The Experts below are selected from a list of 255 Experts worldwide ranked by ideXlab platform
Gerald J Diebold - One of the best experts on this subject based on the ideXlab platform.
-
Heterodyned Photoacoustic Effect generated by irradiation of single particles by two laser beams modulated at different frequencies
Ultrasonics, 2020Co-Authors: Yaqi Zhang, Wenyu Bai, Gerald J DieboldAbstract:When a modulated light beam is absorbed by an incompressible particle, the Photoacoustic Effect can take place through heat diffusion into the surrounding fluid followed by thermal expansion and the generation of sound. When two laser beams modulated at different frequencies irradiate a particle in aqueous solution, the Effect of one laser is to modulate the thermal expansion coefficient of the solution in the proximity of the particle at its modulation frequency. Heat diffusion into the same region of fluid from absorption of radiation from the second laser takes place in fluid where the thermal expansion coefficient is modulated so that the Photoacoustic Effect is produced at the sum and difference frequencies of the two lasers. Here, a theory for the Photoacoustic Effect at the heterodyne frequency for a single particle and the corresponding experiments with carbon particles of different sizes are reported.
-
Emissivity determination using the Photoacoustic Effect.
Applied optics, 2018Co-Authors: Yaqi Zhang, Gerald J DieboldAbstract:We show that emissivities in the near infrared can be determined relative to a reference surface employing the Photoacoustic Effect. The Photoacoustic cell is equipped with two windows and a pair of synchronously moving chopping wheels so that the cell alternately views the test and the reference surface. The acoustic signals produced in the cell are detected with a microphone and that output is fed to a lock-in amplifier. The temperature of the test surface is varied to produce a null in the lock-in amplifier, which permits determination of a relative emissivity. Results of measurements for several plastic and metal surfaces are reported.
-
Photoacoustic Effect Generated from an Expanding Spherical Source
International Journal of Thermophysics, 2018Co-Authors: Wenyu Bai, Gerald J DieboldAbstract:Although the Photoacoustic Effect is typically generated by amplitude-modulated continuous or pulsed radiation, the form of the wave equation for pressure that governs the generation of sound indicates that optical sources moving in an absorbing fluid can produce sound as well. Here, the characteristics of the acoustic wave produced by a radially symmetric Gaussian source expanding outwardly from the origin are found. The unique feature of the Photoacoustic Effect from the spherical source is a trailing compressive wave that arises from reflection of an inwardly propagating component of the wave. Similar to the one-dimensional geometry, an unbounded amplification Effect is found for the Gaussian source expanding at the sound speed.
-
Photoacoustic Effect generated by moving optical sources: Motion in three dimensions
The Journal of the Acoustical Society of America, 2017Co-Authors: Wenyu Bai, Gerald J DieboldAbstract:Although the Photoacoustic Effect is commonly produced through use of pulsed or amplitude-modulated radiation, it can also be generated by a steady source moving in space. Here, the properties of the Photoacoustic Effect generated by moving sources in three dimensions are investigated. The mathematics for the moving Photoacoustic point source are shown to be closely related to that for derivation of the Lienard-Wiechert potential for a moving point charge. The cases of rectilinear motion with the speeds lower than, equal to, and greater than the sound speed, as well as a point source oscillating in space are reported. Of note is that a bounded amplification Effect is found for a Gaussian source moving at the sound speed, which is in contrast to the unbounded amplification seen in a one-dimensional geometry.
-
Photoacoustic Effect generated by moving optical sources: Motion in one dimension
Journal of Applied Physics, 2016Co-Authors: Wenyu Bai, Gerald J DieboldAbstract:Although the Photoacoustic Effect is typically generated by pulsed or amplitude modulated optical beams, it is clear from examination of the wave equation for pressure that motion of an optical source in space will result in the production of sound as well. Here, the properties of the Photoacoustic Effect generated by moving sources in one dimension are investigated. The cases of a moving Gaussian beam, an oscillating delta function source, and an accelerating Gaussian optical sources are reported. The salient feature of one-dimensional sources in the linear acoustic limit is that the amplitude of the beam increases in time without bound.
