The Experts below are selected from a list of 618 Experts worldwide ranked by ideXlab platform
Jungui Dai - One of the best experts on this subject based on the ideXlab platform.
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two new 5 6 6 polyketide amino acid hybrids from a genetic mutant of Periconia sp f 31
Journal of Asian Natural Products Research, 2021Co-Authors: Min Zhang, Jimei Liu, Ridao Chen, Kebo Xie, Dawei Chen, Jungui DaiAbstract:Peridecalins C and D (1 and 2), one decalin and one oxygen-decalin containing polyketide-amino acid hybrids with 5/6/6 ring system, was isolated from a genetic mutant of Periconia sp. F-31. Their structures were elucidated through extensive spectroscopic data analysis, including 1 D/2D NMR and HR-MS spectra. Biosynthetically, two proposed Diels-Alder reactions are supposed to be involved in the skeleton construction of 1 and 2.
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sesquiterpenes from the endophytic fungus Periconia sp f 31
Journal of Asian Natural Products Research, 2021Co-Authors: Jimei Liu, Dewu Zhang, Ridao Chen, Min Zhang, Jinlian Zhao, Kebo Xie, Jungui DaiAbstract:One new eremophilane sesquiterpene Periconianone L (1), together with four known guaiane-type sesquiterpenes 4,10,11-trihydroxyguaiane (2), (-)-guai-1(10)-ene-4α,11-diolhydroxymecuration (3), guaidiol A (4), and epi-guaidiol A (5) were isolated from the endophytic fungus Periconia sp. F-31. The structure of the new compound was established by spectroscopic methods, including UV, IR, HRESIMS, and extensive NMR techniques. Compound 3 was isolated as natural product for the first time.
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biosynthetic hypothesis guided discovery and total syntheses of pks nrps hybrid metabolites from endophytic fungus Periconia species
Organic Letters, 2019Co-Authors: Dewu Zhang, Xiaoyu Tao, Jimei Liu, Jungui Dai, Yijun Fan, Yuanhao Wang, Jianyuan Zhao, Yefeng TangAbstract:Guided by our biosynthetic hypothesis, pericoannosins C-F, four new PKS-NRPS hybrid metabolites, were discovered from the endophytic fungus Periconia sp. F-31. Their structures and absolute configurations were elucidated by extensive spectroscopic data and electronic circular dichroism analyses. Preliminary biological evaluation revealed that pericoannosins C-D exhibited anti-HIV activities with IC50 values of 15.5 and 13.5 μM. Furthermore, the bioinspired syntheses of pericoannosins C-E have also been completed with high efficiency.
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Biosynthetic Hypothesis-Guided Discovery and Total Syntheses of PKS–NRPS Hybrid Metabolites from Endophytic Fungus Periconia Species
2019Co-Authors: Yijun Fan, Dewu Zhang, Xiaoyu Tao, Jimei Liu, Yuanhao Wang, Jianyuan Zhao, Jungui DaiAbstract:Guided by our biosynthetic hypothesis, pericoannosins C–F, four new PKS–NRPS hybrid metabolites, were discovered from the endophytic fungus Periconia sp. F-31. Their structures and absolute configurations were elucidated by extensive spectroscopic data and electronic circular dichroism analyses. Preliminary biological evaluation revealed that pericoannosins C–D exhibited anti-HIV activities with IC50 values of 15.5 and 13.5 μM. Furthermore, the bioinspired syntheses of pericoannosins C–E have also been completed with high efficiency
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Four new monoterpenoids from an endophytic fungus Periconia sp. F-31
Journal of Asian natural products research, 2017Co-Authors: Jimei Liu, Dewu Zhang, Ridao Chen, Min Zhang, Jinlian Zhao, Kebo Xie, Jungui DaiAbstract:Five monoterpenoids were isolated from the endophytic fungus Periconia sp. F-31, including three new carene-type monoterpenoids, 2-carene-5,8-diol (1), 2-carene-8,10-diol (2), 2-carene-8-acetamide (3), one new menthene-type monoterpenoid 8-hydroxy-1,7-expoxy-2-menthene (4), and one known monoterpenoid anethofuran (5). The structures of all compounds were elucidated based on a comprehensive spectroscopic data analysis, electronic circular dichroism (ECD), and calculated ECD.
