The Experts below are selected from a list of 69291 Experts worldwide ranked by ideXlab platform
Greg R Ford - One of the best experts on this subject based on the ideXlab platform.
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predicting longitudinal changes in caregiver Physical and mental Health a stress process model
Health Psychology, 1998Co-Authors: Kathryn T Goode, William E Haley, David L Roth, Greg R FordAbstract:Kathryn T. Goode University of Alabama at Birmingham William E. Haley University of South Florida David L. Roth and Greg R. Ford University of Alabama at Birmi.ngham Alzheimer's family caregivers (N = 122) reported on Physical and mental Health, as well as stress process variables, at baseline and at a 1-year follow-up. Hierarchical regression analyses of stress process models revealed that increases in primary stressors (e.g., patient self-care and behavioral problems) did not directly affect changes in the mental and Physical Health Outcome variables. However, analyses of models of direct, mediated, and moderated effects revealed that psychosocial resource variables (appraisals, coping responses, and social support) were related to caregiver Outcomes over time through several mechanisms. In particular, benign appraisals of stressors, the use of approach coping, and greater levels of social support were associated with more positive caregiver Health Outcomes over time.
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predicting longitudinal changes in caregiver Physical and mental Health a stress process model
Health Psychology, 1998Co-Authors: Kathryn T Goode, William E Haley, David L Roth, Greg R FordAbstract:Alzheimer's family caregivers (N = 122) reported on Physical and mental Health, as well as stress process variables, at baseline and at a 1-year follow-up. Hierarchical regression analyses of stress process models revealed that increases in primary stressors (e.g., patient self-care and behavioral problems) did not directly affect changes in the mental and Physical Health Outcome variables. However, analyses of models of direct, mediated, and moderated effects revealed that psychosocial resource variables (appraisals, coping responses, and social support) were related to caregiver Outcomes over time through several mechanisms. In particular, benign appraisals of stressors, the use of approach coping, and greater levels of social support were associated with more positive caregiver Health Outcomes over time.
Kathryn T Goode - One of the best experts on this subject based on the ideXlab platform.
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predicting longitudinal changes in caregiver Physical and mental Health a stress process model
Health Psychology, 1998Co-Authors: Kathryn T Goode, William E Haley, David L Roth, Greg R FordAbstract:Kathryn T. Goode University of Alabama at Birmingham William E. Haley University of South Florida David L. Roth and Greg R. Ford University of Alabama at Birmi.ngham Alzheimer's family caregivers (N = 122) reported on Physical and mental Health, as well as stress process variables, at baseline and at a 1-year follow-up. Hierarchical regression analyses of stress process models revealed that increases in primary stressors (e.g., patient self-care and behavioral problems) did not directly affect changes in the mental and Physical Health Outcome variables. However, analyses of models of direct, mediated, and moderated effects revealed that psychosocial resource variables (appraisals, coping responses, and social support) were related to caregiver Outcomes over time through several mechanisms. In particular, benign appraisals of stressors, the use of approach coping, and greater levels of social support were associated with more positive caregiver Health Outcomes over time.
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predicting longitudinal changes in caregiver Physical and mental Health a stress process model
Health Psychology, 1998Co-Authors: Kathryn T Goode, William E Haley, David L Roth, Greg R FordAbstract:Alzheimer's family caregivers (N = 122) reported on Physical and mental Health, as well as stress process variables, at baseline and at a 1-year follow-up. Hierarchical regression analyses of stress process models revealed that increases in primary stressors (e.g., patient self-care and behavioral problems) did not directly affect changes in the mental and Physical Health Outcome variables. However, analyses of models of direct, mediated, and moderated effects revealed that psychosocial resource variables (appraisals, coping responses, and social support) were related to caregiver Outcomes over time through several mechanisms. In particular, benign appraisals of stressors, the use of approach coping, and greater levels of social support were associated with more positive caregiver Health Outcomes over time.
William E Haley - One of the best experts on this subject based on the ideXlab platform.