Dong Wang - One of the best experts on this subject based on the ideXlab platform.
-
Charge transfer NIR dyes for improved Photoacoustic Effect
Dyes and Pigments, 2016Co-Authors: Hui-hui Han, Pei-pei Yang, Yu-juan Gao, Di Zhanng, Jingping Zhang, Dong WangAbstract:Abstract A new class of NIR absorbing dyes accessed by a cycloaddition-cycloreversion reaction of alkynes with 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane is reported. The Photoacoustic Effect of the new NIR dyes was systematically studied. The results validated the positive correlation between the molar extinction coefficient and the Photoacoustic Effect. All of the new NIR dyes showed higher Photoacoustic intensities compared to indocyanine green dye, which is the standard organic dye widely used as a Photoacoustic contrast agent. Finally, the nano-sized liposomes loaded with the NIR dye showed good stabilities and high Photoacoustic intensities, and were utilized to image the cells in agarose gels for a long time. The study guides the future design of NIR dyes for Photoacoustic molecular materials with high intensities and displays promising applications in biomedical Photoacoustic imaging.
-
India ink incorporated multifunctional phase-transition nanodroplets for Photoacoustic/ultrasound dual-modality imaging and Photoacoustic Effect based tumor therapy.
Theranostics, 2014Co-Authors: Jia Jian, Dong Wang, Chengbo Liu, Yuping Gong, Bin Zhang, Zhigang Wang, Yu ZhouAbstract:The in vivo applications of gas-core microbubbles have been limited by gas diffusion, rapid body clearance, and poor vascular permeability. To overcome these limitations, using a modified three-step emulsion process, we have developed a first-of-its-kind India ink incorporated optically-triggerable phase-transition perfluorocarbon nanodroplets (INDs) that can provide not only three types of contrast mechanisms—conventional/thermoelastic Photoacoustic, phase-transition/nonlinear Photoacoustic, and ultrasound imaging contrasts, but also a new avenue for Photoacoustic Effect mediated tumor therapy. Upon pulsed laser illumination above a relatively low energy threshold, liquid-gas phase transition of the INDs has been demonstrated both in vitro and in vivo, offering excellent contrasts for Photoacoustic and ultrasound dual-modality imaging. With further increased laser energy, the nanodroplets have been shown to be capable of destructing cancer cells in vivo, presumably due to the Photoacoustic Effect induced shock-wave generation from the carbon particles of the incorporated India ink. The demonstrated results suggest that the developed multifunctional phase-transition nanodroplets have a great potential for many theranostic biomedical applications, including Photoacoustic/ultrasound dual-modality molecular imaging and targeted, localized cancer therapy.
-
india ink incorporated multifunctional phase transition nanodroplets for Photoacoustic ultrasound dual modality imaging and Photoacoustic Effect based tumor therapy
Theranostics, 2014Co-Authors: Jia Jian, Dong Wang, Chengbo Liu, Yuping Gong, Bin Zhang, Zhigang Wang, Yu Zhou, Yuanyi Zheng, Liang Song, Xiyuan ZhouAbstract:The in vivo applications of gas-core microbubbles have been limited by gas diffusion, rapid body clearance, and poor vascular permeability. To overcome these limitations, using a modified three-step emulsion process, we have developed a first-of-its-kind India ink incorporated optically-triggerable phase-transition perfluorocarbon nanodroplets (INDs) that can provide not only three types of contrast mechanisms—conventional/thermoelastic Photoacoustic, phase-transition/nonlinear Photoacoustic, and ultrasound imaging contrasts, but also a new avenue for Photoacoustic Effect mediated tumor therapy. Upon pulsed laser illumination above a relatively low energy threshold, liquid-gas phase transition of the INDs has been demonstrated both in vitro and in vivo, offering excellent contrasts for Photoacoustic and ultrasound dual-modality imaging. With further increased laser energy, the nanodroplets have been shown to be capable of destructing cancer cells in vivo, presumably due to the Photoacoustic Effect induced shock-wave generation from the carbon particles of the incorporated India ink. The demonstrated results suggest that the developed multifunctional phase-transition nanodroplets have a great potential for many theranostic biomedical applications, including Photoacoustic/ultrasound dual-modality molecular imaging and targeted, localized cancer therapy.
