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Marlene P Freeman - One of the best experts on this subject based on the ideXlab platform.
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Screening to Treatment: Obstacles and Predictors in Perinatal Depression (STOP-PPD) in the Dallas Healthy Start program.
Archives of women's mental health, 2014Co-Authors: Geetha Shivakumar, Anna R. Brandon, Neysa L. Johnson, Marlene P FreemanAbstract:Healthy Start programs have made tremendous contributions toward improving the health of mothers and infants through the screening and early detection of Perinatal Depression. In a collaborative partnership with the Dallas Healthy Start (DHS) program, this pilot study investigated rates of follow-up to systematic referrals for the treatment of Perinatal Depression in the DHS, as well as identified specific barriers and predictors or treatment follow-up. Results of this study support strengthening existing community-based treatment programs for Perinatal Depression.
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Complementary and alternative medicine therapies for Perinatal Depression.
Best practice & research. Clinical obstetrics & gynaecology, 2013Co-Authors: Kristina M. Deligiannidis, Marlene P FreemanAbstract:Complementary and alternative medicine therapies are increasingly sought out by people with psychiatric disorders. In this chapter, we review the evidence for several commonly used CAM therapies (i.e. omega-3 fatty acids, folate, S-adenosyl-methionine, St John's Wort, bright light therapy, exercise, massage, and acupuncture) in the treatment of Perinatal Depression. A number of these treatments may be reasonable to consider for women during pregnancy or postpartum, but the safety and efficacy of these relative to standard treatments must still be systematically determined. Evidence-based use of complementary and alternative medicine therapies treatments for Perinatal Depression is discussed. Adequately powered systematic studies are necessary to determine the role of complementary and alternative medicine therapies in the treatment of Perinatal Depression.
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Complementary and alternative medicine for Perinatal Depression.
Journal of affective disorders, 2008Co-Authors: Marlene P FreemanAbstract:Perinatal Major Depressive Disorder (MDD) is common and poses particular treatment dilemmas. Complementary and Alternative Medicine (CAM) treatments are widely used, accessible, and understudied for well-defined psychiatric indications. Women are more likely than men to both suffer from MDD and use CAM. A PubMed/Medline search was conducted to assess the evidence base for commonly utilized CAM treatments, MDD, and Perinatal Depression. Among CAM treatments, omega-3 fatty acids have received the most specific study in terms of epidemiological, preclinical, and clinical research for Perinatal Depression. Three randomized placebo-controlled trials have been conducted in which investigators assessed omega-3 fatty acids vs. placebo for Perinatal Depression, with conflicting results. CAM interventions that can be easily added to a treatment plan with little risk and general health benefits for most women include omega-3 fatty acids, exercise, and folate, although data are insufficient at this time to recommend any of these as monotherapy for Perinatal Depression. S-adenosyl-methionine (SAMe) and bright light therapy may be reasonable to consider based on the evidence in MDD. St. John's Wort requires further study with regard to safety in pregnancy, and drug interactions can be a potential problem. Further study is required to elucidate the role of CAM treatments for Perinatal Depression, and the clinical context of Perinatal Depression requires safe, effective, and accessible treatment options.
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Complementary and alternative medicine for Perinatal Depression.
Journal of Affective Disorders, 2008Co-Authors: Marlene P FreemanAbstract:Abstract Introduction Perinatal Major Depressive Disorder (MDD) is common and poses particular treatment dilemmas. Complementary and Alternative Medicine (CAM) treatments are widely used, accessible, and understudied for well-defined psychiatric indications. Women are more likely than men to both suffer from MDD and use CAM. Methods A PubMed/Medline search was conducted to assess the evidence base for commonly utilized CAM treatments, MDD, and Perinatal Depression. Results Among CAM treatments, omega-3 fatty acids have received the most specific study in terms of epidemiological, preclinical, and clinical research for Perinatal Depression. Three randomized placebo-controlled trials have been conducted in which investigators assessed omega-3 fatty acids vs. placebo for Perinatal Depression, with conflicting results. CAM interventions that can be easily added to a treatment plan with little risk and general health benefits for most women include omega-3 fatty acids, exercise, and folate, although data are insufficient at this time to recommend any of these as monotherapy for Perinatal Depression. S-adenosyl-methionine (SAMe) and bright light therapy may be reasonable to consider based on the evidence in MDD. St. John's Wort requires further study with regard to safety in pregnancy, and drug interactions can be a potential problem. Discussion Further study is required to elucidate the role of CAM treatments for Perinatal Depression, and the clinical context of Perinatal Depression requires safe, effective, and accessible treatment options.
