The Experts below are selected from a list of 219 Experts worldwide ranked by ideXlab platform
Xican Tang - One of the best experts on this subject based on the ideXlab platform.
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facilitation of cholinergic transmission by huperzine a in toad Paravertebral Ganglia in vitro
Acta Pharmacologica Sinica, 1994Co-Authors: Genbao Zhang, Mengya Wang, Jianquan Zheng, Xican TangAbstract:: Using the intracellular recording techniques of toad Paravertebral Ganglia (PVG), the effects of cholinesterase inhibitor huperzine A (Hup-A), an alkaloid first isolated from Huperzia serrata (Thunb) Trev in China, on the synaptic transmission were studied. In 30 PVG cells tested, no remarkable changes in membrane potential and input resistance were observed during superfusion of Hup-A 0.3 or 1 mumol.L-1 for 15 min. The rate of orthodromic action potential evoked by preganglionic stimulation was increased by Hup-A 0.3 or 1 mumol.L-1 (n = 12, P < 0.05), and much faster, stronger, and longer in action at 50 or 100 mumol.L-1 (n = 11). The amplitude and duration of exogenous acetylcholine-, but not carbachol-, induced depolarization were increased (P < 0.05). It is concluded that Hup-A is a selective and potent cholinesterase inhibitor, by which action it facilitates the cholinergic transmission of PVG neurons.
Steven L Carroll - One of the best experts on this subject based on the ideXlab platform.
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neurotrophin sensitivity of prevertebral and Paravertebral rat sympathetic autonomic Ganglia
Journal of Neuropathology and Experimental Neurology, 1998Co-Authors: Robert E Schmidt, Denise A Dorsey, Lee A Selznick, Peter S Distefano, Steven L CarrollAbstract:Prevertebral and Paravertebral sympathetic autonomic Ganglia respond differently to a large number of experimental and clinical insults. The selective involvement of subpopulations of sympathetic neurons may reflect differences in their response to neurotrophic substances. To test this hypothesis, we investigated the response of prevertebral and Paravertebral rat sympathetic Ganglia to selected neurotrophic substances in vivo and in vitro and identified the ganglionic distribution of neurons expressing high affinity neurotrophin receptor mRNAs. Dissociated cultures of embryonic prevertebral and Paravertebral ganglionic neurons showed comparable responses to NGF deprivation and only small differences in their response to rescue with other trophic substances. In situ hybridization studies of adult rat sympathetic Ganglia using probes specific for the high-affinity neurotrophin receptor transcripts trks A, B, and C demonstrated that neurons in both prevertebral and Paravertebral sympathetic Ganglia express predominantly trkA receptors in vivo. In addition, increased tyrosine hydroxylase (TOH) activity was induced only by doses of neurotrophic substances that activate trkA and showed only small differences between neonatal prevertebral and Paravertebral Ganglia. Although small differences in the sensitivity of pre- and Paravertebral sympathetic neurons to various neurotrophins have been identified in our studies, they are unlikely, in isolation, to explain major differences in the sensitivity of these Ganglia to neuropathologic processes.
Genbao Zhang - One of the best experts on this subject based on the ideXlab platform.
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facilitation of cholinergic transmission by huperzine a in toad Paravertebral Ganglia in vitro
Acta Pharmacologica Sinica, 1994Co-Authors: Genbao Zhang, Mengya Wang, Jianquan Zheng, Xican TangAbstract:: Using the intracellular recording techniques of toad Paravertebral Ganglia (PVG), the effects of cholinesterase inhibitor huperzine A (Hup-A), an alkaloid first isolated from Huperzia serrata (Thunb) Trev in China, on the synaptic transmission were studied. In 30 PVG cells tested, no remarkable changes in membrane potential and input resistance were observed during superfusion of Hup-A 0.3 or 1 mumol.L-1 for 15 min. The rate of orthodromic action potential evoked by preganglionic stimulation was increased by Hup-A 0.3 or 1 mumol.L-1 (n = 12, P < 0.05), and much faster, stronger, and longer in action at 50 or 100 mumol.L-1 (n = 11). The amplitude and duration of exogenous acetylcholine-, but not carbachol-, induced depolarization were increased (P < 0.05). It is concluded that Hup-A is a selective and potent cholinesterase inhibitor, by which action it facilitates the cholinergic transmission of PVG neurons.
F Laczi - One of the best experts on this subject based on the ideXlab platform.
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characterization of oxytocin immunoreactivity in human sympathetic Paravertebral Ganglia
Brain Research, 1990Co-Authors: Miklos Vecsernyes, I Jojart, J Pepo, F LacziAbstract:Abstract Immunoreactive oxytocin (IR-OXT) detected in extracts of human lumbar sympathetic Paravertebral Ganglia was characterized by high-performance liquid chromatography (HPLC). The immunoreactive substance was found to elute at the same position as the reference preparation of oxytocin (OXT). The results revealed the presence of chromatographically identified OXT in human sympathetic Ganglia.
Wolfgang Kummer - One of the best experts on this subject based on the ideXlab platform.
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Nitric oxide synthase in guinea pig sympathetic Ganglia: Correlation with tyrosine hydroxylase and neuropeptides
Histochemistry and Cell Biology, 1995Co-Authors: Brigitte Höhler, Régis Olry, Bernd Mayer, Wolfgang KummerAbstract:Nitric oxide synthase (NOS) has previously been reported in a small population of postganglionic sympathetic neurons in the guinea pig. The present study of Paravertebral Ganglia and the inferior mesenteric ganglion aimed to classify these neurons according to their content of neuropeptides (calcitonin gene-related peptide, neuropeptide Y, vasoactive intestinal peptide) and the rate-limiting enzyme of catecholamine synthesis, tyrosine hydroxylase, by means of immunohistochemical and histochemical double-labelling techniques. NOS-containing neurons belonged to the non-catecholaminergic population of postganglionic neurons, and partial coexistence was found with neuropeptide Y and vasoactive intestinal peptide immunoreactivities but not with calcitonin gene-related peptide. However, most of the NOS-containing neurons contained none of the neuropeptides, thus representing a hitherto unrecognized population of postganglionic neurons. The findings show that NOS is localized to small but neurochemically highly specific populations of postganglionic neurons, which most likely reflects an association with target- and function-specific pathways.