Yu Zhou - One of the best experts on this subject based on the ideXlab platform.
-
India ink incorporated multifunctional phase-transition nanodroplets for Photoacoustic/ultrasound dual-modality imaging and Photoacoustic Effect based tumor therapy.
Theranostics, 2014Co-Authors: Jia Jian, Dong Wang, Chengbo Liu, Yuping Gong, Bin Zhang, Zhigang Wang, Yu ZhouAbstract:The in vivo applications of gas-core microbubbles have been limited by gas diffusion, rapid body clearance, and poor vascular permeability. To overcome these limitations, using a modified three-step emulsion process, we have developed a first-of-its-kind India ink incorporated optically-triggerable phase-transition perfluorocarbon nanodroplets (INDs) that can provide not only three types of contrast mechanisms—conventional/thermoelastic Photoacoustic, phase-transition/nonlinear Photoacoustic, and ultrasound imaging contrasts, but also a new avenue for Photoacoustic Effect mediated tumor therapy. Upon pulsed laser illumination above a relatively low energy threshold, liquid-gas phase transition of the INDs has been demonstrated both in vitro and in vivo, offering excellent contrasts for Photoacoustic and ultrasound dual-modality imaging. With further increased laser energy, the nanodroplets have been shown to be capable of destructing cancer cells in vivo, presumably due to the Photoacoustic Effect induced shock-wave generation from the carbon particles of the incorporated India ink. The demonstrated results suggest that the developed multifunctional phase-transition nanodroplets have a great potential for many theranostic biomedical applications, including Photoacoustic/ultrasound dual-modality molecular imaging and targeted, localized cancer therapy.
-
india ink incorporated multifunctional phase transition nanodroplets for Photoacoustic ultrasound dual modality imaging and Photoacoustic Effect based tumor therapy
Theranostics, 2014Co-Authors: Jia Jian, Dong Wang, Chengbo Liu, Yuping Gong, Bin Zhang, Zhigang Wang, Yu Zhou, Yuanyi Zheng, Liang Song, Xiyuan ZhouAbstract:The in vivo applications of gas-core microbubbles have been limited by gas diffusion, rapid body clearance, and poor vascular permeability. To overcome these limitations, using a modified three-step emulsion process, we have developed a first-of-its-kind India ink incorporated optically-triggerable phase-transition perfluorocarbon nanodroplets (INDs) that can provide not only three types of contrast mechanisms—conventional/thermoelastic Photoacoustic, phase-transition/nonlinear Photoacoustic, and ultrasound imaging contrasts, but also a new avenue for Photoacoustic Effect mediated tumor therapy. Upon pulsed laser illumination above a relatively low energy threshold, liquid-gas phase transition of the INDs has been demonstrated both in vitro and in vivo, offering excellent contrasts for Photoacoustic and ultrasound dual-modality imaging. With further increased laser energy, the nanodroplets have been shown to be capable of destructing cancer cells in vivo, presumably due to the Photoacoustic Effect induced shock-wave generation from the carbon particles of the incorporated India ink. The demonstrated results suggest that the developed multifunctional phase-transition nanodroplets have a great potential for many theranostic biomedical applications, including Photoacoustic/ultrasound dual-modality molecular imaging and targeted, localized cancer therapy.
Jia Jian - One of the best experts on this subject based on the ideXlab platform.
-
India ink incorporated multifunctional phase-transition nanodroplets for Photoacoustic/ultrasound dual-modality imaging and Photoacoustic Effect based tumor therapy.
