The Experts below are selected from a list of 8127 Experts worldwide ranked by ideXlab platform
Xiongwei Deng - One of the best experts on this subject based on the ideXlab platform.
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mesoporous silica coated polydopamine functionalized reduced graphene oxide for synergistic targeted chemo Photothermal Therapy
ACS Applied Materials & Interfaces, 2017Co-Authors: Leihou Shao, Ruirui Zhang, Caiyan Zhao, Xiongwei DengAbstract:The integration of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. Herein, mesoporous silica (MS) coated polydopamine functionalized reduced graphene oxide (pRGO) further modified with hyaluronic acid (HA) (pRGO@MS-HA) has been utilized as a versatile nanoplatform for synergistic targeted chemo-Photothermal Therapy against cancer. A facile and green chemical method is adopted for the simultaneous reduction and noncovalent functionalization of graphene oxide (GO) by using mussel inspired dopamine (DA) to enhance biocompatibility and the Photothermal effect. Then, it was coated with mesoporous silica (MS) (pRGO@MS) to enhance doxorubicin (DOX) loading and be further modified with the targeting moieties hyaluronic acid (HA). The pH-dependent and near-infrared (NIR) laser irradiation-triggered DOX release from pRGO@MS(DOX)-HA is observed, which could enhance the chemo-Photothermal Therapy effect. In vitro experimental results confirm that pRGO@MS(DOX)-HA...
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mesoporous silica coated polydopamine functionalized reduced graphene oxide for synergistic targeted chemo Photothermal Therapy
ACS Applied Materials & Interfaces, 2017Co-Authors: Leihou Shao, Ruirui Zhang, Caiyan Zhao, Xiongwei DengAbstract:The integration of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. Herein, mesoporous silica (MS) coated polydopamine functionalized reduced graphene oxide (pRGO) further modified with hyaluronic acid (HA) (pRGO@MS-HA) has been utilized as a versatile nanoplatform for synergistic targeted chemo-Photothermal Therapy against cancer. A facile and green chemical method is adopted for the simultaneous reduction and noncovalent functionalization of graphene oxide (GO) by using mussel inspired dopamine (DA) to enhance biocompatibility and the Photothermal effect. Then, it was coated with mesoporous silica (MS) (pRGO@MS) to enhance doxorubicin (DOX) loading and be further modified with the targeting moieties hyaluronic acid (HA). The pH-dependent and near-infrared (NIR) laser irradiation-triggered DOX release from pRGO@MS(DOX)-HA is observed, which could enhance the chemo-Photothermal Therapy effect. In vitro experimental results confirm that pRGO@MS(DOX)-HA exhibits good dispersibility, excellent Photothermal property, remarkable tumor cell killing efficiency, and specificity to target tumor cells. In vivo antitumor experiments further demonstrated that pRGO@MS(DOX)-HA could exhibit an excellent synergistic antitumor efficacy, which is much more distinct than any monoTherapy. This work presents a novel nanoplatform which could load chemoTherapy drugs with high efficiency and be used as light-mediated Photothermal cancer Therapy agent.
Yiyun Cheng - One of the best experts on this subject based on the ideXlab platform.
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a polydopamine nanoparticle knotted poly ethylene glycol hydrogel for on demand drug delivery and chemo Photothermal Therapy
Chemistry of Materials, 2017Co-Authors: Xing Wang, Changping Wang, Xinyu Wang, Yitong Wang, Qiang Zhang, Yiyun ChengAbstract:Hydrogels have exhibited remarkable benefits in drug delivery such as local delivery, days or even weeks of continuous drug release with improved bioavailability, and minimized adverse effects. Here we report a polydopamine (PDA) nanoparticle-knotted poly(ethylene glycol) (PEG) hydrogel for on-demand drug delivery and combined chemo-Photothermal Therapy. Anticancer drugs such as 7-ethyl-10-hydroxycamptothecin (SN38) loaded on PDA nanoparticles via π–π interaction in the gel exhibit minimal leakage at physiological conditions and could be released in an on-demand fashion upon near-infrared light exposure. The hydrogel shows excellent biocompatibility and does not induce any foreign-body reaction over a four-month implantation. The in vivo results demonstrate that the PDA nanoparticle-knotted PEG hydrogel loaded with SN38 could efficiently suppress tumor growth by a combined chemo-Photothermal Therapy. This smart hydrogel would benefit a series of local treatments for diverse diseases.
