The Experts below are selected from a list of 189 Experts worldwide ranked by ideXlab platform

Jeffrey A. Stanley - One of the best experts on this subject based on the ideXlab platform.

  • regionally distinct alterations in membrane Phospholipid Metabolism in schizophrenia a meta analysis of phosphorus magnetic resonance spectroscopy studies
    Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2020
    Co-Authors: Connor S Haszto, Jeffrey A. Stanley, Satish Iyengar, Konasale M Prasad
    Abstract:

    Abstract Background Existing data on altered membrane Phospholipid Metabolism in schizophrenia are diverse. We conducted a meta-analysis of studies of phosphorus magnetic resonance spectroscopy, a noninvasive imaging approach that can assess molecular biochemistry of cortex by measuring phosphomonoester (PME) and phosphodiester (PDE) levels, which can provide evidence of altered biochemical processes involved in neuropil membrane expansion and contraction in schizophrenia. Methods We analyzed PME and PDE data in the frontal and temporal lobes in subjects with schizophrenia from 24 peer-reviewed publications using the MAVIS package in R by building random- and fixed-effects models. Heterogeneity of effect sizes, effects of publication bias, and file drawer analysis were also assessed. Results Subjects with schizophrenia showed lower PME levels in the frontal regions (p = .008) and elevated PDE levels in the temporal regions (p Conclusions Despite methodological differences, these phosphorus magnetic resonance spectroscopy studies demonstrate regionally specific imbalance in membrane Phospholipid Metabolism related to neuropil in subjects with schizophrenia compared with control subjects reflecting neuropil contraction. Specifically, decreased PME levels in the frontal regions and elevated PDE levels in the temporal regions provide evidence of decreased synthesis and increased degradation of neuropil membrane, respectively. Notwithstanding significant heterogeneity and publication bias, a large number of negative studies are required to render the results of this meta-analysis nonsignificant. These findings warrant further postmortem and animal studies.

  • Prefrontal membrane Phospholipid Metabolism of child and adolescent offspring at risk for schizophrenia or schizoaffective disorder: an in vivo 31P MRS study
    Molecular psychiatry, 2003
    Co-Authors: Matcheri S. Keshavan, Jeffrey A. Stanley, Debra M. Montrose, Nancy J. Minshew, Jay W. Pettegrew
    Abstract:

    Prefrontal membrane Phospholipid Metabolism of child and adolescent offspring at risk for schizophrenia or schizoaffective disorder: an in vivo 31 P MRS study

  • Membrane Phospholipid Metabolism and schizophrenia: an in vivo 31P-MR spectroscopy study
    Schizophrenia research, 1994
    Co-Authors: Jeffrey A. Stanley, Peter C. Williamson, Dick J. Drost, Thomas J. Carr, R. J. Rylett, S. L. Morrison-stewart, R. T. Thompson
    Abstract:

    Membrane Phospholipid Metabolism was studied with 31P magnetic resonance spectroscopy in the left dorsal prefrontal cortex of 19 male, medicated, schizophrenic patients and compared to 18 normal male controls matched in age, education and parental education level. The schizophrenic patients had significantly decreased phosphomonoester levels (PMEs, metabolites predominantly involved in the synthesis of membrane Phospholipids). Phosphodiester levels (PDEs, breakdown products of membrane Phospholipids) were not statistically different in schizophrenic patients compared to controls. However, a significant increase in the PDE levels was observed in the newly diagnosed patient subgroup. This observed pattern of the PMEs and PDEs would be consistent with the presence of an abnormal neurodevelopment early in the illness of schizophrenia.

Jens Nielsen - One of the best experts on this subject based on the ideXlab platform.

