Particle Concentration

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Paul M Ridker - One of the best experts on this subject based on the ideXlab platform.

  • discordance between circulating atherogenic cholesterol mass and lipoprotein Particle Concentration in relation to future coronary events in women
    Clinical Chemistry, 2017
    Co-Authors: Patrick R Lawler, Akintunde O Akinkuolie, Paul M Ridker, Allan D Sniderman, Julie E Buring, Robert J Glynn, Daniel I Chasman, Samia Mora
    Abstract:

    BACKGROUND: It is uncertain whether measurement of circulating total atherogenic lipoprotein Particle cholesterol mass [non-HDL cholesterol (nonHDLc)] or Particle Concentration [apolipoprotein B (apo B) and LDL Particle Concentration (LDLp)] more accurately reflects risk of incident coronary heart disease (CHD). We evaluated CHD risk among women in whom these markers where discordant. METHODS: Among 27533 initially healthy women in the Women's Health Study (NCT00000479), using residuals from linear regression models, we compared risk among women with higher or lower observed Particle Concentration relative to nonHDLc (highest and lowest residual quartiles, respectively) to individuals with agreement between markers (middle quartiles) using Cox proportional hazards models. RESULTS: Although all 3 biomarkers were correlated (r ≥ 0.77), discordance occurred in up to 20.2% of women. Women with discordant high Particle Concentration were more likely to have metabolic syndrome (MetS) and diabetes (both P < 0.001). Over a median follow-up of 20.4 years, 1246 CHD events occurred (514725 person-years). Women with high Particle Concentration relative to nonHDLc had increased CHD risk: age-adjusted hazard ratio (95% CI) = 1.77 (1.56-2.00) for apo B and 1.70 (1.50-1.92) for LDLp. After adjustment for clinical risk factors including MetS, these risks attenuated to 1.22 (1.07-1.39) for apo B and 1.13 (0.99-1.29) for LDLp. Discordant low apo B or LDLp relative to nonHDLc was not associated with lower risk. CONCLUSIONS: Discordance between atherogenic Particle cholesterol mass and Particle Concentration occurs in a sizeable proportion of apparently healthy women and should be suspected clinically among women with cardiometabolic traits. In such women, direct measurement of lipoprotein Particle Concentration might better inform CHD risk assessment.

  • low density lipoprotein Particle Concentration and size as determined by nuclear magnetic resonance spectroscopy as predictors of cardiovascular disease in women
    Circulation, 2002
    Co-Authors: Gavin J Blake, James D Otvos, Nader Rifai, Paul M Ridker
    Abstract:

    BACKGROUND: Nuclear magnetic resonance (NMR) offers an alternative, spectroscopic means of quantifying LDL and of measuring LDL Particle size. METHODS AND RESULTS: We conducted a prospective nested case-control study among healthy middle-aged women to assess LDL Particle size (NMR) and Concentration (NMR) as risk factors for future myocardial infarction, stroke, or death of coronary heart disease. Median baseline levels of LDL Particle Concentration (NMR) were higher (1597 vs 1404 nmol/L; P= 0.0001) and LDL Particle size (NMR) was lower (21.5 vs 21.8 nm; P=0.046) among women who subsequently had cardiovascular events (n=130) than among those who did not (n= 130). Of these 2 factors, LDL Particle Concentration (NMR) was the stronger predictor (relative risk for the highest compared with the lowest quartile=4.17, 95% CI 1.96-8.87). This compared with a relative risk of 3.11 (95% CI 1.55-6.26) for the ratio of total cholesterol to HDL cholesterol and a relative risk of 5.91 (95% CI 2.65-13.15) for C-reactive protein. The areas under the receiver operating characteristic curves for LDL Particle Concentration (NMR), total cholesterol to HDL cholesterol ratio, and C-reactive protein were 0.64, 0.64, and 0.66, respectively. LDL Particle Concentration (NMR) correlated with several traditionally assessed lipid and nonlipid risk factors, and thus adjustment for these tended to attenuate the magnitude of association between LDL Particle Concentration (NMR) and risk. CONCLUSIONS: In this cohort, LDL Particle Concentration measured by NMR spectroscopy was a predictor of future cardiovascular risk. However, the magnitude of predictive value of LDL Particle Concentration (NMR) was not substantively different from that of the total cholesterol to HDL cholesterol ratio and was less than that of C-reactive protein.

