The Experts below are selected from a list of 7302 Experts worldwide ranked by ideXlab platform
Didier Betbeder - One of the best experts on this subject based on the ideXlab platform.
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Synthetic parasites: a successful mucosal nanoparticle vaccine against Toxoplasma congenital infection in mice
Future Microbiology, 2017Co-Authors: Céline Ducournau, Thi Tl Nguyen, Rodolphe Carpentier, Isabelle Lantier, Stéphanie Germon, Flavien Précausta, Hervé Leroux, Nathalie Van Langendonck, Pierre-jean Pisella, Didier BetbederAbstract:Aim: Development of protein vaccine to prevent congenital infection is a major public health priority. Our goal is the design of mucosal synthetic pathogen inducing protective immune responses against congenital toxoplasmosis. Materials & methods: Mice were immunized intranasally, establishing pregnancy and challenging orally. Placental immune response, congenital infection, pup growth, Parasitic Load rates were studied. Results: Pups born to vaccinated infected dams had significantly fewer brain cysts, no intraocular inflammation and normal growth. Protection was associated with a placental cellular Th1 response downregulated by IL-6 and correlated with persistence of vaccine for few hours in the nose before being totally eliminated. Conclusion: Our vaccine conferred high protection against congenital toxoplasmosis. These results provide support for future studies of other congenital vaccine.
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Synthetic parasites: a successful mucosal nanoparticle vaccine against Toxoplasma congenital infection in mice
Future Microbiology, 2017Co-Authors: Céline Ducournau, Rodolphe Carpentier, Isabelle Lantier, Stéphanie Germon, Flavien Précausta, Hervé Leroux, Pierre-jean Pisella, Thi Thanh Loi Nguyen, Nathalie Van Langendonck, Didier BetbederAbstract:Development of protein vaccine to prevent congenital infection is a major public health priority. Our goal is the design of mucosal synthetic pathogen inducing protective immune responses against congenital toxoplasmosis. Mice were immunized intranasally, establishing pregnancy and challenging orally. Placental immune response, congenital infection, pup growth, Parasitic Load rates were studied. Pups born to vaccinated infected dams had significantly fewer brain cysts, no intraocular inflammation and normal growth. Protection was associated with a placental cellular Th1 response downregulated by IL-6 and correlated with persistence of vaccine for few hours in the nose before being totally eliminated. Our vaccine conferred high protection against congenital toxoplasmosis. These results provide support for future studies of other congenital vaccine.
Céline Ducournau - One of the best experts on this subject based on the ideXlab platform.
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Synthetic parasites: a successful mucosal nanoparticle vaccine against Toxoplasma congenital infection in mice
Future Microbiology, 2017Co-Authors: Céline Ducournau, Thi Tl Nguyen, Rodolphe Carpentier, Isabelle Lantier, Stéphanie Germon, Flavien Précausta, Hervé Leroux, Nathalie Van Langendonck, Pierre-jean Pisella, Didier BetbederAbstract:Aim: Development of protein vaccine to prevent congenital infection is a major public health priority. Our goal is the design of mucosal synthetic pathogen inducing protective immune responses against congenital toxoplasmosis. Materials & methods: Mice were immunized intranasally, establishing pregnancy and challenging orally. Placental immune response, congenital infection, pup growth, Parasitic Load rates were studied. Results: Pups born to vaccinated infected dams had significantly fewer brain cysts, no intraocular inflammation and normal growth. Protection was associated with a placental cellular Th1 response downregulated by IL-6 and correlated with persistence of vaccine for few hours in the nose before being totally eliminated. Conclusion: Our vaccine conferred high protection against congenital toxoplasmosis. These results provide support for future studies of other congenital vaccine.
