The Experts below are selected from a list of 1500 Experts worldwide ranked by ideXlab platform

Rainer Gregor - One of the best experts on this subject based on the ideXlab platform.

  • Stress Impacts the Regulation NeuroPeptides in the Rat Hippocampus and Prefrontal Cortex
    WILEY, 2018
    Co-Authors: Li Wenxue, Papilloud Aurelie, Lozano-montes Laura, Zhao Nan, Ye Xueting, Zhang Xiaozhe, Sandi Carmen, Rainer Gregor
    Abstract:

    Adverse life experiences increase the lifetime risk to several stress-related psychopathologies, such as anxiety or depressive-like symptoms following stress in adulthood. However, the neurochemical modulations triggered by stress have not been fully characterized. NeuroPeptides play an important role as signaling molecules that contribute to physiological regulation and have been linked to neurological and psychiatric diseases. However, little is known about the influence of stress on neuroPeptide regulation in the brain. Here, we have performed an exploratory study of how neuroPeptide expression at adulthood is modulated by experiencing a period of multiple stressful experiences. We have targeted hippocampus and prefrontal cortex (PFC) brain areas, which have previously been shown to be modulated by stressors, employing a targeted liquid chromatography-mass spectrometry (LC-MS) based approach that permits broad Peptide coverage with high sensitivity. We found that in the hippocampus, Met-enkephalin, Met-enkephalin-Arg-Phe, and Met-enkephalin-Arg-Gly-Leu were upregulated, while Leu-enkephalin and Little SAAS were downregulated after stress. In the PFC area, Met-enkephalin-Arg-Phe, Met-enkephalin-Arg-Gly-Leu, Peptide PHI-27, somatostatin-28 (AA1-12), and Little SAAS were all downregulated. This systematic evaluation of neuroPeptide alterations in the hippocampus and PFC suggests that stressors impact neuroPeptides and that neuroPeptide regulation is brain-area specific. These findings suggest several potential Peptide candidates, which warrant further investigations in terms of correlation with depression-associated behaviors

  • Stress Impacts the Regulation NeuroPeptides in the Rat Hippocampus and Prefrontal Cortex
    'Wiley', 2018
    Co-Authors: Li Wenxue, Papilloud Aurelie, Lozano-montes Laura, Zhao Nan, Zhang Xiaozhe, Ye Xuting, Rainer Gregor
    Abstract:

    Adverse life experience increases the lifetime risk to several stress-related psychopathologies, such as anxiety or depressive–like symptom following stress in adulthood. However, the neurochemical modulations triggered by stress have not been fully characterized. NeuroPeptides play an important role as signaling molecules that contribute to physiological regulation and have been linked to neurological and psychiatric diseases. However, little is known about the influence of stress on neuroPeptide regulation in the brain. Here, we have performed an exploratory study of how neuroPeptide expression at adulthood is modulated by experiencing a period of multiple stressful experiences. We have targeted hippocampus and prefrontal cortex (PFC) brain areas, which have previously been shown to be modulated by stressors, employing a targeted Liquid Chromatography-Mass Spectrometry (LC-MS) based approach that permits broad Peptide coverage with high sensitivity. We found that in the hippocampus, Met-enkephalin, Met-enkephalin-Arg-Phe and Met-enkephalin-Arg-Gly-Leu were up regulated, while Leu-enkephalin and Little SAAS were down regulated after stress. In the PFC area, Met-enkephalin-Arg-Phe, Met-enkephalin-Arg-Gly-Leu, Peptide PHI-27, somatostatin-28 (AA1-12) and Little SAAS were all down regulated. This systematic evaluation of neuroPeptide alterations in hippocampus and PFC suggests that stressor impact neuroPeptides and that neuroPeptide regulation is brain area specific. These findings suggest several potential Peptide candidates, which warrant further investigations in terms of correlation with depression-associated behaviors

Li Wenxue - One of the best experts on this subject based on the ideXlab platform.

  • Stress Impacts the Regulation NeuroPeptides in the Rat Hippocampus and Prefrontal Cortex
    WILEY, 2018
    Co-Authors: Li Wenxue, Papilloud Aurelie, Lozano-montes Laura, Zhao Nan, Ye Xueting, Zhang Xiaozhe, Sandi Carmen, Rainer Gregor
    Abstract:

