The Experts below are selected from a list of 537 Experts worldwide ranked by ideXlab platform
Kazue Takeba - One of the best experts on this subject based on the ideXlab platform.
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application of ion exchange cartridge clean up in food analysis iv confirmatory assay of benzylpenicillin Phenoxymethylpenicillin oxacillin cloxacillin nafcillin and dicloxacillin in bovine tissues by liquid chromatography electrospray ionization tandem mass spectrometry
Journal of Chromatography A, 2001Co-Authors: Yuko Ito, Yoshitomo Ikai, Hisao Oka, Hiroshi Matsumoto, Yutaka Miyazaki, Kazue Takeba, Hisamitsu NagaseAbstract:A multiresidue analytical method was developed for the confirmation of benzylpenicillin (PCG), Phenoxymethylpenicillin (PCV), oxacillin (MPIPC), cloxacillin (MCIPC), nafcillin (NFPC) and dicloxacillin (MDIPC) in bovine tissues using electrospray ionization liquid chromatography-tandem mass spectrometry (LC-ESI-MS-MS) with a product ion scan mode. All penicillins gave [M-H]-, [M-H-CO2]- and [M-H-141]- as the product ion, when [M-H]- was selected as the precursor ion. Combination of an ion-exchange cartridge clean-up and the LC-ESI-MS-MS method can reliably identify all of these penicillins fortified at a concentration of 0.05 mg/kg in bovine tissues, including liver, kidney and muscle. The limits of confirmation satisfy the maximum residue limits for each of the penicillins established by the World Health Organization, US Food and Drug Administration, European Union and Japan.
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application of ion exchange cartridge clean up in food analysis iii determination of benzylpenicillin phenoxymethyl penicillin oxacillin cloxacillin nafcillin and dicloxacillin in bovine liver and kidney by liquid chromatography with ultraviolet detection
Journal of Chromatography A, 2000Co-Authors: Yuko Ito, Yoshitomo Ikai, Hisao Oka, Hiroshi Matsumoto, Tadaaki Kagami, Kazue TakebaAbstract:A multiresidue analytical method was developed for the simultaneous determination of benzylpenicillin (PCG), Phenoxymethylpenicillin (PCV), oxacillin (MPIPC), cloxacillin (MCIPC), nafcillin (NFPC) and dicloxacillin (MDIPC) in bovine liver and kidney. The method involves the use of an ion-exchange cartridge for sample clean-up followed by ion-pair high-performance liquid chromatography with ultraviolet detection. The recoveries of PCG, PCV, MPIPC, MCIPC, NFPC and MDIPC from bovine liver spiked at levels of 0.5 mg/kg and 0.1 mg/kg were in the range of 73-91% and 83-96% with coefficients of variation of 1.4-4.2% and 3.4-8.7%, respectively. For bovine kidney spiked at levels of 0.5 mg/kg and 0.1 mg/kg, the recoveries of these compounds were 79-92% and 82-92% with RSDs of 1.8-5.9% and 2.7-7.8%, respectively. The detection limits for the six penicillins were 0.02-0.05 mg/kg in bovine liver and kidney.
Yuko Ito - One of the best experts on this subject based on the ideXlab platform.
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application of ion exchange cartridge clean up in food analysis iv confirmatory assay of benzylpenicillin Phenoxymethylpenicillin oxacillin cloxacillin nafcillin and dicloxacillin in bovine tissues by liquid chromatography electrospray ionization tandem mass spectrometry
Journal of Chromatography A, 2001Co-Authors: Yuko Ito, Yoshitomo Ikai, Hisao Oka, Hiroshi Matsumoto, Yutaka Miyazaki, Kazue Takeba, Hisamitsu NagaseAbstract:A multiresidue analytical method was developed for the confirmation of benzylpenicillin (PCG), Phenoxymethylpenicillin (PCV), oxacillin (MPIPC), cloxacillin (MCIPC), nafcillin (NFPC) and dicloxacillin (MDIPC) in bovine tissues using electrospray ionization liquid chromatography-tandem mass spectrometry (LC-ESI-MS-MS) with a product ion scan mode. All penicillins gave [M-H]-, [M-H-CO2]- and [M-H-141]- as the product ion, when [M-H]- was selected as the precursor ion. Combination of an ion-exchange cartridge clean-up and the LC-ESI-MS-MS method can reliably identify all of these penicillins fortified at a concentration of 0.05 mg/kg in bovine tissues, including liver, kidney and muscle. The limits of confirmation satisfy the maximum residue limits for each of the penicillins established by the World Health Organization, US Food and Drug Administration, European Union and Japan.
