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Hanzlíková Pavla - One of the best experts on this subject based on the ideXlab platform.

  • The pharmacotherapy of the venous thromboembolism
    2011
    Co-Authors: Hanzlíková Pavla
    Abstract:

    Topic: Treatment of venous thromboembolism Author: Pavla Hanzlíková Venous thromboembolism is the designation for the states in which a new rising thrombus in the peripheral venous bloodstream can reach the pulmonary artery. These include deep vein thrombosis or Phlebothrombosis legs and pulmonary embolism. Clinically, this is absolutely a different disease, but which are closely related and often occur together and have the same treatment. Anticoagulants, fibrinolytic, antiplatelet therapy with adenosine diphosphate receptor blockers, inhibitors of platelet glycoprotein receptor IIb / IIIa and venous medication are used in the treatment of thromboembolic disease. An important part of therapy are non- pharmacological approaches. Another promising treatment procedures are in a clinical testing

Andrey A. Karpenko - One of the best experts on this subject based on the ideXlab platform.

  • Phlebothrombosis and pulmonary thromboembolism in patients with thrombophilia
    Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery, 2007
    Co-Authors: Andrey A. Karpenko
    Abstract:

    A study was made of the course of Phlebothrombosis ana pulmonary thromboembolism in 54 patients with thrombophilia. Of these, 23 patients had factor la resistance to protein C, 15 presented with antiphospholipid syndrome, four with protein C deficit, one with protein S deficit, three with antithrombin III deficiency, and three patients with hyperhomocysteinemia. Five patients presented with the following combined forms of thrombophilia: thrombophilia due to protein C deficit and antiphospholipid syndrome; protein C deficit and hyperhomocysteinemia; protein C and antithrombin III deficit; factor Va resistance to protein C and hyperhomocysteinemia; antiphospholipid syndrome and hyperhomocysteinemia. Thrombosis of the inferior vena cava (IVC) was present in 52 and PTE in 27 patients, The recurrence of Phlebothrombosis was recorded in 40 (76.9%), that of PTE in 12 (44.4%) patients. The time elapsed between disease exacerbations accounted for one month to nine years, the number of recurrences constituted two to 6. Initially, thrombosis in three patients was located in lower limb saphenous veins, in 18 in the tibial and femoral veins, in 29 in the femoral and iliac veins; two patients presented with femoroiliocaval Phlebothrombosis. The recent control examination revealed thrombosis of the saphenous veins in two patients. In ten patients, thrombosis was located in the tibiofemoral segment, in 19 patients, it was discovered in the femoroiliac and in two cases, in the femoroiliocaval segment. During observation period, venous thrombosis in the previously intact lower limb developed in nine (16.7%) patients. Thrombosis of other vessels inclusive of the organ ones was present in 14 (25.9%) patients. Of these, seven patients had thrombosis of the arteries of the upper and lower limbs: in four cases, it was located in the system of the IVC and in two cases, in the mesenterial arteries; ischemic stroke was recorded in two cases, thrombosis of the portal vein in one, and myocardial infarction was also marked in one case. In view of different hemostatic changes underlying the development of venous thromboses and PTE, we carried out differentiated therapy applying anticoagulants, platelet inhibitors, and transfusions of quickfrozed plasma. In acute femoroiliac and caval thromboses and PTE, 40 patients were provided implantation into the IVC of the cava filter >. After cava filter implantation 16 patients developed tnrombosis of the IVC. Embolism to the cava filter occurred in seven patients. In three cases, it terminated in occlusion of the IVC and in the remaining cases, in its recanalization. Over the period one to six years, occlusive thrombi of the IVC underwent recanalization in 11 patients. Analysis of the course of phiebothrombosis and PTE in patients with thrombophilia made it possible to define situations that require its goal-oriented search. It is demonstrated that it is advisable to implant the cava filter > to the permanent position in thromboses of the femoral, iliac veins and of the IVC as well as in PTE.

M. V. Starosotskaya - One of the best experts on this subject based on the ideXlab platform.

  • Clinical course of pulmonary embolism and efficacy of thrombolytic therapy in patients with thrombophilia
    Federal Biomedical Research Center, 2018
    Co-Authors: A. A. Karpenko, A. N. Shilova, N. A. Karmadonova, M. V. Starosotskaya
    Abstract:

    The article presents a comparative analysis of the clinical course of pulmonary embolism and the effectiveness of thrombolytic therapy in patients with thrombophilia and in those without identified thrombolytic disorders. The impact of thrombophilia on the incidence of pulmonary embolism and Phlebothrombosis was analyzed. The results obtained indicate the presence of thrombophilia in 25.7% of patients with pulmonary embolism. It was found out that thrombosis and embolism in the vena cava filter occurred more frequently in patients with thrombophilia rather than in those with pulmonary embolism of unknown etiology

H Dalichau - One of the best experts on this subject based on the ideXlab platform.

  • deep leg and pelvic vein thrombosis in aplasia of the inferior vena cava
    Vasa-european Journal of Vascular Medicine, 1999
    Co-Authors: Masoud Mirzaie, B Schorn, Th Meyer, S Lotfi, H Dalichau
    Abstract:

    : Deep phlebothromboses of iliacal vein and aplasia of the inferior vena cava Coincidence of deep phlebothromboses of iliacal vein and aplasia of the inferior vena cava is a rare condition but has significance for further therapy. Two cases of this anatomical malformation with complications are presented and the importance of therapeutical strategies are discussed. We report on our experiences with the operative procedures of venous thrombectomy and arteriovenous fistula, aimed at increasing the venous flow in the collaterals of the aplastic inferior vena cava.

Schmitz-rixen T - One of the best experts on this subject based on the ideXlab platform.

  • Phlebothrombosis of the leg. Diagnostic algorithm and therapeutic implications
    Der Chirurg, 2010
    Co-Authors: Schmitz-rixen T
    Abstract:

    Thromboses in the lower extremities are common. Non-invasive examination techniques, such as compression sonography and color-coded duplex sonography, have a high sensitivity and specificity. Relevant complications are in particular post-thrombotic syndrome and pulmonary arterial embolisms. The gold standard in treatment of Phlebothrombosis of the leg is immediate anticoagulation therapy and compression treatment with early mobilization whereas lysis therapy, operative thrombectomy or implantation of cava filters are indicated only in isolated cases.