    Adverse life experiences increase the lifetime risk to several stress-related psychopathologies, such as anxiety or depressive-like symptoms following stress in adulthood. However, the neurochemical modulations triggered by stress have not been fully characterized. NeuroPeptides play an important role as signaling molecules that contribute to physiological regulation and have been linked to neurological and psychiatric diseases. However, little is known about the influence of stress on neuroPeptide regulation in the brain. Here, we have performed an exploratory study of how neuroPeptide expression at adulthood is modulated by experiencing a period of multiple stressful experiences. We have targeted hippocampus and prefrontal cortex (PFC) brain areas, which have previously been shown to be modulated by stressors, employing a targeted liquid chromatography-mass spectrometry (LC-MS) based approach that permits broad Peptide coverage with high sensitivity. We found that in the hippocampus, Met-enkephalin, Met-enkephalin-Arg-Phe, and Met-enkephalin-Arg-Gly-Leu were upregulated, while Leu-enkephalin and Little SAAS were downregulated after stress. In the PFC area, Met-enkephalin-Arg-Phe, Met-enkephalin-Arg-Gly-Leu, Peptide PHI-27, somatostatin-28 (AA1-12), and Little SAAS were all downregulated. This systematic evaluation of neuroPeptide alterations in the hippocampus and PFC suggests that stressors impact neuroPeptides and that neuroPeptide regulation is brain-area specific. These findings suggest several potential Peptide candidates, which warrant further investigations in terms of correlation with depression-associated behaviors

  • Stress Impacts the Regulation NeuroPeptides in the Rat Hippocampus and Prefrontal Cortex
    'Wiley', 2018
    Co-Authors: Li Wenxue, Papilloud Aurelie, Lozano-montes Laura, Zhao Nan, Zhang Xiaozhe, Ye Xuting, Rainer Gregor
    Abstract:

    Adverse life experience increases the lifetime risk to several stress-related psychopathologies, such as anxiety or depressive–like symptom following stress in adulthood. However, the neurochemical modulations triggered by stress have not been fully characterized. NeuroPeptides play an important role as signaling molecules that contribute to physiological regulation and have been linked to neurological and psychiatric diseases. However, little is known about the influence of stress on neuroPeptide regulation in the brain. Here, we have performed an exploratory study of how neuroPeptide expression at adulthood is modulated by experiencing a period of multiple stressful experiences. We have targeted hippocampus and prefrontal cortex (PFC) brain areas, which have previously been shown to be modulated by stressors, employing a targeted Liquid Chromatography-Mass Spectrometry (LC-MS) based approach that permits broad Peptide coverage with high sensitivity. We found that in the hippocampus, Met-enkephalin, Met-enkephalin-Arg-Phe and Met-enkephalin-Arg-Gly-Leu were up regulated, while Leu-enkephalin and Little SAAS were down regulated after stress. In the PFC area, Met-enkephalin-Arg-Phe, Met-enkephalin-Arg-Gly-Leu, Peptide PHI-27, somatostatin-28 (AA1-12) and Little SAAS were all down regulated. This systematic evaluation of neuroPeptide alterations in hippocampus and PFC suggests that stressor impact neuroPeptides and that neuroPeptide regulation is brain area specific. These findings suggest several potential Peptide candidates, which warrant further investigations in terms of correlation with depression-associated behaviors

Papilloud Aurelie - One of the best experts on this subject based on the ideXlab platform.

  • Stress Impacts the Regulation NeuroPeptides in the Rat Hippocampus and Prefrontal Cortex
    WILEY, 2018
    Co-Authors: Li Wenxue, Papilloud Aurelie, Lozano-montes Laura, Zhao Nan, Ye Xueting, Zhang Xiaozhe, Sandi Carmen, Rainer Gregor
    Abstract:

    Adverse life experiences increase the lifetime risk to several stress-related psychopathologies, such as anxiety or depressive-like symptoms following stress in adulthood. However, the neurochemical modulations triggered by stress have not been fully characterized. NeuroPeptides play an important role as signaling molecules that contribute to physiological regulation and have been linked to neurological and psychiatric diseases. However, little is known about the influence of stress on neuroPeptide regulation in the brain. Here, we have performed an exploratory study of how neuroPeptide expression at adulthood is modulated by experiencing a period of multiple stressful experiences. We have targeted hippocampus and prefrontal cortex (PFC) brain areas, which have previously been shown to be modulated by stressors, employing a targeted liquid chromatography-mass spectrometry (LC-MS) based approach that permits broad Peptide coverage with high sensitivity. We found that in the hippocampus, Met-enkephalin, Met-enkephalin-Arg-Phe, and Met-enkephalin-Arg-Gly-Leu were upregulated, while Leu-enkephalin and Little SAAS were downregulated after stress. In the PFC area, Met-enkephalin-Arg-Phe, Met-enkephalin-Arg-Gly-Leu, Peptide PHI-27, somatostatin-28 (AA1-12), and Little SAAS were all downregulated. This systematic evaluation of neuroPeptide alterations in the hippocampus and PFC suggests that stressors impact neuroPeptides and that neuroPeptide regulation is brain-area specific. These findings suggest several potential Peptide candidates, which warrant further investigations in terms of correlation with depression-associated behaviors

