The Experts below are selected from a list of 324 Experts worldwide ranked by ideXlab platform
Frank Richter - One of the best experts on this subject based on the ideXlab platform.
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Pathophysiology of pain
Langenbeck's Archives of Surgery, 2004Co-Authors: Hans-georg Schaible, Frank RichterAbstract:Pain is a major symptom of many different diseases. Modern pain research has uncovered important neuronal mechanisms that are underlying clinically relevant pain states, and research goes on to define different types of pains on the basis of their neuronal and molecular mechanisms. This review will briefly outline neuronal mechanisms of pathophysiological nociceptive pain resulting from inflammation and injury, and neuropathic pain resulting from nerve damage. Pain is the sensation that is specifically evoked by potential or actual noxious (i.e. tissue damaging) stimuli or by tissue injury. Pain research has not only explored the neuronal and molecular basis of the “pain system” of the healthy subject but has also provided insights into the function and plasticity of the “pain system” during clinically relevant pains such as post-injury pain, inflammatory pain, postoperative pain, cancer pain and neuropathic pain. This review will briefly describe the “pain system” and then address neuronal mechanisms that are involved in clinical pain states.
Hans-georg Schaible - One of the best experts on this subject based on the ideXlab platform.
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Pathophysiology of pain
Langenbeck's Archives of Surgery, 2004Co-Authors: Hans-georg Schaible, Frank RichterAbstract:Pain is a major symptom of many different diseases. Modern pain research has uncovered important neuronal mechanisms that are underlying clinically relevant pain states, and research goes on to define different types of pains on the basis of their neuronal and molecular mechanisms. This review will briefly outline neuronal mechanisms of pathophysiological nociceptive pain resulting from inflammation and injury, and neuropathic pain resulting from nerve damage. Pain is the sensation that is specifically evoked by potential or actual noxious (i.e. tissue damaging) stimuli or by tissue injury. Pain research has not only explored the neuronal and molecular basis of the “pain system” of the healthy subject but has also provided insights into the function and plasticity of the “pain system” during clinically relevant pains such as post-injury pain, inflammatory pain, postoperative pain, cancer pain and neuropathic pain. This review will briefly describe the “pain system” and then address neuronal mechanisms that are involved in clinical pain states.
Marc G Jeschke - One of the best experts on this subject based on the ideXlab platform.
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Pathophysiology of Burn Injuries
Handbook of Burns Volume 1, 2020Co-Authors: Marc G Jeschke, Gerd G GauglitzAbstract:The Pathophysiology after burn is most central as it clearly affects post-burn outcomes. One of the major concerns is this response is extremely complex and an effective treatment to “normalize” this response is virtually impossible. But in order to improve outcomes and minimize adverse events profound understanding of the Pathophysiology is imperative. This chapter will go into depth of not only pathology of each organ but also on systemic level and delineate burn-associated alterations.
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Pathophysiology of burns
Wiener Medizinische Wochenschrift, 2009Co-Authors: Maike Keck, David H. Herndon, L.-p. Kamolz, Manfred Frey, Marc G JeschkeAbstract:Burn injury represents a significant problem worldwide. Advances in therapy strategies, based on better understanding of the pathophysiologic responses after burn injury have improved the clinical outcome of patients with burn injuries over the past years. This article describes the present understanding of the Pathophysiology of a burn injury including both the local and systemic responses, focusing on the many facets of organ and systemic effects directly resulting from hypovolemia and circulating mediators following burn trauma.
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Pathophysiology of burns
Wiener Medizinische Wochenschrift, 2009Co-Authors: Maike Keck, David H. Herndon, L.-p. Kamolz, Manfred Frey, Marc G JeschkeAbstract:Das Verbrennungstrauma stellt weltweit ein bedeutendes Problem in der Medizin dar. Fortschritte im Bereich des therapeutischen Vorgehens, basierend auf einem besseren Verständnis der Pathophysiologie des Verbrennungs-traumas, haben den Therapieerfolg im Laufe der letzten Jahre deutlich verbessern können. Die folgende Arbeit beschreibt die Pathophysiologie des Verbrennungstraumas. Dargestellt werden neben der lokalen und systemischen Reaktion einige organspezifische Veränderungen, resultierend aus einer bestehenden Hypovolämie oder der Freisetzung von Mediatoren. Burn injury represents a significant problem worldwide. Advances in therapy strategies, based on better understanding of the pathophysiologic responses after burn injury have improved the clinical outcome of patients with burn injuries over the past years. This article describes the present understanding of the Pathophysiology of a burn injury including both the local and systemic responses, focusing on the many facets of organ and systemic effects directly resulting from hypovolemia and circulating mediators following burn trauma.
B. J. Nickoloff - One of the best experts on this subject based on the ideXlab platform.
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Pathophysiology of cutaneous inflammation
Archives of Dermatological Research, 1992Co-Authors: B. J. NickoloffAbstract:For the better part of the past century, dermatologists have regarded the skin primarily as a large protective coat. Epidermal keratinocytes were highlighted for their production of keratins and lipids, which contributed to the structural integrity and barrier formation of skin. This “saran-wrap” perspective of skin mentioned keratinocytes only in cutaneous inflammatory reactions as passive targets for damaging diffusion products of infiltrating leukocytes. However, sufficient compelling in vitro and in vivo evidence is rapidly accumulating to support the novel perspective that epidermal keratinocytes can initiate and actively participate in the perperuation of numerous cutaneous inflammatory reactions that involve a highly diverse array of inciting agents. This presentation emphasizes the keratinocyte and highlights the dynamic immunomodulatory capacity of this overlooked epidermal cell.
Harry Shamoon - One of the best experts on this subject based on the ideXlab platform.
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Pathophysiology of Diabetes
Drugs, 1992Co-Authors: Harry ShamoonAbstract:Recent developments in epidemiology, physiology, anatomy and molecular biology have greatly increased our knowledge of the aetiology and immunological mechanisms involved in diabetes mellitus. This understanding has, in turn, facilitated progress in the diagnosis and treatment of the disease. It is generally accepted that both genetic and environmental factors have a role in the pathogenesis of insulin- and non-insulin-dependent diabetes mellitus. The contribution of insulin resistance or decreased insulin secretion to the pathogenesis of non-insulin-dependent diabetes remains controversial but it is likely that both have a role to play. Counterregulatory hormones, principally adrenaline (epinephrine) and glucagon, prevent blood glucose levels falling to extreme levels by antagonising the effect of insulin during hypoglycaemia, and inducing hepatic glucose production. Patients with insulin-dependent diabetes frequently exhibit impaired glucose counterregulation and, although its aetiology is uncertain in some patients, intensification of insulin therapy per se has been implicated. Secondary failure of oral hypoglycaemic agents in patients with non-insulin-dependent diabetes is a major and often inevitable problem, necessitating combined use of sulphonylurea and insulin in most patients. Recently, new treatments for patients with diabetes have been developed, including insulin analogues administered by a variety of novel methods, pancreatic grafts and transplantation of islet cells. Although promising, the clinical viability of these techniques remains to be demonstrated.
