The Experts below are selected from a list of 204 Experts worldwide ranked by ideXlab platform
D S Seidman - One of the best experts on this subject based on the ideXlab platform.
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a new blue light emitting Phototherapy Device a prospective randomized controlled study
The Journal of Pediatrics, 2000Co-Authors: D S Seidman, Jonathan Moise, Zivanit Ergaz, Arie LaorAbstract:Objective: To evaluate the efficacy of a new Phototherapy light source with a narrow luminous blue spectrum. The Device, made with high-intensity gallium nitride light-emitting diodes (LEDs), was compared with conventional Phototherapy at similar light intensities. Setting: Two university-affiliated community hospitals in Jerusalem. Design: Prospective open randomized study. Participants: Sixty-nine jaundiced, but otherwise healthy, term infants who met the entry criteria for Phototherapy set by the American Academy of Pediatrics' Practice Parameter. Main outcome measures: The duration of Phototherapy and the rate of decrease in total serum bilirubin (TSB) concentration. Results: The mean TSB concentrations at initiation and termination of treatment did not differ between newborns receiving LED and those receiving conventional Phototherapy. The duration of Phototherapy and the rate of decrease in TSB concentration were not statistically different in the 2 groups. The average rate of decrease in TSB after adjustment by a linear regression analysis for confounding factors was −3.16 μmol/L/h (95% confidence limits −4.81, −1.51) in newborns receiving LED Phototherapy compared with −2.19 μmol/L/h (−3.99, −0.40) in those treated with conventional Phototherapy ( P Conclusions: The blue gallium nitride LED Device is as effective as conventional Phototherapy and is readily accepted by nursing staff. Future LED Phototherapy Devices can provide much higher irradiance, and thus greater efficacy, and offer a new highly versatile approach to the treatment of jaundice.
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a new blue light emitting Phototherapy Device vs conventional Phototherapy a prospective randomized controlled application in term newborns 1127
Pediatric Research, 1998Co-Authors: D S Seidman, Jonathan Moise, Zivanit Ergaz, A LoarAbstract:Phototherapy (PT) is the standard of care for treatment of hyperbilirubinemia. Its efficacy is dependent upon the light spectrum, irradiance and the exposed surface area of the infant. We have developed a new PT light source using recently introduced high intensity gallium nitride light emitting diodes (LED). This Device has a narrow (30nm) luminous blue spectrum, with peak emission of 460nm (blue light) with no emission of UV or IR radiation. The aim of our study was to evaluate the efficacy of the Device and its approval by the medical staff and parents. We prospectively randomized 22 jaundiced, but otherwise healthy, term infants to either LED or conventional PT. Entry criteria to PT followed the American Academy of Pediatrics' Practice Parameter. Due to safety concerns regarding exposure of infants to very high irradiance, the LED Device was placed at a distance that provided light intensity within the range of the conventional fluorescent PT tubes used, 5-8 uW/cm2/nm.
Jonathan Moise - One of the best experts on this subject based on the ideXlab platform.
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a new blue light emitting Phototherapy Device a prospective randomized controlled study
The Journal of Pediatrics, 2000Co-Authors: D S Seidman, Jonathan Moise, Zivanit Ergaz, Arie LaorAbstract:Objective: To evaluate the efficacy of a new Phototherapy light source with a narrow luminous blue spectrum. The Device, made with high-intensity gallium nitride light-emitting diodes (LEDs), was compared with conventional Phototherapy at similar light intensities. Setting: Two university-affiliated community hospitals in Jerusalem. Design: Prospective open randomized study. Participants: Sixty-nine jaundiced, but otherwise healthy, term infants who met the entry criteria for Phototherapy set by the American Academy of Pediatrics' Practice Parameter. Main outcome measures: The duration of Phototherapy and the rate of decrease in total serum bilirubin (TSB) concentration. Results: The mean TSB concentrations at initiation and termination of treatment did not differ between newborns receiving LED and those receiving conventional Phototherapy. The duration of Phototherapy and the rate of decrease in TSB concentration were not statistically different in the 2 groups. The average rate of decrease in TSB after adjustment by a linear regression analysis for confounding factors was −3.16 μmol/L/h (95% confidence limits −4.81, −1.51) in newborns receiving LED Phototherapy compared with −2.19 μmol/L/h (−3.99, −0.40) in those treated with conventional Phototherapy ( P Conclusions: The blue gallium nitride LED Device is as effective as conventional Phototherapy and is readily accepted by nursing staff. Future LED Phototherapy Devices can provide much higher irradiance, and thus greater efficacy, and offer a new highly versatile approach to the treatment of jaundice.
