The Experts below are selected from a list of 75 Experts worldwide ranked by ideXlab platform

Maria Benedetta Donati - One of the best experts on this subject based on the ideXlab platform.

  • cancer and thrombosis from Phlegmasia Alba Dolens to transgenic mice
    Thrombosis and Haemostasis, 1995
    Co-Authors: Maria Benedetta Donati
    Abstract:

    Thrombosis is the most frequent complication and the second cause of death in patients with overt malignant diseases. Increasing evidence suggests that thrombotic episodes may also precede the diagnosis of cancer by months or years thus representing a potential marker for occult malignancy. Recently, emphasis has been given to the potential risk of cancer therapy (both surgery and chemotherapy) in enhancing the risk for thromboembolic disease. Post-operative deep-vein thrombosis is indeed more frequent in patients operated for malignant diseases than forother disorders. On the other hand, both chemotherapy and hormone therapy are associated with an increased thrombotic risk, which can be prevented by low-dose oral anticoagulation. Possible contributory causes for thromboembolic disease in cancer include the capacity of tumor cells and their products to interact with platelets, clotting and fibrinolytic systems, as well as their interactions with endothelial cells and tumor-associated macrophages. In particular, procoagulant activities of tumor cells have been extensively studied ; one of these, cancer procoagulant, could represent a novel marker of malignancy in both solid tumors and acute promyelocytic leukemia (APL). In solid tumors, CP, a vitamin K dependent enzyme could represent the selective target of the antimetastatic effects of warfarin treatment. In APL, CP may contribute to trigger the well known intravascular coagulation syndrome accompanying the early manifestations of the disease and is depressed by all-trans-retinoic acid, an agent capable to determine complete remission with a rapid amelioration of the bleeding syndrome. Cytokine release, acute phase reaction and neovascularization may contribute, in cancer patients, to in vivo clotting activation, which is well documented by several plasmatic markers of a hypercoagulable state. Last but not least, a direct pathogenetic role of clotting activation in the progression of malignancy has been repeatedly proposed on the basis of pharmacological studies with anticoagulant/fibrinolytic drugs in experimental animals and selected clinical malignancies, as well as, lately, in genetically modified animal models (e.g. mice transgenic for PAI-1). The most recent experiments underline the role of the vascular wall as the relevant biological barrier to reinforce in order to prevent cancer metastases.

Herman Van Roijen - One of the best experts on this subject based on the ideXlab platform.

  • Phlegmasia Alba Dolens caused by a distended bladder
    Urology, 2017
    Co-Authors: Marloes Dekkers, Angela Kotsopoulos, Herman Van Roijen
    Abstract:

    We describe the case of a 64-year-old patient with a deep venous thrombosis unusually caused by the obstruction of a severely distended atonic bladder as a result of an iatrogenic injury. Distention of the urinary bladder has previously been described to elevate pressure in the iliac veins, but has seldom been linked to the development of deep venous thrombosis. Through this case, we want to attract attention to this major complication of bladder distention, and we emphasize the importance of proper physical examination.

Marloes Dekkers - One of the best experts on this subject based on the ideXlab platform.

  • Phlegmasia Alba Dolens caused by a distended bladder
    Urology, 2017
    Co-Authors: Marloes Dekkers, Angela Kotsopoulos, Herman Van Roijen
    Abstract:

    We describe the case of a 64-year-old patient with a deep venous thrombosis unusually caused by the obstruction of a severely distended atonic bladder as a result of an iatrogenic injury. Distention of the urinary bladder has previously been described to elevate pressure in the iliac veins, but has seldom been linked to the development of deep venous thrombosis. Through this case, we want to attract attention to this major complication of bladder distention, and we emphasize the importance of proper physical examination.

Angela Kotsopoulos - One of the best experts on this subject based on the ideXlab platform.

  • Phlegmasia Alba Dolens caused by a distended bladder
    Urology, 2017
    Co-Authors: Marloes Dekkers, Angela Kotsopoulos, Herman Van Roijen
    Abstract:

    We describe the case of a 64-year-old patient with a deep venous thrombosis unusually caused by the obstruction of a severely distended atonic bladder as a result of an iatrogenic injury. Distention of the urinary bladder has previously been described to elevate pressure in the iliac veins, but has seldom been linked to the development of deep venous thrombosis. Through this case, we want to attract attention to this major complication of bladder distention, and we emphasize the importance of proper physical examination.

Isabel Cássio - One of the best experts on this subject based on the ideXlab platform.

  • Primary Iliac Venous Leiomyosarcoma: A Rare Cause of Deep Vein Thrombosis in a Young Patient
    Case Reports in Medicine, 2011
    Co-Authors: Nelson Oliveira, Emanuel Dias, Ricardo Lima, Fernando Oliveira, Isabel Cássio
    Abstract:

    Introduction. Primary venous tumours are a rare cause of deep vein thrombosis. The authors present a case where the definitive diagnosis was delayed by inconclusive complementary imaging. Clinical Case. A thirty-seven-year-old female presented with an iliofemoral venous thrombosis of the right lower limb. The patient had presented with an episode of femoral-popliteal vein thrombosis five months before and was currently under anticoagulation. Phlegmasia Alba Dolens installed progressively, as thrombus rapidly extended to the inferior vena cava despite systemic thrombolysis and anticoagulation. Diagnostic imaging failed to identify the underlying aetiology of the deep vein thrombosis. The definitive diagnosis of primary venous leiomyosarcoma was reached by a subcutaneous abdominal wall nodule biopsy. Conclusion. Primary venous leiomyosarcoma of the iliac vein is a rare cause of deep vein thrombosis, which must be considered in young patients with recurrent or refractory to treatment deep vein thrombosis.