The Experts below are selected from a list of 690 Experts worldwide ranked by ideXlab platform

Zishou Zhang - One of the best experts on this subject based on the ideXlab platform.

  • crystallization behavior and melting characteristics of wollastonite filled β isotactic polypropylene composites
    Thermochimica Acta, 2012
    Co-Authors: Juan Jiang, Chunguang Wang, Gu Li, Zishou Zhang, Qian Ding
    Abstract:

    In order to obtain wollastonite filled β-iPP composites, wollastonite treated with Pimelic Acid (W*) were prepared with various mass ratios of wollastonite/Pimelic Acid (W/PA). The crystallization behavior, melting characteristics and β-nucleating ability of iPP composites filled with wollastonite (W) and W* were investigated by DSC and XRD. The results indicated that addition of wollastonite increased the crystallization temperatures of iPP, but the crystallization temperatures of iPP in iPP/W* composites were higher than those of iPP/W composites, which proved that the β-nucleation of W* is stronger than untreated wollastonite. Although iPP/wollastonite composites mainly form α-phase iPP, modification of wollastonite by PA significantly enhanced nucleation of β-phase iPP. The β-nucleating ability of W* depend on the amount of formed calcium pimelate, therefore the β-phase contents of β-iPP/W* composites increased with increasing W* content and decreasing mass ratio of W/PA. Moreover, there exist different critical mass ratios of W/PA for preparation of β-iPP composites filled with different W* contents with highest β-phase content and low cost.

  • β nucleation of Pimelic Acid supported on metal oxides in isotactic polypropylene
    Polymer International, 2012
    Co-Authors: Zishou Zhang, Chunguang Wang, Zhang Junping, Kancheng Mai
    Abstract:

    To investigate the nucleation of metal pimelate for isotactic polypropylene (iPP) crystallization, iPP filled with a series of metal oxides with and without metal pimelate on their surface was prepared. There was a chemical reaction between Pimelic Acid (PA) and metal oxides MgO, CaO, BaO or ZnO, but not TiO2. The corresponding metal pimelate formed by the chemical reaction between PA and MgO, CaO, BaO or ZnO had a different influence on the crystallization behavior and melting characteristics of iPP. Addition of metal oxides increased the crystallization temperature of iPP and mainly formed α-phase due to the heterogeneous α-nucleation of metal oxides. The α-nucleation of CaO could be easily changed into β-nucleation using CaO-supported PA, and 90.1% β-phase was obtained. The β-nucleation of BaO could be markedly enhanced by barium pimelate formed using supported PA. However, no β-phase was observed for iPP filled with MgO- or ZnO-supported PA. The various metal oxides with supported PA had a different influence on the crystallization behavior and melting characteristics of iPP due to the different structure of metal pimelate formed by chemical reaction between PA and the metal oxides. Copyright © 2012 Society of Chemical Industry

  • crystallization behavior and melting characteristics of pp nucleated by a novel supported β nucleating agent
    Polymer, 2008
    Co-Authors: Zishou Zhang, Chunguang Wang, Zhugen Yang, Chunyan Chen, Kancheng Mai
    Abstract:

    The β-nucleated PP with high β-PP content was prepared by a novel supported β-nucleating agent, which was prepared with Pimelic Acid supported on nano-CaCO3 as support. The influences of the content of the support and supported β-nucleating agent, pre-melting temperature (Tmelt) and scan rates on crystallization behavior and melting characteristics, and the β-PP content of β-nucleated PP were determined by Differential Scanning Calorimeter (DSC) and Wide-Angle X-ray Diffraction (WAXD). The results indicated that the addition of supported β-nucleating agent markedly increased the crystallization temperature (Tc) of PP. Increasing the content of supported β-nucleating agent slightly increased the Tc, but had no influence on the melting temperatures (Tm) of β-nucleated PP. The Tc and Tm of β-nucleated PP decreased slightly with increasing the content of the support nano-CaCO3. The effects of scan rates and multiple scans with different Tmelt on the crystallization and melting behavior of PP nucleated by supported β-nucleating agent are similar to that of PP nucleated by calcium pimelate (CaHA). The β-PP content above 90 percent was obtained in PP nucleated by supported β-nucleating agent and was not influenced by the content of nano-CaCO3. The supported β-nucleating agent prepared by supporting Pimelic Acid on nano-CaCO3 is a β-nucleating agent with high efficiency and selectivity, and low cost.