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a new blue light emitting Phototherapy Device vs conventional Phototherapy a prospective randomized controlled application in term newborns 1127
Pediatric Research, 1998Co-Authors: D S Seidman, Jonathan Moise, Zivanit Ergaz, A LoarAbstract:Phototherapy (PT) is the standard of care for treatment of hyperbilirubinemia. Its efficacy is dependent upon the light spectrum, irradiance and the exposed surface area of the infant. We have developed a new PT light source using recently introduced high intensity gallium nitride light emitting diodes (LED). This Device has a narrow (30nm) luminous blue spectrum, with peak emission of 460nm (blue light) with no emission of UV or IR radiation. The aim of our study was to evaluate the efficacy of the Device and its approval by the medical staff and parents. We prospectively randomized 22 jaundiced, but otherwise healthy, term infants to either LED or conventional PT. Entry criteria to PT followed the American Academy of Pediatrics' Practice Parameter. Due to safety concerns regarding exposure of infants to very high irradiance, the LED Device was placed at a distance that provided light intensity within the range of the conventional fluorescent PT tubes used, 5-8 uW/cm2/nm.
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A New Blue Light Emitting Phototherapy Device vs. Conventional Phototherapy: A Prospective Randomized Controlled Application in Term Newborns † 1127
Pediatric Research, 1998Co-Authors: Daniel S. Seidman, Hendrik J. Vreman, David K. Stevenson, Jonathan Moise, Zivanit Ergaz, A Loar, Rena GaleAbstract:Phototherapy (PT) is the standard of care for treatment of hyperbilirubinemia. Its efficacy is dependent upon the light spectrum, irradiance and the exposed surface area of the infant. We have developed a new PT light source using recently introduced high intensity gallium nitride light emitting diodes (LED). This Device has a narrow (30nm) luminous blue spectrum, with peak emission of 460nm (blue light) with no emission of UV or IR radiation. The aim of our study was to evaluate the efficacy of the Device and its approval by the medical staff and parents. We prospectively randomized 22 jaundiced, but otherwise healthy, term infants to either LED or conventional PT. Entry criteria to PT followed the American Academy of Pediatrics' Practice Parameter. Due to safety concerns regarding exposure of infants to very high irradiance, the LED Device was placed at a distance that provided light intensity within the range of the conventional fluorescent PT tubes used, 5-8 uW/cm2/nm.
Zivanit Ergaz - One of the best experts on this subject based on the ideXlab platform.
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a new blue light emitting Phototherapy Device a prospective randomized controlled study
The Journal of Pediatrics, 2000Co-Authors: D S Seidman, Jonathan Moise, Zivanit Ergaz, Arie LaorAbstract:Objective: To evaluate the efficacy of a new Phototherapy light source with a narrow luminous blue spectrum. The Device, made with high-intensity gallium nitride light-emitting diodes (LEDs), was compared with conventional Phototherapy at similar light intensities. Setting: Two university-affiliated community hospitals in Jerusalem. Design: Prospective open randomized study. Participants: Sixty-nine jaundiced, but otherwise healthy, term infants who met the entry criteria for Phototherapy set by the American Academy of Pediatrics' Practice Parameter. Main outcome measures: The duration of Phototherapy and the rate of decrease in total serum bilirubin (TSB) concentration. Results: The mean TSB concentrations at initiation and termination of treatment did not differ between newborns receiving LED and those receiving conventional Phototherapy. The duration of Phototherapy and the rate of decrease in TSB concentration were not statistically different in the 2 groups. The average rate of decrease in TSB after adjustment by a linear regression analysis for confounding factors was −3.16 μmol/L/h (95% confidence limits −4.81, −1.51) in newborns receiving LED Phototherapy compared with −2.19 μmol/L/h (−3.99, −0.40) in those treated with conventional Phototherapy ( P Conclusions: The blue gallium nitride LED Device is as effective as conventional Phototherapy and is readily accepted by nursing staff. Future LED Phototherapy Devices can provide much higher irradiance, and thus greater efficacy, and offer a new highly versatile approach to the treatment of jaundice.