  • low density lipoprotein Particle Concentration and size as determined by nuclear magnetic resonance spectroscopy as predictors of cardiovascular disease in women
    Circulation, 2002
    Co-Authors: Gavin J Blake, James D Otvos, Nader Rifai, Paul M Ridker
    Abstract:

    Background— Nuclear magnetic resonance (NMR) offers an alternative, spectroscopic means of quantifying LDL and of measuring LDL Particle size. Methods and Results— We conducted a prospective nested case-control study among healthy middle-aged women to assess LDL Particle size (NMR) and Concentration (NMR) as risk factors for future myocardial infarction, stroke, or death of coronary heart disease. Median baseline levels of LDL Particle Concentration (NMR) were higher (1597 vs 1404 nmol/L; P= 0.0001) and LDL Particle size (NMR) was lower (21.5 vs 21.8 nm; P=0.046) among women who subsequently had cardiovascular events (n=130) than among those who did not (n= 130). Of these 2 factors, LDL Particle Concentration (NMR) was the stronger predictor (relative risk for the highest compared with the lowest quartile=4.17, 95% CI 1.96–8.87). This compared with a relative risk of 3.11 (95% CI 1.55–6.26) for the ratio of total cholesterol to HDL cholesterol and a relative risk of 5.91 (95% CI 2.65–13.15) for C-reactive...

Gavin J Blake - One of the best experts on this subject based on the ideXlab platform.

  • low density lipoprotein Particle Concentration and size as determined by nuclear magnetic resonance spectroscopy as predictors of cardiovascular disease in women
    Circulation, 2002
    Co-Authors: Gavin J Blake, James D Otvos, Nader Rifai, Paul M Ridker
    Abstract:

    BACKGROUND: Nuclear magnetic resonance (NMR) offers an alternative, spectroscopic means of quantifying LDL and of measuring LDL Particle size. METHODS AND RESULTS: We conducted a prospective nested case-control study among healthy middle-aged women to assess LDL Particle size (NMR) and Concentration (NMR) as risk factors for future myocardial infarction, stroke, or death of coronary heart disease. Median baseline levels of LDL Particle Concentration (NMR) were higher (1597 vs 1404 nmol/L; P= 0.0001) and LDL Particle size (NMR) was lower (21.5 vs 21.8 nm; P=0.046) among women who subsequently had cardiovascular events (n=130) than among those who did not (n= 130). Of these 2 factors, LDL Particle Concentration (NMR) was the stronger predictor (relative risk for the highest compared with the lowest quartile=4.17, 95% CI 1.96-8.87). This compared with a relative risk of 3.11 (95% CI 1.55-6.26) for the ratio of total cholesterol to HDL cholesterol and a relative risk of 5.91 (95% CI 2.65-13.15) for C-reactive protein. The areas under the receiver operating characteristic curves for LDL Particle Concentration (NMR), total cholesterol to HDL cholesterol ratio, and C-reactive protein were 0.64, 0.64, and 0.66, respectively. LDL Particle Concentration (NMR) correlated with several traditionally assessed lipid and nonlipid risk factors, and thus adjustment for these tended to attenuate the magnitude of association between LDL Particle Concentration (NMR) and risk. CONCLUSIONS: In this cohort, LDL Particle Concentration measured by NMR spectroscopy was a predictor of future cardiovascular risk. However, the magnitude of predictive value of LDL Particle Concentration (NMR) was not substantively different from that of the total cholesterol to HDL cholesterol ratio and was less than that of C-reactive protein.

  • low density lipoprotein Particle Concentration and size as determined by nuclear magnetic resonance spectroscopy as predictors of cardiovascular disease in women
    Circulation, 2002
    Co-Authors: Gavin J Blake, James D Otvos, Nader Rifai, Paul M Ridker
    Abstract:

    Background— Nuclear magnetic resonance (NMR) offers an alternative, spectroscopic means of quantifying LDL and of measuring LDL Particle size. Methods and Results— We conducted a prospective nested case-control study among healthy middle-aged women to assess LDL Particle size (NMR) and Concentration (NMR) as risk factors for future myocardial infarction, stroke, or death of coronary heart disease. Median baseline levels of LDL Particle Concentration (NMR) were higher (1597 vs 1404 nmol/L; P= 0.0001) and LDL Particle size (NMR) was lower (21.5 vs 21.8 nm; P=0.046) among women who subsequently had cardiovascular events (n=130) than among those who did not (n= 130). Of these 2 factors, LDL Particle Concentration (NMR) was the stronger predictor (relative risk for the highest compared with the lowest quartile=4.17, 95% CI 1.96–8.87). This compared with a relative risk of 3.11 (95% CI 1.55–6.26) for the ratio of total cholesterol to HDL cholesterol and a relative risk of 5.91 (95% CI 2.65–13.15) for C-reactive...

