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Martin Rocken - One of the best experts on this subject based on the ideXlab platform.
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DOI: 10.1159/000065857 Phototherapy of Sclerosing Skin Diseases
2015Co-Authors: Martin Rocken, Kamran GhoreschiAbstract:Accessible online at: www.karger.com/journals/drm Sclerosing skin diseases such as localized scleroderma or lichen sclerosus frequently result in significant morbid-ity that requires treatment. Until 10 years ago, no general-ly effective treatment was available for these diseases. In 1992, extracorporeal photopheresis was suggested as treatment for systemic sclerosis, but further studies are required to confirm this early report [1–3]. Two years lat-er, psoralen + UVA, in PUVA bath Photochemotherapy, was proposed as effective and safe treatment for localized scleroderma [4]. Since then, it has been shown that all three modes of Photochemotherapy, oral PUVA, cream PUVA and PUVA bath Photochemotherapy can improve localized scleroderma, but the PUVA bath seems to be th
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puva bath Photochemotherapy and isotretinoin in sclerodermatous graft versus host disease
European Journal of Dermatology, 2008Co-Authors: Kamran Ghoreschi, Peter Thomas, Marius Penovici, Johanna Ullmann, Christian A Sander, Georg Ledderose, Gerd Plewig, Hansjochem Kolb, Martin RockenAbstract:Chronic graft-versus-host disease (GVHD) is almost always associated with skin diseases appearing either as lichenoid GVHD, sclerodermatous GVHD (sGVHD) or as eosinophilic fasciitis-like disease. The two latter frequently result in severe and deep sclerosis. Immunosuppressive therapy is of little help in sclerodermatous or eosinophilic fasciitis-like types of GVHD. Based on data showing that PUVA-bath Photochemotherapy is effective in the treatment of severe localized sclerosis of the skin, we investigated the efficacy of PUVA-bath Photochemotherapy and isotretinoin in sGVHD. In a retrospective study we analyzed fourteen consecutive patients with sGVHD who received PUVA-bath Photochemotherapy, five in combination with oral isotretinoin. Seven patients improved and four showed complete remission. Surprisingly, the therapy was complicated by the development of ulcers within the sclerotic plaques during the early periods of treatment. These ulcers cleared in most patients when PUVA-bath Photochemotherapy was continued. Thus, PUVA-bath Photochemotherapy alone or in combination with isotretinoin may resolve or improve GVHD associated sclerosis in selected patients.
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psoralen bath plus uv a therapy possibilities and limitations
Archives of Dermatology, 1997Co-Authors: Matthias Luftl, Gerd Plewig, Klaus Degitz, Martin RockenAbstract:Oral psoralen plus UV-A (PUVA) therapy was originally developed for the treatment of vitiligo. 1,2 With the introduction of potent UV-A irradiation sources between 1972 and 1974, UV-A irradiation following psoralen application was found to be a highly efficient therapy for proriasis. 3-5 The acronym PUVA was created and the potential use of PUVA was investigated in a large spectrum of different inflammatory and neoplastic skin diseases. 6-8 Psoralen plus UV-A has profoundly influenced the therapeutic concepts of dermatology, as demonstrated in the recent review by Honig et al. 8 An alternative approach, psoralen bath plus UV-A therapy (PUVA bath therapy) that avoids the adverse effects associated with oral PUVA therapy has increasingly been used during recent years. Psoralen bath plus UV-A therapy is not simply a technical variant of Photochemotherapy; it is obviously superior to oral PUVA, at least for some indications, and it has considerably enlarged the spectrum of diseases responsive to Photochemotherapy.