Dewu Zhang - One of the best experts on this subject based on the ideXlab platform.
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sesquiterpenes from the endophytic fungus Periconia sp f 31
Journal of Asian Natural Products Research, 2021Co-Authors: Jimei Liu, Dewu Zhang, Ridao Chen, Min Zhang, Jinlian Zhao, Kebo Xie, Jungui DaiAbstract:One new eremophilane sesquiterpene Periconianone L (1), together with four known guaiane-type sesquiterpenes 4,10,11-trihydroxyguaiane (2), (-)-guai-1(10)-ene-4α,11-diolhydroxymecuration (3), guaidiol A (4), and epi-guaidiol A (5) were isolated from the endophytic fungus Periconia sp. F-31. The structure of the new compound was established by spectroscopic methods, including UV, IR, HRESIMS, and extensive NMR techniques. Compound 3 was isolated as natural product for the first time.
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biosynthetic hypothesis guided discovery and total syntheses of pks nrps hybrid metabolites from endophytic fungus Periconia species
Organic Letters, 2019Co-Authors: Dewu Zhang, Xiaoyu Tao, Jimei Liu, Jungui Dai, Yijun Fan, Yuanhao Wang, Jianyuan Zhao, Yefeng TangAbstract:Guided by our biosynthetic hypothesis, pericoannosins C-F, four new PKS-NRPS hybrid metabolites, were discovered from the endophytic fungus Periconia sp. F-31. Their structures and absolute configurations were elucidated by extensive spectroscopic data and electronic circular dichroism analyses. Preliminary biological evaluation revealed that pericoannosins C-D exhibited anti-HIV activities with IC50 values of 15.5 and 13.5 μM. Furthermore, the bioinspired syntheses of pericoannosins C-E have also been completed with high efficiency.
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Biosynthetic Hypothesis-Guided Discovery and Total Syntheses of PKS–NRPS Hybrid Metabolites from Endophytic Fungus Periconia Species
2019Co-Authors: Yijun Fan, Dewu Zhang, Xiaoyu Tao, Jimei Liu, Yuanhao Wang, Jianyuan Zhao, Jungui DaiAbstract:Guided by our biosynthetic hypothesis, pericoannosins C–F, four new PKS–NRPS hybrid metabolites, were discovered from the endophytic fungus Periconia sp. F-31. Their structures and absolute configurations were elucidated by extensive spectroscopic data and electronic circular dichroism analyses. Preliminary biological evaluation revealed that pericoannosins C–D exhibited anti-HIV activities with IC50 values of 15.5 and 13.5 μM. Furthermore, the bioinspired syntheses of pericoannosins C–E have also been completed with high efficiency
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Four new monoterpenoids from an endophytic fungus Periconia sp. F-31
Journal of Asian natural products research, 2017Co-Authors: Jimei Liu, Dewu Zhang, Ridao Chen, Min Zhang, Jinlian Zhao, Kebo Xie, Jungui DaiAbstract:Five monoterpenoids were isolated from the endophytic fungus Periconia sp. F-31, including three new carene-type monoterpenoids, 2-carene-5,8-diol (1), 2-carene-8,10-diol (2), 2-carene-8-acetamide (3), one new menthene-type monoterpenoid 8-hydroxy-1,7-expoxy-2-menthene (4), and one known monoterpenoid anethofuran (5). The structures of all compounds were elucidated based on a comprehensive spectroscopic data analysis, electronic circular dichroism (ECD), and calculated ECD.
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periconones b e new meroterpenoids from endophytic fungus Periconia sp
Chinese Chemical Letters, 2017Co-Authors: Jimei Liu, Dewu Zhang, Ridao Chen, Min Zhang, Jinlian Zhao, Jianyuan Zhao, Zheng Yan, Nan Wang, Jungui DaiAbstract:Abstract Periconones B–E (1–4), four new polyketide–terpenoid hybrid molecules were isolated from the endophytic fungus Periconia sp. F-31. Their structures and absolute configurations were established by extensive spectroscopic data analysis and electronic circular dichroism (ECD). Compound 4 exhibited in vitro cytotoxic activity against the human MCF-7 tumor cell line with an IC50 value of 4.2 μmol/L, and compound 1 displayed anti-HIV activity with an IC50 value of 18.0 μmol/L.
