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Max Miller - One of the best experts on this subject based on the ideXlab platform.

L Mandel - One of the best experts on this subject based on the ideXlab platform.

  • Parotid Enlargement in children seropositive for human immunodeficiency virus imaging findings
    American Journal of Roentgenology, 1991
    Co-Authors: N Soberman, John C Leonidas, Walter E Berdon, Vincent R Bonagura, J O Haller, Mitchell C Posner, L Mandel
    Abstract:

    We investigated the clinical, immunologic, and imaging features of Parotid Enlargement in 10 children seropositive for human immunodeficiency virus (HIV) who were infected prenatally. In seven patients, sonography revealed many small hypoechoic areas suggestive of lymphoid infiltration. In three older children, large anechoic areas suggesting lymphoepithelial cysts were present. The lesions probably represent generalized lymphoid infiltration akin to pulmonary lymphoid hyperplasia, although only two of our patients had radiologic evidence of pulmonary lymphoid hyperplasia. Four of five of the children with Parotid Enlargement who had immunologic studies were phenotypically HLA-DR5, an immunophenotype associated with improved immune response, occurring in less than one in four in the normal population. This suggests that painless Parotid Enlargement may be a good prognostic sign in HIV-seropositive children. Parotid Enlargement was found in 10 HIV-positive children from 6 months to 11 years old. All except...

Richard T Kelley - One of the best experts on this subject based on the ideXlab platform.

  • wegener s granulomatosis presenting as unilateral Parotid Enlargement
    Laryngoscope, 2004
    Co-Authors: Burke E Chegar, Richard T Kelley
    Abstract:

    Objective: Major salivary gland Enlargement is a rare presenting symptom of Wegener's granulomatosis. The unrecognized occurrence of this entity can delay diagnosis, leading to increased morbidity from disease progression. This report discusses the clinical features and diagnostic testing of salivary gland Enlargement secondary to Wegener's granulomatosis to differentiate it from other, more common, salivary gland diseases. Study Design: A case report of a single subject with unilateral Parotid gland Enlargement secondary to Wegener's granulomatosis. Methods: A review of the clinical course, diagnostic studies, and histopathology related to the presenting disease. Results: A 54-year-old male was evaluated for a 6-week history of progressive right Parotid Enlargement and pain unresponsive to antimicrobial therapy. Computed tomography scans showed diffuse, unilateral Parotid swelling without enhancement and without a mass lesion or sialolith. Multiple open biopsies from the gland were necessary to demonstrate the presence of necrotizing granulomatous inflammation with vasculitis. Elevated antineutrophil cytoplasmic autoantibody, cytoplasmic pattern (c-ANCA) titers confirmed Wegener's granulomatosis. Hemoptysis and acute renal failure requiring hemodialysis developed shortly after diagnosis but eventually resolved after the initiation of corticosteroids and cyclophosphamide. Conclusions: Unilateral Parotid Enlargement is a rare presentation of Wegener's granulomatosis. A high level of clinical suspicion should prompt biopsy and testing of c-ANCA when initial studies or empirical treatment fails to lead to a proper diagnosis. Early treatment may prevent the development of other serious systemic complications such as renal failure.

Stephen B Levine - One of the best experts on this subject based on the ideXlab platform.

Gailute Kirdaite - One of the best experts on this subject based on the ideXlab platform.

  • bilateral Parotid Enlargement due to malnutrition under the influence of the media in an adolescent in lithuania
    Appetite, 2007
    Co-Authors: Diana Mieliauskaite, Algirdas Venalis, Vida Graziene, Gailute Kirdaite
    Abstract:

    The elimination of censorship for the media in post-communist countries in transition has contributed to increases in the prevalence of several medical problems. Children and adolescents are particularly vulnerable to the messages conveyed through the media, which influence their perceptions and behaviour. We describe a case of bilateral Parotid Enlargement due to malnutrition under the influence of self-prescribed diet in an adolescent. A 15-year-old girl reported to our institution under suspicion of Sjogren's syndrome for medical advice. Two months ago she developed persistent bilateral Parotid Enlargement and a dry mouth. Her medical history revealed a weight loss due to "self-prescribed" reduce diet. Social questioning clarified high use of the media and influence on the body concept and self image. On extra oral examination, a diffuse Parotid Enlargement was seen bilaterally. The examination of the mouth showed a low moisture level of the intraoral mucosa. The unstimulated whole salivary flow rate was 2 ml in 15 min. Laboratory findings evidenced anemia (107 g/l). The serum albumin concentration indicated a reduced level (28 g/l). Search for antinuclear antibodies, anti-SSA antibodies, anti-SSB, -Sm, -RNP and anti-double-stranded DNA antibodies was negative. Evaluation for antibodies against hepatitis C, cytomegalovirus and Epstein-Barr virus infection and HIV rendered negative results. A histopathologic examination of labial salivary gland biopsy revealed a picture of sialoadenosis. From the above investigations, a diagnosis of sialoadenosis due to malnutrition was made.