The Experts below are selected from a list of 225 Experts worldwide ranked by ideXlab platform

Hideyuki Shimizu - One of the best experts on this subject based on the ideXlab platform.

  • THREE-DIMENSIONAL ANALYSIS OF NONLINEAR INTERACTION BETWEEN WATER WAVES AND VERTICAL Permeable BREAKWATER
    Coastal Engineering Journal, 2003
    Co-Authors: Aliasghar Golshani, Norimi Mizutani, Dong-soo Hur, Hideyuki Shimizu
    Abstract:

    This paper investigates the wave-induced flow field and water particle movement inside and around a vertical Permeable Structure, which is affected by the interaction between water waves and porous media. A three-dimensional fully nonlinear numerical model is developed to study the interaction between water waves and Permeable Structures. Modified resistance terms inside the equations of motion are proposed, which are able to consider the size of porous material directly inside the governing equations. It is understood that the wave-induced flow field and water particle movement inside and around the Permeable Structure are strongly influenced by the wave period or relative width of the Permeable Structure (Structure width to wavelength ratio). Other parameters such as porous material size, porosity, and resistance coefficients affect the flow field. However, their degree of influence differs depending on the wave period.

Ram Chand Dhakar - One of the best experts on this subject based on the ideXlab platform.

  • NASAL DRUG DELIVERY: SUCCESS THROUGH INTEGRATED DEVICE DEVELOPMENT
    Journal of Drug Delivery and Therapeutics, 2011
    Co-Authors: Ram Chand Dhakar
    Abstract:

    Transmucosal nasal delivery is a promising drug delivery option where common drug administrations (e.g., intravenous, intramuscular, or oral) are inapplicable. Recently, it has been shown that many drugs have better bioavailability by nasal route than by oral route. This has been attributed to rich vasculature and a highly Permeable Structure of the nasal mucosa coupled with avoidance of hepatic first-pass elimination, gut wall metabolism and/or destruction in the gastrointestinal tract. The physiology of the nose presents obstacles, but offers a promising route for non-invasive systemic delivery of numerous therapies and debatably drug delivery route to the brain.  Intranasal microemulsions, gels and microspheres have gained increased interest in recent years as a delivery system for protein and peptides through nasal route. Since building a more efficient nasal drug delivery device requires not only better device design but  a far more versatile technology platform; one that delivers optimal nasal deposition, with formulation flexibility to work successfully with the many variables of the formulation itself. Thus present review focuses on innovations in nasal drug delivery devices.

  • Non-invasive Systemic Drug Delivery via Nasal Route: A Review
    2011
    Co-Authors: Ram Chand Dhakar
    Abstract:

    Transmucosal nasal delivery is a promising drug delivery option where common drug administrations, such as intravenous, intramuscular, or oral are inapplicable. Recently, it has been shown that many drugs have better bioavailability by nasal route than the oral route. This has been attributed to rich vasculature and a highly Permeable Structure of the nasal mucosa coupled with avoidance of hepatic first-pass elimination, gut wall metabolism and/or destruction in the gastrointestinal tract. The physiology of the nose presents obstacles, but offers a promising route for non-invasive systemic delivery of numerous therapies and debatably drug delivery route to the brain. Intranasal microemulsions, gels and microspheres have gained increased interest in recent years as a delivery system for protein and peptides through the nasal route. Thus this review focuses on nasal drug delivery, various aspects of nasal anatomy and physiology, nasal drug absorption mechanisms, various nasal drug delivery systems, and their applications in drug delivery.

  • A review on factors affecting the design of nasal drug delivery system
    International Journal of Drug Delivery, 2011
    Co-Authors: Ram Chand Dhakar, Sheo Datta Maurya, Vijay Kumar Tilak, Anish K. Gupta
    Abstract:

    Transmucosal nasal delivery is a promising drug delivery option where common drug administrations (e.g., intravenous, intramuscular, or oral) are inapplicable. Recently, it has been shown that many drugs have better bioavailability by nasal route than by oral route. This has been attributed to rich vasculature and a highly Permeable Structure of the nasal mucosa coupled with avoidance of hepatic first-pass elimination, gut wall metabolism and/or destruction in the gastrointestinal tract. The physiology of the nose presents obstacles, but offers a promising route for non-invasive systemic delivery of numerous therapies and debatably drug delivery route to the brain. To overcoming problems in nasal drug delivery requires deep understanding of the various factors affecting nasal delivery. Thus present review focuses on various aspects of nasal drug delivery with special emphasis to factors affecting nasal drug administration. Keywords: Transmucosal nasal delivery, hepatic first-pass metabolism, non-invasive, microemulsions, microspheres.

Inigo J. Losada - One of the best experts on this subject based on the ideXlab platform.

  • Chapter 7 Modeling the effects of Permeable and reflective Structures on waves and nearshore flows
    Advances in Coastal Modeling, 2003
    Co-Authors: Inigo J. Losada
    Abstract:

    Publisher Summary This chapter summarizes some of the most recent work available on the modeling of wave interaction with porous Structures. It is shown that the study of wave interaction with Permeable Structures evolved in parallel with wave theories in fluids. Models based on linear wave theory, modified Boussinesq equations or other kinds of shallow water equations and RANS equations are currently available. For any of these models the accuracy of the final results relies greatly on some parameters depending on the flow. Structure permeability modifies the flow in the nearby area, therefore having important consequences on scour and shoreline morphodynamics. Special attention is paid to the effects of wave transmission and combined diffraction-transmission leeward the Structures, as well as the influence of Structure permeability on wave breaking. The validity of current porous flow models for rigid porous media with macroscopic pores, such as artificial block layers in rubble mound Structures, is analyzed. The extension of the Cornell breaking wave and Structure (COBRAS) to three-dimensions implies a considerable improvement to the current modeling of wave and Permeable Structure interaction.