Xiaoyu Tao - One of the best experts on this subject based on the ideXlab platform.
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biosynthetic hypothesis guided discovery and total syntheses of pks nrps hybrid metabolites from endophytic fungus Periconia species
Organic Letters, 2019Co-Authors: Dewu Zhang, Xiaoyu Tao, Jimei Liu, Jungui Dai, Yijun Fan, Yuanhao Wang, Jianyuan Zhao, Yefeng TangAbstract:Guided by our biosynthetic hypothesis, pericoannosins C-F, four new PKS-NRPS hybrid metabolites, were discovered from the endophytic fungus Periconia sp. F-31. Their structures and absolute configurations were elucidated by extensive spectroscopic data and electronic circular dichroism analyses. Preliminary biological evaluation revealed that pericoannosins C-D exhibited anti-HIV activities with IC50 values of 15.5 and 13.5 μM. Furthermore, the bioinspired syntheses of pericoannosins C-E have also been completed with high efficiency.
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Biosynthetic Hypothesis-Guided Discovery and Total Syntheses of PKS–NRPS Hybrid Metabolites from Endophytic Fungus Periconia Species
2019Co-Authors: Yijun Fan, Dewu Zhang, Xiaoyu Tao, Jimei Liu, Yuanhao Wang, Jianyuan Zhao, Jungui DaiAbstract:Guided by our biosynthetic hypothesis, pericoannosins C–F, four new PKS–NRPS hybrid metabolites, were discovered from the endophytic fungus Periconia sp. F-31. Their structures and absolute configurations were elucidated by extensive spectroscopic data and electronic circular dichroism analyses. Preliminary biological evaluation revealed that pericoannosins C–D exhibited anti-HIV activities with IC50 values of 15.5 and 13.5 μM. Furthermore, the bioinspired syntheses of pericoannosins C–E have also been completed with high efficiency
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a new polyketide synthase nonribosomal peptide synthetase hybrid metabolite from plant endophytic fungus Periconia sp
Chinese Chemical Letters, 2016Co-Authors: Dewu Zhang, Xiaoyu Tao, Jimei Liu, Ridao Chen, Min Zhang, Xiaomei Fang, Jungui DaiAbstract:Abstract A new polyketide synthase–nonribosomal peptide synthetase (PKS–NRPS) hybrid metabolite, named pericoannosin B (1), was isolated from endophytic fungus Periconia sp. F-31 of the medicinal plant Annona muricata. The structure and absolute configuration were elucidated by means of extensive spectroscopic analyses (HRMS, NMR, IR, and CD).
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Periconiasin g a new cytochalasan with unprecedented 7 6 5 tricyclic ring system from the endophytic fungus Periconia sp
ChemInform, 2016Co-Authors: Dewu Zhang, Xiaoyu Tao, Jimei Liu, Ridao Chen, Min Zhang, Xiaomei Fang, Jungui DaiAbstract:New cytochalasans, Periconiasin G (I) and Periconiasin H (II) are isolated from Periconia sp.
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Periconiasin g a new cytochalasan with unprecedented 7 6 5 tricyclic ring system from the endophytic fungus Periconia sp
Tetrahedron Letters, 2016Co-Authors: Dewu Zhang, Xiaoyu Tao, Jimei Liu, Ridao Chen, Min Zhang, Xiaomei Fang, Jungui DaiAbstract:Abstract Two new cytochalasans, Periconiasin G ( 1 ) and Periconiasin H ( 2 ) were isolated from endophytic fungus Periconia sp. F-31. Compound 1 is the first cytochalasan with a 7/6/5 tricyclic ring system, and compound 2 possesses a rare sulfoxide group. Their structures including absolute configurations were elucidated by extensive spectroscopic analyses and ECD calculations. A possible biogenetic pathway for these two compounds was proposed. Compound 1 showed weak anti-HIV activity with IC 50 value of 67.0 μM.