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puva bath Photochemotherapy for localized scleroderma evaluation of 17 consecutive patients
Archives of Dermatology, 1996Co-Authors: Martina Kerscher, Christian A Sander, Gerd Plewig, Michael Meurer, Matthias Volkenandt, P Lehmann, Martin RockenAbstract:REPORT OF A CASE A 42-year-old woman who suffered for more than 2 years from disseminated localized scleroderma (LS) (Figure 1) markedly improved during treatment with psoralen with UV-A (PUVA) bath Photochemotherapy with 8-methoxy-psoralen (8-MOP).1The 8-MOP was applied to the skin during a warm water bath, which was immediately followed by UV-A exposure. Clinical, histological, and ultrasound indications of LS (Figure 2) regressed almost completely during PUVA bath Photochemotherapy in this and 2 other patients, 1 with disseminated LS and 1 with contractures caused by linear LS of the dorsal aspects of the left thigh and entire left leg.1 THERAPEUTIC CHALLENGE No single therapy produces uniform disease remission in LS.2-6A safe and effective therapy associated with the least potential complications is required. SOLUTION Since clinical regression of sclerosis was confirmed by ultrasound and histological evaluations, we considered PUVA bath Photochemotherapy a promising novel therapeutic approach
Gerd Plewig - One of the best experts on this subject based on the ideXlab platform.
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puva bath Photochemotherapy and isotretinoin in sclerodermatous graft versus host disease
European Journal of Dermatology, 2008Co-Authors: Kamran Ghoreschi, Peter Thomas, Marius Penovici, Johanna Ullmann, Christian A Sander, Georg Ledderose, Gerd Plewig, Hansjochem Kolb, Martin RockenAbstract:Chronic graft-versus-host disease (GVHD) is almost always associated with skin diseases appearing either as lichenoid GVHD, sclerodermatous GVHD (sGVHD) or as eosinophilic fasciitis-like disease. The two latter frequently result in severe and deep sclerosis. Immunosuppressive therapy is of little help in sclerodermatous or eosinophilic fasciitis-like types of GVHD. Based on data showing that PUVA-bath Photochemotherapy is effective in the treatment of severe localized sclerosis of the skin, we investigated the efficacy of PUVA-bath Photochemotherapy and isotretinoin in sGVHD. In a retrospective study we analyzed fourteen consecutive patients with sGVHD who received PUVA-bath Photochemotherapy, five in combination with oral isotretinoin. Seven patients improved and four showed complete remission. Surprisingly, the therapy was complicated by the development of ulcers within the sclerotic plaques during the early periods of treatment. These ulcers cleared in most patients when PUVA-bath Photochemotherapy was continued. Thus, PUVA-bath Photochemotherapy alone or in combination with isotretinoin may resolve or improve GVHD associated sclerosis in selected patients.
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psoralen bath plus uv a therapy possibilities and limitations
Archives of Dermatology, 1997Co-Authors: Matthias Luftl, Gerd Plewig, Klaus Degitz, Martin RockenAbstract:Oral psoralen plus UV-A (PUVA) therapy was originally developed for the treatment of vitiligo. 1,2 With the introduction of potent UV-A irradiation sources between 1972 and 1974, UV-A irradiation following psoralen application was found to be a highly efficient therapy for proriasis. 3-5 The acronym PUVA was created and the potential use of PUVA was investigated in a large spectrum of different inflammatory and neoplastic skin diseases. 6-8 Psoralen plus UV-A has profoundly influenced the therapeutic concepts of dermatology, as demonstrated in the recent review by Honig et al. 8 An alternative approach, psoralen bath plus UV-A therapy (PUVA bath therapy) that avoids the adverse effects associated with oral PUVA therapy has increasingly been used during recent years. Psoralen bath plus UV-A therapy is not simply a technical variant of Photochemotherapy; it is obviously superior to oral PUVA, at least for some indications, and it has considerably enlarged the spectrum of diseases responsive to Photochemotherapy.