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A Polydopamine Nanoparticle-Knotted Poly(ethylene glycol) Hydrogel for On-Demand Drug Delivery and Chemo-Photothermal Therapy
2017Co-Authors: Xing Wang, Changping Wang, Xinyu Wang, Yitong Wang, Qiang Zhang, Yiyun ChengAbstract:Hydrogels have exhibited remarkable benefits in drug delivery such as local delivery, days or even weeks of continuous drug release with improved bioavailability, and minimized adverse effects. Here we report a polydopamine (PDA) nanoparticle-knotted poly(ethylene glycol) (PEG) hydrogel for on-demand drug delivery and combined chemo-Photothermal Therapy. Anticancer drugs such as 7-ethyl-10-hydroxycamptothecin (SN38) loaded on PDA nanoparticles via π–π interaction in the gel exhibit minimal leakage at physiological conditions and could be released in an on-demand fashion upon near-infrared light exposure. The hydrogel shows excellent biocompatibility and does not induce any foreign-body reaction over a four-month implantation. The in vivo results demonstrate that the PDA nanoparticle-knotted PEG hydrogel loaded with SN38 could efficiently suppress tumor growth by a combined chemo-Photothermal Therapy. This smart hydrogel would benefit a series of local treatments for diverse diseases
Caiyan Zhao - One of the best experts on this subject based on the ideXlab platform.
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mesoporous silica coated polydopamine functionalized reduced graphene oxide for synergistic targeted chemo Photothermal Therapy
ACS Applied Materials & Interfaces, 2017Co-Authors: Leihou Shao, Ruirui Zhang, Caiyan Zhao, Xiongwei DengAbstract:The integration of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. Herein, mesoporous silica (MS) coated polydopamine functionalized reduced graphene oxide (pRGO) further modified with hyaluronic acid (HA) (pRGO@MS-HA) has been utilized as a versatile nanoplatform for synergistic targeted chemo-Photothermal Therapy against cancer. A facile and green chemical method is adopted for the simultaneous reduction and noncovalent functionalization of graphene oxide (GO) by using mussel inspired dopamine (DA) to enhance biocompatibility and the Photothermal effect. Then, it was coated with mesoporous silica (MS) (pRGO@MS) to enhance doxorubicin (DOX) loading and be further modified with the targeting moieties hyaluronic acid (HA). The pH-dependent and near-infrared (NIR) laser irradiation-triggered DOX release from pRGO@MS(DOX)-HA is observed, which could enhance the chemo-Photothermal Therapy effect. In vitro experimental results confirm that pRGO@MS(DOX)-HA...
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mesoporous silica coated polydopamine functionalized reduced graphene oxide for synergistic targeted chemo Photothermal Therapy
ACS Applied Materials & Interfaces, 2017Co-Authors: Leihou Shao, Ruirui Zhang, Caiyan Zhao, Xiongwei DengAbstract:The integration of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. Herein, mesoporous silica (MS) coated polydopamine functionalized reduced graphene oxide (pRGO) further modified with hyaluronic acid (HA) (pRGO@MS-HA) has been utilized as a versatile nanoplatform for synergistic targeted chemo-Photothermal Therapy against cancer. A facile and green chemical method is adopted for the simultaneous reduction and noncovalent functionalization of graphene oxide (GO) by using mussel inspired dopamine (DA) to enhance biocompatibility and the Photothermal effect. Then, it was coated with mesoporous silica (MS) (pRGO@MS) to enhance doxorubicin (DOX) loading and be further modified with the targeting moieties hyaluronic acid (HA). The pH-dependent and near-infrared (NIR) laser irradiation-triggered DOX release from pRGO@MS(DOX)-HA is observed, which could enhance the chemo-Photothermal Therapy effect. In vitro experimental results confirm that pRGO@MS(DOX)-HA exhibits good dispersibility, excellent Photothermal property, remarkable tumor cell killing efficiency, and specificity to target tumor cells. In vivo antitumor experiments further demonstrated that pRGO@MS(DOX)-HA could exhibit an excellent synergistic antitumor efficacy, which is much more distinct than any monoTherapy. This work presents a novel nanoplatform which could load chemoTherapy drugs with high efficiency and be used as light-mediated Photothermal cancer Therapy agent.
Leihou Shao - One of the best experts on this subject based on the ideXlab platform.
