The Experts below are selected from a list of 321 Experts worldwide ranked by ideXlab platform
Dilip K. Bhattacharya - One of the best experts on this subject based on the ideXlab platform.
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Pharmacological studies on the effect of the treatment of swiss a mice with diospyrin a tumour inhibitory plant product and its synthetic derivatives
Phytotherapy Research, 1996Co-Authors: Sampa Pal, Banasri Hazra, Ratnamala Ray, Amalendu Banerjee, Dilip K. BhattacharyaAbstract:Diospyrin, a bisnaphthoquinonoid plant product and its derivatives have shown significant inhibitory activities against murine tumours in vivo. Studies on the haematological status, serum protein and creatinine levels, activities of several serum glycolytic enzymes, and histopathology of the mice inoculated with Ehrlich ascites carcinoma were carried out after treatment with diospyrin and four synthetic derivatives. The prognostic significance of the Pharmacological Parameters acting as markers of the diseased state was evident from these findings. Normal mice were also studied before and after treatment with these compounds which did not cause noticeable adverse effects on the vital Parameters, thereby indicating the possibility of the utilization of diospyrin and derivatives as appropriate therapeutic agents.
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Pharmacological Studies on the Effect of the Treatment of Swiss A Mice with Diospyrin, a Tumour‐inhibitory Plant Product, and its Synthetic Derivatives
Phytotherapy Research, 1996Co-Authors: Sampa Pal, Banasri Hazra, Ratnamala Ray, Amalendu Banerjee, Dilip K. BhattacharyaAbstract:Diospyrin, a bisnaphthoquinonoid plant product and its derivatives have shown significant inhibitory activities against murine tumours in vivo. Studies on the haematological status, serum protein and creatinine levels, activities of several serum glycolytic enzymes, and histopathology of the mice inoculated with Ehrlich ascites carcinoma were carried out after treatment with diospyrin and four synthetic derivatives. The prognostic significance of the Pharmacological Parameters acting as markers of the diseased state was evident from these findings. Normal mice were also studied before and after treatment with these compounds which did not cause noticeable adverse effects on the vital Parameters, thereby indicating the possibility of the utilization of diospyrin and derivatives as appropriate therapeutic agents.
Sampa Pal - One of the best experts on this subject based on the ideXlab platform.
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Pharmacological studies on the effect of the treatment of swiss a mice with diospyrin a tumour inhibitory plant product and its synthetic derivatives
Phytotherapy Research, 1996Co-Authors: Sampa Pal, Banasri Hazra, Ratnamala Ray, Amalendu Banerjee, Dilip K. BhattacharyaAbstract:Diospyrin, a bisnaphthoquinonoid plant product and its derivatives have shown significant inhibitory activities against murine tumours in vivo. Studies on the haematological status, serum protein and creatinine levels, activities of several serum glycolytic enzymes, and histopathology of the mice inoculated with Ehrlich ascites carcinoma were carried out after treatment with diospyrin and four synthetic derivatives. The prognostic significance of the Pharmacological Parameters acting as markers of the diseased state was evident from these findings. Normal mice were also studied before and after treatment with these compounds which did not cause noticeable adverse effects on the vital Parameters, thereby indicating the possibility of the utilization of diospyrin and derivatives as appropriate therapeutic agents.
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Pharmacological Studies on the Effect of the Treatment of Swiss A Mice with Diospyrin, a Tumour‐inhibitory Plant Product, and its Synthetic Derivatives
Phytotherapy Research, 1996Co-Authors: Sampa Pal, Banasri Hazra, Ratnamala Ray, Amalendu Banerjee, Dilip K. BhattacharyaAbstract:Diospyrin, a bisnaphthoquinonoid plant product and its derivatives have shown significant inhibitory activities against murine tumours in vivo. Studies on the haematological status, serum protein and creatinine levels, activities of several serum glycolytic enzymes, and histopathology of the mice inoculated with Ehrlich ascites carcinoma were carried out after treatment with diospyrin and four synthetic derivatives. The prognostic significance of the Pharmacological Parameters acting as markers of the diseased state was evident from these findings. Normal mice were also studied before and after treatment with these compounds which did not cause noticeable adverse effects on the vital Parameters, thereby indicating the possibility of the utilization of diospyrin and derivatives as appropriate therapeutic agents.
Niels Vande Casteele - One of the best experts on this subject based on the ideXlab platform.
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role for therapeutic drug monitoring during induction therapy with tnf antagonists in ibd evolution in the definition and management of primary nonresponse
Inflammatory Bowel Diseases, 2015Co-Authors: Konstantinos Papamichael, Niels Vande Casteele, Ann Gils, Severine Vermeire, William J Sandborn, Barrett G Levesque, Paul RutgeertsAbstract:Abstract : Primary nonresponse and primary nonremission are important limitations of tumor necrosis factor (TNF) antagonists, occurring in 10% to 40% and 50% to 80% of patients with inflammatory bowel disease, respectively. The magnitude of primary nonresponse differs between phase III clinical trials and cohort studies, indicating differences, e.g., in definition, patient population or blinding. The causes of nonresponse can be attributed to the drug (pharmacokinetics, immunogenicity), the patient (genetics, disease activity), the disease (type, location, severity), and/or the treatment strategy (dosing regimen, combination therapy). Primary nonresponse has been attributed to "non-TNF-driven disease" which is an overly simplified and potentially misleading approach to the problem. Many patients with primary nonresponse could successfully be treated with dose optimization during the induction phase or switching to another TNF antagonist. Therefore, primary nonresponse is frequently not a non-TNF-driven disease. Recent studies from rheumatoid arthritis and preliminary data from inflammatory bowel disease evaluating therapeutic drug monitoring have suggested that early measurement of drug and anti-drug antibody concentrations could help to define primary nonresponse and rationalize patient management of this problem. Moreover, a modeling approach including Pharmacological Parameters and patient-related covariants could potentially be predictive for response to the treatment. We describe an overview of this evolution in thinking, underpinned by previous findings, and assess the potential role of early measurement of drug and antidrug antibody concentrations in the definition and management of primary nonresponse.
