The Experts below are selected from a list of 39 Experts worldwide ranked by ideXlab platform

Li Liu - One of the best experts on this subject based on the ideXlab platform.

  • Differential roles of the fan-shaped body and the ellipsoid body in Drosophila visual Pattern Memory
    Learning & memory (Cold Spring Harbor N.Y.), 2009
    Co-Authors: Yufeng Pan, Yanqiong Zhou, Chao Guo, Haiyun Gong, Zhefeng Gong, Li Liu
    Abstract:

    The central complex is a prominent structure in the Drosophila brain. Visual learning experiments in the flight simulator, with flies with genetically altered brains, revealed that two groups of horizontal neurons in one of its substructures, the fan-shaped body, were required for Drosophila visual Pattern Memory. However, little is known about the role of other components of the central complex for visual Pattern Memory. Here we show that a small set of neurons in the ellipsoid body, which is another substructure of the central complex and connected to the fan-shaped body, is also required for visual Pattern Memory. Localized expression of rutabaga adenylyl cyclase in either the fan-shaped body or the ellipsoid body is sufficient to rescue the Memory defect of the rut 2080 mutant. We then performed RNA interference of rutabaga in either structure and found that they both were required for visual Pattern Memory. Additionally, we tested the above rescued flies under several visual Pattern parameters, such as size, contour orientation, and vertical compactness, and revealed differential roles of the fan-shaped body and the ellipsoid body for visual Pattern Memory. Our study defines a complex neural circuit in the central complex for Drosophila visual Pattern Memory.

  • visual Pattern Memory requires foraging function in the central complex of drosophila
    Learning & Memory, 2008
    Co-Authors: Zhipeng Wang, Yufeng Pan, Zhefeng Gong, Huoqing Jiang, Lazaros Chatzimanolis, Jianhong Chang, Li Liu
    Abstract:

    The role of the foraging (for) gene, which encodes a cyclic guanosine-3',5'-monophosphate (cGMP)-dependent protein kinase (PKG), in food-search behavior in Drosophila has been intensively studied. However, its functions in other complex behaviors have not been well-characterized. Here, we show experimentally in Drosophila that the for gene is required in the operant visual learning paradigm. Visual Pattern Memory was normal in a natural variant rover (for(R)) but was impaired in another natural variant sitter (for(S)), which has a lower PKG level. Memory defects in for(S) flies could be rescued by either constitutive or adult-limited expression of for in the fan-shaped body. Interestingly, we showed that such rescue also occurred when for was expressed in the ellipsoid body. Additionally, expression of for in the fifth layer of the fan-shaped body restored sufficient Memory for the Pattern parameter "elevation" but not for "contour orientation," whereas expression of for in the ellipsoid body restored sufficient Memory for both parameters. Our study defines a Drosophila model for further understanding the role of cGMP-PKG signaling in associative learning/Memory and the neural circuit underlying this for-dependent visual Pattern Memory.

Yufeng Pan - One of the best experts on this subject based on the ideXlab platform.

  • Differential roles of the fan-shaped body and the ellipsoid body in Drosophila visual Pattern Memory
    Learning & memory (Cold Spring Harbor N.Y.), 2009
    Co-Authors: Yufeng Pan, Yanqiong Zhou, Chao Guo, Haiyun Gong, Zhefeng Gong, Li Liu
    Abstract:

    The central complex is a prominent structure in the Drosophila brain. Visual learning experiments in the flight simulator, with flies with genetically altered brains, revealed that two groups of horizontal neurons in one of its substructures, the fan-shaped body, were required for Drosophila visual Pattern Memory. However, little is known about the role of other components of the central complex for visual Pattern Memory. Here we show that a small set of neurons in the ellipsoid body, which is another substructure of the central complex and connected to the fan-shaped body, is also required for visual Pattern Memory. Localized expression of rutabaga adenylyl cyclase in either the fan-shaped body or the ellipsoid body is sufficient to rescue the Memory defect of the rut 2080 mutant. We then performed RNA interference of rutabaga in either structure and found that they both were required for visual Pattern Memory. Additionally, we tested the above rescued flies under several visual Pattern parameters, such as size, contour orientation, and vertical compactness, and revealed differential roles of the fan-shaped body and the ellipsoid body for visual Pattern Memory. Our study defines a complex neural circuit in the central complex for Drosophila visual Pattern Memory.

  • visual Pattern Memory requires foraging function in the central complex of drosophila
    Learning & Memory, 2008
    Co-Authors: Zhipeng Wang, Yufeng Pan, Zhefeng Gong, Huoqing Jiang, Lazaros Chatzimanolis, Jianhong Chang, Li Liu
    Abstract:

    The role of the foraging (for) gene, which encodes a cyclic guanosine-3',5'-monophosphate (cGMP)-dependent protein kinase (PKG), in food-search behavior in Drosophila has been intensively studied. However, its functions in other complex behaviors have not been well-characterized. Here, we show experimentally in Drosophila that the for gene is required in the operant visual learning paradigm. Visual Pattern Memory was normal in a natural variant rover (for(R)) but was impaired in another natural variant sitter (for(S)), which has a lower PKG level. Memory defects in for(S) flies could be rescued by either constitutive or adult-limited expression of for in the fan-shaped body. Interestingly, we showed that such rescue also occurred when for was expressed in the ellipsoid body. Additionally, expression of for in the fifth layer of the fan-shaped body restored sufficient Memory for the Pattern parameter "elevation" but not for "contour orientation," whereas expression of for in the ellipsoid body restored sufficient Memory for both parameters. Our study defines a Drosophila model for further understanding the role of cGMP-PKG signaling in associative learning/Memory and the neural circuit underlying this for-dependent visual Pattern Memory.