Frank J Gonzalez - One of the best experts on this subject based on the ideXlab platform.

  • uplc ms based urine metabolomics reveals indole 3 lactic Acid and phenyllactic Acid as conserved biomarkers for alcohol induced liver disease in the ppara null mouse model
    Journal of Proteome Research, 2011
    Co-Authors: Soumen K Manna, Andrew D Patterson, Qian Yang, Kristopher W Krausz, Jeffrey R Idle, Albert J Fornace, Frank J Gonzalez
    Abstract:

    Since the development and prognosis of alcohol-induced liver disease (ALD) vary significantly with genetic background, identification of a genetic background-independent noninvasive ALD biomarker would significantly improve screening and diagnosis. This study explored the effect of genetic background on the ALD-associated urinary metabolome using the Ppara-null mouse model on two different backgrounds, C57BL/6 (B6) and 129/SvJ (129S), along with their wild-type counterparts. Reversed-phase gradient UPLC-ESI-QTOF-MS analysis revealed that urinary excretion of a number of metabolites, such as ethylsulfate, 4-hydroxyphenylacetic Acid, 4-hydroxyphenylacetic Acid sulfate, adipic Acid, Pimelic Acid, xanthurenic Acid, and taurine, were background-dependent. Elevation of ethyl-β-d-glucuronide and N-acetylglycine was found to be a common signature of the metabolomic response to alcohol exposure in wild-type as well as in Ppara-null mice of both strains. However, increased excretion of indole-3-lactic Acid and phenyllactic Acid was found to be a conserved feature exclusively associated with the alcohol-treated Ppara-null mouse on both backgrounds that develop liver pathologies similar to the early stages of human ALD. These markers reflected the biochemical events associated with early stages of ALD pathogenesis. The results suggest that indole-3-lactic Acid and phenyllactic Acid are potential candidates for conserved and pathology-specific high-throughput noninvasive biomarkers for early stages of ALD.

  • identification of noninvasive biomarkers for alcohol induced liver disease using urinary metabolomics and the ppara null mouse
    Journal of Proteome Research, 2010
    Co-Authors: Soumen K Manna, Andrew D Patterson, Qian Yang, Kristopher W Krausz, Jeffrey R Idle, Albert J Fornace, Frank J Gonzalez
    Abstract:

    Alcohol-induced liver disease (ALD) is a leading cause of nonaccident-related deaths in the United States. Although liver damage caused by ALD is reversible when discovered at the earlier stages, current risk assessment tools are relatively nonspecific. Identification of an early specific signature of ALD would aid in therapeutic intervention and recovery. In this study, the metabolic changes associated with ALD were examined using alcohol-fed male Ppara-null mouse as a model of ALD. Principal components analysis of the mass spectrometry-based urinary metabolic profile showed that alcohol-treated wild-type and Ppara-null mice could be distinguished from control animals without information on history of alcohol consumption. The urinary excretion of ethyl-sulfate, ethyl-beta-d-glucuronide, 4-hydroxyphenylacetic Acid, and 4-hydroxyphenylacetic Acid sulfate was elevated and that of the 2-hydroxyphenylacetic Acid, adipic Acid, and Pimelic Acid was depleted during alcohol treatment in both wild-type and the Ppara-null mice albeit to different extents. However, indole-3-lactic Acid was exclusively elevated by alcohol exposure in Ppara-null mice. The elevation of indole-3-lactic Acid is mechanistically related to the molecular events associated with development of ALD in alcohol-treated Ppara-null mice. This study demonstrated the ability of a metabolomics approach to identify early, noninvasive biomarkers of ALD pathogenesis in Ppara-null mouse model.

