The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform

Zhanlin Li - One of the best experts on this subject based on the ideXlab platform.

  • racemic indole alkaloids from the seeds of Peganum Harmala
    Fitoterapia, 2018
    Co-Authors: Kaibo Wang, Xu Hu, Shengge Li, Xinyu Li, Dahong Li, Zhanlin Li
    Abstract:

    Abstract Five pairs of new 2-oxoindole alkaloids, (±)-Peganumalines A–E (1–5), and a new indole alkaloid, Peganumaline F (6), along with two known analogues, were isolated from the seeds of Peganum Harmala. Their structures and absolute configurations were elucidated through spectroscopic analyses and quantum chemistry calculations. Notably, (±)-Peganumalines A (1) represent a pair of rare 2-oxoindole dimeric alkaloid enantiomer with the hitherto unknown carbon skeleton. All isolates were tested for antiproliferative and antibacterial activities.

  • cytotoxic quinazoline alkaloids from the seeds of Peganum Harmala
    Bioorganic & Medicinal Chemistry Letters, 2018
    Co-Authors: Shengge Li, Kaibo Wang, Dahong Li, Chi Gong, Zhanlin Li
    Abstract:

    Abstract Seventeen quinazoline alkaloids and derivatives, containing two pairs of new epimers, named as ( S )- and ( R )-1-(2-aminobenzyl)-3-hydroxypyrrolidin-2-one β - d -glucopyranosyl-(1 → 6)- β - d -glucopyranoside ( 1 , 2 ), ( S )- and ( R )-vasicinone β - d -glucopyranosyl-(1 → 6)- β - d -glucopyranoside ( 3 , 4 ), and a new enantiomer ( 12b ), together with six known ones ( 5 – 8 , 10 , and 12a ), and three pairs of known enantiomers ( 9 , 11 , and 13 ), were isolated from the ethanol extracts of the seeds of Peganum Harmala L.. Their structures including the absolute configuration were elucidated by using 1D and 2D NMR, and ECD calculation approaches. The cytotoxic activities of all isolated compounds were evaluated. 11 showed moderate cytotoxicity against PC-3 cells with an IC 50 value of 15.41 μM.

  • pegaharmalines a and b two novel β carboline alkaloids with unprecedented carbon skeletons from Peganum Harmala
    RSC Advances, 2014
    Co-Authors: Kaibo Wang, Dahong Li, Chunmao Yuan, Yongkui Jing, Hongping He, Yingtong Di, Zhanlin Li
    Abstract:

    Pegaharmalines A (1) and B (2), two novel β-carboline alkaloids with unprecedented carbon skeletons, were isolated from the seeds of Peganum Harmala. Their structures were determined by spectroscopic methods and the absolute configuration of 1 was elucidated by CD analysis. 1 and 2 exhibited significant cytotoxicities on HL-60 cells with IC50 values of 9.4 and 13.6 μM, respectively.

  • Peganumine a a β carboline dimer with a new octacyclic scaffold from Peganum Harmala
    Organic Letters, 2014
    Co-Authors: Kaibo Wang, Dahong Li, Chunmao Yuan, Yongkui Jing, Hongping He, Yingtong Di, Gang Chen, Zhanlin Li
    Abstract:

    Peganumine A (1), a new dimeric β-carboline alkaloid characterized by a unique 3,9-diazatetracyclo[6.5.2.01,9.03,8]pentadec-2-one scaffold, was isolated from the seeds of Peganum Harmala. The structure including the absolute configuration was determined by spectroscopic data, X-ray crystallography, ECD calculation, and CD exciton chirality approaches. Compound 1 showed moderate cytotoxic activity against MCF-7, PC-3, and HepG2 cells and selective effects on HL-60 cells with an IC50 value of 5.8 μM.

Kaibo Wang - One of the best experts on this subject based on the ideXlab platform.

