The Experts below are selected from a list of 4539 Experts worldwide ranked by ideXlab platform

Sofia Martin - One of the best experts on this subject based on the ideXlab platform.

  • contact lens induced corneal Peripheral Swelling orbscan repeatability
    Optometry and Vision Science, 2009
    Co-Authors: Raul Martin, Victoria De Juan, Guadalupe Rodriguez, Soraya Fonseca, Sofia Martin
    Abstract:

    PURPOSE To compare the repeatability and agreement of corneal thickness measurements using central and Peripheral ultrasound and Orbscan pachymetry to detect contact lens (CL)-induced corneal Swelling after extended wear (EW). METHODS Corneal thickness was measured in five corneal locations (central, superior, inferior, nasal, and temporal) with ultrasound and Orbscan pachymetry 1 week before CL wear commenced and after 1 week of EW. High oxygen permeability (lotrafilcon A) and low oxygen permeability (etafilcon A) CL were randomly fitted for EW in the right and left eyes of 20 subjects with normal ocular health to induce different amount of corneal Swelling. RESULTS Poor repeatability and poor agreement in Peripheral ultrasound and Orbscan pachymetry was found between corneas with and without corneal Swelling. Ultrasound coefficients of repeatability (central, superior, inferior, nasal, and temporal) in corneas without (0.95, 2.1, 3.2, 3.9, and 3.8%) and with (0.91, 1.89, 2.45, 2.66, and 2.26%) corneal Swelling were higher than Orbscan coefficients of repeatability without (0.74, 1.67, 1.29, 1.11, and 1.11%) and with (0.74, 1.47, 1.28, 1.78, and 1.23%) corneal Swelling. Lotrafilcon A induced significantly less corneal Swelling in all five corneal locations compared with etafilcon A. Peripheral corneal Swelling differences between lens types were significant only with Orbscan measurements (p < 0.05, Paired t-test and re-analysis of variance). CONCLUSIONS The assessment of corneal thickness shows higher repeatability using Orbscan pachymetry than using ultrasound to measure corneas with and without corneal Swelling and could be useful to study central and Peripheral corneal Swelling variations in CL EW.

  • Contact lens-induced corneal Peripheral Swelling differences with extended wear.
    Cornea, 2008
    Co-Authors: Raul Martin, Victoria De Juan, Guadalupe Rodriguez, Soraya Fonseca, Sofia Martin
    Abstract:

    PURPOSE To compare central and Peripheral corneal Swelling with high-Dk (lotrafilcon A) and low-Dk (etafilcon A) contact lenses (CLs) during extended wear (EW). METHODS Corneal thickness was measured in 5 corneal locations (central, superior, inferior, nasal, and temporal) with Orbscan II pachymetry 1 week before the wearing of CLs and after 1 week of EW. High-Dk (lotrafilcon A) and low-Dk (etafilcon A) soft CLs were randomly fitted for EW in the right and left eyes of 20 subjects with normal ocular health. Orbscan was also performed before CL removal after 3 and 7 days of EW. RESULTS Lotrafilcon A induced a lower percentage of corneal Swelling in all 5 corneal locations than etafilcon A (P 0.05, repeated-measures analysis of variance). CONCLUSIONS Central and Peripheral corneal thicknesses increase more with etafilcon A than with lotrafilcon A during EW, as measured by Orbscan pachymetry.

Alvin E Davis - One of the best experts on this subject based on the ideXlab platform.

  • Hereditary and acquired angioedema: Problems and progress: Proceedings of the third C1 esterase inhibitor deficiency workshop and beyond
    Journal of Allergy and Clinical Immunology, 2004
    Co-Authors: Angelo Agostoni, Emel Aygören-pürsün, Anthony J. Castaldo, Karen E Binkley, Marco Cicardi, Christoph Bucher, Laurence Bouillet, Alvaro Blanch, Konrad Bork, Alvin E Davis
    Abstract:

    Hereditary angioedema (HAE), a rare but life-threatening condition, manifests as acute attacks of facial, laryngeal, genital, or Peripheral Swelling or abdominal pain secondary to intra-abdominal edema. Resulting from mutations affecting C1 esterase inhibitor (C1-INH), inhibitor of the first complement system component, attacks are not histamine-mediated and do not respond to antihistamines or corticosteroids. Low awareness and resemblance to other disorders often delay diagnosis; despite availability of C1-INH replacement in some countries, no approved, safe acute attack therapy exists in the United States. The biennial C1 Esterase Inhibitor Deficiency Workshops resulted from a European initiative for better knowledge and treatment of HAE and related diseases. This supplement contains work presented at the third workshop and expanded content toward a definitive picture of angioedema in the absence of allergy. Most notably, it includes cumulative genetic investigations; multinational laboratory diagnosis recommendations; current pathogenesis hypotheses; suggested prophylaxis and acute attack treatment, including home treatment; future treatment options; and analysis of patient subpopulations, including pediatric patients and patients whose angioedema worsened during pregnancy or hormone administration. Causes and management of acquired angioedema and a new type of angioedema with normal C1-INH are also discussed. Collaborative patient and physician efforts, crucial in rare diseases, are emphasized. This supplement seeks to raise awareness and aid diagnosis of HAE, optimize treatment for all patients, and provide a platform for further research in this rare, partially understood disorder.

Raul Martin - One of the best experts on this subject based on the ideXlab platform.

  • contact lens induced corneal Peripheral Swelling orbscan repeatability
    Optometry and Vision Science, 2009
    Co-Authors: Raul Martin, Victoria De Juan, Guadalupe Rodriguez, Soraya Fonseca, Sofia Martin
    Abstract:

    PURPOSE To compare the repeatability and agreement of corneal thickness measurements using central and Peripheral ultrasound and Orbscan pachymetry to detect contact lens (CL)-induced corneal Swelling after extended wear (EW). METHODS Corneal thickness was measured in five corneal locations (central, superior, inferior, nasal, and temporal) with ultrasound and Orbscan pachymetry 1 week before CL wear commenced and after 1 week of EW. High oxygen permeability (lotrafilcon A) and low oxygen permeability (etafilcon A) CL were randomly fitted for EW in the right and left eyes of 20 subjects with normal ocular health to induce different amount of corneal Swelling. RESULTS Poor repeatability and poor agreement in Peripheral ultrasound and Orbscan pachymetry was found between corneas with and without corneal Swelling. Ultrasound coefficients of repeatability (central, superior, inferior, nasal, and temporal) in corneas without (0.95, 2.1, 3.2, 3.9, and 3.8%) and with (0.91, 1.89, 2.45, 2.66, and 2.26%) corneal Swelling were higher than Orbscan coefficients of repeatability without (0.74, 1.67, 1.29, 1.11, and 1.11%) and with (0.74, 1.47, 1.28, 1.78, and 1.23%) corneal Swelling. Lotrafilcon A induced significantly less corneal Swelling in all five corneal locations compared with etafilcon A. Peripheral corneal Swelling differences between lens types were significant only with Orbscan measurements (p < 0.05, Paired t-test and re-analysis of variance). CONCLUSIONS The assessment of corneal thickness shows higher repeatability using Orbscan pachymetry than using ultrasound to measure corneas with and without corneal Swelling and could be useful to study central and Peripheral corneal Swelling variations in CL EW.

  • Contact lens-induced corneal Peripheral Swelling differences with extended wear.
    Cornea, 2008
    Co-Authors: Raul Martin, Victoria De Juan, Guadalupe Rodriguez, Soraya Fonseca, Sofia Martin
    Abstract:

    PURPOSE To compare central and Peripheral corneal Swelling with high-Dk (lotrafilcon A) and low-Dk (etafilcon A) contact lenses (CLs) during extended wear (EW). METHODS Corneal thickness was measured in 5 corneal locations (central, superior, inferior, nasal, and temporal) with Orbscan II pachymetry 1 week before the wearing of CLs and after 1 week of EW. High-Dk (lotrafilcon A) and low-Dk (etafilcon A) soft CLs were randomly fitted for EW in the right and left eyes of 20 subjects with normal ocular health. Orbscan was also performed before CL removal after 3 and 7 days of EW. RESULTS Lotrafilcon A induced a lower percentage of corneal Swelling in all 5 corneal locations than etafilcon A (P 0.05, repeated-measures analysis of variance). CONCLUSIONS Central and Peripheral corneal thicknesses increase more with etafilcon A than with lotrafilcon A during EW, as measured by Orbscan pachymetry.

Angelo Agostoni - One of the best experts on this subject based on the ideXlab platform.