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a new blue light emitting Phototherapy Device vs conventional Phototherapy a prospective randomized controlled application in term newborns 1127
Pediatric Research, 1998Co-Authors: D S Seidman, Jonathan Moise, Zivanit Ergaz, A LoarAbstract:Phototherapy (PT) is the standard of care for treatment of hyperbilirubinemia. Its efficacy is dependent upon the light spectrum, irradiance and the exposed surface area of the infant. We have developed a new PT light source using recently introduced high intensity gallium nitride light emitting diodes (LED). This Device has a narrow (30nm) luminous blue spectrum, with peak emission of 460nm (blue light) with no emission of UV or IR radiation. The aim of our study was to evaluate the efficacy of the Device and its approval by the medical staff and parents. We prospectively randomized 22 jaundiced, but otherwise healthy, term infants to either LED or conventional PT. Entry criteria to PT followed the American Academy of Pediatrics' Practice Parameter. Due to safety concerns regarding exposure of infants to very high irradiance, the LED Device was placed at a distance that provided light intensity within the range of the conventional fluorescent PT tubes used, 5-8 uW/cm2/nm.
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A New Blue Light Emitting Phototherapy Device vs. Conventional Phototherapy: A Prospective Randomized Controlled Application in Term Newborns † 1127
Pediatric Research, 1998Co-Authors: Daniel S. Seidman, Hendrik J. Vreman, David K. Stevenson, Jonathan Moise, Zivanit Ergaz, A Loar, Rena GaleAbstract:Phototherapy (PT) is the standard of care for treatment of hyperbilirubinemia. Its efficacy is dependent upon the light spectrum, irradiance and the exposed surface area of the infant. We have developed a new PT light source using recently introduced high intensity gallium nitride light emitting diodes (LED). This Device has a narrow (30nm) luminous blue spectrum, with peak emission of 460nm (blue light) with no emission of UV or IR radiation. The aim of our study was to evaluate the efficacy of the Device and its approval by the medical staff and parents. We prospectively randomized 22 jaundiced, but otherwise healthy, term infants to either LED or conventional PT. Entry criteria to PT followed the American Academy of Pediatrics' Practice Parameter. Due to safety concerns regarding exposure of infants to very high irradiance, the LED Device was placed at a distance that provided light intensity within the range of the conventional fluorescent PT tubes used, 5-8 uW/cm2/nm.
Daniel S. Seidman - One of the best experts on this subject based on the ideXlab platform.
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Light-Emitting Diodes: A Novel Light Source for Phototherapy
Pediatric Research, 1998Co-Authors: Hendrik J. Vreman, SIDNEY D READER, Rena Gale, Roger K. Route, Martin M. Fejer, Ronald J. Wong, David K. Stevenson, Daniel S. SeidmanAbstract:High intensity light-emitting diodes (LEDs) are being studied as possible light sources for the Phototherapy of hyperbilirubinemic neonates. These power-efficient, low heat-producing light sources have the potential to deliver high intensity light of narrow wavelength band in the blue-green portion of the visible light spectrum, which overlaps the absorption spectrum of bilirubin (BR). We compared the efficacy between single LEDs of different color and then constructed a prototype Phototherapy Device using 300 blue LEDs. The efficacy of this Device was compared with that of conventional Phototherapy Devices by measuring the in vitro photodegradation of BR in human serum albumin. When blue, blue-green, green, and white LEDs were compared, the blue light was the most effective in degrading BR by 28% of dark control, followed by blue-green (18% of control), and then white light (14% of control). Green light was the least effective (11% of control). The prototype Device with three focused arrays, each with 100 blue LEDs, generated greater irradiance (>200 µW·cm^-2·nm^-1) than any of the conventional Devices tested. It also supported the greatest rate of BR photodegradation. We conclude that light from LEDs should be considered a more effective treatment for hyperbilirubinemia than light from presently used Phototherapy Devices. Furthermore, the unique characteristics of this light source may make it especially suitable for use in safe and lightweight home Phototherapy Devices.