  • Modelling of wave loads and hydraulic performance of vertical Permeable Structures
    Coastal Engineering, 2002
    Co-Authors: S. Requejo, César Vidal, Inigo J. Losada
    Abstract:

    Abstract Using an eigenfunction expansion method, the potential flow around and inside vertical porous breakwaters has been solved for regular waves. The extension to irregular waves is indicated in this paper. Analytical expressions for functional performance variables (reflection, transmission and dissipation) and for stability (horizontal and vertical forces, including the corresponding overturning moments) have been obtained. These expressions have been numerically exploited to demonstrate the capability of the model for design purposes. The parameters required in the porous flow model are expressed in terms of the porous material characteristics and have been investigated experimentally. Some additional experiments using a vertical Permeable Structure with an imPermeable backwall are carried out to validate the model.

Aliasghar Golshani - One of the best experts on this subject based on the ideXlab platform.

  • THREE-DIMENSIONAL ANALYSIS OF NONLINEAR INTERACTION BETWEEN WATER WAVES AND VERTICAL Permeable BREAKWATER
    Coastal Engineering Journal, 2003
    Co-Authors: Aliasghar Golshani, Norimi Mizutani, Dong-soo Hur, Hideyuki Shimizu
    Abstract:

    This paper investigates the wave-induced flow field and water particle movement inside and around a vertical Permeable Structure, which is affected by the interaction between water waves and porous media. A three-dimensional fully nonlinear numerical model is developed to study the interaction between water waves and Permeable Structures. Modified resistance terms inside the equations of motion are proposed, which are able to consider the size of porous material directly inside the governing equations. It is understood that the wave-induced flow field and water particle movement inside and around the Permeable Structure are strongly influenced by the wave period or relative width of the Permeable Structure (Structure width to wavelength ratio). Other parameters such as porous material size, porosity, and resistance coefficients affect the flow field. However, their degree of influence differs depending on the wave period.

Dong-sheng Jeng - One of the best experts on this subject based on the ideXlab platform.

  • numerical study for waves propagating over a porous seabed around a submerged Permeable breakwater poro wssi ii model
    Ocean Engineering, 2011
    Co-Authors: Ji-sheng Zhang, Dong-sheng Jeng
    Abstract:

    The phenomenon of the wave, seabed and Structure interactions has attracted great attentions from coastal geotechnical engineers in recent years. Most previous investigations have based on individual approaches, which focused on either flow region or seabed domain. In this study, an integrated model (PORO-WSSI II), based on the Volume-Averaged/Reynolds-Averaged Navier-Stokes (VARANS) equations and Biot's poro-elastic theory, is developed to investigate the mechanism of the wave-Permeable Structure-porous seabed interactions. The new model is verified with the previous experimental data. Based on the present model, parametric studies have been carried out to investigate the influences of wave, soil and Structure parameters on the wave-induced pore pressure. Numerical results indicated: (i) longer wave period and larger wave height will obviously induce a higher magnitude of pore pressure at the leading edge of a breakwater; (ii) after a full wave-Structure interaction, the magnitude of pore pressure below the lee side of a breakwater decreases with an increasing Structure porosity while it varies dramatically with a change of Structure height; and (iii) the seabed thickness, soil permeability and the degree of saturation can also significantly affect the dynamic soil behaviour.

  • An integrated model of wave-seabed-Structure interactions
    Journal of Hydrodynamics, 2010
    Co-Authors: Ji-sheng Zhang, Dong-sheng Jeng, Bo Wang, Philip L. -f. Liu, Ping Dong
    Abstract:

    The phenomenon of wave-seabed-Structure interactions have occurred in the marine environment with a coastal Permeable (or partially Permeable) Structure, which has attracted great attention from coastal engineers involved in the design of marine Structures. In this study, a porous seabed model based on Biot’s consolidation equation and pore-elastic theory is integrated into the COBRAS wave-Structure model. This integrated model is verified by the laboratory experiments. Some dominant factors affecting the wave motion and its induced seabed response are examined by using this model, including wave parameters and Structure properties.

  • An integrated model of wave-seabed-Structure interactions
    Journal of Hydrodynamics, 2010
    Co-Authors: Ji-sheng Zhang, Dong-sheng Jeng, Bo Wang, Philip L. -f. Liu, Ping Dong
    Abstract:

    The phenomenon of wave-seabed-Structure interactions have occurred in the marine environment with a coastal Permeable (or partially Permeable) Structure, which has attracted great attention from coastal engineers involved in the design of marine Structures. In this study, a porous seabed model based on Biot's consolidation equation and pore-elastic theory is integrated into the COBRAS wave-Structure model. This integrated model is verified by the laboratory experiments. Some dominant factors affecting the wave motion and its induced seabed response are examined by using this model, including wave parameters and Structure properties.No Full Tex