Theranostics, 2014Co-Authors: Jia Jian, Dong Wang, Chengbo Liu, Yuping Gong, Bin Zhang, Zhigang Wang, Yu ZhouAbstract:The in vivo applications of gas-core microbubbles have been limited by gas diffusion, rapid body clearance, and poor vascular permeability. To overcome these limitations, using a modified three-step emulsion process, we have developed a first-of-its-kind India ink incorporated optically-triggerable phase-transition perfluorocarbon nanodroplets (INDs) that can provide not only three types of contrast mechanisms—conventional/thermoelastic Photoacoustic, phase-transition/nonlinear Photoacoustic, and ultrasound imaging contrasts, but also a new avenue for Photoacoustic Effect mediated tumor therapy. Upon pulsed laser illumination above a relatively low energy threshold, liquid-gas phase transition of the INDs has been demonstrated both in vitro and in vivo, offering excellent contrasts for Photoacoustic and ultrasound dual-modality imaging. With further increased laser energy, the nanodroplets have been shown to be capable of destructing cancer cells in vivo, presumably due to the Photoacoustic Effect induced shock-wave generation from the carbon particles of the incorporated India ink. The demonstrated results suggest that the developed multifunctional phase-transition nanodroplets have a great potential for many theranostic biomedical applications, including Photoacoustic/ultrasound dual-modality molecular imaging and targeted, localized cancer therapy.
-
india ink incorporated multifunctional phase transition nanodroplets for Photoacoustic ultrasound dual modality imaging and Photoacoustic Effect based tumor therapy
Theranostics, 2014Co-Authors: Jia Jian, Dong Wang, Chengbo Liu, Yuping Gong, Bin Zhang, Zhigang Wang, Yu Zhou, Yuanyi Zheng, Liang Song, Xiyuan ZhouAbstract:The in vivo applications of gas-core microbubbles have been limited by gas diffusion, rapid body clearance, and poor vascular permeability. To overcome these limitations, using a modified three-step emulsion process, we have developed a first-of-its-kind India ink incorporated optically-triggerable phase-transition perfluorocarbon nanodroplets (INDs) that can provide not only three types of contrast mechanisms—conventional/thermoelastic Photoacoustic, phase-transition/nonlinear Photoacoustic, and ultrasound imaging contrasts, but also a new avenue for Photoacoustic Effect mediated tumor therapy. Upon pulsed laser illumination above a relatively low energy threshold, liquid-gas phase transition of the INDs has been demonstrated both in vitro and in vivo, offering excellent contrasts for Photoacoustic and ultrasound dual-modality imaging. With further increased laser energy, the nanodroplets have been shown to be capable of destructing cancer cells in vivo, presumably due to the Photoacoustic Effect induced shock-wave generation from the carbon particles of the incorporated India ink. The demonstrated results suggest that the developed multifunctional phase-transition nanodroplets have a great potential for many theranostic biomedical applications, including Photoacoustic/ultrasound dual-modality molecular imaging and targeted, localized cancer therapy.
Xiyuan Zhou - One of the best experts on this subject based on the ideXlab platform.
-
india ink incorporated multifunctional phase transition nanodroplets for Photoacoustic ultrasound dual modality imaging and Photoacoustic Effect based tumor therapy
Theranostics, 2014Co-Authors: Jia Jian, Dong Wang, Chengbo Liu, Yuping Gong, Bin Zhang, Zhigang Wang, Yu Zhou, Yuanyi Zheng, Liang Song, Xiyuan ZhouAbstract:The in vivo applications of gas-core microbubbles have been limited by gas diffusion, rapid body clearance, and poor vascular permeability. To overcome these limitations, using a modified three-step emulsion process, we have developed a first-of-its-kind India ink incorporated optically-triggerable phase-transition perfluorocarbon nanodroplets (INDs) that can provide not only three types of contrast mechanisms—conventional/thermoelastic Photoacoustic, phase-transition/nonlinear Photoacoustic, and ultrasound imaging contrasts, but also a new avenue for Photoacoustic Effect mediated tumor therapy. Upon pulsed laser illumination above a relatively low energy threshold, liquid-gas phase transition of the INDs has been demonstrated both in vitro and in vivo, offering excellent contrasts for Photoacoustic and ultrasound dual-modality imaging. With further increased laser energy, the nanodroplets have been shown to be capable of destructing cancer cells in vivo, presumably due to the Photoacoustic Effect induced shock-wave generation from the carbon particles of the incorporated India ink. The demonstrated results suggest that the developed multifunctional phase-transition nanodroplets have a great potential for many theranostic biomedical applications, including Photoacoustic/ultrasound dual-modality molecular imaging and targeted, localized cancer therapy.