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predicting longitudinal changes in caregiver Physical and mental Health a stress process model
Health Psychology, 1998Co-Authors: Kathryn T Goode, William E Haley, David L Roth, Greg R FordAbstract:Kathryn T. Goode University of Alabama at Birmingham William E. Haley University of South Florida David L. Roth and Greg R. Ford University of Alabama at Birmi.ngham Alzheimer's family caregivers (N = 122) reported on Physical and mental Health, as well as stress process variables, at baseline and at a 1-year follow-up. Hierarchical regression analyses of stress process models revealed that increases in primary stressors (e.g., patient self-care and behavioral problems) did not directly affect changes in the mental and Physical Health Outcome variables. However, analyses of models of direct, mediated, and moderated effects revealed that psychosocial resource variables (appraisals, coping responses, and social support) were related to caregiver Outcomes over time through several mechanisms. In particular, benign appraisals of stressors, the use of approach coping, and greater levels of social support were associated with more positive caregiver Health Outcomes over time.
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predicting longitudinal changes in caregiver Physical and mental Health a stress process model
Health Psychology, 1998Co-Authors: Kathryn T Goode, William E Haley, David L Roth, Greg R FordAbstract:Alzheimer's family caregivers (N = 122) reported on Physical and mental Health, as well as stress process variables, at baseline and at a 1-year follow-up. Hierarchical regression analyses of stress process models revealed that increases in primary stressors (e.g., patient self-care and behavioral problems) did not directly affect changes in the mental and Physical Health Outcome variables. However, analyses of models of direct, mediated, and moderated effects revealed that psychosocial resource variables (appraisals, coping responses, and social support) were related to caregiver Outcomes over time through several mechanisms. In particular, benign appraisals of stressors, the use of approach coping, and greater levels of social support were associated with more positive caregiver Health Outcomes over time.
David L Roth - One of the best experts on this subject based on the ideXlab platform.
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predicting longitudinal changes in caregiver Physical and mental Health a stress process model
Health Psychology, 1998Co-Authors: Kathryn T Goode, William E Haley, David L Roth, Greg R FordAbstract:Kathryn T. Goode University of Alabama at Birmingham William E. Haley University of South Florida David L. Roth and Greg R. Ford University of Alabama at Birmi.ngham Alzheimer's family caregivers (N = 122) reported on Physical and mental Health, as well as stress process variables, at baseline and at a 1-year follow-up. Hierarchical regression analyses of stress process models revealed that increases in primary stressors (e.g., patient self-care and behavioral problems) did not directly affect changes in the mental and Physical Health Outcome variables. However, analyses of models of direct, mediated, and moderated effects revealed that psychosocial resource variables (appraisals, coping responses, and social support) were related to caregiver Outcomes over time through several mechanisms. In particular, benign appraisals of stressors, the use of approach coping, and greater levels of social support were associated with more positive caregiver Health Outcomes over time.
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predicting longitudinal changes in caregiver Physical and mental Health a stress process model
Health Psychology, 1998Co-Authors: Kathryn T Goode, William E Haley, David L Roth, Greg R FordAbstract:Alzheimer's family caregivers (N = 122) reported on Physical and mental Health, as well as stress process variables, at baseline and at a 1-year follow-up. Hierarchical regression analyses of stress process models revealed that increases in primary stressors (e.g., patient self-care and behavioral problems) did not directly affect changes in the mental and Physical Health Outcome variables. However, analyses of models of direct, mediated, and moderated effects revealed that psychosocial resource variables (appraisals, coping responses, and social support) were related to caregiver Outcomes over time through several mechanisms. In particular, benign appraisals of stressors, the use of approach coping, and greater levels of social support were associated with more positive caregiver Health Outcomes over time.
Khan Shahid - One of the best experts on this subject based on the ideXlab platform.
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Effects of immunomodulatory drugs on depressive symptoms: A mega-analysis of randomized, placebo-controlled clinical trials in inflammatory disorders.
'Organisation for Economic Co-Operation and Development (OECD)', 2020Co-Authors: Wittenberg, Gayle M, Stylianou Annie, Zhang Yun, Yu Sun, Gupta Ashutosh, Ps Jagannatha, Wang Dai, Hsu Benjamin, Curran, Mark E, Khan ShahidAbstract:Activation of the innate immune system can cause depression. Immuno-modulatory drugs may have efficacy for depressive symptoms co-morbidly associated with inflammatory disorders. We report a large-scale re-analysis by standardized procedures (mega-analysis) of patient-level data combined from 18 randomized clinical trials conducted by Janssen or GlaxoSmithKline for one of 9 disorders (N=10,745 participants). Core depressive symptoms (low mood and anhedonia) were measured, usually by the Short Form Survey (SF-36), and participants were stratified as high-depressive (N=1,921) based on baseline ratings. Placebo-controlled change from baseline after 4-16 weeks of treatment was estimated by the standardized mean difference (SMD) on average over all trials and for each subgroup of trials targeting one of 7 mechanisms (IL-6, TNF-α, IL12/23, CD20, COX2, BLγS and p38/MAPK14). In the high-depressive stratum there were modest but significant effects on core depressive symptoms (SMD = 0.27, 95% CI [0.11-0.43]) and related SF36 measures of mental Health and vitality. Anti-IL6 antibodies (SMD = 0.8, 95% CI [0.20-1.41]) and an anti-IL12/23 antibody (SMD = 0.48, 95% CI [0.26-0.70]) had numerically larger effects on depressive symptoms than other drug classes. Adjustments for Physical Health Outcome marginally attenuated the average treatment effect on depressive symptoms (SMD=0.20, 95% CI: 0.05-0.34), but more strongly attenuated effects on mental Health and vitality. Effects of anti-IL12/23 and anti-IL6 antibodies remained significant after controlling for Physical response to treatment. Novel immune-therapeutics can produce anti-depressant effects in depressed patients with primary inflammatory disorders that are not entirely explained by treatment-related changes in Physical Health.MR
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Effects of immunomodulatory drugs on depressive symptoms: A mega-analysis of randomized, placebo-controlled clinical trials in inflammatory disorders
'Organisation for Economic Co-Operation and Development (OECD)', 2020Co-Authors: Wittenberg, Gayle M, Stylianou Annie, Zhang Yun, Yu Sun, Gupta Ashutosh, Wang Dai, Hsu Benjamin, Curran, Mark E, Jagannatha P. S., Khan ShahidAbstract:Funder: GlaxoSmithKlineFunder: Janssen Research & Development, LLCAbstract: Activation of the innate immune system is commonly associated with depression. Immunomodulatory drugs may have efficacy for depressive symptoms that are co-morbidly associated with inflammatory disorders. We report a large-scale re-analysis by standardized procedures (mega-analysis) of patient-level data combined from 18 randomized clinical trials conducted by Janssen or GlaxoSmithKline for one of nine disorders (N = 10,743 participants). Core depressive symptoms (low mood, anhedonia) were measured by the Short Form Survey (SF-36) or the Hospital Anxiety and Depression Scale (HADS), and participants were stratified into high (N = 1921) versus low-depressive strata based on baseline ratings. Placebo-controlled change from baseline after 4–16 weeks of treatment was estimated by the standardized mean difference (SMD) over all trials and for each subgroup of trials targeting one of 7 mechanisms (IL-6, TNF-α, IL-12/23, CD20, COX2, BLγS, p38/MAPK14). Patients in the high depressive stratum showed modest but significant effects on core depressive symptoms (SMD = 0.29, 95% CI [0.12–0.45]) and related SF-36 measures of mental Health and vitality. Anti-IL-6 antibodies (SMD = 0.8, 95% CI [0.20–1.41]) and an anti-IL-12/23 antibody (SMD = 0.48, 95% CI [0.26–0.70]) had larger effects on depressive symptoms than other drug classes. Adjustments for Physical Health Outcome marginally attenuated the average treatment effect on depressive symptoms (SMD = 0.20, 95% CI: 0.06–0.35), but more strongly attenuated effects on mental Health and vitality. Effects of anti-IL-12/23 remained significant and anti-IL-6 antibodies became a trend after controlling for Physical response to treatment. Novel immune-therapeutics can produce antidepressant effects in depressed patients with primary inflammatory disorders that are not entirely explained by treatment-related changes in Physical Health
