The Experts below are selected from a list of 57 Experts worldwide ranked by ideXlab platform

Vidya Radhakrishnan - One of the best experts on this subject based on the ideXlab platform.

  • Novel Phenanthridine (PHE-4i) Derivative inhibits carrageenan-induced rat hind paw oedema through suppression of hydrogen sulfide
    Inflammopharmacology, 2016
    Co-Authors: Leema George, Tamizhselvi Ramasamy, Venkatraman Manickam, Sathiyanarayanan Kulathu Iyer, Vidya Radhakrishnan
    Abstract:

    This study was conducted to assess the anti-inflammatory effect of a novel synthesized Phenanthridine alkaloid (PHE-4i) and to examine the possible involvement of hydrogen sulfide (H_2S) in anti-inflammatory mechanism. The synthesized Phenanthridine Derivative PHE-4i (2, 5, and 10 mg/kg) was administered intraperitoneally to rats. One hour following treatment, inflammation was induced by intraplantar injection of carrageenan (1 %), in the hind paw. Paw volume as the index of inflammation was measured before and after carrageenan injection. Neutrophil sequestration into the hind paw was quantified by measuring tissue myeloperoxidase (MPO) activity and was compared for the inhibition of H_2S production. Pretreatment with PHE-4i significantly reduced carrageenan-induced hind paw weight, MPO activity, leukocyte infiltration, and H_2S production in a dose-dependent manner ( p  

  • novel Phenanthridine phe 4i Derivative inhibits carrageenan induced rat hind paw oedema through suppression of hydrogen sulfide
    Inflammopharmacology, 2016
    Co-Authors: Leema George, Tamizhselvi Ramasamy, Venkatraman Manickam, Sathiyanarayanan Kulathu Iyer, Vidya Radhakrishnan
    Abstract:

    This study was conducted to assess the anti-inflammatory effect of a novel synthesized Phenanthridine alkaloid (PHE-4i) and to examine the possible involvement of hydrogen sulfide (H2S) in anti-inflammatory mechanism. The synthesized Phenanthridine Derivative PHE-4i (2, 5, and 10 mg/kg) was administered intraperitoneally to rats. One hour following treatment, inflammation was induced by intraplantar injection of carrageenan (1 %), in the hind paw. Paw volume as the index of inflammation was measured before and after carrageenan injection. Neutrophil sequestration into the hind paw was quantified by measuring tissue myeloperoxidase (MPO) activity and was compared for the inhibition of H2S production. Pretreatment with PHE-4i significantly reduced carrageenan-induced hind paw weight, MPO activity, leukocyte infiltration, and H2S production in a dose-dependent manner (p < 0.001). These results indicate that the anti-inflammatory effect of PHE-4i on carrageenan-induced rat paw oedema could be via the inhibition of the gaseous mediator H2S.

Leema George - One of the best experts on this subject based on the ideXlab platform.

  • Novel Phenanthridine (PHE-4i) Derivative inhibits carrageenan-induced rat hind paw oedema through suppression of hydrogen sulfide
    Inflammopharmacology, 2016
    Co-Authors: Leema George, Tamizhselvi Ramasamy, Venkatraman Manickam, Sathiyanarayanan Kulathu Iyer, Vidya Radhakrishnan
    Abstract:

    This study was conducted to assess the anti-inflammatory effect of a novel synthesized Phenanthridine alkaloid (PHE-4i) and to examine the possible involvement of hydrogen sulfide (H_2S) in anti-inflammatory mechanism. The synthesized Phenanthridine Derivative PHE-4i (2, 5, and 10 mg/kg) was administered intraperitoneally to rats. One hour following treatment, inflammation was induced by intraplantar injection of carrageenan (1 %), in the hind paw. Paw volume as the index of inflammation was measured before and after carrageenan injection. Neutrophil sequestration into the hind paw was quantified by measuring tissue myeloperoxidase (MPO) activity and was compared for the inhibition of H_2S production. Pretreatment with PHE-4i significantly reduced carrageenan-induced hind paw weight, MPO activity, leukocyte infiltration, and H_2S production in a dose-dependent manner ( p  

  • novel Phenanthridine phe 4i Derivative inhibits carrageenan induced rat hind paw oedema through suppression of hydrogen sulfide
    Inflammopharmacology, 2016
    Co-Authors: Leema George, Tamizhselvi Ramasamy, Venkatraman Manickam, Sathiyanarayanan Kulathu Iyer, Vidya Radhakrishnan
    Abstract:

