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Guangying Chen - One of the best experts on this subject based on the ideXlab platform.

  • Two new benzophenones and one new natural amide alkaloid isolated from a mangrove-derived Fungus Penicillium citrinum
    2018
    Co-Authors: Cai-juan Zheng, Guo-lei Huang, Xueming Zhou, Guangying Chen, Hai-xia Liao, Rong-qing Mei, Lu-jia Yang, Tai-ming Shao, Chang-yun Wang
    Abstract:

    Two new compounds penibenzophenones A-B (1–2), and the synthetic α,β-unsaturated amide alkaloid (E)-tert-butyl(3-cinnamamidopropyl)carbamate (4), newly identified as a natural product, alone with three known ones (3, 5–6) were isolated from the EtOAc extract of the endophytic fungus Penicillium citrinum HL-5126 isolated from the mangrove Bruguiera sexangula var. rhynchopetala collected in the South China Sea. Compound 1 was a chlorinated benzophenone. The structures of 1–6 were elucidated by extensive NMR spectral interpretation, MS data and X-ray analysis. The new compound 2 displayed cytotoxic activity against human A549 cell lines with an IC50 value of 15.7 μg/mL, and 1 showed antibacterial activity against Staphylococcus aureus with a MIC value of 20 μg/mL.

  • new chlorinated xanthone and anthraquinone produced by a mangrove derived fungus Penicillium citrinum hl 5126
    The Journal of Antibiotics, 2017
    Co-Authors: Cheng Zhang, Cai-juan Zheng, Guo-lei Huang, Yiru Duan, Chunyan Yang, Guangying Chen
    Abstract:

    New chlorinated xanthone and anthraquinone produced by a mangrove-derived fungus Penicillium citrinum HL-5126

  • dihydroisocoumarins from the mangrove derived fungus Penicillium citrinum
    Marine Drugs, 2016
    Co-Authors: Guo-lei Huang, Cai-juan Zheng, Xueming Zhou, Meng Bai, Yuxin Liu, Yanlei Zhao, Youping Luo, Yanyan Niu, Guangying Chen
    Abstract:

    Three new dihydroisocoumarin penicimarins G–I (1–3), together with one known dihydroisocoumarin (4) and three known meroterpenoids (5–7), were obtained from a fungus Penicillium citrinum isolated from the mangrove Bruguiera sexangula var. rhynchopetala collected in the South China Sea. Their structures were elucidated by the detailed analysis of spectroscopic data. The absolute configuration of 1 was determined by the X-ray diffraction analysis using Cu Kα radiation. The absolute configurations of 2 and 3 were determined by comparison of their circular dichroism (CD) spectra with the literature. All compounds were evaluated for their antibacterial activities and cytotoxic activities.

Guo-lei Huang - One of the best experts on this subject based on the ideXlab platform.

  • Two new benzophenones and one new natural amide alkaloid isolated from a mangrove-derived Fungus Penicillium citrinum
    2018
    Co-Authors: Cai-juan Zheng, Guo-lei Huang, Xueming Zhou, Guangying Chen, Hai-xia Liao, Rong-qing Mei, Lu-jia Yang, Tai-ming Shao, Chang-yun Wang
    Abstract:

    Two new compounds penibenzophenones A-B (1–2), and the synthetic α,β-unsaturated amide alkaloid (E)-tert-butyl(3-cinnamamidopropyl)carbamate (4), newly identified as a natural product, alone with three known ones (3, 5–6) were isolated from the EtOAc extract of the endophytic fungus Penicillium citrinum HL-5126 isolated from the mangrove Bruguiera sexangula var. rhynchopetala collected in the South China Sea. Compound 1 was a chlorinated benzophenone. The structures of 1–6 were elucidated by extensive NMR spectral interpretation, MS data and X-ray analysis. The new compound 2 displayed cytotoxic activity against human A549 cell lines with an IC50 value of 15.7 μg/mL, and 1 showed antibacterial activity against Staphylococcus aureus with a MIC value of 20 μg/mL.

