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C Theodore - One of the best experts on this subject based on the ideXlab platform.
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squamous cell carcinoma of the Penis multivariate analysis of prognostic factors and natural history in a monocentric study with a conservative policy
Annals of Oncology, 1997Co-Authors: J C Soria, K Fizazi, D Piron, Andrew Kramar, A Gerbaulet, C Haiemeder, J L Perrin, B Court, P Wibault, C TheodoreAbstract:Summary Background Penile carcinoma is uncommon in Western countries. Here we report on a large series of patients with squamous cell carcinoma (SCC) of the Penis, describing prognostic factors, survival and therapeutic results. Patients and methods From 1973 to 1993, 102 patients with invasive SCC of the Penis were treated at the Institut Gustave Roussy. PreCancerous lesions and conditions associated with Penis Cancer were analyzed retrospectively. Survival curves were estimated by the Kaplan-Meier method, and groups were compared for outcome by the log rank test for univariate comparisons and by Cox's proportional hazards model for multivariate analysis. Results The median age at onset was 58 years. Sixty-nine patients presented with Jackson's stage I disease, 17 with stage II and 15 with stage III. The interval between the manifestation of symptoms and the diagnosis was more than a year in 13.7% of cases. PreCancerous lesions were found in 17 (16.6%) patients, and a history of phimosis was noted in 25 (24.5%). In situ and invasive carcinoma were observed together in 17 (16.6%) cases and dysplasia was associated with invasive carcinoma in eight (7.8%) further cases. Conservative treatment was administered whenever feasible. Interstitial brachytherapy was performed alone or associated with limited surgery (local excision or circumcision) in 72 (70.6%) patients. Of the 28 patients with a local relapse, nine have died of their neoplasrns (32%) compared to 21 of 28 patients with lymph node relapse (75%). The median follow-up was 111 months. Disease-free survival, disease-specific survival and overall survival were, respectively, 56%, 72% and 63% at five years and 42%, 66% and 50% at 10 years. Age (P = 0.01), the N status (P Conclusions Corpus involvement and clinically palpable nodes are highly statistically significant independent factors influencing overall survival. Node relapses remain a major cause of death. Thus, better management of lymph nodes is essential for improving survival even when conservative ther apy is used to treat the primary.
J C Soria - One of the best experts on this subject based on the ideXlab platform.
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squamous cell carcinoma of the Penis multivariate analysis of prognostic factors and natural history in a monocentric study with a conservative policy
Annals of Oncology, 1997Co-Authors: J C Soria, K Fizazi, D Piron, Andrew Kramar, A Gerbaulet, C Haiemeder, J L Perrin, B Court, P Wibault, C TheodoreAbstract:Summary Background Penile carcinoma is uncommon in Western countries. Here we report on a large series of patients with squamous cell carcinoma (SCC) of the Penis, describing prognostic factors, survival and therapeutic results. Patients and methods From 1973 to 1993, 102 patients with invasive SCC of the Penis were treated at the Institut Gustave Roussy. PreCancerous lesions and conditions associated with Penis Cancer were analyzed retrospectively. Survival curves were estimated by the Kaplan-Meier method, and groups were compared for outcome by the log rank test for univariate comparisons and by Cox's proportional hazards model for multivariate analysis. Results The median age at onset was 58 years. Sixty-nine patients presented with Jackson's stage I disease, 17 with stage II and 15 with stage III. The interval between the manifestation of symptoms and the diagnosis was more than a year in 13.7% of cases. PreCancerous lesions were found in 17 (16.6%) patients, and a history of phimosis was noted in 25 (24.5%). In situ and invasive carcinoma were observed together in 17 (16.6%) cases and dysplasia was associated with invasive carcinoma in eight (7.8%) further cases. Conservative treatment was administered whenever feasible. Interstitial brachytherapy was performed alone or associated with limited surgery (local excision or circumcision) in 72 (70.6%) patients. Of the 28 patients with a local relapse, nine have died of their neoplasrns (32%) compared to 21 of 28 patients with lymph node relapse (75%). The median follow-up was 111 months. Disease-free survival, disease-specific survival and overall survival were, respectively, 56%, 72% and 63% at five years and 42%, 66% and 50% at 10 years. Age (P = 0.01), the N status (P Conclusions Corpus involvement and clinically palpable nodes are highly statistically significant independent factors influencing overall survival. Node relapses remain a major cause of death. Thus, better management of lymph nodes is essential for improving survival even when conservative ther apy is used to treat the primary.
C B Bunker - One of the best experts on this subject based on the ideXlab platform.