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Synthetic parasites: a successful mucosal nanoparticle vaccine against Toxoplasma congenital infection in mice
Future Microbiology, 2017Co-Authors: Céline Ducournau, Rodolphe Carpentier, Isabelle Lantier, Stéphanie Germon, Flavien Précausta, Hervé Leroux, Pierre-jean Pisella, Thi Thanh Loi Nguyen, Nathalie Van Langendonck, Didier BetbederAbstract:Development of protein vaccine to prevent congenital infection is a major public health priority. Our goal is the design of mucosal synthetic pathogen inducing protective immune responses against congenital toxoplasmosis. Mice were immunized intranasally, establishing pregnancy and challenging orally. Placental immune response, congenital infection, pup growth, Parasitic Load rates were studied. Pups born to vaccinated infected dams had significantly fewer brain cysts, no intraocular inflammation and normal growth. Protection was associated with a placental cellular Th1 response downregulated by IL-6 and correlated with persistence of vaccine for few hours in the nose before being totally eliminated. Our vaccine conferred high protection against congenital toxoplasmosis. These results provide support for future studies of other congenital vaccine.
Stéphanie Germon - One of the best experts on this subject based on the ideXlab platform.
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Synthetic parasites: a successful mucosal nanoparticle vaccine against Toxoplasma congenital infection in mice
Future Microbiology, 2017Co-Authors: Céline Ducournau, Thi Tl Nguyen, Rodolphe Carpentier, Isabelle Lantier, Stéphanie Germon, Flavien Précausta, Hervé Leroux, Nathalie Van Langendonck, Pierre-jean Pisella, Didier BetbederAbstract:Aim: Development of protein vaccine to prevent congenital infection is a major public health priority. Our goal is the design of mucosal synthetic pathogen inducing protective immune responses against congenital toxoplasmosis. Materials & methods: Mice were immunized intranasally, establishing pregnancy and challenging orally. Placental immune response, congenital infection, pup growth, Parasitic Load rates were studied. Results: Pups born to vaccinated infected dams had significantly fewer brain cysts, no intraocular inflammation and normal growth. Protection was associated with a placental cellular Th1 response downregulated by IL-6 and correlated with persistence of vaccine for few hours in the nose before being totally eliminated. Conclusion: Our vaccine conferred high protection against congenital toxoplasmosis. These results provide support for future studies of other congenital vaccine.
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Synthetic parasites: a successful mucosal nanoparticle vaccine against Toxoplasma congenital infection in mice
Future Microbiology, 2017Co-Authors: Céline Ducournau, Rodolphe Carpentier, Isabelle Lantier, Stéphanie Germon, Flavien Précausta, Hervé Leroux, Pierre-jean Pisella, Thi Thanh Loi Nguyen, Nathalie Van Langendonck, Didier BetbederAbstract:Development of protein vaccine to prevent congenital infection is a major public health priority. Our goal is the design of mucosal synthetic pathogen inducing protective immune responses against congenital toxoplasmosis. Mice were immunized intranasally, establishing pregnancy and challenging orally. Placental immune response, congenital infection, pup growth, Parasitic Load rates were studied. Pups born to vaccinated infected dams had significantly fewer brain cysts, no intraocular inflammation and normal growth. Protection was associated with a placental cellular Th1 response downregulated by IL-6 and correlated with persistence of vaccine for few hours in the nose before being totally eliminated. Our vaccine conferred high protection against congenital toxoplasmosis. These results provide support for future studies of other congenital vaccine.
Hervé Leroux - One of the best experts on this subject based on the ideXlab platform.
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Synthetic parasites: a successful mucosal nanoparticle vaccine against Toxoplasma congenital infection in mice
Future Microbiology, 2017Co-Authors: Céline Ducournau, Thi Tl Nguyen, Rodolphe Carpentier, Isabelle Lantier, Stéphanie Germon, Flavien Précausta, Hervé Leroux, Nathalie Van Langendonck, Pierre-jean Pisella, Didier BetbederAbstract:Aim: Development of protein vaccine to prevent congenital infection is a major public health priority. Our goal is the design of mucosal synthetic pathogen inducing protective immune responses against congenital toxoplasmosis. Materials & methods: Mice were immunized intranasally, establishing pregnancy and challenging orally. Placental immune response, congenital infection, pup growth, Parasitic Load rates were studied. Results: Pups born to vaccinated infected dams had significantly fewer brain cysts, no intraocular inflammation and normal growth. Protection was associated with a placental cellular Th1 response downregulated by IL-6 and correlated with persistence of vaccine for few hours in the nose before being totally eliminated. Conclusion: Our vaccine conferred high protection against congenital toxoplasmosis. These results provide support for future studies of other congenital vaccine.