  • racemic indole alkaloids from the seeds of Peganum Harmala
    Fitoterapia, 2018
    Co-Authors: Kaibo Wang, Xu Hu, Shengge Li, Xinyu Li, Dahong Li, Zhanlin Li
    Abstract:

    Abstract Five pairs of new 2-oxoindole alkaloids, (±)-Peganumalines A–E (1–5), and a new indole alkaloid, Peganumaline F (6), along with two known analogues, were isolated from the seeds of Peganum Harmala. Their structures and absolute configurations were elucidated through spectroscopic analyses and quantum chemistry calculations. Notably, (±)-Peganumalines A (1) represent a pair of rare 2-oxoindole dimeric alkaloid enantiomer with the hitherto unknown carbon skeleton. All isolates were tested for antiproliferative and antibacterial activities.

  • cytotoxic quinazoline alkaloids from the seeds of Peganum Harmala
    Bioorganic & Medicinal Chemistry Letters, 2018
    Co-Authors: Shengge Li, Kaibo Wang, Dahong Li, Chi Gong, Zhanlin Li
    Abstract:

    Abstract Seventeen quinazoline alkaloids and derivatives, containing two pairs of new epimers, named as ( S )- and ( R )-1-(2-aminobenzyl)-3-hydroxypyrrolidin-2-one β - d -glucopyranosyl-(1 → 6)- β - d -glucopyranoside ( 1 , 2 ), ( S )- and ( R )-vasicinone β - d -glucopyranosyl-(1 → 6)- β - d -glucopyranoside ( 3 , 4 ), and a new enantiomer ( 12b ), together with six known ones ( 5 – 8 , 10 , and 12a ), and three pairs of known enantiomers ( 9 , 11 , and 13 ), were isolated from the ethanol extracts of the seeds of Peganum Harmala L.. Their structures including the absolute configuration were elucidated by using 1D and 2D NMR, and ECD calculation approaches. The cytotoxic activities of all isolated compounds were evaluated. 11 showed moderate cytotoxicity against PC-3 cells with an IC 50 value of 15.41 μM.

  • pegaharmalines a and b two novel β carboline alkaloids with unprecedented carbon skeletons from Peganum Harmala
    RSC Advances, 2014
    Co-Authors: Kaibo Wang, Dahong Li, Chunmao Yuan, Yongkui Jing, Hongping He, Yingtong Di, Zhanlin Li
    Abstract:

    Pegaharmalines A (1) and B (2), two novel β-carboline alkaloids with unprecedented carbon skeletons, were isolated from the seeds of Peganum Harmala. Their structures were determined by spectroscopic methods and the absolute configuration of 1 was elucidated by CD analysis. 1 and 2 exhibited significant cytotoxicities on HL-60 cells with IC50 values of 9.4 and 13.6 μM, respectively.

  • Peganumine a a β carboline dimer with a new octacyclic scaffold from Peganum Harmala
    Organic Letters, 2014
    Co-Authors: Kaibo Wang, Dahong Li, Chunmao Yuan, Yongkui Jing, Hongping He, Yingtong Di, Gang Chen, Zhanlin Li
    Abstract:

    Peganumine A (1), a new dimeric β-carboline alkaloid characterized by a unique 3,9-diazatetracyclo[6.5.2.01,9.03,8]pentadec-2-one scaffold, was isolated from the seeds of Peganum Harmala. The structure including the absolute configuration was determined by spectroscopic data, X-ray crystallography, ECD calculation, and CD exciton chirality approaches. Compound 1 showed moderate cytotoxic activity against MCF-7, PC-3, and HepG2 cells and selective effects on HL-60 cells with an IC50 value of 5.8 μM.

Dahong Li - One of the best experts on this subject based on the ideXlab platform.

  • racemic indole alkaloids from the seeds of Peganum Harmala
    Fitoterapia, 2018
    Co-Authors: Kaibo Wang, Xu Hu, Shengge Li, Xinyu Li, Dahong Li, Zhanlin Li
    Abstract:

    Abstract Five pairs of new 2-oxoindole alkaloids, (±)-Peganumalines A–E (1–5), and a new indole alkaloid, Peganumaline F (6), along with two known analogues, were isolated from the seeds of Peganum Harmala. Their structures and absolute configurations were elucidated through spectroscopic analyses and quantum chemistry calculations. Notably, (±)-Peganumalines A (1) represent a pair of rare 2-oxoindole dimeric alkaloid enantiomer with the hitherto unknown carbon skeleton. All isolates were tested for antiproliferative and antibacterial activities.