  • Engineering yeast Phospholipid Metabolism for de novo oleoylethanolamide production
    Nature Chemical Biology, 2020
    Co-Authors: Anastasia Krivoruchko, Sakda Khoomrung, Jens Nielsen
    Abstract:

    Phospholipids, the most abundant membrane lipid components, are crucial in maintaining membrane structures and homeostasis for biofunctions. As a structurally diverse and tightly regulated system involved in multiple organelles, Phospholipid Metabolism is complicated to manipulate. Thus, repurposing Phospholipids for lipid-derived chemical production remains unexplored. Herein, we develop a Saccharomyces cerevisiae platform for de novo production of oleoylethanolamide, a Phospholipid derivative with promising pharmacological applications in ameliorating lipid dysfunction and neurobehavioral symptoms. Through deregulation of Phospholipid Metabolism, screening of biosynthetic enzymes, engineering of subcellular trafficking and process optimization, we could produce oleoylethanolamide at a titer of 8,115.7 µg l^−1 and a yield on glucose of 405.8 µg g^−1. Our work provides a proof-of-concept study for systemically repurposing Phospholipid Metabolism for conversion towards value-added biological chemicals, and this multi-faceted framework may shed light on tailoring Phospholipid Metabolism in other microbial hosts. A combinatorial engineering strategy encompassing pathway regulation, heterologous enzymes and subcellular trafficking enables repurposing of the Phospholipid biosynthetic pathway in Saccharomyces cerevisiae for the production of oleoylethanolamide.

R. T. Thompson - One of the best experts on this subject based on the ideXlab platform.

  • Membrane Phospholipid Metabolism and schizophrenia: an in vivo 31P-MR spectroscopy study
    Schizophrenia research, 1994
    Co-Authors: Jeffrey A. Stanley, Peter C. Williamson, Dick J. Drost, Thomas J. Carr, R. J. Rylett, S. L. Morrison-stewart, R. T. Thompson
    Abstract:

    Membrane Phospholipid Metabolism was studied with 31P magnetic resonance spectroscopy in the left dorsal prefrontal cortex of 19 male, medicated, schizophrenic patients and compared to 18 normal male controls matched in age, education and parental education level. The schizophrenic patients had significantly decreased phosphomonoester levels (PMEs, metabolites predominantly involved in the synthesis of membrane Phospholipids). Phosphodiester levels (PDEs, breakdown products of membrane Phospholipids) were not statistically different in schizophrenic patients compared to controls. However, a significant increase in the PDE levels was observed in the newly diagnosed patient subgroup. This observed pattern of the PMEs and PDEs would be consistent with the presence of an abnormal neurodevelopment early in the illness of schizophrenia.

Symeon Siniossoglou - One of the best experts on this subject based on the ideXlab platform.

  • Phospholipid Metabolism and nuclear function roles of the lipin family of phosphatidic acid phosphatases
    Biochimica et Biophysica Acta, 2013
    Co-Authors: Symeon Siniossoglou
    Abstract:

    Phospholipids play important roles in nuclear function as dynamic building blocks for the biogenesis of the nuclear membrane, as well as signals by which the nucleus communicates with other organelles, and regulate a variety of nuclear events. The mechanisms underlying the nuclear roles of Phospholipids remain poorly understood. Lipins represent a family of phosphatidic acid (PA) phosphatases that are conserved from yeasts to humans and perform essential functions in lipid Metabolism. Several studies have identified key roles for lipins and their regulators in nuclear envelope organization, gene expression and the maintenance of lipid homeostasis in yeast and metazoans. This review discusses recent advances in understanding the roles of lipins in nuclear structure and function. This article is part of a Special Issue entitled Phospholipids and Phospholipid Metabolism.

Rama K. Mallampalli - One of the best experts on this subject based on the ideXlab platform.

  • Surfactant Phospholipid Metabolism
    Biochimica et biophysica acta, 2012
    Co-Authors: Marianna Agassandian, Rama K. Mallampalli
    Abstract:

    Pulmonary surfactant is essential for life and is composed of a complex lipoprotein-like mixture that lines the inner surface of the lung to prevent alveolar collapse at the end of expiration. The molecular composition of surfactant depends on highly integrated and regulated processes involving its biosynthesis, remodeling, degradation, and intracellular trafficking. Despite its multicomponent composition, the study of surfactant Phospholipid Metabolism has focused on two predominant components, disaturated phosphatidylcholine that confers surface-tension lowering activities, and phosphatidylglycerol, recently implicated in innate immune defense. Future studies providing a better understanding of the molecular control and physiological relevance of minor surfactant lipid components are needed. This article is part of a Special Issue entitled Phospholipids and Phospholipid Metabolism.