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Synthetic parasites: a successful mucosal nanoparticle vaccine against Toxoplasma congenital infection in mice
Future Microbiology, 2017Co-Authors: Céline Ducournau, Rodolphe Carpentier, Isabelle Lantier, Stéphanie Germon, Flavien Précausta, Hervé Leroux, Pierre-jean Pisella, Thi Thanh Loi Nguyen, Nathalie Van Langendonck, Didier BetbederAbstract:Development of protein vaccine to prevent congenital infection is a major public health priority. Our goal is the design of mucosal synthetic pathogen inducing protective immune responses against congenital toxoplasmosis. Mice were immunized intranasally, establishing pregnancy and challenging orally. Placental immune response, congenital infection, pup growth, Parasitic Load rates were studied. Pups born to vaccinated infected dams had significantly fewer brain cysts, no intraocular inflammation and normal growth. Protection was associated with a placental cellular Th1 response downregulated by IL-6 and correlated with persistence of vaccine for few hours in the nose before being totally eliminated. Our vaccine conferred high protection against congenital toxoplasmosis. These results provide support for future studies of other congenital vaccine.
Flavien Précausta - One of the best experts on this subject based on the ideXlab platform.
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Synthetic parasites: a successful mucosal nanoparticle vaccine against Toxoplasma congenital infection in mice
Future Microbiology, 2017Co-Authors: Céline Ducournau, Thi Tl Nguyen, Rodolphe Carpentier, Isabelle Lantier, Stéphanie Germon, Flavien Précausta, Hervé Leroux, Nathalie Van Langendonck, Pierre-jean Pisella, Didier BetbederAbstract:Aim: Development of protein vaccine to prevent congenital infection is a major public health priority. Our goal is the design of mucosal synthetic pathogen inducing protective immune responses against congenital toxoplasmosis. Materials & methods: Mice were immunized intranasally, establishing pregnancy and challenging orally. Placental immune response, congenital infection, pup growth, Parasitic Load rates were studied. Results: Pups born to vaccinated infected dams had significantly fewer brain cysts, no intraocular inflammation and normal growth. Protection was associated with a placental cellular Th1 response downregulated by IL-6 and correlated with persistence of vaccine for few hours in the nose before being totally eliminated. Conclusion: Our vaccine conferred high protection against congenital toxoplasmosis. These results provide support for future studies of other congenital vaccine.
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Synthetic parasites: a successful mucosal nanoparticle vaccine against Toxoplasma congenital infection in mice
Future Microbiology, 2017Co-Authors: Céline Ducournau, Rodolphe Carpentier, Isabelle Lantier, Stéphanie Germon, Flavien Précausta, Hervé Leroux, Pierre-jean Pisella, Thi Thanh Loi Nguyen, Nathalie Van Langendonck, Didier BetbederAbstract:Development of protein vaccine to prevent congenital infection is a major public health priority. Our goal is the design of mucosal synthetic pathogen inducing protective immune responses against congenital toxoplasmosis. Mice were immunized intranasally, establishing pregnancy and challenging orally. Placental immune response, congenital infection, pup growth, Parasitic Load rates were studied. Pups born to vaccinated infected dams had significantly fewer brain cysts, no intraocular inflammation and normal growth. Protection was associated with a placental cellular Th1 response downregulated by IL-6 and correlated with persistence of vaccine for few hours in the nose before being totally eliminated. Our vaccine conferred high protection against congenital toxoplasmosis. These results provide support for future studies of other congenital vaccine.
