The Experts below are selected from a list of 39 Experts worldwide ranked by ideXlab platform
B Robinson - One of the best experts on this subject based on the ideXlab platform.
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the absolute configurations of the alkaloids of Physostigma Venenosum seeds
Journal of Pharmacy and Pharmacology, 2011Co-Authors: R B Longmore, B RobinsonAbstract:The absolute configuration of physostigmine has been established by correlating the configuration of its C-3a atom with that of the asymmetric carbon atom in (+)-3-ethyl-3-methoxycarbonyl-3-methylpropionic acid. Comparison of the optical rotatory dispersion spectra of physostigmine, Na-norphysostigmine, geneserine, physovenine and eseramine have shown that all five alkaloids have the same absolute configurations.
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the anti acetylcholinesterase activities of the alkaloids of Physostigma Venenosum seeds
Journal of Pharmacy and Pharmacology, 2011Co-Authors: B Robinson, J B RobinsonAbstract:Anti-acetylcholinesterase activities of physostigmine, physovenine, Na-norphysostigmine, geneserine and eseramine have been investigated in vitro using erythrocyte acetylcholinesterase. The former three bases show comparable activities whereas geneserine and eseramine are inactive under the same experimental conditions. The biologically active form of these bases is discussed in light of these enzyme inhibitory studies.
Gordon T. Plant - One of the best experts on this subject based on the ideXlab platform.
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douglas argyll robertson 1837 1909 what did he do other than describe the argyll robertson pupil
Acta Ophthalmologica, 2008Co-Authors: Andrzej Grzybowski, Gordon T. PlantAbstract:Purpose To study medical achievements of Douglas Argyll Robertson in ophthalmology. Methods The data dealt with in this paper is analysed both from the historical and present-day perspectives. Results Douglas Argyll Robertson (1837-1909) was the first surgeon in Scotland to practice entirely in the field of ophthalmology. In this he was no doubt encouraged by the memory of his father, John Argyll Robertson, who was one of the founders of the Edinburgh Eye Dipensary but who had died when his son was only 18 years of age. Douglas completed his medical education under von Arlt in Prague and Albrecht von Graefe in Berlin. Argyll Robertson made major contributions to ophthalmic surgery. He introduced extracts of Calabar bean (Physostigma Venenosum), in the treatment of glaucoma. He also described in cases of spinal cord disease that there may be loss of the light reflex of the pupil but retention of its movement in accommodation. This condition was named the "Argyll Robertson pupil" and as a clinical sign is almost always indicative of neurosyphilis. His other contributions include: lupus of the eyelid, aetiology of glaucoma, melanotic tumor, diphtheritic ophthalmia, sympathetic ophthalmia, retinitis pigmentosa, hypertrophy of the lacrimal gland, senile entropion, hydrophthalmos, asteroid hyalitis, pulsating exophthalmos, conjunctival filiariasis, albuminuric retinitis, miner’s nystagmus and microphthalmos. Argyll Robertson is also credited with being the first to recommend trephining the sclera in those cases of glaucoma where extensive degenerative changes in the iris made an iridectomy impracticable. Conclusion As we approach the centenary of his death Argyll Robertson deserves to be celebrated for more than his pupil.
R B Longmore - One of the best experts on this subject based on the ideXlab platform.
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the absolute configurations of the alkaloids of Physostigma Venenosum seeds
Journal of Pharmacy and Pharmacology, 2011Co-Authors: R B Longmore, B RobinsonAbstract:The absolute configuration of physostigmine has been established by correlating the configuration of its C-3a atom with that of the asymmetric carbon atom in (+)-3-ethyl-3-methoxycarbonyl-3-methylpropionic acid. Comparison of the optical rotatory dispersion spectra of physostigmine, Na-norphysostigmine, geneserine, physovenine and eseramine have shown that all five alkaloids have the same absolute configurations.
Andrzej Grzybowski - One of the best experts on this subject based on the ideXlab platform.
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douglas argyll robertson 1837 1909 what did he do other than describe the argyll robertson pupil
Acta Ophthalmologica, 2008Co-Authors: Andrzej Grzybowski, Gordon T. PlantAbstract:Purpose To study medical achievements of Douglas Argyll Robertson in ophthalmology. Methods The data dealt with in this paper is analysed both from the historical and present-day perspectives. Results Douglas Argyll Robertson (1837-1909) was the first surgeon in Scotland to practice entirely in the field of ophthalmology. In this he was no doubt encouraged by the memory of his father, John Argyll Robertson, who was one of the founders of the Edinburgh Eye Dipensary but who had died when his son was only 18 years of age. Douglas completed his medical education under von Arlt in Prague and Albrecht von Graefe in Berlin. Argyll Robertson made major contributions to ophthalmic surgery. He introduced extracts of Calabar bean (Physostigma Venenosum), in the treatment of glaucoma. He also described in cases of spinal cord disease that there may be loss of the light reflex of the pupil but retention of its movement in accommodation. This condition was named the "Argyll Robertson pupil" and as a clinical sign is almost always indicative of neurosyphilis. His other contributions include: lupus of the eyelid, aetiology of glaucoma, melanotic tumor, diphtheritic ophthalmia, sympathetic ophthalmia, retinitis pigmentosa, hypertrophy of the lacrimal gland, senile entropion, hydrophthalmos, asteroid hyalitis, pulsating exophthalmos, conjunctival filiariasis, albuminuric retinitis, miner’s nystagmus and microphthalmos. Argyll Robertson is also credited with being the first to recommend trephining the sclera in those cases of glaucoma where extensive degenerative changes in the iris made an iridectomy impracticable. Conclusion As we approach the centenary of his death Argyll Robertson deserves to be celebrated for more than his pupil.
J B Robinson - One of the best experts on this subject based on the ideXlab platform.
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the anti acetylcholinesterase activities of the alkaloids of Physostigma Venenosum seeds
Journal of Pharmacy and Pharmacology, 2011Co-Authors: B Robinson, J B RobinsonAbstract:Anti-acetylcholinesterase activities of physostigmine, physovenine, Na-norphysostigmine, geneserine and eseramine have been investigated in vitro using erythrocyte acetylcholinesterase. The former three bases show comparable activities whereas geneserine and eseramine are inactive under the same experimental conditions. The biologically active form of these bases is discussed in light of these enzyme inhibitory studies.