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Omega-3 fatty acids and Perinatal Depression: a review of the literature and recommendations for future research.
Prostaglandins Leukotrienes and Essential Fatty Acids, 2006Co-Authors: Marlene P FreemanAbstract:Introduction: Perinatal Depression refers to major Depression in the context of pregnancy and postpartum. In consideration of its prevalence and consequences, the treatment and prevention of Perinatal Depression should be important public health priorities. Omega-3 fatty acids are attractive for consideration in Perinatal women, due to known health benefits for the mother and baby. Antidepressant medications may pose risks in utero and in breastfeeding. Methods: MEDLINE and manual searches were conducted. Results: Epidemiological and preclinical data support a role of omega-3 fatty acids in Perinatal Depression. Two studies failed to support a role of omega-3 fatty acids for postpartum Depression prophylaxis, although one included a small sample, and the other utilized a low dosage. Two pilot studies suggest good tolerability and potential efficacy in the acute treatment of Perinatal Depression. Conclusions: Further research studies are warranted to determine the role of omega-3 fatty acids in the treatment of Perinatal Depression.
Katherine L. Wisner - One of the best experts on this subject based on the ideXlab platform.
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Screening and Treatment After Implementation of a Universal Perinatal Depression Screening Program.
Obstetrics and gynecology, 2019Co-Authors: Emily S. Miller, Katherine L. Wisner, Jacqueline K Gollan, Sara Hamade, Dana R. Gossett, William A. GrobmanAbstract:OBJECTIVE To evaluate whether initiation of an institutional policy of universal Perinatal Depression screening was associated with sustained increases in frequency in screening and of Depression treatment subsequent to a positive screen. METHODS This retrospective cohort study included women receiving prenatal care in outpatient offices at a single academic medical center from 2008 to 2015. In 2009, an institutional policy of universal Perinatal Depression screening was disseminated in which screening twice antenatally and again postpartum were recommended. The frequency of screen completion at each recommended time point was compared between the prepolicy and postpolicy cohorts. A test of trend that assessed the frequency of screening each year after policy initiation was used to assess changes over time. The frequency with which care plans were created for women who screened positive for Perinatal Depression were compared before and after implementation. RESULTS Of the 5,127 women who met inclusion criteria, 4,005 (78%) were in the postpolicy cohort. The frequency of completion of Depression screening at the first prenatal visit (0.1% vs 65.5%), in the third trimester (0.0% vs 42.7%), and at the postpartum visit (69.5% vs 90.0%) increased after initiation of the policy (P
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Plasma and cerebrospinal fluid inflammatory cytokines in Perinatal Depression.
American journal of obstetrics and gynecology, 2018Co-Authors: Emily S. Miller, Allie Sakowicz, Archana Roy, Amy Yang, John T. Sullivan, William A. Grobman, Katherine L. WisnerAbstract:Background While Perinatal Depression is one of the most common complications of pregnancy, there is an insufficient understanding of the mechanistic underpinnings of disease. While an association between peripheral inflammatory cytokines and major depressive disorder has been demonstrated, cytokines cannot freely cross the blood-brain barrier, and thus, they give little insight into alternations in brain function. Because the brain is in direct communication with the cerebrospinal fluid, assessment of inflammation in the cerebrospinal fluid may be more directly related to the biologic markers of affective change. Objective Our objectives were to examine the association between Perinatal Depression and inflammatory cytokines in plasma, the association between Perinatal Depression and inflammatory cytokines in cerebrospinal fluid, and the correlations between plasma and cerebrospinal fluid inflammatory cytokines. Study Design This was a prospective, observational study of women with a singleton gestation at term undergoing a scheduled cesarean delivery. Women were screened for Depression and those with depressive symptomatology preferentially enrolled. The Mini-International Neuropsychiatric Interview was administered to confirm the clinical diagnosis of Depression. Maternal plasma and cerebrospinal fluid were collected preoperatively and cytokines measured via flow cytometry. Bivariable and multivariable analyses were used to determine the association between each cytokine and Perinatal Depression. Correlations were measured between the cytokines in plasma and cerebrospinal fluid. Results Of the 117 women who met inclusion criteria, 76 (65%) screened positive for Depression, 15 (20%) of whom met the clinical diagnostic criteria for Depression. There were no significant associations between any of the plasma cytokines and Perinatal Depression in our sample. Conversely, in multivariable analyses, higher cerebrospinal fluid interleukin-1β (adjusted odds ratio, 232.7, 95% confidence interval, 5.9–9148.5), interleukin-23 (adjusted odds ratio, 22.1, 95% confidence interval, 1.7–294.5), and interleukin-33 (adjusted odds ratio, 1.7, 95% confidence interval, 1.1–2.6) concentrations were significantly associated with increased odds of Perinatal Depression. The plasma and cerebrospinal fluid cytokine concentrations were not strongly correlated. Conclusion Higher concentrations of cerebrospinal fluid cytokines were associated with Perinatal Depression. These cerebrospinal fluid cytokines were not strongly correlated with plasma cytokines, and accordingly, plasma cytokines were not significantly associated with Perinatal Depression. Central neuroinflammation, as opposed to peripheral inflammation, may represent a mechanistic pathway that contributes to Perinatal Depression.
