The Experts below are selected from a list of 1047 Experts worldwide ranked by ideXlab platform
Timo Kaila - One of the best experts on this subject based on the ideXlab platform.
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Spectral Analysis of Heart Rate Variability as a Quantitative Measure of Parasympatholytic Effect-Integrated Pharmacokinetics and Pharmacodynamics of Three Anticholinergic Drugs
Therapeutic drug monitoring, 1999Co-Authors: Harry Scheinin, Antti Helminen, Sakke Huhtala, Paula Grönroos, Job A. Bosch, Tom Kuusela, Jussi Kanto, Timo KailaAbstract:Summary:The time course and concentration-effect relationship of Parasympatholytic effects of three anticholinergic drugs were investigated using spectral analysis of heart rate (HR) variability. Single intravenous (IV) doses of atropine (10 µg/kg), glycopyrrolate (5 µg/kg), scopolamine (5 µg/kg), a
Harry Scheinin - One of the best experts on this subject based on the ideXlab platform.
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Spectral Analysis of Heart Rate Variability as a Quantitative Measure of Parasympatholytic Effect-Integrated Pharmacokinetics and Pharmacodynamics of Three Anticholinergic Drugs
Therapeutic drug monitoring, 1999Co-Authors: Harry Scheinin, Antti Helminen, Sakke Huhtala, Paula Grönroos, Job A. Bosch, Tom Kuusela, Jussi Kanto, Timo KailaAbstract:Summary:The time course and concentration-effect relationship of Parasympatholytic effects of three anticholinergic drugs were investigated using spectral analysis of heart rate (HR) variability. Single intravenous (IV) doses of atropine (10 µg/kg), glycopyrrolate (5 µg/kg), scopolamine (5 µg/kg), a
H. G. Zapotoczky - One of the best experts on this subject based on the ideXlab platform.
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Influence of age on the Parasympatholytic property of tricyclic antidepressants.
Psychiatry research, 1999Co-Authors: Michael Lehofer, Maximilian Moser, Rudolf Hoehn-saric, Daniel R. Mcleod, Gunther Hildebrandt, S. Egner, Birgit Steinbrenner, Peter M. Liebmann, H. G. ZapotoczkyAbstract:Clinical evidence indicates that Parasympatholytic effects of tricyclic antidepressants increase with age. The aim of the present study was to determine the possible physiological reason for this phenomenon. Subjects included 23 patients (14 female) with major depression, melancholic type, and 23 age- and sex-matched healthy control subjects. Cardiac vagal tone was measured at rest using both spectral analysis and a time domain beat-to-beat method. Results of the spectral and time domain methods for the estimation of vagal tone used in this study were highly correlated in control subjects as well as in medicated depressed subjects. Both patients and control subjects showed an age-related decline in cardiac vagal tone. Tricyclic antidepressants decreased vagal tone significantly by 25-49% depending on age (20-60 years), although the age difference was not significant. The greater effect of tricyclic antidepressants on parasympathetic activity typically seen in older age groups may reflect the fact that predrug levels of vagal tone are already low in older patients. Measurement of vagal tone prior to drug administration may therefore be of prognostic value for anticholinergic side effects.
Tom Kuusela - One of the best experts on this subject based on the ideXlab platform.
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Spectral Analysis of Heart Rate Variability as a Quantitative Measure of Parasympatholytic Effect-Integrated Pharmacokinetics and Pharmacodynamics of Three Anticholinergic Drugs
Therapeutic drug monitoring, 1999Co-Authors: Harry Scheinin, Antti Helminen, Sakke Huhtala, Paula Grönroos, Job A. Bosch, Tom Kuusela, Jussi Kanto, Timo KailaAbstract:Summary:The time course and concentration-effect relationship of Parasympatholytic effects of three anticholinergic drugs were investigated using spectral analysis of heart rate (HR) variability. Single intravenous (IV) doses of atropine (10 µg/kg), glycopyrrolate (5 µg/kg), scopolamine (5 µg/kg), a
Jussi Kanto - One of the best experts on this subject based on the ideXlab platform.
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Spectral Analysis of Heart Rate Variability as a Quantitative Measure of Parasympatholytic Effect-Integrated Pharmacokinetics and Pharmacodynamics of Three Anticholinergic Drugs
Therapeutic drug monitoring, 1999Co-Authors: Harry Scheinin, Antti Helminen, Sakke Huhtala, Paula Grönroos, Job A. Bosch, Tom Kuusela, Jussi Kanto, Timo KailaAbstract:Summary:The time course and concentration-effect relationship of Parasympatholytic effects of three anticholinergic drugs were investigated using spectral analysis of heart rate (HR) variability. Single intravenous (IV) doses of atropine (10 µg/kg), glycopyrrolate (5 µg/kg), scopolamine (5 µg/kg), a
