The Experts below are selected from a list of 33 Experts worldwide ranked by ideXlab platform
Bruce J Baum - One of the best experts on this subject based on the ideXlab platform.
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pilocarpine treatment of salivary gland hypofunction and dry mouth xerostomia
JAMA Internal Medicine, 1991Co-Authors: Jane C Atkinson, Alice A Macynski, Andy Wolff, David S Kung, Ingrid H Valdez, William L Jackson, Robert A Delapenha, Jeffrey Shiroky, Bruce J BaumAbstract:We studied the effects of pilocarpine hydrochloride, a Parasympathomimetic Agent, on major salivary gland output and subjective responses in 31 patients with salivary hypofunction. Pilocarpine hydrochloride (5-mg capsules, three times daily) was given for 5 months and a placebo was randomly assigned for 1 month in a double-blind fashion. Objective measurements of major salivary gland output, subjective impressions of oral moisture, treatment-related side effects, and a number of physiologic measures were assessed monthly. Pilocarpine significantly increased salivary output in 21 of the 31 patients. Subjective improvement in the feeling of oral dryness, speaking, chewing, and swallowing were reported by 27 individuals. Side effects, while common, generally were mild and tolerable. There were no significant alterations in cardiovascular or other physiologic measures. We conclude that pilocarpine is an effective and safe treatment for salivary gland hypofunction and xerostomia in selected patients. The increase in major gland output provides beneficial natural secretions and relief of oral dryness. (Arch Intern Med. 1991;151:1149-1152)
Jane C Atkinson - One of the best experts on this subject based on the ideXlab platform.
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pilocarpine treatment of salivary gland hypofunction and dry mouth xerostomia
JAMA Internal Medicine, 1991Co-Authors: Jane C Atkinson, Alice A Macynski, Andy Wolff, David S Kung, Ingrid H Valdez, William L Jackson, Robert A Delapenha, Jeffrey Shiroky, Bruce J BaumAbstract:We studied the effects of pilocarpine hydrochloride, a Parasympathomimetic Agent, on major salivary gland output and subjective responses in 31 patients with salivary hypofunction. Pilocarpine hydrochloride (5-mg capsules, three times daily) was given for 5 months and a placebo was randomly assigned for 1 month in a double-blind fashion. Objective measurements of major salivary gland output, subjective impressions of oral moisture, treatment-related side effects, and a number of physiologic measures were assessed monthly. Pilocarpine significantly increased salivary output in 21 of the 31 patients. Subjective improvement in the feeling of oral dryness, speaking, chewing, and swallowing were reported by 27 individuals. Side effects, while common, generally were mild and tolerable. There were no significant alterations in cardiovascular or other physiologic measures. We conclude that pilocarpine is an effective and safe treatment for salivary gland hypofunction and xerostomia in selected patients. The increase in major gland output provides beneficial natural secretions and relief of oral dryness. (Arch Intern Med. 1991;151:1149-1152)
Ingrid H Valdez - One of the best experts on this subject based on the ideXlab platform.
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pilocarpine treatment of salivary gland hypofunction and dry mouth xerostomia
JAMA Internal Medicine, 1991Co-Authors: Jane C Atkinson, Alice A Macynski, Andy Wolff, David S Kung, Ingrid H Valdez, William L Jackson, Robert A Delapenha, Jeffrey Shiroky, Bruce J BaumAbstract:We studied the effects of pilocarpine hydrochloride, a Parasympathomimetic Agent, on major salivary gland output and subjective responses in 31 patients with salivary hypofunction. Pilocarpine hydrochloride (5-mg capsules, three times daily) was given for 5 months and a placebo was randomly assigned for 1 month in a double-blind fashion. Objective measurements of major salivary gland output, subjective impressions of oral moisture, treatment-related side effects, and a number of physiologic measures were assessed monthly. Pilocarpine significantly increased salivary output in 21 of the 31 patients. Subjective improvement in the feeling of oral dryness, speaking, chewing, and swallowing were reported by 27 individuals. Side effects, while common, generally were mild and tolerable. There were no significant alterations in cardiovascular or other physiologic measures. We conclude that pilocarpine is an effective and safe treatment for salivary gland hypofunction and xerostomia in selected patients. The increase in major gland output provides beneficial natural secretions and relief of oral dryness. (Arch Intern Med. 1991;151:1149-1152)
William L Jackson - One of the best experts on this subject based on the ideXlab platform.
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pilocarpine treatment of salivary gland hypofunction and dry mouth xerostomia
JAMA Internal Medicine, 1991Co-Authors: Jane C Atkinson, Alice A Macynski, Andy Wolff, David S Kung, Ingrid H Valdez, William L Jackson, Robert A Delapenha, Jeffrey Shiroky, Bruce J BaumAbstract:We studied the effects of pilocarpine hydrochloride, a Parasympathomimetic Agent, on major salivary gland output and subjective responses in 31 patients with salivary hypofunction. Pilocarpine hydrochloride (5-mg capsules, three times daily) was given for 5 months and a placebo was randomly assigned for 1 month in a double-blind fashion. Objective measurements of major salivary gland output, subjective impressions of oral moisture, treatment-related side effects, and a number of physiologic measures were assessed monthly. Pilocarpine significantly increased salivary output in 21 of the 31 patients. Subjective improvement in the feeling of oral dryness, speaking, chewing, and swallowing were reported by 27 individuals. Side effects, while common, generally were mild and tolerable. There were no significant alterations in cardiovascular or other physiologic measures. We conclude that pilocarpine is an effective and safe treatment for salivary gland hypofunction and xerostomia in selected patients. The increase in major gland output provides beneficial natural secretions and relief of oral dryness. (Arch Intern Med. 1991;151:1149-1152)
David S Kung - One of the best experts on this subject based on the ideXlab platform.
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pilocarpine treatment of salivary gland hypofunction and dry mouth xerostomia
JAMA Internal Medicine, 1991Co-Authors: Jane C Atkinson, Alice A Macynski, Andy Wolff, David S Kung, Ingrid H Valdez, William L Jackson, Robert A Delapenha, Jeffrey Shiroky, Bruce J BaumAbstract:We studied the effects of pilocarpine hydrochloride, a Parasympathomimetic Agent, on major salivary gland output and subjective responses in 31 patients with salivary hypofunction. Pilocarpine hydrochloride (5-mg capsules, three times daily) was given for 5 months and a placebo was randomly assigned for 1 month in a double-blind fashion. Objective measurements of major salivary gland output, subjective impressions of oral moisture, treatment-related side effects, and a number of physiologic measures were assessed monthly. Pilocarpine significantly increased salivary output in 21 of the 31 patients. Subjective improvement in the feeling of oral dryness, speaking, chewing, and swallowing were reported by 27 individuals. Side effects, while common, generally were mild and tolerable. There were no significant alterations in cardiovascular or other physiologic measures. We conclude that pilocarpine is an effective and safe treatment for salivary gland hypofunction and xerostomia in selected patients. The increase in major gland output provides beneficial natural secretions and relief of oral dryness. (Arch Intern Med. 1991;151:1149-1152)