  • Stress Impacts the Regulation NeuroPeptides in the Rat Hippocampus and Prefrontal Cortex
    'Wiley', 2018
    Co-Authors: Li Wenxue, Papilloud Aurelie, Lozano-montes Laura, Zhao Nan, Zhang Xiaozhe, Ye Xuting, Rainer Gregor
    Abstract:

    Adverse life experience increases the lifetime risk to several stress-related psychopathologies, such as anxiety or depressive–like symptom following stress in adulthood. However, the neurochemical modulations triggered by stress have not been fully characterized. NeuroPeptides play an important role as signaling molecules that contribute to physiological regulation and have been linked to neurological and psychiatric diseases. However, little is known about the influence of stress on neuroPeptide regulation in the brain. Here, we have performed an exploratory study of how neuroPeptide expression at adulthood is modulated by experiencing a period of multiple stressful experiences. We have targeted hippocampus and prefrontal cortex (PFC) brain areas, which have previously been shown to be modulated by stressors, employing a targeted Liquid Chromatography-Mass Spectrometry (LC-MS) based approach that permits broad Peptide coverage with high sensitivity. We found that in the hippocampus, Met-enkephalin, Met-enkephalin-Arg-Phe and Met-enkephalin-Arg-Gly-Leu were up regulated, while Leu-enkephalin and Little SAAS were down regulated after stress. In the PFC area, Met-enkephalin-Arg-Phe, Met-enkephalin-Arg-Gly-Leu, Peptide PHI-27, somatostatin-28 (AA1-12) and Little SAAS were all down regulated. This systematic evaluation of neuroPeptide alterations in hippocampus and PFC suggests that stressor impact neuroPeptides and that neuroPeptide regulation is brain area specific. These findings suggest several potential Peptide candidates, which warrant further investigations in terms of correlation with depression-associated behaviors

Lozano-montes Laura - One of the best experts on this subject based on the ideXlab platform.

  • Stress Impacts the Regulation NeuroPeptides in the Rat Hippocampus and Prefrontal Cortex
    WILEY, 2018
    Co-Authors: Li Wenxue, Papilloud Aurelie, Lozano-montes Laura, Zhao Nan, Ye Xueting, Zhang Xiaozhe, Sandi Carmen, Rainer Gregor
    Abstract:

    Adverse life experiences increase the lifetime risk to several stress-related psychopathologies, such as anxiety or depressive-like symptoms following stress in adulthood. However, the neurochemical modulations triggered by stress have not been fully characterized. NeuroPeptides play an important role as signaling molecules that contribute to physiological regulation and have been linked to neurological and psychiatric diseases. However, little is known about the influence of stress on neuroPeptide regulation in the brain. Here, we have performed an exploratory study of how neuroPeptide expression at adulthood is modulated by experiencing a period of multiple stressful experiences. We have targeted hippocampus and prefrontal cortex (PFC) brain areas, which have previously been shown to be modulated by stressors, employing a targeted liquid chromatography-mass spectrometry (LC-MS) based approach that permits broad Peptide coverage with high sensitivity. We found that in the hippocampus, Met-enkephalin, Met-enkephalin-Arg-Phe, and Met-enkephalin-Arg-Gly-Leu were upregulated, while Leu-enkephalin and Little SAAS were downregulated after stress. In the PFC area, Met-enkephalin-Arg-Phe, Met-enkephalin-Arg-Gly-Leu, Peptide PHI-27, somatostatin-28 (AA1-12), and Little SAAS were all downregulated. This systematic evaluation of neuroPeptide alterations in the hippocampus and PFC suggests that stressors impact neuroPeptides and that neuroPeptide regulation is brain-area specific. These findings suggest several potential Peptide candidates, which warrant further investigations in terms of correlation with depression-associated behaviors

  • Stress Impacts the Regulation NeuroPeptides in the Rat Hippocampus and Prefrontal Cortex
    'Wiley', 2018
    Co-Authors: Li Wenxue, Papilloud Aurelie, Lozano-montes Laura, Zhao Nan, Zhang Xiaozhe, Ye Xuting, Rainer Gregor
    Abstract:

    Adverse life experience increases the lifetime risk to several stress-related psychopathologies, such as anxiety or depressive–like symptom following stress in adulthood. However, the neurochemical modulations triggered by stress have not been fully characterized. NeuroPeptides play an important role as signaling molecules that contribute to physiological regulation and have been linked to neurological and psychiatric diseases. However, little is known about the influence of stress on neuroPeptide regulation in the brain. Here, we have performed an exploratory study of how neuroPeptide expression at adulthood is modulated by experiencing a period of multiple stressful experiences. We have targeted hippocampus and prefrontal cortex (PFC) brain areas, which have previously been shown to be modulated by stressors, employing a targeted Liquid Chromatography-Mass Spectrometry (LC-MS) based approach that permits broad Peptide coverage with high sensitivity. We found that in the hippocampus, Met-enkephalin, Met-enkephalin-Arg-Phe and Met-enkephalin-Arg-Gly-Leu were up regulated, while Leu-enkephalin and Little SAAS were down regulated after stress. In the PFC area, Met-enkephalin-Arg-Phe, Met-enkephalin-Arg-Gly-Leu, Peptide PHI-27, somatostatin-28 (AA1-12) and Little SAAS were all down regulated. This systematic evaluation of neuroPeptide alterations in hippocampus and PFC suggests that stressor impact neuroPeptides and that neuroPeptide regulation is brain area specific. These findings suggest several potential Peptide candidates, which warrant further investigations in terms of correlation with depression-associated behaviors

Zhao Nan - One of the best experts on this subject based on the ideXlab platform.

  • Stress Impacts the Regulation NeuroPeptides in the Rat Hippocampus and Prefrontal Cortex
    WILEY, 2018
    Co-Authors: Li Wenxue, Papilloud Aurelie, Lozano-montes Laura, Zhao Nan, Ye Xueting, Zhang Xiaozhe, Sandi Carmen, Rainer Gregor
    Abstract:

    Adverse life experiences increase the lifetime risk to several stress-related psychopathologies, such as anxiety or depressive-like symptoms following stress in adulthood. However, the neurochemical modulations triggered by stress have not been fully characterized. NeuroPeptides play an important role as signaling molecules that contribute to physiological regulation and have been linked to neurological and psychiatric diseases. However, little is known about the influence of stress on neuroPeptide regulation in the brain. Here, we have performed an exploratory study of how neuroPeptide expression at adulthood is modulated by experiencing a period of multiple stressful experiences. We have targeted hippocampus and prefrontal cortex (PFC) brain areas, which have previously been shown to be modulated by stressors, employing a targeted liquid chromatography-mass spectrometry (LC-MS) based approach that permits broad Peptide coverage with high sensitivity. We found that in the hippocampus, Met-enkephalin, Met-enkephalin-Arg-Phe, and Met-enkephalin-Arg-Gly-Leu were upregulated, while Leu-enkephalin and Little SAAS were downregulated after stress. In the PFC area, Met-enkephalin-Arg-Phe, Met-enkephalin-Arg-Gly-Leu, Peptide PHI-27, somatostatin-28 (AA1-12), and Little SAAS were all downregulated. This systematic evaluation of neuroPeptide alterations in the hippocampus and PFC suggests that stressors impact neuroPeptides and that neuroPeptide regulation is brain-area specific. These findings suggest several potential Peptide candidates, which warrant further investigations in terms of correlation with depression-associated behaviors

  • Stress Impacts the Regulation NeuroPeptides in the Rat Hippocampus and Prefrontal Cortex
    'Wiley', 2018
    Co-Authors: Li Wenxue, Papilloud Aurelie, Lozano-montes Laura, Zhao Nan, Zhang Xiaozhe, Ye Xuting, Rainer Gregor
    Abstract:

    Adverse life experience increases the lifetime risk to several stress-related psychopathologies, such as anxiety or depressive–like symptom following stress in adulthood. However, the neurochemical modulations triggered by stress have not been fully characterized. NeuroPeptides play an important role as signaling molecules that contribute to physiological regulation and have been linked to neurological and psychiatric diseases. However, little is known about the influence of stress on neuroPeptide regulation in the brain. Here, we have performed an exploratory study of how neuroPeptide expression at adulthood is modulated by experiencing a period of multiple stressful experiences. We have targeted hippocampus and prefrontal cortex (PFC) brain areas, which have previously been shown to be modulated by stressors, employing a targeted Liquid Chromatography-Mass Spectrometry (LC-MS) based approach that permits broad Peptide coverage with high sensitivity. We found that in the hippocampus, Met-enkephalin, Met-enkephalin-Arg-Phe and Met-enkephalin-Arg-Gly-Leu were up regulated, while Leu-enkephalin and Little SAAS were down regulated after stress. In the PFC area, Met-enkephalin-Arg-Phe, Met-enkephalin-Arg-Gly-Leu, Peptide PHI-27, somatostatin-28 (AA1-12) and Little SAAS were all down regulated. This systematic evaluation of neuroPeptide alterations in hippocampus and PFC suggests that stressor impact neuroPeptides and that neuroPeptide regulation is brain area specific. These findings suggest several potential Peptide candidates, which warrant further investigations in terms of correlation with depression-associated behaviors