  • cytotoxic quinazoline alkaloids from the seeds of Peganum Harmala
    Bioorganic & Medicinal Chemistry Letters, 2018
    Co-Authors: Shengge Li, Kaibo Wang, Dahong Li, Chi Gong, Zhanlin Li
    Abstract:

    Abstract Seventeen quinazoline alkaloids and derivatives, containing two pairs of new epimers, named as ( S )- and ( R )-1-(2-aminobenzyl)-3-hydroxypyrrolidin-2-one β - d -glucopyranosyl-(1 → 6)- β - d -glucopyranoside ( 1 , 2 ), ( S )- and ( R )-vasicinone β - d -glucopyranosyl-(1 → 6)- β - d -glucopyranoside ( 3 , 4 ), and a new enantiomer ( 12b ), together with six known ones ( 5 – 8 , 10 , and 12a ), and three pairs of known enantiomers ( 9 , 11 , and 13 ), were isolated from the ethanol extracts of the seeds of Peganum Harmala L.. Their structures including the absolute configuration were elucidated by using 1D and 2D NMR, and ECD calculation approaches. The cytotoxic activities of all isolated compounds were evaluated. 11 showed moderate cytotoxicity against PC-3 cells with an IC 50 value of 15.41 μM.

  • pegaharmalines a and b two novel β carboline alkaloids with unprecedented carbon skeletons from Peganum Harmala
    RSC Advances, 2014
    Co-Authors: Kaibo Wang, Dahong Li, Chunmao Yuan, Yongkui Jing, Hongping He, Yingtong Di, Zhanlin Li
    Abstract:

    Pegaharmalines A (1) and B (2), two novel β-carboline alkaloids with unprecedented carbon skeletons, were isolated from the seeds of Peganum Harmala. Their structures were determined by spectroscopic methods and the absolute configuration of 1 was elucidated by CD analysis. 1 and 2 exhibited significant cytotoxicities on HL-60 cells with IC50 values of 9.4 and 13.6 μM, respectively.

  • Peganumine a a β carboline dimer with a new octacyclic scaffold from Peganum Harmala
    Organic Letters, 2014
    Co-Authors: Kaibo Wang, Dahong Li, Chunmao Yuan, Yongkui Jing, Hongping He, Yingtong Di, Gang Chen, Zhanlin Li
    Abstract:

    Peganumine A (1), a new dimeric β-carboline alkaloid characterized by a unique 3,9-diazatetracyclo[6.5.2.01,9.03,8]pentadec-2-one scaffold, was isolated from the seeds of Peganum Harmala. The structure including the absolute configuration was determined by spectroscopic data, X-ray crystallography, ECD calculation, and CD exciton chirality approaches. Compound 1 showed moderate cytotoxic activity against MCF-7, PC-3, and HepG2 cells and selective effects on HL-60 cells with an IC50 value of 5.8 μM.

Xiangjiu He - One of the best experts on this subject based on the ideXlab platform.

  • cytotoxic constituents and mechanism from Peganum Harmala
    Chemistry & Biodiversity, 2016
    Co-Authors: Chunhua Wang, Zhenxue Zhang, Yihai Wang, Xiangjiu He
    Abstract:

    Peganum Harmala L. is a traditional Chinese and Uygur medicine used to treat cancer. Bioactivity-guided fractionation was applied to determine the cytotoxic constituents from P. Harmala. A novel triterpenoid and a phenolic glycoside were isolated and identified, as well as seven known compounds. The novel metabolites were elucidated to be 3α-acetoxy-27-hydroxyolean-12-en-28-oic acid methyl ester (1, OA) and N-acetyl-9-syringinoside (9). Some compounds exhibited potent cytotoxicity against human tumor cells. Among them, OA showed the highest cytotoxicity against human lung cancer cells A549 with an IC50 value of 8.03 ± 0.81 μm. OA had a potent anti-NSCLC cell activity by interfering with the epidermal growth factor receptor (EGFR) activation and its downstream signaling, and could exert an antiproliferative effect by inactivation of EGFR-driven antiapoptotic pathway followed by the release of mitochondrial cytochrome c, which might prove to be a promising leading compound for the development of an anti-lung cancer drug.