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clinical parameters in male genital lichen sclerosus a case series of 329 patients
Journal of The European Academy of Dermatology and Venereology, 2012Co-Authors: E V J Edmonds, S Hunt, D Hawkins, M Dinneen, N Francis, C B BunkerAbstract:Background The dermatological aspects of male genital lichen sclerosus (MGLSc) have not received much prominence in the literature. Sexual morbidity appears under-appreciated, the role of histology is unclear, the relative places of topical medical treatment and circumcision are not established, the prognosis for sexual function, urinary function and Penis Cancer is uncertain and the pathogenesis has not been specifically studied although autoimmunity (as in women) and HPV infection have been mooted. Objective To illuminate the above by analysing the clinical parameters of a large series of patients with MGLSc. Methods A total of 329 patients with a clinical diagnosis of MGLSc were identified retrospectively from a dermatology-centred multidisciplinary setting. Their clinical and histopathological features and outcomes have been abstracted from the records and analysed by simple descriptive statistics. Results The collation and analysis of clinical data derived from the largest series of men with MGLSc ever studied from a dermatological perspective has been achieved. These data allow the conclusions below to be drawn. Conclusions MGLSc is unequivocally a disease of the uncircumcised male; the adult peak is late in the fourth decade; dyspareunia is a common presenting complaint; non-specific histology requires careful interpretation; most men are either cured by topical treatment with ultrapotent steroid (50–60%) or by circumcision (>75%); effective and definitive management appears to abrogate the risk of developing penile squamous cell carcinoma; urinary contact is implicated in the pathogenesis of MGLSc; HPV infection and autoimmunity seem unimportant.
Andrew Kramar - One of the best experts on this subject based on the ideXlab platform.
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squamous cell carcinoma of the Penis multivariate analysis of prognostic factors and natural history in a monocentric study with a conservative policy
Annals of Oncology, 1997Co-Authors: J C Soria, K Fizazi, D Piron, Andrew Kramar, A Gerbaulet, C Haiemeder, J L Perrin, B Court, P Wibault, C TheodoreAbstract:Summary Background Penile carcinoma is uncommon in Western countries. Here we report on a large series of patients with squamous cell carcinoma (SCC) of the Penis, describing prognostic factors, survival and therapeutic results. Patients and methods From 1973 to 1993, 102 patients with invasive SCC of the Penis were treated at the Institut Gustave Roussy. PreCancerous lesions and conditions associated with Penis Cancer were analyzed retrospectively. Survival curves were estimated by the Kaplan-Meier method, and groups were compared for outcome by the log rank test for univariate comparisons and by Cox's proportional hazards model for multivariate analysis. Results The median age at onset was 58 years. Sixty-nine patients presented with Jackson's stage I disease, 17 with stage II and 15 with stage III. The interval between the manifestation of symptoms and the diagnosis was more than a year in 13.7% of cases. PreCancerous lesions were found in 17 (16.6%) patients, and a history of phimosis was noted in 25 (24.5%). In situ and invasive carcinoma were observed together in 17 (16.6%) cases and dysplasia was associated with invasive carcinoma in eight (7.8%) further cases. Conservative treatment was administered whenever feasible. Interstitial brachytherapy was performed alone or associated with limited surgery (local excision or circumcision) in 72 (70.6%) patients. Of the 28 patients with a local relapse, nine have died of their neoplasrns (32%) compared to 21 of 28 patients with lymph node relapse (75%). The median follow-up was 111 months. Disease-free survival, disease-specific survival and overall survival were, respectively, 56%, 72% and 63% at five years and 42%, 66% and 50% at 10 years. Age (P = 0.01), the N status (P Conclusions Corpus involvement and clinically palpable nodes are highly statistically significant independent factors influencing overall survival. Node relapses remain a major cause of death. Thus, better management of lymph nodes is essential for improving survival even when conservative ther apy is used to treat the primary.
D Piron - One of the best experts on this subject based on the ideXlab platform.
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squamous cell carcinoma of the Penis multivariate analysis of prognostic factors and natural history in a monocentric study with a conservative policy
Annals of Oncology, 1997Co-Authors: J C Soria, K Fizazi, D Piron, Andrew Kramar, A Gerbaulet, C Haiemeder, J L Perrin, B Court, P Wibault, C TheodoreAbstract:Summary Background Penile carcinoma is uncommon in Western countries. Here we report on a large series of patients with squamous cell carcinoma (SCC) of the Penis, describing prognostic factors, survival and therapeutic results. Patients and methods From 1973 to 1993, 102 patients with invasive SCC of the Penis were treated at the Institut Gustave Roussy. PreCancerous lesions and conditions associated with Penis Cancer were analyzed retrospectively. Survival curves were estimated by the Kaplan-Meier method, and groups were compared for outcome by the log rank test for univariate comparisons and by Cox's proportional hazards model for multivariate analysis. Results The median age at onset was 58 years. Sixty-nine patients presented with Jackson's stage I disease, 17 with stage II and 15 with stage III. The interval between the manifestation of symptoms and the diagnosis was more than a year in 13.7% of cases. PreCancerous lesions were found in 17 (16.6%) patients, and a history of phimosis was noted in 25 (24.5%). In situ and invasive carcinoma were observed together in 17 (16.6%) cases and dysplasia was associated with invasive carcinoma in eight (7.8%) further cases. Conservative treatment was administered whenever feasible. Interstitial brachytherapy was performed alone or associated with limited surgery (local excision or circumcision) in 72 (70.6%) patients. Of the 28 patients with a local relapse, nine have died of their neoplasrns (32%) compared to 21 of 28 patients with lymph node relapse (75%). The median follow-up was 111 months. Disease-free survival, disease-specific survival and overall survival were, respectively, 56%, 72% and 63% at five years and 42%, 66% and 50% at 10 years. Age (P = 0.01), the N status (P Conclusions Corpus involvement and clinically palpable nodes are highly statistically significant independent factors influencing overall survival. Node relapses remain a major cause of death. Thus, better management of lymph nodes is essential for improving survival even when conservative ther apy is used to treat the primary.