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Perinatal Depression among Spanish-Speaking and Latin American Women - Perinatal Depression among Spanish-speaking and Latin American women
2014Co-Authors: Sandraluz Lara-cinisomo, Katherine L. WisnerAbstract:Perinatal Depression among Spanish-speaking and Latin American women : , Perinatal Depression among Spanish-speaking and Latin American women : , کتابخانه دیجیتال جندی شاپور اهواز
Gracia Fellmeth - One of the best experts on this subject based on the ideXlab platform.
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Migrant Perinatal Depression study: a prospective cohort study of Perinatal Depression on the Thai-Myanmar border.
BMJ open, 2018Co-Authors: Gracia Fellmeth, Emma Plugge, Verena I. Carrara, Mina Fazel, Yuwapha Phichitphadungtham, Mupawjay Pimanpanarak, Naw Kerry Wai, Prakaykaew CharunwatthanaAbstract:Purpose Perinatal Depression is a significant contributor to maternal morbidity. Migrant women in resource-poor settings may be at increased risk, yet little research has been conducted in low-income and middle-income settings. This prospective cohort study of migrant women on the Thai-Myanmar border aims to establish prevalence of Perinatal Depression, identify risk factors for Perinatal Depression and examine associations with infant outcomes. Participants Participating women are labour migrants and refugees living on the Thai-Myanmar border. A total of 568 women were recruited in their first trimester of pregnancy and are being followed up to 1-year postpartum. Findings to date At baseline, women in our study had a median age of 25 years, the predominant ethnicity was Sgaw Karen (48.9%), agriculture was the main employment sector (39.2%) and educational attainment was low with a median of 4 years of education. In the first trimester of pregnancy, a quarter (25.8%; 95% CI 22.3 to 29.5) of all women were depressed as diagnosed by the Structured Clinical Interview for the Diagnosis of DSM-IV Disorders . Future plans Follow-up is ongoing and expected to continue until January 2018. The prevalence of Depression at later stages of pregnancy and during the first postpartum year will be identified, and associations between Depression status and demographic, social, migration-related, medical, obstetric and infant factors will be quantified. Trial registration number NCT02790905.
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Perinatal Depression in refugee and labour migrant women on the Thai-Myanmar border : prevalence, risk factors and experiences
2018Co-Authors: Gracia FellmethAbstract:Background: Perinatal Depression is a significant contributor to maternal morbidity and mortality worldwide. Left untreated, Perinatal Depression has severe and far-reaching consequences for women, their families and wider society. Migrant women, including labour migrants and refugees, may be particularly prone to developing Perinatal Depression as a result of multiple stressors associated with displacement. Despite the vast majority of global migration flows occurring within low- and middle-income countries, evidence from these regions is severely lacking. This research addresses this imbalance by examining Perinatal Depression in migrant women living on the Thai-Myanmar border: a resource-poor setting of political tension and socio-economic disadvantage. Aims: This research aims to review the existing evidence around Perinatal Depression among migrant women from low- and middle-income settings; identify an appropriate tool to detect Perinatal Depression in migrant women on the Thai-Myanmar border; determine the prevalence of, and risk factors for, Perinatal Depression in this setting; explore women's experiences of Perinatal Depression; and develop recommendations for policy and practice. Methods: A sequential-exploratory mixed-methods design was used. The research included the following five study components: a systematic literature review; a validation study to identify a culturally-acceptable and appropriate assessment tool; a prospective cohort study of migrant women on the Thai-Myanmar border followed-up from the first trimester of pregnancy to one month post-partum; in-depth interviews with a subgroup of women with severe Perinatal Depression; and an informal exploration of stakeholder views. Findings: The systematic review found a wide range in prevalence of Perinatal Depression among migrant women and confirmed the absence of studies conducted in low-and middle-income destination countries. A total of 568 migrant women on the Thai-Myanmar border participated in the prospective cohort study, of whom 18.5% experienced moderate-severe Depression and 39.8% experienced Depression of any severity during the Perinatal period. Almost a third (29%) of women reported suicidal ideation. Interpersonal violence (OR 4.5), experience of trauma (OR 2.4), a self-reported history of Depression (OR 2.3) and perceived insufficiency of social support (OR 2.1) were significantly associated with Perinatal Depression. Lives of women with severe Perinatal Depression were characterised by difficult partner relationships, alcohol use among partners and interpersonal violence. A lack of mental health services currently limits the effective management of Perinatal Depression in this setting. Alongside training of health staff, primary, secondary and tertiary prevention efforts are required to effectively address Perinatal Depression on the Thai-Myanmar border.
