The Experts below are selected from a list of 27 Experts worldwide ranked by ideXlab platform
Ming-wu Ding - One of the best experts on this subject based on the ideXlab platform.
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synthesis of 2 3 dihydro 1h 2 benzazepin 1 ones and 3h 2 benzoxepin 1 ones by isocyanide based multicomponent reaction wittig sequence starting from phosphonium salt precursors
Journal of Organic Chemistry, 2015Co-Authors: Long Wang, Zhi-lin Ren, Ming-wu DingAbstract:A one-pot synthesis of multisubstituted 2,3-dihydro-1H-2-benzazepin-1-ones and 3H-2-benzoxepin-1-ones by an I-MCR/Wittig sequence was developed. The reaction of phosphonium salt 3, arylglyoxals 4, amine 5 (or without), and isocyanide 6 produced the 2,3-dihydro-1H-2-benzazepin-1-ones 8 or 3H-2-benzoxepin-1-ones 10 in good yields via a sequential Ugi or Passerini Condensation and intramolecular Wittig reaction in the presence of NEt3.
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Synthesis of 2,3-Dihydro‑1H‑2-benzazepin-1-ones and 3H‑2-Benzoxepin-1-ones by Isocyanide-Based Multicomponent Reaction/Wittig Sequence Starting from Phosphonium Salt Precursors
2015Co-Authors: Long Wang, Zhi-lin Ren, Ming-wu DingAbstract:A one-pot synthesis of multisubstituted 2,3-dihydro-1H-2-benzazepin-1-ones and 3H-2-benzoxepin-1-ones by an I-MCR/Wittig sequence was developed. The reaction of phosphonium salt 3, arylglyoxals 4, amine 5 (or without), and isocyanide 6 produced the 2,3-dihydro-1H-2-benzazepin-1-ones 8 or 3H-2-benzoxepin-1-ones 10 in good yields via a sequential Ugi or Passerini Condensation and intramolecular Wittig reaction in the presence of NEt3
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Synthesis of 2,3-Dihydro-1H-2-benzazepin-1-ones and 3H-2-Benzoxepin-1-ones by Isocyanide-Based Multicomponent Reaction/Wittig Sequence Starting from Phosphonium Salt Precursors
The Journal of organic chemistry, 2014Co-Authors: Long Wang, Zhi-lin Ren, Ming-wu DingAbstract:A one-pot synthesis of multisubstituted 2,3-dihydro-1H-2-benzazepin-1-ones and 3H-2-benzoxepin-1-ones by an I-MCR/Wittig sequence was developed. The reaction of phosphonium salt 3, arylglyoxals 4, amine 5 (or without), and isocyanide 6 produced the 2,3-dihydro-1H-2-benzazepin-1-ones 8 or 3H-2-benzoxepin-1-ones 10 in good yields via a sequential Ugi or Passerini Condensation and intramolecular Wittig reaction in the presence of NEt3.
Long Wang - One of the best experts on this subject based on the ideXlab platform.
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synthesis of 2 3 dihydro 1h 2 benzazepin 1 ones and 3h 2 benzoxepin 1 ones by isocyanide based multicomponent reaction wittig sequence starting from phosphonium salt precursors
Journal of Organic Chemistry, 2015Co-Authors: Long Wang, Zhi-lin Ren, Ming-wu DingAbstract:A one-pot synthesis of multisubstituted 2,3-dihydro-1H-2-benzazepin-1-ones and 3H-2-benzoxepin-1-ones by an I-MCR/Wittig sequence was developed. The reaction of phosphonium salt 3, arylglyoxals 4, amine 5 (or without), and isocyanide 6 produced the 2,3-dihydro-1H-2-benzazepin-1-ones 8 or 3H-2-benzoxepin-1-ones 10 in good yields via a sequential Ugi or Passerini Condensation and intramolecular Wittig reaction in the presence of NEt3.
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Synthesis of 2,3-Dihydro‑1H‑2-benzazepin-1-ones and 3H‑2-Benzoxepin-1-ones by Isocyanide-Based Multicomponent Reaction/Wittig Sequence Starting from Phosphonium Salt Precursors
2015Co-Authors: Long Wang, Zhi-lin Ren, Ming-wu DingAbstract:A one-pot synthesis of multisubstituted 2,3-dihydro-1H-2-benzazepin-1-ones and 3H-2-benzoxepin-1-ones by an I-MCR/Wittig sequence was developed. The reaction of phosphonium salt 3, arylglyoxals 4, amine 5 (or without), and isocyanide 6 produced the 2,3-dihydro-1H-2-benzazepin-1-ones 8 or 3H-2-benzoxepin-1-ones 10 in good yields via a sequential Ugi or Passerini Condensation and intramolecular Wittig reaction in the presence of NEt3
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Synthesis of 2,3-Dihydro-1H-2-benzazepin-1-ones and 3H-2-Benzoxepin-1-ones by Isocyanide-Based Multicomponent Reaction/Wittig Sequence Starting from Phosphonium Salt Precursors
The Journal of organic chemistry, 2014Co-Authors: Long Wang, Zhi-lin Ren, Ming-wu DingAbstract:A one-pot synthesis of multisubstituted 2,3-dihydro-1H-2-benzazepin-1-ones and 3H-2-benzoxepin-1-ones by an I-MCR/Wittig sequence was developed. The reaction of phosphonium salt 3, arylglyoxals 4, amine 5 (or without), and isocyanide 6 produced the 2,3-dihydro-1H-2-benzazepin-1-ones 8 or 3H-2-benzoxepin-1-ones 10 in good yields via a sequential Ugi or Passerini Condensation and intramolecular Wittig reaction in the presence of NEt3.
