The Experts below are selected from a list of 27 Experts worldwide ranked by ideXlab platform
Lance R. Mcmahon - One of the best experts on this subject based on the ideXlab platform.
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Discriminative stimulus effects of mecamylamine and nicotine in rhesus monkeys: Central and peripheral mechanisms.
Pharmacology Biochemistry and Behavior, 2019Co-Authors: Colin S. Cunningham, Megan J. Moerke, Lance R. McmahonAbstract:Abstract Mecamylamine is a non-competitive nicotinic acetylcholine receptor (nAChR) antagonist that has been prescribed for hypertension and as an off-label smoking cessation aid. Here, we examined pharmacological mechanisms underlying the interoceptive effects (i.e., discriminative stimulus effects) of mecamylamine (5.6 mg/kg s.c.) and compared the effects of nAChR antagonists in this discrimination assay to their capacity to block a nicotine discriminative stimulus (1.78 mg/kg s.c.) in rhesus monkeys. Central (Pempidine) and peripherally restricted nAChR antagonists (pentolinium and chlorisondamine) dose-dependently substituted for the mecamylamine discriminative stimulus in the following rank order potency (pentolinium > Pempidine > chlorisondamine > mecamylamine). In contrast, at equi-effective doses based on substitution for mecamylamine, only mecamylamine antagonized the discriminative stimulus effects of nicotine, i.e., pentolinium, chlorisondamine, and Pempidine did not. NMDA receptor antagonists produced dose-dependent substitution for mecamylamine with the following rank order potency (MK-801 > phencyclidine > ketamine). In contrast, behaviorally active doses of smoking cessation aids including nAChR agonists (nicotine, varenicline, and cytisine), the smoking cessation aid and antidepressant bupropion, and the benzodiazepine midazolam did not substitute for the discriminative stimulus effects of mecamylamine. These data suggest that peripheral nAChRs and NMDA receptors may contribute to the interoceptive stimulus effects produced by mecamylamine. Based on the current results, the therapeutic use of mecamylamine (i.e., for smoking or to alleviate green tobacco sickness) should be weighed against the potential for mecamylamine to produce interoceptive effects that overlap with another class of abused drugs (i.e., NMDA receptor agonists).
Jeffrey M Cumming - One of the best experts on this subject based on the ideXlab platform.
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sexual selection and the evolution of dance fly mating systems diptera empididae empidinae
Canadian Entomologist, 1994Co-Authors: Jeffrey M CummingAbstract:Courtship displays of empidine dance flies (Diptera: Empididae), which include transfers of nuptial gifts during mating, are reviewed in light of sexual selection theory. Sex-role reversed courtship behavior, involving female swarming and male choice, appears to be correlated with certain female secondary sexual characters that are widespread throughout the Empidinae. The tendency to shift mate choice from females to males, and the apparent development of autogeny in many empidine species, are both hypothesized to have resulted from males monopolizing the proteinaceous food source of non-hunting females, through transfers of nuptial gifts of prey. The autogenous condition appears to have led to the ritualized presentation of various types of inedible nuptial gifts by males of several species, possibly including the development of secreted nuptial gifts, or balloons, as displays of male fitness.
Cumming, Jeffrey M. - One of the best experts on this subject based on the ideXlab platform.
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Sexual Selection and the Evolution of Dance Fly Mating Systems (Diptera: Empididae; Empidinae)
Hosted by Utah State University Libraries, 1994Co-Authors: Cumming, Jeffrey M.Abstract:Courtship displays of empidine dance flies (Diptera: Empididae), which include transfers of nuptial gifts during mating, are reviewed in light of sexual selection theory. Sex-role reversed courtship behavior, involving female swarming and male choice, appears to be correlated with certain female secondary sexual characters that are widespread throughout the Empidinae. The tendency to shift mate choice from females to males, and the apparent development of autogeny in many empidine species, are both hypothesized to have resulted from males monopolizing the proteinaceous food source of non-hunting females, through transfers of nuptial gifts of prey. The autogenous condition appears to have led to the ritualized presentation of various types of inedible nuptial gifts by males of several species, possibly including the development of secreted nuptial gifts, or balloons, as displays of male fitness
Colin S. Cunningham - One of the best experts on this subject based on the ideXlab platform.