Chunguang Wang - One of the best experts on this subject based on the ideXlab platform.

  • crystallization behavior and melting characteristics of wollastonite filled β isotactic polypropylene composites
    Thermochimica Acta, 2012
    Co-Authors: Juan Jiang, Chunguang Wang, Gu Li, Zishou Zhang, Qian Ding
    Abstract:

    In order to obtain wollastonite filled β-iPP composites, wollastonite treated with Pimelic Acid (W*) were prepared with various mass ratios of wollastonite/Pimelic Acid (W/PA). The crystallization behavior, melting characteristics and β-nucleating ability of iPP composites filled with wollastonite (W) and W* were investigated by DSC and XRD. The results indicated that addition of wollastonite increased the crystallization temperatures of iPP, but the crystallization temperatures of iPP in iPP/W* composites were higher than those of iPP/W composites, which proved that the β-nucleation of W* is stronger than untreated wollastonite. Although iPP/wollastonite composites mainly form α-phase iPP, modification of wollastonite by PA significantly enhanced nucleation of β-phase iPP. The β-nucleating ability of W* depend on the amount of formed calcium pimelate, therefore the β-phase contents of β-iPP/W* composites increased with increasing W* content and decreasing mass ratio of W/PA. Moreover, there exist different critical mass ratios of W/PA for preparation of β-iPP composites filled with different W* contents with highest β-phase content and low cost.

  • β nucleation of Pimelic Acid supported on metal oxides in isotactic polypropylene
    Polymer International, 2012
    Co-Authors: Zishou Zhang, Chunguang Wang, Zhang Junping, Kancheng Mai
    Abstract:

    To investigate the nucleation of metal pimelate for isotactic polypropylene (iPP) crystallization, iPP filled with a series of metal oxides with and without metal pimelate on their surface was prepared. There was a chemical reaction between Pimelic Acid (PA) and metal oxides MgO, CaO, BaO or ZnO, but not TiO2. The corresponding metal pimelate formed by the chemical reaction between PA and MgO, CaO, BaO or ZnO had a different influence on the crystallization behavior and melting characteristics of iPP. Addition of metal oxides increased the crystallization temperature of iPP and mainly formed α-phase due to the heterogeneous α-nucleation of metal oxides. The α-nucleation of CaO could be easily changed into β-nucleation using CaO-supported PA, and 90.1% β-phase was obtained. The β-nucleation of BaO could be markedly enhanced by barium pimelate formed using supported PA. However, no β-phase was observed for iPP filled with MgO- or ZnO-supported PA. The various metal oxides with supported PA had a different influence on the crystallization behavior and melting characteristics of iPP due to the different structure of metal pimelate formed by chemical reaction between PA and the metal oxides. Copyright © 2012 Society of Chemical Industry

  • crystallization behavior and melting characteristics of pp nucleated by a novel supported β nucleating agent
    Polymer, 2008
    Co-Authors: Zishou Zhang, Chunguang Wang, Zhugen Yang, Chunyan Chen, Kancheng Mai
    Abstract:

    The β-nucleated PP with high β-PP content was prepared by a novel supported β-nucleating agent, which was prepared with Pimelic Acid supported on nano-CaCO3 as support. The influences of the content of the support and supported β-nucleating agent, pre-melting temperature (Tmelt) and scan rates on crystallization behavior and melting characteristics, and the β-PP content of β-nucleated PP were determined by Differential Scanning Calorimeter (DSC) and Wide-Angle X-ray Diffraction (WAXD). The results indicated that the addition of supported β-nucleating agent markedly increased the crystallization temperature (Tc) of PP. Increasing the content of supported β-nucleating agent slightly increased the Tc, but had no influence on the melting temperatures (Tm) of β-nucleated PP. The Tc and Tm of β-nucleated PP decreased slightly with increasing the content of the support nano-CaCO3. The effects of scan rates and multiple scans with different Tmelt on the crystallization and melting behavior of PP nucleated by supported β-nucleating agent are similar to that of PP nucleated by calcium pimelate (CaHA). The β-PP content above 90 percent was obtained in PP nucleated by supported β-nucleating agent and was not influenced by the content of nano-CaCO3. The supported β-nucleating agent prepared by supporting Pimelic Acid on nano-CaCO3 is a β-nucleating agent with high efficiency and selectivity, and low cost.

