The Experts below are selected from a list of 94512 Experts worldwide ranked by ideXlab platform
V G Montana - One of the best experts on this subject based on the ideXlab platform.
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novel selective small molecule agonists for Peroxisome proliferator activated Receptor δ pparδ synthesis and biological activity
Bioorganic & Medicinal Chemistry Letters, 2003Co-Authors: Marcos L Sznaidman, Patrick Maloney, Esther Y Chao, D M Goreham, Michael Lawrence Sierra, Christelle Legrumelec, Curt D. Haffner, Adam M Fivush, Eric H Xu, V G MontanaAbstract:Abstract We report the synthesis and biological activity of a new series of small molecule agonists of the human Peroxisome Proliferator-Activated Receptor δ (PPARδ). Several hits were identified from our original libraries containing lipophilic carboxylic acids. Optimization of these hits by structure-guided design led to 7k (GW501516) and 7l (GW0742), which shows an EC50 of 1.1 nM against PPARδ with 1000-fold selectivity over the other human subtypes.
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novel selective small molecule agonists for Peroxisome proliferator activated Receptor δ pparδ synthesis and biological activity
Bioorganic & Medicinal Chemistry Letters, 2003Co-Authors: Marcos L Sznaidman, Patrick Maloney, Esther Y Chao, D M Goreham, Michael Lawrence Sierra, Christelle Legrumelec, Curt D. Haffner, Adam M Fivush, Eric H Xu, V G MontanaAbstract:Abstract We report the synthesis and biological activity of a new series of small molecule agonists of the human Peroxisome Proliferator-Activated Receptor δ (PPARδ). Several hits were identified from our original libraries containing lipophilic carboxylic acids. Optimization of these hits by structure-guided design led to 7k (GW501516) and 7l (GW0742), which shows an EC50 of 1.1 nM against PPARδ with 1000-fold selectivity over the other human subtypes.
Marcos L Sznaidman - One of the best experts on this subject based on the ideXlab platform.
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novel selective small molecule agonists for Peroxisome proliferator activated Receptor δ pparδ synthesis and biological activity
Bioorganic & Medicinal Chemistry Letters, 2003Co-Authors: Marcos L Sznaidman, Patrick Maloney, Esther Y Chao, D M Goreham, Michael Lawrence Sierra, Christelle Legrumelec, Curt D. Haffner, Adam M Fivush, Eric H Xu, V G MontanaAbstract:Abstract We report the synthesis and biological activity of a new series of small molecule agonists of the human Peroxisome Proliferator-Activated Receptor δ (PPARδ). Several hits were identified from our original libraries containing lipophilic carboxylic acids. Optimization of these hits by structure-guided design led to 7k (GW501516) and 7l (GW0742), which shows an EC50 of 1.1 nM against PPARδ with 1000-fold selectivity over the other human subtypes.
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novel selective small molecule agonists for Peroxisome proliferator activated Receptor δ pparδ synthesis and biological activity
Bioorganic & Medicinal Chemistry Letters, 2003Co-Authors: Marcos L Sznaidman, Patrick Maloney, Esther Y Chao, D M Goreham, Michael Lawrence Sierra, Christelle Legrumelec, Curt D. Haffner, Adam M Fivush, Eric H Xu, V G MontanaAbstract:Abstract We report the synthesis and biological activity of a new series of small molecule agonists of the human Peroxisome Proliferator-Activated Receptor δ (PPARδ). Several hits were identified from our original libraries containing lipophilic carboxylic acids. Optimization of these hits by structure-guided design led to 7k (GW501516) and 7l (GW0742), which shows an EC50 of 1.1 nM against PPARδ with 1000-fold selectivity over the other human subtypes.
Michael Lawrence Sierra - One of the best experts on this subject based on the ideXlab platform.
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novel selective small molecule agonists for Peroxisome proliferator activated Receptor δ pparδ synthesis and biological activity
Bioorganic & Medicinal Chemistry Letters, 2003Co-Authors: Marcos L Sznaidman, Patrick Maloney, Esther Y Chao, D M Goreham, Michael Lawrence Sierra, Christelle Legrumelec, Curt D. Haffner, Adam M Fivush, Eric H Xu, V G MontanaAbstract:Abstract We report the synthesis and biological activity of a new series of small molecule agonists of the human Peroxisome Proliferator-Activated Receptor δ (PPARδ). Several hits were identified from our original libraries containing lipophilic carboxylic acids. Optimization of these hits by structure-guided design led to 7k (GW501516) and 7l (GW0742), which shows an EC50 of 1.1 nM against PPARδ with 1000-fold selectivity over the other human subtypes.