  • new chlorinated xanthone and anthraquinone produced by a mangrove derived fungus Penicillium citrinum hl 5126
    The Journal of Antibiotics, 2017
    Co-Authors: Cheng Zhang, Cai-juan Zheng, Guo-lei Huang, Yiru Duan, Chunyan Yang, Guangying Chen
    Abstract:

    New chlorinated xanthone and anthraquinone produced by a mangrove-derived fungus Penicillium citrinum HL-5126

  • dihydroisocoumarins from the mangrove derived fungus Penicillium citrinum
    Marine Drugs, 2016
    Co-Authors: Guo-lei Huang, Cai-juan Zheng, Xueming Zhou, Meng Bai, Yuxin Liu, Yanlei Zhao, Youping Luo, Yanyan Niu, Guangying Chen
    Abstract:

    Three new dihydroisocoumarin penicimarins G–I (1–3), together with one known dihydroisocoumarin (4) and three known meroterpenoids (5–7), were obtained from a fungus Penicillium citrinum isolated from the mangrove Bruguiera sexangula var. rhynchopetala collected in the South China Sea. Their structures were elucidated by the detailed analysis of spectroscopic data. The absolute configuration of 1 was determined by the X-ray diffraction analysis using Cu Kα radiation. The absolute configurations of 2 and 3 were determined by comparison of their circular dichroism (CD) spectra with the literature. All compounds were evaluated for their antibacterial activities and cytotoxic activities.

  • A new benzopyrans derivatives from a mangrove-derived fungus Penicillium citrinum from the South China Sea
    Natural Product Research, 2015
    Co-Authors: Cai-juan Zheng, Guo-lei Huang, Xin-ming Song, Jun Yao, Hui Liu, Ruo-ping Wang, Xue-ping Sun
    Abstract:

    One new benzopyran derivative (2R(*),4R(*))-3,4-dihydro-5-methoxy-2-methyl-2H-1-benzopyran-4-ol (1), together with five known compounds (2-6), were obtained from the EtOAc extract of the endophytic fungus Penicillium citrinum HL-5126 isolated from the mangrove Brguiera sexangula var. rhynchopetala collected in the South China Sea. Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. All compounds were evaluated for their antibacterial activities. Compound 6 exhibited potent inhibitory activity against Bacillus subtilis, Bacillus cereus and Micrococcus tetragenus with the same MIC values of 6.94 μM.

Cai-juan Zheng - One of the best experts on this subject based on the ideXlab platform.

  • Two new benzophenones and one new natural amide alkaloid isolated from a mangrove-derived Fungus Penicillium citrinum
    2018
    Co-Authors: Cai-juan Zheng, Guo-lei Huang, Xueming Zhou, Guangying Chen, Hai-xia Liao, Rong-qing Mei, Lu-jia Yang, Tai-ming Shao, Chang-yun Wang
    Abstract:

    Two new compounds penibenzophenones A-B (1–2), and the synthetic α,β-unsaturated amide alkaloid (E)-tert-butyl(3-cinnamamidopropyl)carbamate (4), newly identified as a natural product, alone with three known ones (3, 5–6) were isolated from the EtOAc extract of the endophytic fungus Penicillium citrinum HL-5126 isolated from the mangrove Bruguiera sexangula var. rhynchopetala collected in the South China Sea. Compound 1 was a chlorinated benzophenone. The structures of 1–6 were elucidated by extensive NMR spectral interpretation, MS data and X-ray analysis. The new compound 2 displayed cytotoxic activity against human A549 cell lines with an IC50 value of 15.7 μg/mL, and 1 showed antibacterial activity against Staphylococcus aureus with a MIC value of 20 μg/mL.

  • new chlorinated xanthone and anthraquinone produced by a mangrove derived fungus Penicillium citrinum hl 5126
    The Journal of Antibiotics, 2017
    Co-Authors: Cheng Zhang, Cai-juan Zheng, Guo-lei Huang, Yiru Duan, Chunyan Yang, Guangying Chen
    Abstract:

    New chlorinated xanthone and anthraquinone produced by a mangrove-derived fungus Penicillium citrinum HL-5126

  • dihydroisocoumarins from the mangrove derived fungus Penicillium citrinum
    Marine Drugs, 2016
    Co-Authors: Guo-lei Huang, Cai-juan Zheng, Xueming Zhou, Meng Bai, Yuxin Liu, Yanlei Zhao, Youping Luo, Yanyan Niu, Guangying Chen
    Abstract:

    Three new dihydroisocoumarin penicimarins G–I (1–3), together with one known dihydroisocoumarin (4) and three known meroterpenoids (5–7), were obtained from a fungus Penicillium citrinum isolated from the mangrove Bruguiera sexangula var. rhynchopetala collected in the South China Sea. Their structures were elucidated by the detailed analysis of spectroscopic data. The absolute configuration of 1 was determined by the X-ray diffraction analysis using Cu Kα radiation. The absolute configurations of 2 and 3 were determined by comparison of their circular dichroism (CD) spectra with the literature. All compounds were evaluated for their antibacterial activities and cytotoxic activities.