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puva bath Photochemotherapy for localized scleroderma evaluation of 17 consecutive patients
Archives of Dermatology, 1996Co-Authors: Martina Kerscher, Christian A Sander, Gerd Plewig, Michael Meurer, Matthias Volkenandt, P Lehmann, Martin RockenAbstract:REPORT OF A CASE A 42-year-old woman who suffered for more than 2 years from disseminated localized scleroderma (LS) (Figure 1) markedly improved during treatment with psoralen with UV-A (PUVA) bath Photochemotherapy with 8-methoxy-psoralen (8-MOP).1The 8-MOP was applied to the skin during a warm water bath, which was immediately followed by UV-A exposure. Clinical, histological, and ultrasound indications of LS (Figure 2) regressed almost completely during PUVA bath Photochemotherapy in this and 2 other patients, 1 with disseminated LS and 1 with contractures caused by linear LS of the dorsal aspects of the left thigh and entire left leg.1 THERAPEUTIC CHALLENGE No single therapy produces uniform disease remission in LS.2-6A safe and effective therapy associated with the least potential complications is required. SOLUTION Since clinical regression of sclerosis was confirmed by ultrasound and histological evaluations, we considered PUVA bath Photochemotherapy a promising novel therapeutic approach
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puva bath therapy indications and practical implementation
Hautarzt, 1994Co-Authors: Martina Kerscher, P Lehmann, Gerd PlewigAbstract:Systemic PUVA Photochemotherapy is widely used for a variety of skin diseases. Administration of 8-methoxypsoralen in a dilute bathwater solution may be an effective alternative therapy with no systemic side-effects and requiring smaller amounts of UVA to induce the required phototoxic response. PUVA baths of the palms and soles are an interesting alternative for dermatoses confined to these sites. This article reviews the authors' experience with PUVA bath therapy. Indications for and applications of this technique are discussed.
Mark Goodfield - One of the best experts on this subject based on the ideXlab platform.
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puva therapy in lichen aureus
Journal of The American Academy of Dermatology, 2001Co-Authors: T.c. Ling, V. Goulden, Mark GoodfieldAbstract:Abstract Lichen aureus is one of the subtypes of a rare group of diseases, pigmented purpuric dermatoses. The natural course of the disease is slow evolution and slow resolution. Treatment is generally limited. We report a case of lichen aureus that responded dramatically to Photochemotherapy (PUVA). (J Am Acad Dermatol 2001;45:145-6.)
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PUVA therapy in lichen aureus.
Journal of the American Academy of Dermatology, 2001Co-Authors: T.c. Ling, V. Goulden, Mark GoodfieldAbstract:Lichen aureus is one of the subtypes of a rare group of diseases, pigmented purpuric dermatoses. The natural course of the disease is slow evolution and slow resolution. Treatment is generally limited. We report a case of lichen aureus that responded dramatically to Photochemotherapy (PUVA).
Christian A Sander - One of the best experts on this subject based on the ideXlab platform.
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puva bath Photochemotherapy and isotretinoin in sclerodermatous graft versus host disease
European Journal of Dermatology, 2008Co-Authors: Kamran Ghoreschi, Peter Thomas, Marius Penovici, Johanna Ullmann, Christian A Sander, Georg Ledderose, Gerd Plewig, Hansjochem Kolb, Martin RockenAbstract:Chronic graft-versus-host disease (GVHD) is almost always associated with skin diseases appearing either as lichenoid GVHD, sclerodermatous GVHD (sGVHD) or as eosinophilic fasciitis-like disease. The two latter frequently result in severe and deep sclerosis. Immunosuppressive therapy is of little help in sclerodermatous or eosinophilic fasciitis-like types of GVHD. Based on data showing that PUVA-bath Photochemotherapy is effective in the treatment of severe localized sclerosis of the skin, we investigated the efficacy of PUVA-bath Photochemotherapy and isotretinoin in sGVHD. In a retrospective study we analyzed fourteen consecutive patients with sGVHD who received PUVA-bath Photochemotherapy, five in combination with oral isotretinoin. Seven patients improved and four showed complete remission. Surprisingly, the therapy was complicated by the development of ulcers within the sclerotic plaques during the early periods of treatment. These ulcers cleared in most patients when PUVA-bath Photochemotherapy was continued. Thus, PUVA-bath Photochemotherapy alone or in combination with isotretinoin may resolve or improve GVHD associated sclerosis in selected patients.
