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Sohsuke Yamada - One of the best experts on this subject based on the ideXlab platform.

  • cytopathological findings of proliferating pilomatricoma misdiagnosed as a malignant Parotid Gland Tumor
    Diagnostic Pathology, 2018
    Co-Authors: Nozomu Kurose, Manabu Yamashita, Mariko Nakano, Xin Guo, Akihiro Shioya, Satoko Nakada, Hiroshi Minato, Sohsuke Yamada
    Abstract:

    Pilomatricoma is a relatively common benign cutaneous adnexal neoplasm with differentiation towards the hair matrix, inner sheath of hair follicle and hair cortex. Proliferating pilomatricoma is a rare variant of pilomatricoma that can rapidly increase and may be misidentified as a malignant Tumor. We herein report the cytopathological findings of proliferating pilomatricoma misdiagnosed as a malignant Parotid Tumor. A 64-year-old man noticed an acne-like nodule in the left Parotid region. It was painless, but it increased to a maximum diameter of 4.5 cm over 2 years. Clinically, left Parotid Gland carcinoma was suspected, and fine-needle aspiration cytology was performed. Clusters of epithelial cells were observed in a necrotic background, and malignant epithelial cells derived from salivary Glands were suspected. Histologically, the resected Tumor was diagnosed as proliferating pilomatricoma composed of basophilic cells and shadow cells apart from the Parotid Gland. However, on a re-evaluation of the cytological specimens, the irregular-shaped epithelial cells were considered to be from basophilic cells. Shadow cells with nuclear disappearance were also confirmed. Tumor recurrence and metastasis have not been observed in the four years since surgery. The present case was first interpreted as a malignant Parotid Gland Tumor, but it was actually a benign skin appendage Tumor. Pilomatricoma sometimes rapidly increases and may be mistaken for a malignant Tumor. Although it is critical to recognize not only basophilic cells but also shadow cells, it cannot be diagnosed by cytological findings. The final diagnosis should be made on excision specimen only.

  • Cytopathological findings of proliferating pilomatricoma misdiagnosed as a malignant Parotid Gland Tumor
    BMC, 2018
    Co-Authors: Nozomu Kurose, Manabu Yamashita, Mariko Nakano, Xin Guo, Akihiro Shioya, Satoko Nakada, Hiroshi Minato, Sohsuke Yamada
    Abstract:

    Abstract Background Pilomatricoma is a relatively common benign cutaneous adnexal neoplasm with differentiation towards the hair matrix, inner sheath of hair follicle and hair cortex. Proliferating pilomatricoma is a rare variant of pilomatricoma that can rapidly increase and may be misidentified as a malignant Tumor. We herein report the cytopathological findings of proliferating pilomatricoma misdiagnosed as a malignant Parotid Tumor. Case presentation A 64-year-old man noticed an acne-like nodule in the left Parotid region. It was painless, but it increased to a maximum diameter of 4.5 cm over 2 years. Clinically, left Parotid Gland carcinoma was suspected, and fine-needle aspiration cytology was performed. Clusters of epithelial cells were observed in a necrotic background, and malignant epithelial cells derived from salivary Glands were suspected. Histologically, the resected Tumor was diagnosed as proliferating pilomatricoma composed of basophilic cells and shadow cells apart from the Parotid Gland. However, on a re-evaluation of the cytological specimens, the irregular-shaped epithelial cells were considered to be from basophilic cells. Shadow cells with nuclear disappearance were also confirmed. Tumor recurrence and metastasis have not been observed in the four years since surgery. Conclusion The present case was first interpreted as a malignant Parotid Gland Tumor, but it was actually a benign skin appendage Tumor. Pilomatricoma sometimes rapidly increases and may be mistaken for a malignant Tumor. Although it is critical to recognize not only basophilic cells but also shadow cells, it cannot be diagnosed by cytological findings. The final diagnosis should be made on excision specimen only

Thomas Cramer - One of the best experts on this subject based on the ideXlab platform.