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A New Blue Light Emitting Phototherapy Device vs. Conventional Phototherapy: A Prospective Randomized Controlled Application in Term Newborns † 1127
Pediatric Research, 1998Co-Authors: Daniel S. Seidman, Hendrik J. Vreman, David K. Stevenson, Jonathan Moise, Zivanit Ergaz, A Loar, Rena GaleAbstract:Phototherapy (PT) is the standard of care for treatment of hyperbilirubinemia. Its efficacy is dependent upon the light spectrum, irradiance and the exposed surface area of the infant. We have developed a new PT light source using recently introduced high intensity gallium nitride light emitting diodes (LED). This Device has a narrow (30nm) luminous blue spectrum, with peak emission of 460nm (blue light) with no emission of UV or IR radiation. The aim of our study was to evaluate the efficacy of the Device and its approval by the medical staff and parents. We prospectively randomized 22 jaundiced, but otherwise healthy, term infants to either LED or conventional PT. Entry criteria to PT followed the American Academy of Pediatrics' Practice Parameter. Due to safety concerns regarding exposure of infants to very high irradiance, the LED Device was placed at a distance that provided light intensity within the range of the conventional fluorescent PT tubes used, 5-8 uW/cm2/nm.
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Light-Emitting Diodes: A Novel Light Source for Phototherapy
Pediatric Research, 1998Co-Authors: Hendrik J. Vreman, SIDNEY D READER, Rena Gale, Roger K. Route, Martin M. Fejer, Ronald J. Wong, David K. Stevenson, Daniel S. SeidmanAbstract:High intensity light-emitting diodes (LEDs) are being studied as possible light sources for the Phototherapy of hyperbilirubinemic neonates. These power-efficient, low heat-producing light sources have the potential to deliver high intensity light of narrow wavelength band in the blue-green portion of the visible light spectrum, which overlaps the absorption spectrum of bilirubin (BR). We compared the efficacy between single LEDs of different color and then constructed a prototype Phototherapy Device using 300 blue LEDs. The efficacy of this Device was compared with that of conventional Phototherapy Devices by measuring the in vitro photodegradation of BR in human serum albumin. When blue, blue-green, green, and white LEDs were compared, the blue light was the most effective in degrading BR by 28% of dark control, followed by blue-green (18% of control), and then white light (14% of control). Green light was the least effective (11% of control). The prototype Device with three focused arrays, each with 100 blue LEDs, generated greater irradiance (>200 [micro]W[middle dot]cm-2[middle dot]nm-1) than any of the conventional Devices tested. It also supported the greatest rate of BR photodegradation. We conclude that light from LEDs should be considered a more effective treatment for hyperbilirubinemia than light from presently used Phototherapy Devices. Furthermore, the unique characteristics of this light source may make it especially suitable for use in safe and lightweight home Phototherapy Devices. (C) International Pediatrics Research Foundation, Inc. 1998. All Rights Reserved.
Hendrik J. Vreman - One of the best experts on this subject based on the ideXlab platform.
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Phototherapy Device effectiveness in nigeria irradiance assessment and potential for improvement
Journal of Tropical Pediatrics, 2013Co-Authors: Benjamin K Cline, Hendrik J. Vreman, Kelly Faber, Krista M Donaldson, Emmanuel Amuabunosi, Gabriel E Ofovwe, Vinod K Bhutani, Bolajoko O Olusanya, Tina M SlusherAbstract:: This study investigated the effectiveness of simple-to-implement adjustments of Phototherapy Devices on irradiance levels in a cross-section of Nigerian hospitals. A total of 76 Phototherapy Devices were evaluated in 16 hospitals while adjustments were implemented for a subset of 25 Devices for which consent was obtained. The mean irradiance level was 7.6 ± 5.9 µW/cm(2)/nm for all Devices prior to adjustments. The average irradiance level improved from 9.0 µW/cm(2)/nm to 27.3 µW/cm(2)/nm for the adjusted group (n = 25) compared with 6.8 ± 5.4 µW/cm(2)/nm for the unadjusted group (n = 51). Simple, inexpensive adjustments to Phototherapy Devices with sub-optimal irradiance levels can significantly improve their effectiveness to acceptable international standards and should be widely promoted in resource-constrained settings.