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therapeutic drug monitoring in inflammatory bowel disease current state and future perspectives
Current Gastroenterology Reports, 2014Co-Authors: Niels Vande Casteele, Brian G Feagan, Ann Gils, Severine Vermeire, Reena Khanna, William J Sandborn, Barrett G LevesqueAbstract:Current available anti-inflammatory drugs, in particular monoclonal antibodies directed against the cytokine tumor necrosis factor α (TNF), have greatly enhanced the treatment of inflammatory bowel diseases (IBD). Although many patients respond to ant-TNF therapy, a proportion of patients will not respond (primary non-response) or will lose response to the drug over time (secondary non-response). This loss of response can be caused by patient, TNF-inhibitor, or disease-related factors influencing the pharmacokinetics and pharmacodynamics of the drug. Therefore, monitoring Pharmacological Parameters (i.e. therapeutic drug monitoring) may help guide therapeutic decisions. This review emphasizes interesting and important new findings, and provides an updated overview, on the subject of therapeutic drug monitoring. While exploring the hypothesis that “one size does not fit all”, we focused on the first prospective studies investigating the novel approach in IBD of ‘target concentration adjusted dosing’ and personalized medicine.
Banasri Hazra - One of the best experts on this subject based on the ideXlab platform.
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Pharmacological studies on the effect of the treatment of swiss a mice with diospyrin a tumour inhibitory plant product and its synthetic derivatives
Phytotherapy Research, 1996Co-Authors: Sampa Pal, Banasri Hazra, Ratnamala Ray, Amalendu Banerjee, Dilip K. BhattacharyaAbstract:Diospyrin, a bisnaphthoquinonoid plant product and its derivatives have shown significant inhibitory activities against murine tumours in vivo. Studies on the haematological status, serum protein and creatinine levels, activities of several serum glycolytic enzymes, and histopathology of the mice inoculated with Ehrlich ascites carcinoma were carried out after treatment with diospyrin and four synthetic derivatives. The prognostic significance of the Pharmacological Parameters acting as markers of the diseased state was evident from these findings. Normal mice were also studied before and after treatment with these compounds which did not cause noticeable adverse effects on the vital Parameters, thereby indicating the possibility of the utilization of diospyrin and derivatives as appropriate therapeutic agents.
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Pharmacological Studies on the Effect of the Treatment of Swiss A Mice with Diospyrin, a Tumour‐inhibitory Plant Product, and its Synthetic Derivatives
Phytotherapy Research, 1996Co-Authors: Sampa Pal, Banasri Hazra, Ratnamala Ray, Amalendu Banerjee, Dilip K. BhattacharyaAbstract:Diospyrin, a bisnaphthoquinonoid plant product and its derivatives have shown significant inhibitory activities against murine tumours in vivo. Studies on the haematological status, serum protein and creatinine levels, activities of several serum glycolytic enzymes, and histopathology of the mice inoculated with Ehrlich ascites carcinoma were carried out after treatment with diospyrin and four synthetic derivatives. The prognostic significance of the Pharmacological Parameters acting as markers of the diseased state was evident from these findings. Normal mice were also studied before and after treatment with these compounds which did not cause noticeable adverse effects on the vital Parameters, thereby indicating the possibility of the utilization of diospyrin and derivatives as appropriate therapeutic agents.
Ratnamala Ray - One of the best experts on this subject based on the ideXlab platform.
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Pharmacological studies on the effect of the treatment of swiss a mice with diospyrin a tumour inhibitory plant product and its synthetic derivatives
Phytotherapy Research, 1996Co-Authors: Sampa Pal, Banasri Hazra, Ratnamala Ray, Amalendu Banerjee, Dilip K. BhattacharyaAbstract:Diospyrin, a bisnaphthoquinonoid plant product and its derivatives have shown significant inhibitory activities against murine tumours in vivo. Studies on the haematological status, serum protein and creatinine levels, activities of several serum glycolytic enzymes, and histopathology of the mice inoculated with Ehrlich ascites carcinoma were carried out after treatment with diospyrin and four synthetic derivatives. The prognostic significance of the Pharmacological Parameters acting as markers of the diseased state was evident from these findings. Normal mice were also studied before and after treatment with these compounds which did not cause noticeable adverse effects on the vital Parameters, thereby indicating the possibility of the utilization of diospyrin and derivatives as appropriate therapeutic agents.
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Pharmacological Studies on the Effect of the Treatment of Swiss A Mice with Diospyrin, a Tumour‐inhibitory Plant Product, and its Synthetic Derivatives
Phytotherapy Research, 1996Co-Authors: Sampa Pal, Banasri Hazra, Ratnamala Ray, Amalendu Banerjee, Dilip K. BhattacharyaAbstract:Diospyrin, a bisnaphthoquinonoid plant product and its derivatives have shown significant inhibitory activities against murine tumours in vivo. Studies on the haematological status, serum protein and creatinine levels, activities of several serum glycolytic enzymes, and histopathology of the mice inoculated with Ehrlich ascites carcinoma were carried out after treatment with diospyrin and four synthetic derivatives. The prognostic significance of the Pharmacological Parameters acting as markers of the diseased state was evident from these findings. Normal mice were also studied before and after treatment with these compounds which did not cause noticeable adverse effects on the vital Parameters, thereby indicating the possibility of the utilization of diospyrin and derivatives as appropriate therapeutic agents.