  • cytotoxic indole alkaloids against human leukemia cell lines from the toxic plant Peganum Harmala
    Toxins, 2015
    Co-Authors: Chunhua Wang, Zhenxue Zhang, Yihai Wang, Xiangjiu He
    Abstract:

    Bioactivity-guided fractionation was used to determine the cytotoxic alkaloids from the toxic plant Peganum Harmala. Two novel indole alkaloids, together with ten known ones, were isolated and identified. The novel alkaloids were elucidated to be 2-(indol-3-yl)ethyl-α-L-rhamnopyranosyl-(1 → 6)-β-D-glucopyranoside (2) and 3-hydroxy-3-(N-acetyl-2-aminoethyl)-6-methoxyindol-2-one (3). The cytotoxicity against human leukemia cells was assayed for the alkaloids and some of them showed potent activity. Harmalacidine (compound 8, HMC) exhibited the highest cytotoxicity against U-937 cells with IC50 value of 3.1 ± 0.2 μmol/L. The cytotoxic mechanism of HMC was targeting the mitochondrial and protein tyrosine kinase signaling pathways (PTKs-Ras/Raf/ERK). The results strongly demonstrated that the alkaloids from Peganum Harmala could be a promising candidate for the therapy of leukemia.

  • antitumor quinazoline alkaloids from the seeds of Peganum Harmala
    Journal of Asian Natural Products Research, 2015
    Co-Authors: Chunhua Wang, Yihai Wang, Hong Zeng, Chuan Li, Jun Cheng, Zhijun Ye, Xiangjiu He
    Abstract:

    A phytochemical study on the methanol extracts from the seeds of Peganum Harmala L. led to a new quizonaline alkaloid (S)-vasicinone-1-O-β-d-glucopyranoside (1) and four known ones, (R)-vasicinone-1-O-β-d-glucopyranoside (2), (S)-vasicinone (3), vasicine (4), and deoxyvasicinone (5). Their structures were elucidated by spectroscopic analysis including IR, HR-ESI-MS, 1D and 2D NMR, and specific rotation as well as by comparison of the data with those in the literature. All of the alkaloids were screened for antiproliferative activity against human gastric cancer cells MCG-803 with MTT method. Compounds 1 and 3 exhibited moderate inhibitory activity.

Mohsen Bameriniafar - One of the best experts on this subject based on the ideXlab platform.

  • evaluation of antidiabetic and antihyperlipidemic effects of Peganum Harmala seeds in diabetic rats
    Cholesterol, 2016
    Co-Authors: Gholamreza Komeili, Mohammad Hashemi, Mohsen Bameriniafar
    Abstract:

    The present study was carried out to investigate the antidiabetic and antihyperlipidemic properties of hydroalcoholic extract of Peganum Harmala in streptozotocin-induced diabetic male rats. In an experimental study, 64 normal Wistar albino male rats (200–230 g) were randomly divided into 8 groups. Control and diabetic rats were treated with normal saline and three different doses (30, 60, and 120 mg/kg) of hydroalcoholic extract of Peganum Harmala seeds for 4 weeks orally. At the end of treatment, blood samples were taken and glucose, triglycerides, total cholesterol, LDL-c, HDL-c, malondialdehyde (MDA), total antioxidant capacity (TCA), ALT, AST, GGT, bilirubin, and glycosylated hemoglobin () were determined. STZ-induced diabetic rats showed significant changes in the values of glucose, triglycerides, total cholesterol, LDL-c, MDA, TAC, ALT, AST, GGT, bilirubin, and in comparison with normal rats. Administration of the extract to diabetic rats resulted in a remarkable decrease in glucose, lipid profiles, MDA, ALT, AST, GGT, bilirubin, and levels and increase in TAC relative to diabetic group. The results of this study indicated that hydroalcoholic extract of Peganum Harmala seeds possesses antidiabetic and hypolipidemic activities and could be useful in treatment of diabetes.