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Light-Emitting Diodes: A Novel Light Source for Phototherapy
Pediatric Research, 1998Co-Authors: Hendrik J. Vreman, SIDNEY D READER, Rena Gale, Roger K. Route, Martin M. Fejer, Ronald J. Wong, David K. Stevenson, Daniel S. SeidmanAbstract:High intensity light-emitting diodes (LEDs) are being studied as possible light sources for the Phototherapy of hyperbilirubinemic neonates. These power-efficient, low heat-producing light sources have the potential to deliver high intensity light of narrow wavelength band in the blue-green portion of the visible light spectrum, which overlaps the absorption spectrum of bilirubin (BR). We compared the efficacy between single LEDs of different color and then constructed a prototype Phototherapy Device using 300 blue LEDs. The efficacy of this Device was compared with that of conventional Phototherapy Devices by measuring the in vitro photodegradation of BR in human serum albumin. When blue, blue-green, green, and white LEDs were compared, the blue light was the most effective in degrading BR by 28% of dark control, followed by blue-green (18% of control), and then white light (14% of control). Green light was the least effective (11% of control). The prototype Device with three focused arrays, each with 100 blue LEDs, generated greater irradiance (>200 µW·cm^-2·nm^-1) than any of the conventional Devices tested. It also supported the greatest rate of BR photodegradation. We conclude that light from LEDs should be considered a more effective treatment for hyperbilirubinemia than light from presently used Phototherapy Devices. Furthermore, the unique characteristics of this light source may make it especially suitable for use in safe and lightweight home Phototherapy Devices.
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A New Blue Light Emitting Phototherapy Device vs. Conventional Phototherapy: A Prospective Randomized Controlled Application in Term Newborns † 1127
Pediatric Research, 1998Co-Authors: Daniel S. Seidman, Hendrik J. Vreman, David K. Stevenson, Jonathan Moise, Zivanit Ergaz, A Loar, Rena GaleAbstract:Phototherapy (PT) is the standard of care for treatment of hyperbilirubinemia. Its efficacy is dependent upon the light spectrum, irradiance and the exposed surface area of the infant. We have developed a new PT light source using recently introduced high intensity gallium nitride light emitting diodes (LED). This Device has a narrow (30nm) luminous blue spectrum, with peak emission of 460nm (blue light) with no emission of UV or IR radiation. The aim of our study was to evaluate the efficacy of the Device and its approval by the medical staff and parents. We prospectively randomized 22 jaundiced, but otherwise healthy, term infants to either LED or conventional PT. Entry criteria to PT followed the American Academy of Pediatrics' Practice Parameter. Due to safety concerns regarding exposure of infants to very high irradiance, the LED Device was placed at a distance that provided light intensity within the range of the conventional fluorescent PT tubes used, 5-8 uW/cm2/nm.
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Light-Emitting Diodes: A Novel Light Source for Phototherapy
Pediatric Research, 1998Co-Authors: Hendrik J. Vreman, SIDNEY D READER, Rena Gale, Roger K. Route, Martin M. Fejer, Ronald J. Wong, David K. Stevenson, Daniel S. SeidmanAbstract:High intensity light-emitting diodes (LEDs) are being studied as possible light sources for the Phototherapy of hyperbilirubinemic neonates. These power-efficient, low heat-producing light sources have the potential to deliver high intensity light of narrow wavelength band in the blue-green portion of the visible light spectrum, which overlaps the absorption spectrum of bilirubin (BR). We compared the efficacy between single LEDs of different color and then constructed a prototype Phototherapy Device using 300 blue LEDs. The efficacy of this Device was compared with that of conventional Phototherapy Devices by measuring the in vitro photodegradation of BR in human serum albumin. When blue, blue-green, green, and white LEDs were compared, the blue light was the most effective in degrading BR by 28% of dark control, followed by blue-green (18% of control), and then white light (14% of control). Green light was the least effective (11% of control). The prototype Device with three focused arrays, each with 100 blue LEDs, generated greater irradiance (>200 [micro]W[middle dot]cm-2[middle dot]nm-1) than any of the conventional Devices tested. It also supported the greatest rate of BR photodegradation. We conclude that light from LEDs should be considered a more effective treatment for hyperbilirubinemia than light from presently used Phototherapy Devices. Furthermore, the unique characteristics of this light source may make it especially suitable for use in safe and lightweight home Phototherapy Devices. (C) International Pediatrics Research Foundation, Inc. 1998. All Rights Reserved.