The Experts below are selected from a list of 9 Experts worldwide ranked by ideXlab platform
Toshihiro Murafuji - One of the best experts on this subject based on the ideXlab platform.
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The Reaction of [(1-Azaazulen-2-yl)imino]Phosphorane with Arylaldehydes: Formation of Bis[(1-azaazulen-2-yl)amino]arylmethanes.
ChemInform, 2011Co-Authors: Hiroyuki Fujii, Kentaro Nagamatsu, Takahiro Gunji, Toshihiro MurafujiAbstract:Phosphorane Derivative (I) undergoes a reaction with arylaldehydes (II) via the corresponding azaazulenylimine intermediates to afford the bis[(azaazulenyl)-amino]arylmethanes (III) in low to moderate yields.
Wolfgang Frey - One of the best experts on this subject based on the ideXlab platform.
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Naphthyridines. Part 3: First example of the polyfunctionally substituted 1,2,4-triazolo[1,5-g][1,6]naphthyridines ring system
Tetrahedron, 2009Co-Authors: Ramadan Ahmed Mekheimer, Yusria R. Ibrahim, Eltaib A. Ahmed, Wolfgang FreyAbstract:Abstract Treatment of 1,2,4-triazoles (1) with diethylmalonate in bromobenzene gave 1,2,4-triazolo-[1,5-a]pyridines 2. Chlorination of 2 using POCl3/DMF (Vilsmeier reagent) led to the isolation of 7-chloro-6-formyl-1,2,4-triazolo[1,5-a]pyridine Derivative 4, which reacted with the stabilized ylid 5 to afford 6-ethoxycarbonylvinyl-1,2,4-triazolo[1,5-a]-pyridines 6. Azidation of 6 yielded the corresponding azido compound 7, (Scheme 2). Reduction of 7 with Na2S2O4 gave the corresponding 7-amino compound 8, which cyclized in boiling DMF to give the novel 1,2,4-triazolo[1,5-g][1,6]naphthyridines 9. On the other hand, reacting 7 with one equivalent of PPh3 (aza-Wittig reaction) in CH2Cl2 gave 7-imino-Phosphorane Derivative 10, and subsequent cyclization in boiling DMF afforded the new 1,2,4-triazolo[1,5-g][1,6]naphthyridine Derivative 11 (Scheme 3). However, treatment of 10 with phenyl isothiocyanate in 1,2-dichlorobenzene at reflux temperature gave the new 1,2,4-triazolo[1,5-g][1,6]naphthyridine Derivative 14 (Scheme 4). Refluxing 6 with excess of a primary amines 15a,b in absolute. EtOH yielded the corresponding 7-alkyl-amino-1,2,4-triazolo[1,5-a]pyridines 16a,b. These obtained amines 16a,b underwent intramolecular heterocyclization in boiling DMF to give the novel 9-alkyl-1,2,4-triazolo[1,5-g][1,6]-naphthyridines 17a,b, in excellent yields (Scheme 5).
Hiroyuki Fujii - One of the best experts on this subject based on the ideXlab platform.
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The Reaction of [(1-Azaazulen-2-yl)imino]Phosphorane with Arylaldehydes: Formation of Bis[(1-azaazulen-2-yl)amino]arylmethanes.
ChemInform, 2011Co-Authors: Hiroyuki Fujii, Kentaro Nagamatsu, Takahiro Gunji, Toshihiro MurafujiAbstract:Phosphorane Derivative (I) undergoes a reaction with arylaldehydes (II) via the corresponding azaazulenylimine intermediates to afford the bis[(azaazulenyl)-amino]arylmethanes (III) in low to moderate yields.
Ramadan Ahmed Mekheimer - One of the best experts on this subject based on the ideXlab platform.
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Naphthyridines. Part 3: First example of the polyfunctionally substituted 1,2,4-triazolo[1,5-g][1,6]naphthyridines ring system
Tetrahedron, 2009Co-Authors: Ramadan Ahmed Mekheimer, Yusria R. Ibrahim, Eltaib A. Ahmed, Wolfgang FreyAbstract:Abstract Treatment of 1,2,4-triazoles (1) with diethylmalonate in bromobenzene gave 1,2,4-triazolo-[1,5-a]pyridines 2. Chlorination of 2 using POCl3/DMF (Vilsmeier reagent) led to the isolation of 7-chloro-6-formyl-1,2,4-triazolo[1,5-a]pyridine Derivative 4, which reacted with the stabilized ylid 5 to afford 6-ethoxycarbonylvinyl-1,2,4-triazolo[1,5-a]-pyridines 6. Azidation of 6 yielded the corresponding azido compound 7, (Scheme 2). Reduction of 7 with Na2S2O4 gave the corresponding 7-amino compound 8, which cyclized in boiling DMF to give the novel 1,2,4-triazolo[1,5-g][1,6]naphthyridines 9. On the other hand, reacting 7 with one equivalent of PPh3 (aza-Wittig reaction) in CH2Cl2 gave 7-imino-Phosphorane Derivative 10, and subsequent cyclization in boiling DMF afforded the new 1,2,4-triazolo[1,5-g][1,6]naphthyridine Derivative 11 (Scheme 3). However, treatment of 10 with phenyl isothiocyanate in 1,2-dichlorobenzene at reflux temperature gave the new 1,2,4-triazolo[1,5-g][1,6]naphthyridine Derivative 14 (Scheme 4). Refluxing 6 with excess of a primary amines 15a,b in absolute. EtOH yielded the corresponding 7-alkyl-amino-1,2,4-triazolo[1,5-a]pyridines 16a,b. These obtained amines 16a,b underwent intramolecular heterocyclization in boiling DMF to give the novel 9-alkyl-1,2,4-triazolo[1,5-g][1,6]-naphthyridines 17a,b, in excellent yields (Scheme 5).
Kentaro Nagamatsu - One of the best experts on this subject based on the ideXlab platform.
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The Reaction of [(1-Azaazulen-2-yl)imino]Phosphorane with Arylaldehydes: Formation of Bis[(1-azaazulen-2-yl)amino]arylmethanes.
ChemInform, 2011Co-Authors: Hiroyuki Fujii, Kentaro Nagamatsu, Takahiro Gunji, Toshihiro MurafujiAbstract:Phosphorane Derivative (I) undergoes a reaction with arylaldehydes (II) via the corresponding azaazulenylimine intermediates to afford the bis[(azaazulenyl)-amino]arylmethanes (III) in low to moderate yields.