Ridao Chen - One of the best experts on this subject based on the ideXlab platform.
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two new 5 6 6 polyketide amino acid hybrids from a genetic mutant of Periconia sp f 31
Journal of Asian Natural Products Research, 2021Co-Authors: Min Zhang, Jimei Liu, Ridao Chen, Kebo Xie, Dawei Chen, Jungui DaiAbstract:Peridecalins C and D (1 and 2), one decalin and one oxygen-decalin containing polyketide-amino acid hybrids with 5/6/6 ring system, was isolated from a genetic mutant of Periconia sp. F-31. Their structures were elucidated through extensive spectroscopic data analysis, including 1 D/2D NMR and HR-MS spectra. Biosynthetically, two proposed Diels-Alder reactions are supposed to be involved in the skeleton construction of 1 and 2.
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sesquiterpenes from the endophytic fungus Periconia sp f 31
Journal of Asian Natural Products Research, 2021Co-Authors: Jimei Liu, Dewu Zhang, Ridao Chen, Min Zhang, Jinlian Zhao, Kebo Xie, Jungui DaiAbstract:One new eremophilane sesquiterpene Periconianone L (1), together with four known guaiane-type sesquiterpenes 4,10,11-trihydroxyguaiane (2), (-)-guai-1(10)-ene-4α,11-diolhydroxymecuration (3), guaidiol A (4), and epi-guaidiol A (5) were isolated from the endophytic fungus Periconia sp. F-31. The structure of the new compound was established by spectroscopic methods, including UV, IR, HRESIMS, and extensive NMR techniques. Compound 3 was isolated as natural product for the first time.
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Four new monoterpenoids from an endophytic fungus Periconia sp. F-31
Journal of Asian natural products research, 2017Co-Authors: Jimei Liu, Dewu Zhang, Ridao Chen, Min Zhang, Jinlian Zhao, Kebo Xie, Jungui DaiAbstract:Five monoterpenoids were isolated from the endophytic fungus Periconia sp. F-31, including three new carene-type monoterpenoids, 2-carene-5,8-diol (1), 2-carene-8,10-diol (2), 2-carene-8-acetamide (3), one new menthene-type monoterpenoid 8-hydroxy-1,7-expoxy-2-menthene (4), and one known monoterpenoid anethofuran (5). The structures of all compounds were elucidated based on a comprehensive spectroscopic data analysis, electronic circular dichroism (ECD), and calculated ECD.
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periconones b e new meroterpenoids from endophytic fungus Periconia sp
Chinese Chemical Letters, 2017Co-Authors: Jimei Liu, Dewu Zhang, Ridao Chen, Min Zhang, Jinlian Zhao, Jianyuan Zhao, Zheng Yan, Nan Wang, Jungui DaiAbstract:Abstract Periconones B–E (1–4), four new polyketide–terpenoid hybrid molecules were isolated from the endophytic fungus Periconia sp. F-31. Their structures and absolute configurations were established by extensive spectroscopic data analysis and electronic circular dichroism (ECD). Compound 4 exhibited in vitro cytotoxic activity against the human MCF-7 tumor cell line with an IC50 value of 4.2 μmol/L, and compound 1 displayed anti-HIV activity with an IC50 value of 18.0 μmol/L.
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Periconiasins i and j two new cytochalasans from an endophytic fungus Periconia sp
Tetrahedron Letters, 2016Co-Authors: Jimei Liu, Dewu Zhang, Ridao Chen, Min Zhang, Jinlian Zhao, Nan Wang, Xia Liu, Jungui DaiAbstract:Abstract Two new cytochalasans, Periconiasin I (1) with 9/6/5 tricyclic ring, and Periconiasin J (2) with 5/6/6/5 tetracyclic ring, were isolated from the endophytic fungus Periconia sp. F-31. Their structures including absolute configurations were elucidated through extensive spectroscopic analyses, calculated ECD, and the circular dichroism data of the [Rh2(OCOCF3)4] complex. Compound 1 showed in vitro cytotoxicity against human MCF-7 tumor cell line with an IC50 value of 4.8 μM, compound 2 exhibited weak anti-HIV activity with an IC50 value of 25.0 μM.