Dongtao Huang - One of the best experts on this subject based on the ideXlab platform.

  • comparison of indoor aerosol Particle Concentration and deposition in different ventilated rooms by numerical method
    Building and Environment, 2004
    Co-Authors: Bin Zhao, Ying Zhang, Xianting Li, Xudong Yang, Dongtao Huang
    Abstract:

    Abstract The air movement and aerosol Particle Concentration and deposition in displacement and mixing ventilation rooms are studied numerically. The discrete trajectory model is adopted to simulate Particle tracks while the Eulerian method for solving the continuous fluid flow is combined and validated by the case from literature. The results show that Particle deposition and Concentration are mainly influenced by the ventilation conditions. For the same Particle properties, a displacement ventilated room has a lower Particle deposition rate and larger escaped Particle mass than the mixing one, while the average Particle Concentration of the displacement case is higher than the mixing case. It is also found that Particles with different sizes (1, 2.5, 5 and 10 μm ) have different movements in the two ventilated rooms.

James D Otvos - One of the best experts on this subject based on the ideXlab platform.

  • low density lipoprotein Particle Concentration and size as determined by nuclear magnetic resonance spectroscopy as predictors of cardiovascular disease in women
    Circulation, 2002
    Co-Authors: Gavin J Blake, James D Otvos, Nader Rifai, Paul M Ridker
    Abstract:

    BACKGROUND: Nuclear magnetic resonance (NMR) offers an alternative, spectroscopic means of quantifying LDL and of measuring LDL Particle size. METHODS AND RESULTS: We conducted a prospective nested case-control study among healthy middle-aged women to assess LDL Particle size (NMR) and Concentration (NMR) as risk factors for future myocardial infarction, stroke, or death of coronary heart disease. Median baseline levels of LDL Particle Concentration (NMR) were higher (1597 vs 1404 nmol/L; P= 0.0001) and LDL Particle size (NMR) was lower (21.5 vs 21.8 nm; P=0.046) among women who subsequently had cardiovascular events (n=130) than among those who did not (n= 130). Of these 2 factors, LDL Particle Concentration (NMR) was the stronger predictor (relative risk for the highest compared with the lowest quartile=4.17, 95% CI 1.96-8.87). This compared with a relative risk of 3.11 (95% CI 1.55-6.26) for the ratio of total cholesterol to HDL cholesterol and a relative risk of 5.91 (95% CI 2.65-13.15) for C-reactive protein. The areas under the receiver operating characteristic curves for LDL Particle Concentration (NMR), total cholesterol to HDL cholesterol ratio, and C-reactive protein were 0.64, 0.64, and 0.66, respectively. LDL Particle Concentration (NMR) correlated with several traditionally assessed lipid and nonlipid risk factors, and thus adjustment for these tended to attenuate the magnitude of association between LDL Particle Concentration (NMR) and risk. CONCLUSIONS: In this cohort, LDL Particle Concentration measured by NMR spectroscopy was a predictor of future cardiovascular risk. However, the magnitude of predictive value of LDL Particle Concentration (NMR) was not substantively different from that of the total cholesterol to HDL cholesterol ratio and was less than that of C-reactive protein.