  • A new benzopyrans derivatives from a mangrove-derived fungus Penicillium citrinum from the South China Sea
    Natural Product Research, 2015
    Co-Authors: Cai-juan Zheng, Guo-lei Huang, Xin-ming Song, Jun Yao, Hui Liu, Ruo-ping Wang, Xue-ping Sun
    Abstract:

    One new benzopyran derivative (2R(*),4R(*))-3,4-dihydro-5-methoxy-2-methyl-2H-1-benzopyran-4-ol (1), together with five known compounds (2-6), were obtained from the EtOAc extract of the endophytic fungus Penicillium citrinum HL-5126 isolated from the mangrove Brguiera sexangula var. rhynchopetala collected in the South China Sea. Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. All compounds were evaluated for their antibacterial activities. Compound 6 exhibited potent inhibitory activity against Bacillus subtilis, Bacillus cereus and Micrococcus tetragenus with the same MIC values of 6.94 μM.

Jariya Sakayaroj - One of the best experts on this subject based on the ideXlab platform.

  • benzopyranone benzophenone and xanthone derivatives from the soil fungus Penicillium citrinum psu rspg95
    Tetrahedron Letters, 2014
    Co-Authors: Kongkiat Trisuwan, Vatcharin Rukachaisirikul, Kawitsara Borwornwiriyapan, Souwalak Phongpaichit, Jariya Sakayaroj
    Abstract:

    Two new benzopyranones, named coniochaetones E (1) and F (2), one new xanthone, penicillone C (3), and one new benzophenone, penicillanone (4), are isolated from the soil fungus Penicillium citrinum PSU-RSPG95, together with ten known compounds. Their structures are identified on the basis of spectroscopic data. The isolated compounds are evaluated for their cytotoxic activity.

  • bioactive polyketides from the sea fan derived fungus Penicillium citrinum psu f51
    Tetrahedron, 2012
    Co-Authors: Nanthaphong Khamthong, Vatcharin Rukachaisirikul, Souwalak Phongpaichit, Sita Preedanon, Jariya Sakayaroj
    Abstract:

    Five new polyketides including two benzopyranones (1 and 2), one isochroman (3) and two anthraquinone-citrinin derivatives (4 and 5) were isolated from the sea fan-derived fungus Penicillium citrinum PSU-F51 together with thirteen known compounds. The structures were determined by spectroscopic methods. The anthraquinone-citrinin derivatives are rare natural products. Compound 4 displayed moderate antibacterial activity against both Staphylococcus aureus and methicillin-resistant S. aureus with equal MIC values of 16 μg/mL, while the known coniochaetone A displayed moderate antifungal activity against Candida albicans with MIC value of 16 μg/mL.

Xiaoyan Zhou - One of the best experts on this subject based on the ideXlab platform.

  • a novel hemiacetal from the marine derived fungus Penicillium citrinum
    Acta pharmaceutica Sinica, 2011
    Co-Authors: Xiaoyan Zhou
    Abstract:

    A novel hemiacetal, citrinacetal (1) was isolated from a marine-derived fungus Penicillium citrinum by column chromatography on silica gel, Sephadex LH-20 and semi-preparative HPLC. Its structure and stereochemistry was established on the basis of HR-ESI-MS, 1D and 2D NMR spectroscopic methods. The NMR spectrum showed this compound exists in solution as a mixture of two stereoisomers. The cytotoxic effect of compound 1 was evaluated in A-549, HL-60, HeLa, and K562 cancer cell lines. However, compound 1 only displayed weak cytotoxic activity on HL-60 cell, with IC50 value 77.4 micromol x L(-1).