Prakaykaew Charunwatthana - One of the best experts on this subject based on the ideXlab platform.
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Migrant Perinatal Depression study: a prospective cohort study of Perinatal Depression on the Thai-Myanmar border.
BMJ open, 2018Co-Authors: Gracia Fellmeth, Emma Plugge, Verena I. Carrara, Mina Fazel, Yuwapha Phichitphadungtham, Mupawjay Pimanpanarak, Naw Kerry Wai, Prakaykaew CharunwatthanaAbstract:Purpose Perinatal Depression is a significant contributor to maternal morbidity. Migrant women in resource-poor settings may be at increased risk, yet little research has been conducted in low-income and middle-income settings. This prospective cohort study of migrant women on the Thai-Myanmar border aims to establish prevalence of Perinatal Depression, identify risk factors for Perinatal Depression and examine associations with infant outcomes. Participants Participating women are labour migrants and refugees living on the Thai-Myanmar border. A total of 568 women were recruited in their first trimester of pregnancy and are being followed up to 1-year postpartum. Findings to date At baseline, women in our study had a median age of 25 years, the predominant ethnicity was Sgaw Karen (48.9%), agriculture was the main employment sector (39.2%) and educational attainment was low with a median of 4 years of education. In the first trimester of pregnancy, a quarter (25.8%; 95% CI 22.3 to 29.5) of all women were depressed as diagnosed by the Structured Clinical Interview for the Diagnosis of DSM-IV Disorders . Future plans Follow-up is ongoing and expected to continue until January 2018. The prevalence of Depression at later stages of pregnancy and during the first postpartum year will be identified, and associations between Depression status and demographic, social, migration-related, medical, obstetric and infant factors will be quantified. Trial registration number NCT02790905.
Catherine Monk - One of the best experts on this subject based on the ideXlab platform.
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Perinatal Depression the fourth inflammatory morbidity of pregnancy theory and literature review
Psychoneuroendocrinology, 2013Co-Authors: Lauren M. Osborne, Catherine MonkAbstract:Perinatal Depression is one of the leading causes of maternal morbidity and mortality. The biological etiology of this disorder remains in question, despite considerable research into the contributions of hormonal imbalance, the role of monoamines, and dysregulation of the HPA axis. Because inflammation is known to be associated with major Depression in men and non-Perinatal women as well as with other important morbidities of pregnancy (such as preeclampsia, preterm birth, and gestational diabetes), and because these morbidities may correlate with Perinatal Depression, inflammation may be a common physiological pathway that can also help explain Perinatal Depression. In this paper, we review the theoretical background of inflammation in Perinatal Depression and then review the literature concerning immune and inflammatory factors in the etiology and course of Perinatal Depression. We close with recommendations for future studies in this still relatively unexplored area. Identification and understanding of a common pathophysiology between other pregnancy morbidities and Perinatal Depression would link physical and mental well-being, likely leading to better treatment and prevention.
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Perinatal Depression—The fourth inflammatory morbidity of pregnancy?: Theory and literature review
Psychoneuroendocrinology, 2013Co-Authors: Lauren M. Osborne, Catherine MonkAbstract:Perinatal Depression is one of the leading causes of maternal morbidity and mortality. The biological etiology of this disorder remains in question, despite considerable research into the contributions of hormonal imbalance, the role of monoamines, and dysregulation of the HPA axis. Because inflammation is known to be associated with major Depression in men and non-Perinatal women as well as with other important morbidities of pregnancy (such as preeclampsia, preterm birth, and gestational diabetes), and because these morbidities may correlate with Perinatal Depression, inflammation may be a common physiological pathway that can also help explain Perinatal Depression. In this paper, we review the theoretical background of inflammation in Perinatal Depression and then review the literature concerning immune and inflammatory factors in the etiology and course of Perinatal Depression. We close with recommendations for future studies in this still relatively unexplored area. Identification and understanding of a common pathophysiology between other pregnancy morbidities and Perinatal Depression would link physical and mental well-being, likely leading to better treatment and prevention.