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Jan A Moynihan - One of the best experts on this subject based on the ideXlab platform.

  • the effects of chemical sympathectomy on t Cell cytokine responses are not mediated by altered Peritoneal Exudate Cell function or an inflammatory response
    Brain Behavior and Immunity, 2002
    Co-Authors: Tracy A Callahan, Jan A Moynihan
    Abstract:

    Ablation of the sympathetic nervous system by chemical sympathectomy is a standard model for the study of sympathetic nervous system regulation of immune function. We have previously documented that chemical denervation results in enhanced antigen-specific, but suppressed mitogen-induced, cytokine production by spleen Cells. In our investigation into the mechanisms of sympathectomy-induced immune alterations, we first evaluated the Peritoneal environment into which the protein antigen keyhole limpet hemocyanin is administered. Denervation resulted in increased production of tumor necrosis factor-alpha by Peritoneal Exudate Cells and these Cells appeared to have enhanced antigen presenting capability. We hypothesized that nerve terminal destruction may be inducing an inflammatory response by monocyte/macrophages and other Cell types throughout the periphery that could differentially alter subsequent mitogen versus antigen-specific responses. However, no evidence of sympathectomy-induced systemic or local splenic inflammatory responses was observed, as indicated by measuring the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta. These experiments indicate that an inflammatory response is not likely to be responsible for sympathectomy-induced immune alterations, eliminating a potential confounding factor in interpreting sympathectomy studies.

D K Ganguly - One of the best experts on this subject based on the ideXlab platform.

  • trigonella foenum graecum fenugreek seed extract as an antineoplastic agent
    Phytotherapy Research, 2001
    Co-Authors: P Sur, M Das, Aparna Gomes, J R Vedasiromoni, Niranjan P Sahu, S Banerjee, Richa Sharma, D K Ganguly
    Abstract:

    The antineoplastic effect of Trigonella foenum graecum seed extract has been evaluated in the Ehrlich ascites carcinoma (EAC) model in Balb-C mice. Intra-Peritoneal administration of the alcohol extract of the seed both before and after inoculation of EAC Cell in mice produced more than 70% inhibition of tumour Cell growth with respect to the control. Treatment with the extract was found to enhance both the Peritoneal Exudate Cell and macrophage Cell counts. The extract also produced a significant antiinflammatory effect. We report here the antiinflammatory and antineoplastic effects, of Trigonella foenum graecum seed extract.

Tracy A Callahan - One of the best experts on this subject based on the ideXlab platform.

  • the effects of chemical sympathectomy on t Cell cytokine responses are not mediated by altered Peritoneal Exudate Cell function or an inflammatory response
    Brain Behavior and Immunity, 2002
    Co-Authors: Tracy A Callahan, Jan A Moynihan
    Abstract:

    Ablation of the sympathetic nervous system by chemical sympathectomy is a standard model for the study of sympathetic nervous system regulation of immune function. We have previously documented that chemical denervation results in enhanced antigen-specific, but suppressed mitogen-induced, cytokine production by spleen Cells. In our investigation into the mechanisms of sympathectomy-induced immune alterations, we first evaluated the Peritoneal environment into which the protein antigen keyhole limpet hemocyanin is administered. Denervation resulted in increased production of tumor necrosis factor-alpha by Peritoneal Exudate Cells and these Cells appeared to have enhanced antigen presenting capability. We hypothesized that nerve terminal destruction may be inducing an inflammatory response by monocyte/macrophages and other Cell types throughout the periphery that could differentially alter subsequent mitogen versus antigen-specific responses. However, no evidence of sympathectomy-induced systemic or local splenic inflammatory responses was observed, as indicated by measuring the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta. These experiments indicate that an inflammatory response is not likely to be responsible for sympathectomy-induced immune alterations, eliminating a potential confounding factor in interpreting sympathectomy studies.

P Sur - One of the best experts on this subject based on the ideXlab platform.

  • trigonella foenum graecum fenugreek seed extract as an antineoplastic agent
    Phytotherapy Research, 2001
    Co-Authors: P Sur, M Das, Aparna Gomes, J R Vedasiromoni, Niranjan P Sahu, S Banerjee, Richa Sharma, D K Ganguly
    Abstract:

    The antineoplastic effect of Trigonella foenum graecum seed extract has been evaluated in the Ehrlich ascites carcinoma (EAC) model in Balb-C mice. Intra-Peritoneal administration of the alcohol extract of the seed both before and after inoculation of EAC Cell in mice produced more than 70% inhibition of tumour Cell growth with respect to the control. Treatment with the extract was found to enhance both the Peritoneal Exudate Cell and macrophage Cell counts. The extract also produced a significant antiinflammatory effect. We report here the antiinflammatory and antineoplastic effects, of Trigonella foenum graecum seed extract.

Daan J A Crommelin - One of the best experts on this subject based on the ideXlab platform.

  • effects of intraPeritoneal administration of free and liposome entrapped doxorubicin on rat Peritoneal Exudate Cell populations
    Journal of Drug Targeting, 1996
    Co-Authors: Gert Storm, P A Steerenberg, M Van Borssum Waalkes, Daan J A Crommelin
    Abstract:

    In the present paper effects of i.p. treatment with free or liposome-entrapped doxorubicin (DXR) on rat Peritoneal Exudate Cell (PEC) populations were examined. Two types of DXR-liposomes were used: one type consisting of egg-phosphatidylcholine/phosphatidylserine/cholesterol (molar ratio 10/1/4, mean size approx. 0.3 micron) and the other type of distearoylphosphatidylcholine/dipalmitoylglycerol/cholesterol (molar ratio 10/1/10, mean size approx. 0.8 micron). Dramatically fewer PEC could be recovered from rats given free DXR or DXR-liposomes i.p. (10 mg DXR/kg body weight) 24 h before sacrifice than from control rats. Also the ratio of leukocyte species was modified by treatment with DXR, in free or liposomal form; in both cases the relative number of macrophages tended to increase. HPLC determination of the amount of DXR associated with monolayers obtained by seeding PEC harvested after a single i.p. dose of free DXR or liposomal DXR suggests that Peritoneal macrophages are not particularly active in endocytosing DXR-liposomes. It was observed that the Peritoneal macrophages phagocytosed DXR-containing granules from degranulating mast Cells after both i.p. treatment with free DXR and DXR-liposomes. Decreased yields of PEC following i.p. treatment with free or liposomal DXR as well as an involvement of mast Cells in the processing of both free DXR and liposome-encapsulated DXR in the Peritoneal cavity may have important consequences for approaches to i.p. chemotherapy.