Jimei Liu - One of the best experts on this subject based on the ideXlab platform.
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two new 5 6 6 polyketide amino acid hybrids from a genetic mutant of Periconia sp f 31
Journal of Asian Natural Products Research, 2021Co-Authors: Min Zhang, Jimei Liu, Ridao Chen, Kebo Xie, Dawei Chen, Jungui DaiAbstract:Peridecalins C and D (1 and 2), one decalin and one oxygen-decalin containing polyketide-amino acid hybrids with 5/6/6 ring system, was isolated from a genetic mutant of Periconia sp. F-31. Their structures were elucidated through extensive spectroscopic data analysis, including 1 D/2D NMR and HR-MS spectra. Biosynthetically, two proposed Diels-Alder reactions are supposed to be involved in the skeleton construction of 1 and 2.
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sesquiterpenes from the endophytic fungus Periconia sp f 31
Journal of Asian Natural Products Research, 2021Co-Authors: Jimei Liu, Dewu Zhang, Ridao Chen, Min Zhang, Jinlian Zhao, Kebo Xie, Jungui DaiAbstract:One new eremophilane sesquiterpene Periconianone L (1), together with four known guaiane-type sesquiterpenes 4,10,11-trihydroxyguaiane (2), (-)-guai-1(10)-ene-4α,11-diolhydroxymecuration (3), guaidiol A (4), and epi-guaidiol A (5) were isolated from the endophytic fungus Periconia sp. F-31. The structure of the new compound was established by spectroscopic methods, including UV, IR, HRESIMS, and extensive NMR techniques. Compound 3 was isolated as natural product for the first time.
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biosynthetic hypothesis guided discovery and total syntheses of pks nrps hybrid metabolites from endophytic fungus Periconia species
Organic Letters, 2019Co-Authors: Dewu Zhang, Xiaoyu Tao, Jimei Liu, Jungui Dai, Yijun Fan, Yuanhao Wang, Jianyuan Zhao, Yefeng TangAbstract:Guided by our biosynthetic hypothesis, pericoannosins C-F, four new PKS-NRPS hybrid metabolites, were discovered from the endophytic fungus Periconia sp. F-31. Their structures and absolute configurations were elucidated by extensive spectroscopic data and electronic circular dichroism analyses. Preliminary biological evaluation revealed that pericoannosins C-D exhibited anti-HIV activities with IC50 values of 15.5 and 13.5 μM. Furthermore, the bioinspired syntheses of pericoannosins C-E have also been completed with high efficiency.
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Biosynthetic Hypothesis-Guided Discovery and Total Syntheses of PKS–NRPS Hybrid Metabolites from Endophytic Fungus Periconia Species
2019Co-Authors: Yijun Fan, Dewu Zhang, Xiaoyu Tao, Jimei Liu, Yuanhao Wang, Jianyuan Zhao, Jungui DaiAbstract:Guided by our biosynthetic hypothesis, pericoannosins C–F, four new PKS–NRPS hybrid metabolites, were discovered from the endophytic fungus Periconia sp. F-31. Their structures and absolute configurations were elucidated by extensive spectroscopic data and electronic circular dichroism analyses. Preliminary biological evaluation revealed that pericoannosins C–D exhibited anti-HIV activities with IC50 values of 15.5 and 13.5 μM. Furthermore, the bioinspired syntheses of pericoannosins C–E have also been completed with high efficiency
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Four new monoterpenoids from an endophytic fungus Periconia sp. F-31
Journal of Asian natural products research, 2017Co-Authors: Jimei Liu, Dewu Zhang, Ridao Chen, Min Zhang, Jinlian Zhao, Kebo Xie, Jungui DaiAbstract:Five monoterpenoids were isolated from the endophytic fungus Periconia sp. F-31, including three new carene-type monoterpenoids, 2-carene-5,8-diol (1), 2-carene-8,10-diol (2), 2-carene-8-acetamide (3), one new menthene-type monoterpenoid 8-hydroxy-1,7-expoxy-2-menthene (4), and one known monoterpenoid anethofuran (5). The structures of all compounds were elucidated based on a comprehensive spectroscopic data analysis, electronic circular dichroism (ECD), and calculated ECD.