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Discriminative stimulus effects of mecamylamine and nicotine in rhesus monkeys: Central and peripheral mechanisms.
Pharmacology Biochemistry and Behavior, 2019Co-Authors: Colin S. Cunningham, Megan J. Moerke, Lance R. McmahonAbstract:Abstract Mecamylamine is a non-competitive nicotinic acetylcholine receptor (nAChR) antagonist that has been prescribed for hypertension and as an off-label smoking cessation aid. Here, we examined pharmacological mechanisms underlying the interoceptive effects (i.e., discriminative stimulus effects) of mecamylamine (5.6 mg/kg s.c.) and compared the effects of nAChR antagonists in this discrimination assay to their capacity to block a nicotine discriminative stimulus (1.78 mg/kg s.c.) in rhesus monkeys. Central (Pempidine) and peripherally restricted nAChR antagonists (pentolinium and chlorisondamine) dose-dependently substituted for the mecamylamine discriminative stimulus in the following rank order potency (pentolinium > Pempidine > chlorisondamine > mecamylamine). In contrast, at equi-effective doses based on substitution for mecamylamine, only mecamylamine antagonized the discriminative stimulus effects of nicotine, i.e., pentolinium, chlorisondamine, and Pempidine did not. NMDA receptor antagonists produced dose-dependent substitution for mecamylamine with the following rank order potency (MK-801 > phencyclidine > ketamine). In contrast, behaviorally active doses of smoking cessation aids including nAChR agonists (nicotine, varenicline, and cytisine), the smoking cessation aid and antidepressant bupropion, and the benzodiazepine midazolam did not substitute for the discriminative stimulus effects of mecamylamine. These data suggest that peripheral nAChRs and NMDA receptors may contribute to the interoceptive stimulus effects produced by mecamylamine. Based on the current results, the therapeutic use of mecamylamine (i.e., for smoking or to alleviate green tobacco sickness) should be weighed against the potential for mecamylamine to produce interoceptive effects that overlap with another class of abused drugs (i.e., NMDA receptor agonists).
Megan J. Moerke - One of the best experts on this subject based on the ideXlab platform.
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Discriminative stimulus effects of mecamylamine and nicotine in rhesus monkeys: Central and peripheral mechanisms.
Pharmacology Biochemistry and Behavior, 2019Co-Authors: Colin S. Cunningham, Megan J. Moerke, Lance R. McmahonAbstract:Abstract Mecamylamine is a non-competitive nicotinic acetylcholine receptor (nAChR) antagonist that has been prescribed for hypertension and as an off-label smoking cessation aid. Here, we examined pharmacological mechanisms underlying the interoceptive effects (i.e., discriminative stimulus effects) of mecamylamine (5.6 mg/kg s.c.) and compared the effects of nAChR antagonists in this discrimination assay to their capacity to block a nicotine discriminative stimulus (1.78 mg/kg s.c.) in rhesus monkeys. Central (Pempidine) and peripherally restricted nAChR antagonists (pentolinium and chlorisondamine) dose-dependently substituted for the mecamylamine discriminative stimulus in the following rank order potency (pentolinium > Pempidine > chlorisondamine > mecamylamine). In contrast, at equi-effective doses based on substitution for mecamylamine, only mecamylamine antagonized the discriminative stimulus effects of nicotine, i.e., pentolinium, chlorisondamine, and Pempidine did not. NMDA receptor antagonists produced dose-dependent substitution for mecamylamine with the following rank order potency (MK-801 > phencyclidine > ketamine). In contrast, behaviorally active doses of smoking cessation aids including nAChR agonists (nicotine, varenicline, and cytisine), the smoking cessation aid and antidepressant bupropion, and the benzodiazepine midazolam did not substitute for the discriminative stimulus effects of mecamylamine. These data suggest that peripheral nAChRs and NMDA receptors may contribute to the interoceptive stimulus effects produced by mecamylamine. Based on the current results, the therapeutic use of mecamylamine (i.e., for smoking or to alleviate green tobacco sickness) should be weighed against the potential for mecamylamine to produce interoceptive effects that overlap with another class of abused drugs (i.e., NMDA receptor agonists).