  • YAP1-MAML2-Rearranged Poroid Squamous Cell Carcinoma (Squamoid Porocarcinoma) Presenting as a Primary Parotid Gland Tumor
    Head and Neck Pathology, 2020
    Co-Authors: Abbas Agaimy, Robert Stoehr, Lars Tögel, Arndt Hartmann, Thomas Cramer
    Abstract:

    Porocarcinoma (synonym: malignant eccrine poroma) is a rare aggressive carcinoma type with terminal sweat Gland duct differentiation. The squamous variant of porocarcinoma is even less frequent and might be indistinguishable from conventional squamous cell carcinoma (SCC). We herein describe the first case of a carcinoma presenting as a primary Parotid Gland malignancy in a 24-year-old male without any other primary Tumor. Total Parotidectomy and neck dissection were performed followed by adjuvant chemoradiation. The patient remained alive and well 10 months after diagnosis. Histology showed keratinizing SCC infiltrating extensively the Parotid Gland with subtle poroid cell features. Oncogenic HPV infection was excluded by DNA-based testing. NGS analysis using the TruSight RNA fusion panel (Illumina) revealed a novel YAP1-MAML2 gene fusion. This gene fusion was reported recently in a subset of cutaneous porocarcinoma and poroma. This case of poroid SCC (or squamoid porocarcinoma) adds to the differential diagnosis of SCC presenting as Parotid Gland Tumor and highlights the value of molecular testing in cases with unusual presentation.

Nozomu Kurose - One of the best experts on this subject based on the ideXlab platform.

  • cytopathological findings of proliferating pilomatricoma misdiagnosed as a malignant Parotid Gland Tumor
    Diagnostic Pathology, 2018
    Co-Authors: Nozomu Kurose, Manabu Yamashita, Mariko Nakano, Xin Guo, Akihiro Shioya, Satoko Nakada, Hiroshi Minato, Sohsuke Yamada
    Abstract:

    Pilomatricoma is a relatively common benign cutaneous adnexal neoplasm with differentiation towards the hair matrix, inner sheath of hair follicle and hair cortex. Proliferating pilomatricoma is a rare variant of pilomatricoma that can rapidly increase and may be misidentified as a malignant Tumor. We herein report the cytopathological findings of proliferating pilomatricoma misdiagnosed as a malignant Parotid Tumor. A 64-year-old man noticed an acne-like nodule in the left Parotid region. It was painless, but it increased to a maximum diameter of 4.5 cm over 2 years. Clinically, left Parotid Gland carcinoma was suspected, and fine-needle aspiration cytology was performed. Clusters of epithelial cells were observed in a necrotic background, and malignant epithelial cells derived from salivary Glands were suspected. Histologically, the resected Tumor was diagnosed as proliferating pilomatricoma composed of basophilic cells and shadow cells apart from the Parotid Gland. However, on a re-evaluation of the cytological specimens, the irregular-shaped epithelial cells were considered to be from basophilic cells. Shadow cells with nuclear disappearance were also confirmed. Tumor recurrence and metastasis have not been observed in the four years since surgery. The present case was first interpreted as a malignant Parotid Gland Tumor, but it was actually a benign skin appendage Tumor. Pilomatricoma sometimes rapidly increases and may be mistaken for a malignant Tumor. Although it is critical to recognize not only basophilic cells but also shadow cells, it cannot be diagnosed by cytological findings. The final diagnosis should be made on excision specimen only.

  • Cytopathological findings of proliferating pilomatricoma misdiagnosed as a malignant Parotid Gland Tumor
    BMC, 2018
    Co-Authors: Nozomu Kurose, Manabu Yamashita, Mariko Nakano, Xin Guo, Akihiro Shioya, Satoko Nakada, Hiroshi Minato, Sohsuke Yamada
    Abstract:

    Abstract Background Pilomatricoma is a relatively common benign cutaneous adnexal neoplasm with differentiation towards the hair matrix, inner sheath of hair follicle and hair cortex. Proliferating pilomatricoma is a rare variant of pilomatricoma that can rapidly increase and may be misidentified as a malignant Tumor. We herein report the cytopathological findings of proliferating pilomatricoma misdiagnosed as a malignant Parotid Tumor. Case presentation A 64-year-old man noticed an acne-like nodule in the left Parotid region. It was painless, but it increased to a maximum diameter of 4.5 cm over 2 years. Clinically, left Parotid Gland carcinoma was suspected, and fine-needle aspiration cytology was performed. Clusters of epithelial cells were observed in a necrotic background, and malignant epithelial cells derived from salivary Glands were suspected. Histologically, the resected Tumor was diagnosed as proliferating pilomatricoma composed of basophilic cells and shadow cells apart from the Parotid Gland. However, on a re-evaluation of the cytological specimens, the irregular-shaped epithelial cells were considered to be from basophilic cells. Shadow cells with nuclear disappearance were also confirmed. Tumor recurrence and metastasis have not been observed in the four years since surgery. Conclusion The present case was first interpreted as a malignant Parotid Gland Tumor, but it was actually a benign skin appendage Tumor. Pilomatricoma sometimes rapidly increases and may be mistaken for a malignant Tumor. Although it is critical to recognize not only basophilic cells but also shadow cells, it cannot be diagnosed by cytological findings. The final diagnosis should be made on excision specimen only

M Jaehne - One of the best experts on this subject based on the ideXlab platform.