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mesoporous silica coated polydopamine functionalized reduced graphene oxide for synergistic targeted chemo Photothermal Therapy
ACS Applied Materials & Interfaces, 2017Co-Authors: Leihou Shao, Ruirui Zhang, Caiyan Zhao, Xiongwei DengAbstract:The integration of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. Herein, mesoporous silica (MS) coated polydopamine functionalized reduced graphene oxide (pRGO) further modified with hyaluronic acid (HA) (pRGO@MS-HA) has been utilized as a versatile nanoplatform for synergistic targeted chemo-Photothermal Therapy against cancer. A facile and green chemical method is adopted for the simultaneous reduction and noncovalent functionalization of graphene oxide (GO) by using mussel inspired dopamine (DA) to enhance biocompatibility and the Photothermal effect. Then, it was coated with mesoporous silica (MS) (pRGO@MS) to enhance doxorubicin (DOX) loading and be further modified with the targeting moieties hyaluronic acid (HA). The pH-dependent and near-infrared (NIR) laser irradiation-triggered DOX release from pRGO@MS(DOX)-HA is observed, which could enhance the chemo-Photothermal Therapy effect. In vitro experimental results confirm that pRGO@MS(DOX)-HA...
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mesoporous silica coated polydopamine functionalized reduced graphene oxide for synergistic targeted chemo Photothermal Therapy
ACS Applied Materials & Interfaces, 2017Co-Authors: Leihou Shao, Ruirui Zhang, Caiyan Zhao, Xiongwei DengAbstract:The integration of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. Herein, mesoporous silica (MS) coated polydopamine functionalized reduced graphene oxide (pRGO) further modified with hyaluronic acid (HA) (pRGO@MS-HA) has been utilized as a versatile nanoplatform for synergistic targeted chemo-Photothermal Therapy against cancer. A facile and green chemical method is adopted for the simultaneous reduction and noncovalent functionalization of graphene oxide (GO) by using mussel inspired dopamine (DA) to enhance biocompatibility and the Photothermal effect. Then, it was coated with mesoporous silica (MS) (pRGO@MS) to enhance doxorubicin (DOX) loading and be further modified with the targeting moieties hyaluronic acid (HA). The pH-dependent and near-infrared (NIR) laser irradiation-triggered DOX release from pRGO@MS(DOX)-HA is observed, which could enhance the chemo-Photothermal Therapy effect. In vitro experimental results confirm that pRGO@MS(DOX)-HA exhibits good dispersibility, excellent Photothermal property, remarkable tumor cell killing efficiency, and specificity to target tumor cells. In vivo antitumor experiments further demonstrated that pRGO@MS(DOX)-HA could exhibit an excellent synergistic antitumor efficacy, which is much more distinct than any monoTherapy. This work presents a novel nanoplatform which could load chemoTherapy drugs with high efficiency and be used as light-mediated Photothermal cancer Therapy agent.
Wei R Chen - One of the best experts on this subject based on the ideXlab platform.
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indocyanine green containing nanostructure as near infrared dual functional targeting probes for optical imaging and Photothermal Therapy
Molecular Pharmaceutics, 2011Co-Authors: Xiaohui Zheng, Da Xing, Feifan Zhou, Wei R ChenAbstract:Indocyanine green (ICG) is a near-infrared (NIR) imaging agent and is also an ideal light absorber for laser-mediated Photothermal Therapy. This NIR dye could serve as a basis of a dual-functional ...
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cancer Photothermal Therapy in the near infrared region by using single walled carbon nanotubes
Journal of Biomedical Optics, 2009Co-Authors: Feifan Zhou, Da Xing, Zhongmin Ou, Baoyan Wu, Daniel E Resasco, Wei R ChenAbstract:Single-walled carbon nanotubes (SWNTs) have a high optical absorbance in the near-infrared (NIR) region. In this special optical window, biological systems are known to be highly transparent. The optical properties of SWNTs provide an opportunity for selective Photothermal Therapy for cancer treatment. Specifically, CoMoCAT® nanotubes with a uniform size (about 0.81 nm) and a narrow absorption peak at 980 nm are ideal candidates for such a novel approach. Here, CoMoCAT® SWNTs are conjugated to folate, which can bind specifically to the surface of the folate receptor tumor markers. Folate-SWNT (FA-SWNT) targeted tumor cells were irradiated by a 980-nm laser. In our in vitro and in vivo experiments, FA-SWNT effectively enhanced the Photothermal destruction on tumor cells and noticeably spared the Photothermal destruction for nontargeted normal cells. Thus, SWNTs, combined with suitable tumor markers, can be used as novel nanomaterials for selective Photothermal Therapy for cancer treatment.