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novel selective small molecule agonists for Peroxisome proliferator activated Receptor δ pparδ synthesis and biological activity
Bioorganic & Medicinal Chemistry Letters, 2003Co-Authors: Marcos L Sznaidman, Patrick Maloney, Esther Y Chao, D M Goreham, Michael Lawrence Sierra, Christelle Legrumelec, Curt D. Haffner, Adam M Fivush, Eric H Xu, V G MontanaAbstract:Abstract We report the synthesis and biological activity of a new series of small molecule agonists of the human Peroxisome Proliferator-Activated Receptor δ (PPARδ). Several hits were identified from our original libraries containing lipophilic carboxylic acids. Optimization of these hits by structure-guided design led to 7k (GW501516) and 7l (GW0742), which shows an EC50 of 1.1 nM against PPARδ with 1000-fold selectivity over the other human subtypes.
Christelle Legrumelec - One of the best experts on this subject based on the ideXlab platform.
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novel selective small molecule agonists for Peroxisome proliferator activated Receptor δ pparδ synthesis and biological activity
Bioorganic & Medicinal Chemistry Letters, 2003Co-Authors: Marcos L Sznaidman, Patrick Maloney, Esther Y Chao, D M Goreham, Michael Lawrence Sierra, Christelle Legrumelec, Curt D. Haffner, Adam M Fivush, Eric H Xu, V G MontanaAbstract:Abstract We report the synthesis and biological activity of a new series of small molecule agonists of the human Peroxisome Proliferator-Activated Receptor δ (PPARδ). Several hits were identified from our original libraries containing lipophilic carboxylic acids. Optimization of these hits by structure-guided design led to 7k (GW501516) and 7l (GW0742), which shows an EC50 of 1.1 nM against PPARδ with 1000-fold selectivity over the other human subtypes.
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novel selective small molecule agonists for Peroxisome proliferator activated Receptor δ pparδ synthesis and biological activity
Bioorganic & Medicinal Chemistry Letters, 2003Co-Authors: Marcos L Sznaidman, Patrick Maloney, Esther Y Chao, D M Goreham, Michael Lawrence Sierra, Christelle Legrumelec, Curt D. Haffner, Adam M Fivush, Eric H Xu, V G MontanaAbstract:Abstract We report the synthesis and biological activity of a new series of small molecule agonists of the human Peroxisome Proliferator-Activated Receptor δ (PPARδ). Several hits were identified from our original libraries containing lipophilic carboxylic acids. Optimization of these hits by structure-guided design led to 7k (GW501516) and 7l (GW0742), which shows an EC50 of 1.1 nM against PPARδ with 1000-fold selectivity over the other human subtypes.
Adam M Fivush - One of the best experts on this subject based on the ideXlab platform.
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novel selective small molecule agonists for Peroxisome proliferator activated Receptor δ pparδ synthesis and biological activity
Bioorganic & Medicinal Chemistry Letters, 2003Co-Authors: Marcos L Sznaidman, Patrick Maloney, Esther Y Chao, D M Goreham, Michael Lawrence Sierra, Christelle Legrumelec, Curt D. Haffner, Adam M Fivush, Eric H Xu, V G MontanaAbstract:Abstract We report the synthesis and biological activity of a new series of small molecule agonists of the human Peroxisome Proliferator-Activated Receptor δ (PPARδ). Several hits were identified from our original libraries containing lipophilic carboxylic acids. Optimization of these hits by structure-guided design led to 7k (GW501516) and 7l (GW0742), which shows an EC50 of 1.1 nM against PPARδ with 1000-fold selectivity over the other human subtypes.
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novel selective small molecule agonists for Peroxisome proliferator activated Receptor δ pparδ synthesis and biological activity
Bioorganic & Medicinal Chemistry Letters, 2003Co-Authors: Marcos L Sznaidman, Patrick Maloney, Esther Y Chao, D M Goreham, Michael Lawrence Sierra, Christelle Legrumelec, Curt D. Haffner, Adam M Fivush, Eric H Xu, V G MontanaAbstract:Abstract We report the synthesis and biological activity of a new series of small molecule agonists of the human Peroxisome Proliferator-Activated Receptor δ (PPARδ). Several hits were identified from our original libraries containing lipophilic carboxylic acids. Optimization of these hits by structure-guided design led to 7k (GW501516) and 7l (GW0742), which shows an EC50 of 1.1 nM against PPARδ with 1000-fold selectivity over the other human subtypes.