  • diffusion weighted echo planar mr imaging of primary Parotid Gland Tumors is a prediction of different histologic subtypes possible
    American Journal of Neuroradiology, 2009
    Co-Authors: C R Habermann, C Arndt, Joachim Graessner, L Diestel, Kay Uwe Petersen, Fabian Reitmeier, J O Ussmueller, Gerhard Adam, M Jaehne
    Abstract:

    BACKGROUND AND PURPOSE: Our aim was to determine the value of echo-planar diffusion-weighted MR imaging (epiDWI) in differentiating various types of primary Parotid Gland Tumors. MATERIALS AND METHODS: One hundred forty-nine consecutive patients with suspected Tumors of the Parotid Gland were examined with an epiDWI sequence by using a 1.5T unit. Image analysis was performed by 2 radiologists independently, and the intraclass correlation coefficient was computed. Histologic diagnosis was obtained in every patient. For comparison of apparent diffusion coefficients (ADCs), a paired 2-tailed Student t test with a Bonferroni correction was used. RESULTS: In 136 patients, a primary Parotid Gland Tumor was confirmed by histology. Among the observers, a high correlation was calculated (0.98). ADC values of pleomorphic adenomas were significantly higher than those of all other entities, except for myoepithelial adenomas (P = .054). ADC values of Warthin Tumors were different from those of myoepithelial adenomas, lipomas, and salivary duct carcinomas (P CONCLUSION: epiDWI has the potential to differentiate pleomorphic adenoma and myoepithelial adenomas from all other examined entities. Due to an overlap not only within the group of benign and malignant lesions but also between groups, diagnoses should not be addressed on the basis of ADC values solely. Therefore, further studies combining DWI, morphologic criteria, and probably other MR imaging techniques seem warranted.

P Halimi - One of the best experts on this subject based on the ideXlab platform.

  • warthin s Tumor of Parotid Gland surgery or follow up diagnostic value of a decisional algorithm with functional mri
    Diagnostic and interventional imaging, 2016
    Co-Authors: S Espinoza, A Felter, D Malinvaud, C Badoual, G Chatellier, N Siauve, P Halimi
    Abstract:

    Abstract Purpose Warthin's Tumor is the second most frequent benign Tumor of the Parotid Gland, with no risk of malignant evolution. That is why surgery should be avoided if the preoperative diagnosis is certain. The aim of the study was to assess the added value of a decisional algorithm for the preoperative diagnosis of Warthin's Tumor. Materials and methods This retrospective IRB-approved study included 75 patients who underwent standardised MRI with conventional sequences (T1- and T2-weighted images, and T1 post-contrast sequences with fat saturation) and functional sequences: diffusion (b0, b1000) and perfusion MR. Two independent readers reviewed the images using the decisional algorithm. The conclusion of each reader was: the lesion is or is not a Warthin's Tumor. The MRI conclusion was compared with histology or with cytology and follow-up. We calculated the Cohen's kappa coefficient between the two observers and the sensitivity and specificity of the algorithm-helped-reading for the diagnosis of Warthin's Tumor. Results Seventy-five patients; histology (n = 61) or cytology and follow-up (n = 14) results revealed 20 Warthin's Tumors and 55 other Tumors. Using the algorithm, sensitivity and specificity were 80–96%, and 85–100%, respectively for readers 1 and 2. The Cohen's kappa coefficient between the two observers was 0.79 (P  Conclusion Our decisional algorithm helps the preoperative diagnosis of Warthin's Tumor. The specificity of the technique is sufficient to avoid surgery if a Parotid Gland Tumor presents all the MRI characteristics of a Warthin's Tumor.

  • interpretation pearls for mr imaging of Parotid Gland Tumor
    European Annals of Otorhinolaryngology Head and Neck Diseases, 2013
    Co-Authors: S Espinoza, P Halimi
    Abstract:

    European Annals of Otorhinolaryngology, Head and Neck Diseases - Vol. 130 - N° 1 - p. 30-35