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application of ion exchange cartridge clean up in food analysis iii determination of benzylpenicillin phenoxymethyl penicillin oxacillin cloxacillin nafcillin and dicloxacillin in bovine liver and kidney by liquid chromatography with ultraviolet detection
Journal of Chromatography A, 2000Co-Authors: Yuko Ito, Yoshitomo Ikai, Hisao Oka, Hiroshi Matsumoto, Tadaaki Kagami, Kazue TakebaAbstract:A multiresidue analytical method was developed for the simultaneous determination of benzylpenicillin (PCG), Phenoxymethylpenicillin (PCV), oxacillin (MPIPC), cloxacillin (MCIPC), nafcillin (NFPC) and dicloxacillin (MDIPC) in bovine liver and kidney. The method involves the use of an ion-exchange cartridge for sample clean-up followed by ion-pair high-performance liquid chromatography with ultraviolet detection. The recoveries of PCG, PCV, MPIPC, MCIPC, NFPC and MDIPC from bovine liver spiked at levels of 0.5 mg/kg and 0.1 mg/kg were in the range of 73-91% and 83-96% with coefficients of variation of 1.4-4.2% and 3.4-8.7%, respectively. For bovine kidney spiked at levels of 0.5 mg/kg and 0.1 mg/kg, the recoveries of these compounds were 79-92% and 82-92% with RSDs of 1.8-5.9% and 2.7-7.8%, respectively. The detection limits for the six penicillins were 0.02-0.05 mg/kg in bovine liver and kidney.
Hisamitsu Nagase - One of the best experts on this subject based on the ideXlab platform.
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application of ion exchange cartridge clean up in food analysis iv confirmatory assay of benzylpenicillin Phenoxymethylpenicillin oxacillin cloxacillin nafcillin and dicloxacillin in bovine tissues by liquid chromatography electrospray ionization tandem mass spectrometry
Journal of Chromatography A, 2001Co-Authors: Yuko Ito, Yoshitomo Ikai, Hisao Oka, Hiroshi Matsumoto, Yutaka Miyazaki, Kazue Takeba, Hisamitsu NagaseAbstract:A multiresidue analytical method was developed for the confirmation of benzylpenicillin (PCG), Phenoxymethylpenicillin (PCV), oxacillin (MPIPC), cloxacillin (MCIPC), nafcillin (NFPC) and dicloxacillin (MDIPC) in bovine tissues using electrospray ionization liquid chromatography-tandem mass spectrometry (LC-ESI-MS-MS) with a product ion scan mode. All penicillins gave [M-H]-, [M-H-CO2]- and [M-H-141]- as the product ion, when [M-H]- was selected as the precursor ion. Combination of an ion-exchange cartridge clean-up and the LC-ESI-MS-MS method can reliably identify all of these penicillins fortified at a concentration of 0.05 mg/kg in bovine tissues, including liver, kidney and muscle. The limits of confirmation satisfy the maximum residue limits for each of the penicillins established by the World Health Organization, US Food and Drug Administration, European Union and Japan.
Yoshitomo Ikai - One of the best experts on this subject based on the ideXlab platform.
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application of ion exchange cartridge clean up in food analysis iv confirmatory assay of benzylpenicillin Phenoxymethylpenicillin oxacillin cloxacillin nafcillin and dicloxacillin in bovine tissues by liquid chromatography electrospray ionization tandem mass spectrometry
Journal of Chromatography A, 2001Co-Authors: Yuko Ito, Yoshitomo Ikai, Hisao Oka, Hiroshi Matsumoto, Yutaka Miyazaki, Kazue Takeba, Hisamitsu NagaseAbstract:A multiresidue analytical method was developed for the confirmation of benzylpenicillin (PCG), Phenoxymethylpenicillin (PCV), oxacillin (MPIPC), cloxacillin (MCIPC), nafcillin (NFPC) and dicloxacillin (MDIPC) in bovine tissues using electrospray ionization liquid chromatography-tandem mass spectrometry (LC-ESI-MS-MS) with a product ion scan mode. All penicillins gave [M-H]-, [M-H-CO2]- and [M-H-141]- as the product ion, when [M-H]- was selected as the precursor ion. Combination of an ion-exchange cartridge clean-up and the LC-ESI-MS-MS method can reliably identify all of these penicillins fortified at a concentration of 0.05 mg/kg in bovine tissues, including liver, kidney and muscle. The limits of confirmation satisfy the maximum residue limits for each of the penicillins established by the World Health Organization, US Food and Drug Administration, European Union and Japan.
