Parasites

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Whitelaw, Jamie A. - One of the best experts on this subject based on the ideXlab platform.

  • Apicomplexan F‐actin is required for efficient nuclear entry during host cell invasion
    'EMBO', 2019
    Co-Authors: Rosario, Mario Del, Periz Javier, Pavlou Georgios, Lyth Oliver, Das Sujaan, Pall, Gurman S., Lemgruber Leandro, Latorre‐barragan Fernanda, Stortz, Johannes Felix, Whitelaw, Jamie A.
    Abstract:

    The obligate intracellular Parasites Toxoplasma gondii and Plasmodium spp. invade host cells by injecting a protein complex into the membrane of the targeted cell that bridges the two cells through the assembly of a ring‐like junction. This circular junction stretches while the Parasites apply a traction force to pass through, a step that typically concurs with transient constriction of the parasite body. Here we analyse F‐actin dynamics during host cell invasion. Super‐resolution microscopy and real‐time imaging highlighted an F‐actin pool at the apex of pre‐invading parasite, an F‐actin ring at the junction area during invasion but also networks of perinuclear and posteriorly localised F‐actin. Mutant Parasites with dysfunctional acto‐myosin showed significant decrease of junctional and perinuclear F‐actin and are coincidently affected in nuclear passage through the junction. We propose that the F‐actin machinery eases nuclear passage by stabilising the junction and pushing the nucleus through the constriction. Our analysis suggests that the junction opposes resistance to the passage of the parasite's nucleus and provides the first evidence for a dual contribution of actin‐forces during host cell invasion by apicomplexan Parasites

Whitelaw Jamie - One of the best experts on this subject based on the ideXlab platform.

  • Apicomplexan F-actin is required for efficient nuclear entry during host cell invasion
    'EMBO', 2019
    Co-Authors: Del Rosario Mario, Periz Javier, Pavlou Georgios, Lyth Oliver, Latorre-barragan Fernanda, Das Sujaan, Pall, Gurman S., Stortz Johannes, Lemgruber Leandro, Whitelaw Jamie
    Abstract:

    The obligate intracellular Parasites Toxoplasma gondii and Plasmodium spp. invade host cells by injecting a protein complex into the membrane of the targeted cell that bridges the two cells through the assembly of a ring‐like junction. This circular junction stretches while the Parasites apply a traction force to pass through, a step that typically concurs with transient constriction of the parasite body. Here we analyse F‐actin dynamics during host cell invasion. Super‐resolution microscopy and real‐time imaging highlighted an F‐actin pool at the apex of pre‐invading parasite, an F‐actin ring at the junction area during invasion but also networks of perinuclear and posteriorly localised F‐actin. Mutant Parasites with dysfunctional acto‐myosin showed significant decrease of junctional and perinuclear F‐actin and are coincidently affected in nuclear passage through the junction. We propose that the F‐actin machinery eases nuclear passage by stabilising the junction and pushing the nucleus through the constriction. Our analysis suggests that the junction opposes resistance to the passage of the parasite's nucleus and provides the first evidence for a dual contribution of actin‐forces during host cell invasion by apicomplexan Parasites

Lyth Oliver - One of the best experts on this subject based on the ideXlab platform.

  • Apicomplexan F-actin is required for efficient nuclear entry during host cell invasion
    'EMBO', 2019
    Co-Authors: Del Rosario Mario, Periz Javier, Pavlou Georgios, Lyth Oliver, Latorre-barragan Fernanda, Das Sujaan, Pall, Gurman S., Stortz Johannes, Lemgruber Leandro, Whitelaw Jamie
    Abstract:

    The obligate intracellular Parasites Toxoplasma gondii and Plasmodium spp. invade host cells by injecting a protein complex into the membrane of the targeted cell that bridges the two cells through the assembly of a ring‐like junction. This circular junction stretches while the Parasites apply a traction force to pass through, a step that typically concurs with transient constriction of the parasite body. Here we analyse F‐actin dynamics during host cell invasion. Super‐resolution microscopy and real‐time imaging highlighted an F‐actin pool at the apex of pre‐invading parasite, an F‐actin ring at the junction area during invasion but also networks of perinuclear and posteriorly localised F‐actin. Mutant Parasites with dysfunctional acto‐myosin showed significant decrease of junctional and perinuclear F‐actin and are coincidently affected in nuclear passage through the junction. We propose that the F‐actin machinery eases nuclear passage by stabilising the junction and pushing the nucleus through the constriction. Our analysis suggests that the junction opposes resistance to the passage of the parasite's nucleus and provides the first evidence for a dual contribution of actin‐forces during host cell invasion by apicomplexan Parasites

  • Apicomplexan F‐actin is required for efficient nuclear entry during host cell invasion
    'EMBO', 2019
    Co-Authors: Rosario, Mario Del, Periz Javier, Pavlou Georgios, Lyth Oliver, Das Sujaan, Pall, Gurman S., Lemgruber Leandro, Latorre‐barragan Fernanda, Stortz, Johannes Felix, Whitelaw, Jamie A.
    Abstract:

    The obligate intracellular Parasites Toxoplasma gondii and Plasmodium spp. invade host cells by injecting a protein complex into the membrane of the targeted cell that bridges the two cells through the assembly of a ring‐like junction. This circular junction stretches while the Parasites apply a traction force to pass through, a step that typically concurs with transient constriction of the parasite body. Here we analyse F‐actin dynamics during host cell invasion. Super‐resolution microscopy and real‐time imaging highlighted an F‐actin pool at the apex of pre‐invading parasite, an F‐actin ring at the junction area during invasion but also networks of perinuclear and posteriorly localised F‐actin. Mutant Parasites with dysfunctional acto‐myosin showed significant decrease of junctional and perinuclear F‐actin and are coincidently affected in nuclear passage through the junction. We propose that the F‐actin machinery eases nuclear passage by stabilising the junction and pushing the nucleus through the constriction. Our analysis suggests that the junction opposes resistance to the passage of the parasite's nucleus and provides the first evidence for a dual contribution of actin‐forces during host cell invasion by apicomplexan Parasites

Lemgruber Leandro - One of the best experts on this subject based on the ideXlab platform.

  • Apicomplexan F-actin is required for efficient nuclear entry during host cell invasion
    'EMBO', 2019
    Co-Authors: Del Rosario Mario, Periz Javier, Pavlou Georgios, Lyth Oliver, Latorre-barragan Fernanda, Das Sujaan, Pall, Gurman S., Stortz Johannes, Lemgruber Leandro, Whitelaw Jamie
    Abstract:

    The obligate intracellular Parasites Toxoplasma gondii and Plasmodium spp. invade host cells by injecting a protein complex into the membrane of the targeted cell that bridges the two cells through the assembly of a ring‐like junction. This circular junction stretches while the Parasites apply a traction force to pass through, a step that typically concurs with transient constriction of the parasite body. Here we analyse F‐actin dynamics during host cell invasion. Super‐resolution microscopy and real‐time imaging highlighted an F‐actin pool at the apex of pre‐invading parasite, an F‐actin ring at the junction area during invasion but also networks of perinuclear and posteriorly localised F‐actin. Mutant Parasites with dysfunctional acto‐myosin showed significant decrease of junctional and perinuclear F‐actin and are coincidently affected in nuclear passage through the junction. We propose that the F‐actin machinery eases nuclear passage by stabilising the junction and pushing the nucleus through the constriction. Our analysis suggests that the junction opposes resistance to the passage of the parasite's nucleus and provides the first evidence for a dual contribution of actin‐forces during host cell invasion by apicomplexan Parasites

  • Apicomplexan F‐actin is required for efficient nuclear entry during host cell invasion
    'EMBO', 2019
    Co-Authors: Rosario, Mario Del, Periz Javier, Pavlou Georgios, Lyth Oliver, Das Sujaan, Pall, Gurman S., Lemgruber Leandro, Latorre‐barragan Fernanda, Stortz, Johannes Felix, Whitelaw, Jamie A.
    Abstract:

    The obligate intracellular Parasites Toxoplasma gondii and Plasmodium spp. invade host cells by injecting a protein complex into the membrane of the targeted cell that bridges the two cells through the assembly of a ring‐like junction. This circular junction stretches while the Parasites apply a traction force to pass through, a step that typically concurs with transient constriction of the parasite body. Here we analyse F‐actin dynamics during host cell invasion. Super‐resolution microscopy and real‐time imaging highlighted an F‐actin pool at the apex of pre‐invading parasite, an F‐actin ring at the junction area during invasion but also networks of perinuclear and posteriorly localised F‐actin. Mutant Parasites with dysfunctional acto‐myosin showed significant decrease of junctional and perinuclear F‐actin and are coincidently affected in nuclear passage through the junction. We propose that the F‐actin machinery eases nuclear passage by stabilising the junction and pushing the nucleus through the constriction. Our analysis suggests that the junction opposes resistance to the passage of the parasite's nucleus and provides the first evidence for a dual contribution of actin‐forces during host cell invasion by apicomplexan Parasites

Das Sujaan - One of the best experts on this subject based on the ideXlab platform.

  • Apicomplexan F-actin is required for efficient nuclear entry during host cell invasion
    'EMBO', 2019
    Co-Authors: Del Rosario Mario, Periz Javier, Pavlou Georgios, Lyth Oliver, Latorre-barragan Fernanda, Das Sujaan, Pall, Gurman S., Stortz Johannes, Lemgruber Leandro, Whitelaw Jamie
    Abstract:

    The obligate intracellular Parasites Toxoplasma gondii and Plasmodium spp. invade host cells by injecting a protein complex into the membrane of the targeted cell that bridges the two cells through the assembly of a ring‐like junction. This circular junction stretches while the Parasites apply a traction force to pass through, a step that typically concurs with transient constriction of the parasite body. Here we analyse F‐actin dynamics during host cell invasion. Super‐resolution microscopy and real‐time imaging highlighted an F‐actin pool at the apex of pre‐invading parasite, an F‐actin ring at the junction area during invasion but also networks of perinuclear and posteriorly localised F‐actin. Mutant Parasites with dysfunctional acto‐myosin showed significant decrease of junctional and perinuclear F‐actin and are coincidently affected in nuclear passage through the junction. We propose that the F‐actin machinery eases nuclear passage by stabilising the junction and pushing the nucleus through the constriction. Our analysis suggests that the junction opposes resistance to the passage of the parasite's nucleus and provides the first evidence for a dual contribution of actin‐forces during host cell invasion by apicomplexan Parasites

  • Apicomplexan F‐actin is required for efficient nuclear entry during host cell invasion
    'EMBO', 2019
    Co-Authors: Rosario, Mario Del, Periz Javier, Pavlou Georgios, Lyth Oliver, Das Sujaan, Pall, Gurman S., Lemgruber Leandro, Latorre‐barragan Fernanda, Stortz, Johannes Felix, Whitelaw, Jamie A.
    Abstract:

    The obligate intracellular Parasites Toxoplasma gondii and Plasmodium spp. invade host cells by injecting a protein complex into the membrane of the targeted cell that bridges the two cells through the assembly of a ring‐like junction. This circular junction stretches while the Parasites apply a traction force to pass through, a step that typically concurs with transient constriction of the parasite body. Here we analyse F‐actin dynamics during host cell invasion. Super‐resolution microscopy and real‐time imaging highlighted an F‐actin pool at the apex of pre‐invading parasite, an F‐actin ring at the junction area during invasion but also networks of perinuclear and posteriorly localised F‐actin. Mutant Parasites with dysfunctional acto‐myosin showed significant decrease of junctional and perinuclear F‐actin and are coincidently affected in nuclear passage through the junction. We propose that the F‐actin machinery eases nuclear passage by stabilising the junction and pushing the nucleus through the constriction. Our analysis suggests that the junction opposes resistance to the passage of the parasite's nucleus and provides the first evidence for a dual contribution of actin‐forces during host cell invasion by apicomplexan Parasites