Zhipeng Wang - One of the best experts on this subject based on the ideXlab platform.

  • visual Pattern Memory requires foraging function in the central complex of drosophila
    Learning & Memory, 2008
    Co-Authors: Zhipeng Wang, Yufeng Pan, Zhefeng Gong, Huoqing Jiang, Lazaros Chatzimanolis, Jianhong Chang, Li Liu
    Abstract:

    The role of the foraging (for) gene, which encodes a cyclic guanosine-3',5'-monophosphate (cGMP)-dependent protein kinase (PKG), in food-search behavior in Drosophila has been intensively studied. However, its functions in other complex behaviors have not been well-characterized. Here, we show experimentally in Drosophila that the for gene is required in the operant visual learning paradigm. Visual Pattern Memory was normal in a natural variant rover (for(R)) but was impaired in another natural variant sitter (for(S)), which has a lower PKG level. Memory defects in for(S) flies could be rescued by either constitutive or adult-limited expression of for in the fan-shaped body. Interestingly, we showed that such rescue also occurred when for was expressed in the ellipsoid body. Additionally, expression of for in the fifth layer of the fan-shaped body restored sufficient Memory for the Pattern parameter "elevation" but not for "contour orientation," whereas expression of for in the ellipsoid body restored sufficient Memory for both parameters. Our study defines a Drosophila model for further understanding the role of cGMP-PKG signaling in associative learning/Memory and the neural circuit underlying this for-dependent visual Pattern Memory.

Zhefeng Gong - One of the best experts on this subject based on the ideXlab platform.

  • Differential roles of the fan-shaped body and the ellipsoid body in Drosophila visual Pattern Memory
    Learning & memory (Cold Spring Harbor N.Y.), 2009
    Co-Authors: Yufeng Pan, Yanqiong Zhou, Chao Guo, Haiyun Gong, Zhefeng Gong, Li Liu
    Abstract:

    The central complex is a prominent structure in the Drosophila brain. Visual learning experiments in the flight simulator, with flies with genetically altered brains, revealed that two groups of horizontal neurons in one of its substructures, the fan-shaped body, were required for Drosophila visual Pattern Memory. However, little is known about the role of other components of the central complex for visual Pattern Memory. Here we show that a small set of neurons in the ellipsoid body, which is another substructure of the central complex and connected to the fan-shaped body, is also required for visual Pattern Memory. Localized expression of rutabaga adenylyl cyclase in either the fan-shaped body or the ellipsoid body is sufficient to rescue the Memory defect of the rut 2080 mutant. We then performed RNA interference of rutabaga in either structure and found that they both were required for visual Pattern Memory. Additionally, we tested the above rescued flies under several visual Pattern parameters, such as size, contour orientation, and vertical compactness, and revealed differential roles of the fan-shaped body and the ellipsoid body for visual Pattern Memory. Our study defines a complex neural circuit in the central complex for Drosophila visual Pattern Memory.

  • visual Pattern Memory requires foraging function in the central complex of drosophila
    Learning & Memory, 2008
    Co-Authors: Zhipeng Wang, Yufeng Pan, Zhefeng Gong, Huoqing Jiang, Lazaros Chatzimanolis, Jianhong Chang, Li Liu
    Abstract:

    The role of the foraging (for) gene, which encodes a cyclic guanosine-3',5'-monophosphate (cGMP)-dependent protein kinase (PKG), in food-search behavior in Drosophila has been intensively studied. However, its functions in other complex behaviors have not been well-characterized. Here, we show experimentally in Drosophila that the for gene is required in the operant visual learning paradigm. Visual Pattern Memory was normal in a natural variant rover (for(R)) but was impaired in another natural variant sitter (for(S)), which has a lower PKG level. Memory defects in for(S) flies could be rescued by either constitutive or adult-limited expression of for in the fan-shaped body. Interestingly, we showed that such rescue also occurred when for was expressed in the ellipsoid body. Additionally, expression of for in the fifth layer of the fan-shaped body restored sufficient Memory for the Pattern parameter "elevation" but not for "contour orientation," whereas expression of for in the ellipsoid body restored sufficient Memory for both parameters. Our study defines a Drosophila model for further understanding the role of cGMP-PKG signaling in associative learning/Memory and the neural circuit underlying this for-dependent visual Pattern Memory.

Huoqing Jiang - One of the best experts on this subject based on the ideXlab platform.

  • visual Pattern Memory requires foraging function in the central complex of drosophila
    Learning & Memory, 2008
    Co-Authors: Zhipeng Wang, Yufeng Pan, Zhefeng Gong, Huoqing Jiang, Lazaros Chatzimanolis, Jianhong Chang, Li Liu
    Abstract:

    The role of the foraging (for) gene, which encodes a cyclic guanosine-3',5'-monophosphate (cGMP)-dependent protein kinase (PKG), in food-search behavior in Drosophila has been intensively studied. However, its functions in other complex behaviors have not been well-characterized. Here, we show experimentally in Drosophila that the for gene is required in the operant visual learning paradigm. Visual Pattern Memory was normal in a natural variant rover (for(R)) but was impaired in another natural variant sitter (for(S)), which has a lower PKG level. Memory defects in for(S) flies could be rescued by either constitutive or adult-limited expression of for in the fan-shaped body. Interestingly, we showed that such rescue also occurred when for was expressed in the ellipsoid body. Additionally, expression of for in the fifth layer of the fan-shaped body restored sufficient Memory for the Pattern parameter "elevation" but not for "contour orientation," whereas expression of for in the ellipsoid body restored sufficient Memory for both parameters. Our study defines a Drosophila model for further understanding the role of cGMP-PKG signaling in associative learning/Memory and the neural circuit underlying this for-dependent visual Pattern Memory.