    This study was conducted to assess the anti-inflammatory effect of a novel synthesized Phenanthridine alkaloid (PHE-4i) and to examine the possible involvement of hydrogen sulfide (H2S) in anti-inflammatory mechanism. The synthesized Phenanthridine Derivative PHE-4i (2, 5, and 10 mg/kg) was administered intraperitoneally to rats. One hour following treatment, inflammation was induced by intraplantar injection of carrageenan (1 %), in the hind paw. Paw volume as the index of inflammation was measured before and after carrageenan injection. Neutrophil sequestration into the hind paw was quantified by measuring tissue myeloperoxidase (MPO) activity and was compared for the inhibition of H2S production. Pretreatment with PHE-4i significantly reduced carrageenan-induced hind paw weight, MPO activity, leukocyte infiltration, and H2S production in a dose-dependent manner (p < 0.001). These results indicate that the anti-inflammatory effect of PHE-4i on carrageenan-induced rat paw oedema could be via the inhibition of the gaseous mediator H2S.

Venkatraman Manickam - One of the best experts on this subject based on the ideXlab platform.

  • Novel Phenanthridine (PHE-4i) Derivative inhibits carrageenan-induced rat hind paw oedema through suppression of hydrogen sulfide
    Inflammopharmacology, 2016
    Co-Authors: Leema George, Tamizhselvi Ramasamy, Venkatraman Manickam, Sathiyanarayanan Kulathu Iyer, Vidya Radhakrishnan
    Abstract:

    This study was conducted to assess the anti-inflammatory effect of a novel synthesized Phenanthridine alkaloid (PHE-4i) and to examine the possible involvement of hydrogen sulfide (H_2S) in anti-inflammatory mechanism. The synthesized Phenanthridine Derivative PHE-4i (2, 5, and 10 mg/kg) was administered intraperitoneally to rats. One hour following treatment, inflammation was induced by intraplantar injection of carrageenan (1 %), in the hind paw. Paw volume as the index of inflammation was measured before and after carrageenan injection. Neutrophil sequestration into the hind paw was quantified by measuring tissue myeloperoxidase (MPO) activity and was compared for the inhibition of H_2S production. Pretreatment with PHE-4i significantly reduced carrageenan-induced hind paw weight, MPO activity, leukocyte infiltration, and H_2S production in a dose-dependent manner ( p  

  • novel Phenanthridine phe 4i Derivative inhibits carrageenan induced rat hind paw oedema through suppression of hydrogen sulfide
    Inflammopharmacology, 2016
    Co-Authors: Leema George, Tamizhselvi Ramasamy, Venkatraman Manickam, Sathiyanarayanan Kulathu Iyer, Vidya Radhakrishnan
    Abstract:

    This study was conducted to assess the anti-inflammatory effect of a novel synthesized Phenanthridine alkaloid (PHE-4i) and to examine the possible involvement of hydrogen sulfide (H2S) in anti-inflammatory mechanism. The synthesized Phenanthridine Derivative PHE-4i (2, 5, and 10 mg/kg) was administered intraperitoneally to rats. One hour following treatment, inflammation was induced by intraplantar injection of carrageenan (1 %), in the hind paw. Paw volume as the index of inflammation was measured before and after carrageenan injection. Neutrophil sequestration into the hind paw was quantified by measuring tissue myeloperoxidase (MPO) activity and was compared for the inhibition of H2S production. Pretreatment with PHE-4i significantly reduced carrageenan-induced hind paw weight, MPO activity, leukocyte infiltration, and H2S production in a dose-dependent manner (p < 0.001). These results indicate that the anti-inflammatory effect of PHE-4i on carrageenan-induced rat paw oedema could be via the inhibition of the gaseous mediator H2S.

Sathiyanarayanan Kulathu Iyer - One of the best experts on this subject based on the ideXlab platform.

  • Novel Phenanthridine (PHE-4i) Derivative inhibits carrageenan-induced rat hind paw oedema through suppression of hydrogen sulfide
    Inflammopharmacology, 2016
    Co-Authors: Leema George, Tamizhselvi Ramasamy, Venkatraman Manickam, Sathiyanarayanan Kulathu Iyer, Vidya Radhakrishnan
    Abstract:

    This study was conducted to assess the anti-inflammatory effect of a novel synthesized Phenanthridine alkaloid (PHE-4i) and to examine the possible involvement of hydrogen sulfide (H_2S) in anti-inflammatory mechanism. The synthesized Phenanthridine Derivative PHE-4i (2, 5, and 10 mg/kg) was administered intraperitoneally to rats. One hour following treatment, inflammation was induced by intraplantar injection of carrageenan (1 %), in the hind paw. Paw volume as the index of inflammation was measured before and after carrageenan injection. Neutrophil sequestration into the hind paw was quantified by measuring tissue myeloperoxidase (MPO) activity and was compared for the inhibition of H_2S production. Pretreatment with PHE-4i significantly reduced carrageenan-induced hind paw weight, MPO activity, leukocyte infiltration, and H_2S production in a dose-dependent manner ( p  

  • novel Phenanthridine phe 4i Derivative inhibits carrageenan induced rat hind paw oedema through suppression of hydrogen sulfide
    Inflammopharmacology, 2016
    Co-Authors: Leema George, Tamizhselvi Ramasamy, Venkatraman Manickam, Sathiyanarayanan Kulathu Iyer, Vidya Radhakrishnan
    Abstract:

    This study was conducted to assess the anti-inflammatory effect of a novel synthesized Phenanthridine alkaloid (PHE-4i) and to examine the possible involvement of hydrogen sulfide (H2S) in anti-inflammatory mechanism. The synthesized Phenanthridine Derivative PHE-4i (2, 5, and 10 mg/kg) was administered intraperitoneally to rats. One hour following treatment, inflammation was induced by intraplantar injection of carrageenan (1 %), in the hind paw. Paw volume as the index of inflammation was measured before and after carrageenan injection. Neutrophil sequestration into the hind paw was quantified by measuring tissue myeloperoxidase (MPO) activity and was compared for the inhibition of H2S production. Pretreatment with PHE-4i significantly reduced carrageenan-induced hind paw weight, MPO activity, leukocyte infiltration, and H2S production in a dose-dependent manner (p < 0.001). These results indicate that the anti-inflammatory effect of PHE-4i on carrageenan-induced rat paw oedema could be via the inhibition of the gaseous mediator H2S.

Tamizhselvi Ramasamy - One of the best experts on this subject based on the ideXlab platform.

  • Novel Phenanthridine (PHE-4i) Derivative inhibits carrageenan-induced rat hind paw oedema through suppression of hydrogen sulfide
    Inflammopharmacology, 2016
    Co-Authors: Leema George, Tamizhselvi Ramasamy, Venkatraman Manickam, Sathiyanarayanan Kulathu Iyer, Vidya Radhakrishnan
    Abstract:

    This study was conducted to assess the anti-inflammatory effect of a novel synthesized Phenanthridine alkaloid (PHE-4i) and to examine the possible involvement of hydrogen sulfide (H_2S) in anti-inflammatory mechanism. The synthesized Phenanthridine Derivative PHE-4i (2, 5, and 10 mg/kg) was administered intraperitoneally to rats. One hour following treatment, inflammation was induced by intraplantar injection of carrageenan (1 %), in the hind paw. Paw volume as the index of inflammation was measured before and after carrageenan injection. Neutrophil sequestration into the hind paw was quantified by measuring tissue myeloperoxidase (MPO) activity and was compared for the inhibition of H_2S production. Pretreatment with PHE-4i significantly reduced carrageenan-induced hind paw weight, MPO activity, leukocyte infiltration, and H_2S production in a dose-dependent manner ( p  

  • novel Phenanthridine phe 4i Derivative inhibits carrageenan induced rat hind paw oedema through suppression of hydrogen sulfide
    Inflammopharmacology, 2016
    Co-Authors: Leema George, Tamizhselvi Ramasamy, Venkatraman Manickam, Sathiyanarayanan Kulathu Iyer, Vidya Radhakrishnan
    Abstract:

    This study was conducted to assess the anti-inflammatory effect of a novel synthesized Phenanthridine alkaloid (PHE-4i) and to examine the possible involvement of hydrogen sulfide (H2S) in anti-inflammatory mechanism. The synthesized Phenanthridine Derivative PHE-4i (2, 5, and 10 mg/kg) was administered intraperitoneally to rats. One hour following treatment, inflammation was induced by intraplantar injection of carrageenan (1 %), in the hind paw. Paw volume as the index of inflammation was measured before and after carrageenan injection. Neutrophil sequestration into the hind paw was quantified by measuring tissue myeloperoxidase (MPO) activity and was compared for the inhibition of H2S production. Pretreatment with PHE-4i significantly reduced carrageenan-induced hind paw weight, MPO activity, leukocyte infiltration, and H2S production in a dose-dependent manner (p < 0.001). These results indicate that the anti-inflammatory effect of PHE-4i on carrageenan-induced rat paw oedema could be via the inhibition of the gaseous mediator H2S.