  • Hereditary and acquired angioedema: Problems and progress: Proceedings of the third C1 esterase inhibitor deficiency workshop and beyond
    Journal of Allergy and Clinical Immunology, 2004
    Co-Authors: Angelo Agostoni, Emel Aygören-pürsün, Anthony J. Castaldo, Karen E Binkley, Marco Cicardi, Christoph Bucher, Laurence Bouillet, Alvaro Blanch, Konrad Bork, Alvin E Davis
    Abstract:

    Hereditary angioedema (HAE), a rare but life-threatening condition, manifests as acute attacks of facial, laryngeal, genital, or Peripheral Swelling or abdominal pain secondary to intra-abdominal edema. Resulting from mutations affecting C1 esterase inhibitor (C1-INH), inhibitor of the first complement system component, attacks are not histamine-mediated and do not respond to antihistamines or corticosteroids. Low awareness and resemblance to other disorders often delay diagnosis; despite availability of C1-INH replacement in some countries, no approved, safe acute attack therapy exists in the United States. The biennial C1 Esterase Inhibitor Deficiency Workshops resulted from a European initiative for better knowledge and treatment of HAE and related diseases. This supplement contains work presented at the third workshop and expanded content toward a definitive picture of angioedema in the absence of allergy. Most notably, it includes cumulative genetic investigations; multinational laboratory diagnosis recommendations; current pathogenesis hypotheses; suggested prophylaxis and acute attack treatment, including home treatment; future treatment options; and analysis of patient subpopulations, including pediatric patients and patients whose angioedema worsened during pregnancy or hormone administration. Causes and management of acquired angioedema and a new type of angioedema with normal C1-INH are also discussed. Collaborative patient and physician efforts, crucial in rare diseases, are emphasized. This supplement seeks to raise awareness and aid diagnosis of HAE, optimize treatment for all patients, and provide a platform for further research in this rare, partially understood disorder.

Victoria De Juan - One of the best experts on this subject based on the ideXlab platform.

  • contact lens induced corneal Peripheral Swelling orbscan repeatability
    Optometry and Vision Science, 2009
    Co-Authors: Raul Martin, Victoria De Juan, Guadalupe Rodriguez, Soraya Fonseca, Sofia Martin
    Abstract:

    PURPOSE To compare the repeatability and agreement of corneal thickness measurements using central and Peripheral ultrasound and Orbscan pachymetry to detect contact lens (CL)-induced corneal Swelling after extended wear (EW). METHODS Corneal thickness was measured in five corneal locations (central, superior, inferior, nasal, and temporal) with ultrasound and Orbscan pachymetry 1 week before CL wear commenced and after 1 week of EW. High oxygen permeability (lotrafilcon A) and low oxygen permeability (etafilcon A) CL were randomly fitted for EW in the right and left eyes of 20 subjects with normal ocular health to induce different amount of corneal Swelling. RESULTS Poor repeatability and poor agreement in Peripheral ultrasound and Orbscan pachymetry was found between corneas with and without corneal Swelling. Ultrasound coefficients of repeatability (central, superior, inferior, nasal, and temporal) in corneas without (0.95, 2.1, 3.2, 3.9, and 3.8%) and with (0.91, 1.89, 2.45, 2.66, and 2.26%) corneal Swelling were higher than Orbscan coefficients of repeatability without (0.74, 1.67, 1.29, 1.11, and 1.11%) and with (0.74, 1.47, 1.28, 1.78, and 1.23%) corneal Swelling. Lotrafilcon A induced significantly less corneal Swelling in all five corneal locations compared with etafilcon A. Peripheral corneal Swelling differences between lens types were significant only with Orbscan measurements (p < 0.05, Paired t-test and re-analysis of variance). CONCLUSIONS The assessment of corneal thickness shows higher repeatability using Orbscan pachymetry than using ultrasound to measure corneas with and without corneal Swelling and could be useful to study central and Peripheral corneal Swelling variations in CL EW.

  • Contact lens-induced corneal Peripheral Swelling differences with extended wear.
    Cornea, 2008
    Co-Authors: Raul Martin, Victoria De Juan, Guadalupe Rodriguez, Soraya Fonseca, Sofia Martin
    Abstract:

    PURPOSE To compare central and Peripheral corneal Swelling with high-Dk (lotrafilcon A) and low-Dk (etafilcon A) contact lenses (CLs) during extended wear (EW). METHODS Corneal thickness was measured in 5 corneal locations (central, superior, inferior, nasal, and temporal) with Orbscan II pachymetry 1 week before the wearing of CLs and after 1 week of EW. High-Dk (lotrafilcon A) and low-Dk (etafilcon A) soft CLs were randomly fitted for EW in the right and left eyes of 20 subjects with normal ocular health. Orbscan was also performed before CL removal after 3 and 7 days of EW. RESULTS Lotrafilcon A induced a lower percentage of corneal Swelling in all 5 corneal locations than etafilcon A (P 0.05, repeated-measures analysis of variance). CONCLUSIONS Central and Peripheral corneal thicknesses increase more with etafilcon A than with lotrafilcon A during EW, as measured by Orbscan pachymetry.