Zhi-lin Ren - One of the best experts on this subject based on the ideXlab platform.
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synthesis of 2 3 dihydro 1h 2 benzazepin 1 ones and 3h 2 benzoxepin 1 ones by isocyanide based multicomponent reaction wittig sequence starting from phosphonium salt precursors
Journal of Organic Chemistry, 2015Co-Authors: Long Wang, Zhi-lin Ren, Ming-wu DingAbstract:A one-pot synthesis of multisubstituted 2,3-dihydro-1H-2-benzazepin-1-ones and 3H-2-benzoxepin-1-ones by an I-MCR/Wittig sequence was developed. The reaction of phosphonium salt 3, arylglyoxals 4, amine 5 (or without), and isocyanide 6 produced the 2,3-dihydro-1H-2-benzazepin-1-ones 8 or 3H-2-benzoxepin-1-ones 10 in good yields via a sequential Ugi or Passerini Condensation and intramolecular Wittig reaction in the presence of NEt3.
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Synthesis of 2,3-Dihydro‑1H‑2-benzazepin-1-ones and 3H‑2-Benzoxepin-1-ones by Isocyanide-Based Multicomponent Reaction/Wittig Sequence Starting from Phosphonium Salt Precursors
2015Co-Authors: Long Wang, Zhi-lin Ren, Ming-wu DingAbstract:A one-pot synthesis of multisubstituted 2,3-dihydro-1H-2-benzazepin-1-ones and 3H-2-benzoxepin-1-ones by an I-MCR/Wittig sequence was developed. The reaction of phosphonium salt 3, arylglyoxals 4, amine 5 (or without), and isocyanide 6 produced the 2,3-dihydro-1H-2-benzazepin-1-ones 8 or 3H-2-benzoxepin-1-ones 10 in good yields via a sequential Ugi or Passerini Condensation and intramolecular Wittig reaction in the presence of NEt3
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Synthesis of 2,3-Dihydro-1H-2-benzazepin-1-ones and 3H-2-Benzoxepin-1-ones by Isocyanide-Based Multicomponent Reaction/Wittig Sequence Starting from Phosphonium Salt Precursors
The Journal of organic chemistry, 2014Co-Authors: Long Wang, Zhi-lin Ren, Ming-wu DingAbstract:A one-pot synthesis of multisubstituted 2,3-dihydro-1H-2-benzazepin-1-ones and 3H-2-benzoxepin-1-ones by an I-MCR/Wittig sequence was developed. The reaction of phosphonium salt 3, arylglyoxals 4, amine 5 (or without), and isocyanide 6 produced the 2,3-dihydro-1H-2-benzazepin-1-ones 8 or 3H-2-benzoxepin-1-ones 10 in good yields via a sequential Ugi or Passerini Condensation and intramolecular Wittig reaction in the presence of NEt3.
Emiliano Calcagno - One of the best experts on this subject based on the ideXlab platform.
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short synthesis of protease inhibitors via modified Passerini Condensation of n boc α aminoaldehydes
Tetrahedron Letters, 2002Co-Authors: Luca Banfi, Giuseppe Guanti, Renata Riva, Andrea Basso, Emiliano CalcagnoAbstract:Extension of the previously reported modification of Passerini multicomponent reaction (involving Condensation with N-Boc-α-aminoaldehydes followed by a deprotection–transacylation step) to α-aminoacid derived carboxylic or isocyanide components, allowed the highly convergent and short synthesis of complex peptidomimetic structures, including known potent inhibitors of serine proteases.
Luca Banfi - One of the best experts on this subject based on the ideXlab platform.
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short synthesis of protease inhibitors via modified Passerini Condensation of n boc α aminoaldehydes
Tetrahedron Letters, 2002Co-Authors: Luca Banfi, Giuseppe Guanti, Renata Riva, Andrea Basso, Emiliano CalcagnoAbstract:Extension of the previously reported modification of Passerini multicomponent reaction (involving Condensation with N-Boc-α-aminoaldehydes followed by a deprotection–transacylation step) to α-aminoacid derived carboxylic or isocyanide components, allowed the highly convergent and short synthesis of complex peptidomimetic structures, including known potent inhibitors of serine proteases.
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Passerini multicomponent reaction of protected α aminoaldehydes as a tool for combinatorial synthesis of enzyme inhibitors
ChemInform, 2000Co-Authors: Luca Banfi, Giuseppe Guanti, Renata RivaAbstract:Three-component Passerini Condensation of N-Boc-α-aminoaldehydes with various isocyanides and carboxylic acids leads, after Boc-deprotection/transacylation, to complex peptide-like structures containing an α-hydroxy-β-aminoacid unit or, after oxidation, an α-oxo-β-aminoacid unit.