  • low density lipoprotein Particle Concentration and size as determined by nuclear magnetic resonance spectroscopy as predictors of cardiovascular disease in women
    Circulation, 2002
    Co-Authors: Gavin J Blake, James D Otvos, Nader Rifai, Paul M Ridker
    Abstract:

    Background— Nuclear magnetic resonance (NMR) offers an alternative, spectroscopic means of quantifying LDL and of measuring LDL Particle size. Methods and Results— We conducted a prospective nested case-control study among healthy middle-aged women to assess LDL Particle size (NMR) and Concentration (NMR) as risk factors for future myocardial infarction, stroke, or death of coronary heart disease. Median baseline levels of LDL Particle Concentration (NMR) were higher (1597 vs 1404 nmol/L; P= 0.0001) and LDL Particle size (NMR) was lower (21.5 vs 21.8 nm; P=0.046) among women who subsequently had cardiovascular events (n=130) than among those who did not (n= 130). Of these 2 factors, LDL Particle Concentration (NMR) was the stronger predictor (relative risk for the highest compared with the lowest quartile=4.17, 95% CI 1.96–8.87). This compared with a relative risk of 3.11 (95% CI 1.55–6.26) for the ratio of total cholesterol to HDL cholesterol and a relative risk of 5.91 (95% CI 2.65–13.15) for C-reactive...

Nader Rifai - One of the best experts on this subject based on the ideXlab platform.

  • low density lipoprotein Particle Concentration and size as determined by nuclear magnetic resonance spectroscopy as predictors of cardiovascular disease in women
    Circulation, 2002
    Co-Authors: Gavin J Blake, James D Otvos, Nader Rifai, Paul M Ridker
    Abstract:

    BACKGROUND: Nuclear magnetic resonance (NMR) offers an alternative, spectroscopic means of quantifying LDL and of measuring LDL Particle size. METHODS AND RESULTS: We conducted a prospective nested case-control study among healthy middle-aged women to assess LDL Particle size (NMR) and Concentration (NMR) as risk factors for future myocardial infarction, stroke, or death of coronary heart disease. Median baseline levels of LDL Particle Concentration (NMR) were higher (1597 vs 1404 nmol/L; P= 0.0001) and LDL Particle size (NMR) was lower (21.5 vs 21.8 nm; P=0.046) among women who subsequently had cardiovascular events (n=130) than among those who did not (n= 130). Of these 2 factors, LDL Particle Concentration (NMR) was the stronger predictor (relative risk for the highest compared with the lowest quartile=4.17, 95% CI 1.96-8.87). This compared with a relative risk of 3.11 (95% CI 1.55-6.26) for the ratio of total cholesterol to HDL cholesterol and a relative risk of 5.91 (95% CI 2.65-13.15) for C-reactive protein. The areas under the receiver operating characteristic curves for LDL Particle Concentration (NMR), total cholesterol to HDL cholesterol ratio, and C-reactive protein were 0.64, 0.64, and 0.66, respectively. LDL Particle Concentration (NMR) correlated with several traditionally assessed lipid and nonlipid risk factors, and thus adjustment for these tended to attenuate the magnitude of association between LDL Particle Concentration (NMR) and risk. CONCLUSIONS: In this cohort, LDL Particle Concentration measured by NMR spectroscopy was a predictor of future cardiovascular risk. However, the magnitude of predictive value of LDL Particle Concentration (NMR) was not substantively different from that of the total cholesterol to HDL cholesterol ratio and was less than that of C-reactive protein.

  • low density lipoprotein Particle Concentration and size as determined by nuclear magnetic resonance spectroscopy as predictors of cardiovascular disease in women
    Circulation, 2002
    Co-Authors: Gavin J Blake, James D Otvos, Nader Rifai, Paul M Ridker
    Abstract:

    Background— Nuclear magnetic resonance (NMR) offers an alternative, spectroscopic means of quantifying LDL and of measuring LDL Particle size. Methods and Results— We conducted a prospective nested case-control study among healthy middle-aged women to assess LDL Particle size (NMR) and Concentration (NMR) as risk factors for future myocardial infarction, stroke, or death of coronary heart disease. Median baseline levels of LDL Particle Concentration (NMR) were higher (1597 vs 1404 nmol/L; P= 0.0001) and LDL Particle size (NMR) was lower (21.5 vs 21.8 nm; P=0.046) among women who subsequently had cardiovascular events (n=130) than among those who did not (n= 130). Of these 2 factors, LDL Particle Concentration (NMR) was the stronger predictor (relative risk for the highest compared with the lowest quartile=4.17, 95% CI 1.96–8.87). This compared with a relative risk of 3.11 (95% CI 1.55–6.26) for the ratio of total cholesterol to HDL cholesterol and a relative risk of 5.91 (95% CI 2.65–13.15) for C-reactive...