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puva bath Photochemotherapy for localized scleroderma evaluation of 17 consecutive patients
Archives of Dermatology, 1996Co-Authors: Martina Kerscher, Christian A Sander, Gerd Plewig, Michael Meurer, Matthias Volkenandt, P Lehmann, Martin RockenAbstract:REPORT OF A CASE A 42-year-old woman who suffered for more than 2 years from disseminated localized scleroderma (LS) (Figure 1) markedly improved during treatment with psoralen with UV-A (PUVA) bath Photochemotherapy with 8-methoxy-psoralen (8-MOP).1The 8-MOP was applied to the skin during a warm water bath, which was immediately followed by UV-A exposure. Clinical, histological, and ultrasound indications of LS (Figure 2) regressed almost completely during PUVA bath Photochemotherapy in this and 2 other patients, 1 with disseminated LS and 1 with contractures caused by linear LS of the dorsal aspects of the left thigh and entire left leg.1 THERAPEUTIC CHALLENGE No single therapy produces uniform disease remission in LS.2-6A safe and effective therapy associated with the least potential complications is required. SOLUTION Since clinical regression of sclerosis was confirmed by ultrasound and histological evaluations, we considered PUVA bath Photochemotherapy a promising novel therapeutic approach
Kamran Ghoreschi - One of the best experts on this subject based on the ideXlab platform.
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DOI: 10.1159/000065857 Phototherapy of Sclerosing Skin Diseases
2015Co-Authors: Martin Rocken, Kamran GhoreschiAbstract:Accessible online at: www.karger.com/journals/drm Sclerosing skin diseases such as localized scleroderma or lichen sclerosus frequently result in significant morbid-ity that requires treatment. Until 10 years ago, no general-ly effective treatment was available for these diseases. In 1992, extracorporeal photopheresis was suggested as treatment for systemic sclerosis, but further studies are required to confirm this early report [1–3]. Two years lat-er, psoralen + UVA, in PUVA bath Photochemotherapy, was proposed as effective and safe treatment for localized scleroderma [4]. Since then, it has been shown that all three modes of Photochemotherapy, oral PUVA, cream PUVA and PUVA bath Photochemotherapy can improve localized scleroderma, but the PUVA bath seems to be th
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puva bath Photochemotherapy and isotretinoin in sclerodermatous graft versus host disease
European Journal of Dermatology, 2008Co-Authors: Kamran Ghoreschi, Peter Thomas, Marius Penovici, Johanna Ullmann, Christian A Sander, Georg Ledderose, Gerd Plewig, Hansjochem Kolb, Martin RockenAbstract:Chronic graft-versus-host disease (GVHD) is almost always associated with skin diseases appearing either as lichenoid GVHD, sclerodermatous GVHD (sGVHD) or as eosinophilic fasciitis-like disease. The two latter frequently result in severe and deep sclerosis. Immunosuppressive therapy is of little help in sclerodermatous or eosinophilic fasciitis-like types of GVHD. Based on data showing that PUVA-bath Photochemotherapy is effective in the treatment of severe localized sclerosis of the skin, we investigated the efficacy of PUVA-bath Photochemotherapy and isotretinoin in sGVHD. In a retrospective study we analyzed fourteen consecutive patients with sGVHD who received PUVA-bath Photochemotherapy, five in combination with oral isotretinoin. Seven patients improved and four showed complete remission. Surprisingly, the therapy was complicated by the development of ulcers within the sclerotic plaques during the early periods of treatment. These ulcers cleared in most patients when PUVA-bath Photochemotherapy was continued. Thus, PUVA-bath Photochemotherapy alone or in combination with isotretinoin may resolve or improve GVHD associated sclerosis in selected patients.