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application of ion exchange cartridge clean up in food analysis iii determination of benzylpenicillin phenoxymethyl penicillin oxacillin cloxacillin nafcillin and dicloxacillin in bovine liver and kidney by liquid chromatography with ultraviolet detection
Journal of Chromatography A, 2000Co-Authors: Yuko Ito, Yoshitomo Ikai, Hisao Oka, Hiroshi Matsumoto, Tadaaki Kagami, Kazue TakebaAbstract:A multiresidue analytical method was developed for the simultaneous determination of benzylpenicillin (PCG), Phenoxymethylpenicillin (PCV), oxacillin (MPIPC), cloxacillin (MCIPC), nafcillin (NFPC) and dicloxacillin (MDIPC) in bovine liver and kidney. The method involves the use of an ion-exchange cartridge for sample clean-up followed by ion-pair high-performance liquid chromatography with ultraviolet detection. The recoveries of PCG, PCV, MPIPC, MCIPC, NFPC and MDIPC from bovine liver spiked at levels of 0.5 mg/kg and 0.1 mg/kg were in the range of 73-91% and 83-96% with coefficients of variation of 1.4-4.2% and 3.4-8.7%, respectively. For bovine kidney spiked at levels of 0.5 mg/kg and 0.1 mg/kg, the recoveries of these compounds were 79-92% and 82-92% with RSDs of 1.8-5.9% and 2.7-7.8%, respectively. The detection limits for the six penicillins were 0.02-0.05 mg/kg in bovine liver and kidney.
Hisao Oka - One of the best experts on this subject based on the ideXlab platform.
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application of ion exchange cartridge clean up in food analysis iv confirmatory assay of benzylpenicillin Phenoxymethylpenicillin oxacillin cloxacillin nafcillin and dicloxacillin in bovine tissues by liquid chromatography electrospray ionization tandem mass spectrometry
Journal of Chromatography A, 2001Co-Authors: Yuko Ito, Yoshitomo Ikai, Hisao Oka, Hiroshi Matsumoto, Yutaka Miyazaki, Kazue Takeba, Hisamitsu NagaseAbstract:A multiresidue analytical method was developed for the confirmation of benzylpenicillin (PCG), Phenoxymethylpenicillin (PCV), oxacillin (MPIPC), cloxacillin (MCIPC), nafcillin (NFPC) and dicloxacillin (MDIPC) in bovine tissues using electrospray ionization liquid chromatography-tandem mass spectrometry (LC-ESI-MS-MS) with a product ion scan mode. All penicillins gave [M-H]-, [M-H-CO2]- and [M-H-141]- as the product ion, when [M-H]- was selected as the precursor ion. Combination of an ion-exchange cartridge clean-up and the LC-ESI-MS-MS method can reliably identify all of these penicillins fortified at a concentration of 0.05 mg/kg in bovine tissues, including liver, kidney and muscle. The limits of confirmation satisfy the maximum residue limits for each of the penicillins established by the World Health Organization, US Food and Drug Administration, European Union and Japan.
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application of ion exchange cartridge clean up in food analysis iii determination of benzylpenicillin phenoxymethyl penicillin oxacillin cloxacillin nafcillin and dicloxacillin in bovine liver and kidney by liquid chromatography with ultraviolet detection
Journal of Chromatography A, 2000Co-Authors: Yuko Ito, Yoshitomo Ikai, Hisao Oka, Hiroshi Matsumoto, Tadaaki Kagami, Kazue TakebaAbstract:A multiresidue analytical method was developed for the simultaneous determination of benzylpenicillin (PCG), Phenoxymethylpenicillin (PCV), oxacillin (MPIPC), cloxacillin (MCIPC), nafcillin (NFPC) and dicloxacillin (MDIPC) in bovine liver and kidney. The method involves the use of an ion-exchange cartridge for sample clean-up followed by ion-pair high-performance liquid chromatography with ultraviolet detection. The recoveries of PCG, PCV, MPIPC, MCIPC, NFPC and MDIPC from bovine liver spiked at levels of 0.5 mg/kg and 0.1 mg/kg were in the range of 73-91% and 83-96% with coefficients of variation of 1.4-4.2% and 3.4-8.7%, respectively. For bovine kidney spiked at levels of 0.5 mg/kg and 0.1 mg/kg, the recoveries of these compounds were 79-92% and 82-92% with RSDs of 1.8-5.9% and 2.7-7.8%, respectively. The detection limits for the six penicillins were 0.02-0.05 mg/kg in bovine liver and kidney.