgentinaFil: Gismondi, Maria Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; ArgentinaFil: Rosenzvit, Mara Cecilia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médicas; Argentin
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Genome-wide identification of microRNA targets in the neglected disease pathogens of the genus Echinococcus
'Elsevier BV', 2017Co-Authors: Macchiaroli Natalia, Zarowiecki Magdalena, Cucher, Marcela Alejandra, Gismondi, Maria Ines, Kamenetzky Laura, Maldonado, Lucas Luciano, Rosenzvit, Mara CeciliaAbstract:MicroRNAs (miRNAs), a class of small non-coding RNAs, are key regulators of gene expression at post-transcriptional level and play essential roles in biological processes such as development. MiRNAs silence target mRNAs by binding to complementary sequences in the 3´untranslated regions (3´UTRs). The parasitic helminths of the genus Echinococcus are the causative agents of echinococcosis, a zoonotic neglected disease. In previous work, we performed a comprehensive identification and characterization of Echinococcus miRNAs. However, current knowledge about their targets is limited. Since target prediction algorithms rely on complementarity between 3´UTRs and miRNA sequences, a major limitation is the lack of accurate sequence information of 3´UTR for most species including parasitic helminths. We performed RNA-seq and developed a pipeline that integrates the transcriptomic data with available genomic data of this Parasite in order to identify 3´UTRs of E. canadensis. The high confidence set of 3´UTRs obtained allowed the prediction of miRNA targets in Echinococcus through a bioinformatic approach. We performed for the first time a comparative analysis of miRNA targets in Echinococcus and Taenia. We found that many evolutionarily conserved target sites in Echinococcus and Taenia may be functional and under selective pressure. Signaling pathways such as MAPK and Wnt were among the most represented pathways indicating miRNA roles in Parasite growth and development. Genome-wide identification and characterization of miRNA target genes in Echinococcus provide valuable information to guide experimental studies in order to understand miRNA functions in the Parasites biology. miRNAs involved in essential functions, especially those being absent in the host or showing sequence divergence with respect to host orthologs, might be considered as novel therapeutic targets for echinococcosis control.Fil: Macchiaroli, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Maldonado, Lucas Luciano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Zarowiecki, Magdalena. Parasite Genomics Group; Reino UnidoFil: Cucher, Marcela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Gismondi, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas; ArgentinaFil: Kamenetzky, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Rosenzvit, Mara Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentin
