The Experts below are selected from a list of 150 Experts worldwide ranked by ideXlab platform

James L. Brunton - One of the best experts on this subject based on the ideXlab platform.

Bruce H. Campbell - One of the best experts on this subject based on the ideXlab platform.

  • Report of the first case of invasive fungal sinusitis caused by Scopulariopsis acremonium: Review of Scopulariopsis infections
    Archives of otolaryngology--head & neck surgery, 1998
    Co-Authors: Matthew D. Ellison, Richard T. Hung, Kevin Harris, Bruce H. Campbell
    Abstract:

    Scopulariopsis acremonium is a species of saprophytic fungus not previously reported to cause invasive disease in humans, although invasive infections from other species of Scopulariopsis have been reported and are reviewed. Deep infection with this fungus is associated with a high mortality rate. Invasive fungal sinusitis, in general, is a potentially fatal disease that typically affects immunocompromised Patients, such as those receiving intensive chemotherapy or undergoing bone marrow transplantation. We report a case of invasive fungal sinusitis caused by Scopulariopsis acremonium in a Patient with Leukemia, who was successfully treated with amphotericin B, itraconazole, endoscopic sinus surgery, and granulocyte colony-stimulating factor.

Wayne L. Gold - One of the best experts on this subject based on the ideXlab platform.

Jianxiang Wang - One of the best experts on this subject based on the ideXlab platform.

  • Chimeric antigen receptor-modified T-cell therapy for bone marrow and skin relapse Philadelphia chromosome-like acute lymphoblastic Leukemia: A case report.
    Medicine, 2020
    Co-Authors: Mianzeng Yang, Bingcheng Liu, Ying Wang, Yuntao Liu, X Y Gong, Benfa Gong, Min Wang, Jianxiang Wang
    Abstract:

    Rationale Chimeric antigen receptor-modified T-cell (CART) therapy has revolutionized the treatment of Patients with relapsed or refractory B-cell acute lymphoblastic Leukemia (ALL). However, the capacity of CART therapy has not yet been fully elucidated. Patient concerns An 18-year-old Chinese male Patient presented with multiple firm masses on the skin all over his body following regular chemotherapy. Diagnoses Bone marrow smear and skin biopsy confirmed that it was a bone marrow and skin relapse from the initial B-cell ALL. Interventions CD19 CART-cell therapy was performed to manage the bone marrow and skin of the relapsed B-cell ALL. Outcomes During CART-cell therapy, cytokine release syndrome and central nervous encephalopathy occurred. Eventually, the lesions disappeared, and the bone marrow and skin tested minimal residual disease (MRD) negative. The Patient achieved complete remission (CR). Fourteen days after testing MRD negative, he received allogeneic hematopoietic stem-cell transplantation and has remained disease free to date. Lessons The CR of this Patient with Leukemia cutis demonstrated that CART exhibited efficacy in this case. While further research is still required, this treatment could potentially be used as a therapy for skin Leukemia, lymphoma, and other primary skin cancers.

Kiyoshi Negayama - One of the best experts on this subject based on the ideXlab platform.

  • trichosporon cutaneum trichosporon asahii infection mimicking hand eczema in a Patient with Leukemia
    Journal of The American Academy of Dermatology, 2000
    Co-Authors: Toshifumi Nakagawa, Kuniyuki Nakashima, Takashi Takaiwa, Kiyoshi Negayama
    Abstract:

    Abstract Trichosporon Cutaneum is a yeast-like fungus that causes white piedra and onychomycosis. Recently, it has also been recognized as an opportunistic pathogen in immunocompromised hosts. We describe a 64-year-old woman who developed a superficial Trichosporon infection mimicking hand eczema during chemotherapy for her chronic myelocytic Leukemia. To our knowledge, no cases of superficial infection like this one have previously been reported. This case suggests that careful examination is required in diagnosing Trichosporon infection in immunocompromised hosts, because the infection can be invasive or unusual in appearance. (J Am Acad Dermatol 2000;42:929-31.)