Kancheng Mai - One of the best experts on this subject based on the ideXlab platform.

  • β nucleation of Pimelic Acid supported on metal oxides in isotactic polypropylene
    Polymer International, 2012
    Co-Authors: Zishou Zhang, Chunguang Wang, Zhang Junping, Kancheng Mai
    Abstract:

    To investigate the nucleation of metal pimelate for isotactic polypropylene (iPP) crystallization, iPP filled with a series of metal oxides with and without metal pimelate on their surface was prepared. There was a chemical reaction between Pimelic Acid (PA) and metal oxides MgO, CaO, BaO or ZnO, but not TiO2. The corresponding metal pimelate formed by the chemical reaction between PA and MgO, CaO, BaO or ZnO had a different influence on the crystallization behavior and melting characteristics of iPP. Addition of metal oxides increased the crystallization temperature of iPP and mainly formed α-phase due to the heterogeneous α-nucleation of metal oxides. The α-nucleation of CaO could be easily changed into β-nucleation using CaO-supported PA, and 90.1% β-phase was obtained. The β-nucleation of BaO could be markedly enhanced by barium pimelate formed using supported PA. However, no β-phase was observed for iPP filled with MgO- or ZnO-supported PA. The various metal oxides with supported PA had a different influence on the crystallization behavior and melting characteristics of iPP due to the different structure of metal pimelate formed by chemical reaction between PA and the metal oxides. Copyright © 2012 Society of Chemical Industry

  • crystallization behavior and melting characteristics of pp nucleated by a novel supported β nucleating agent
    Polymer, 2008
    Co-Authors: Zishou Zhang, Chunguang Wang, Zhugen Yang, Chunyan Chen, Kancheng Mai
    Abstract:

    The β-nucleated PP with high β-PP content was prepared by a novel supported β-nucleating agent, which was prepared with Pimelic Acid supported on nano-CaCO3 as support. The influences of the content of the support and supported β-nucleating agent, pre-melting temperature (Tmelt) and scan rates on crystallization behavior and melting characteristics, and the β-PP content of β-nucleated PP were determined by Differential Scanning Calorimeter (DSC) and Wide-Angle X-ray Diffraction (WAXD). The results indicated that the addition of supported β-nucleating agent markedly increased the crystallization temperature (Tc) of PP. Increasing the content of supported β-nucleating agent slightly increased the Tc, but had no influence on the melting temperatures (Tm) of β-nucleated PP. The Tc and Tm of β-nucleated PP decreased slightly with increasing the content of the support nano-CaCO3. The effects of scan rates and multiple scans with different Tmelt on the crystallization and melting behavior of PP nucleated by supported β-nucleating agent are similar to that of PP nucleated by calcium pimelate (CaHA). The β-PP content above 90 percent was obtained in PP nucleated by supported β-nucleating agent and was not influenced by the content of nano-CaCO3. The supported β-nucleating agent prepared by supporting Pimelic Acid on nano-CaCO3 is a β-nucleating agent with high efficiency and selectivity, and low cost.

Soumen K Manna - One of the best experts on this subject based on the ideXlab platform.

  • uplc ms based urine metabolomics reveals indole 3 lactic Acid and phenyllactic Acid as conserved biomarkers for alcohol induced liver disease in the ppara null mouse model
    Journal of Proteome Research, 2011
    Co-Authors: Soumen K Manna, Andrew D Patterson, Qian Yang, Kristopher W Krausz, Jeffrey R Idle, Albert J Fornace, Frank J Gonzalez
    Abstract:

    Since the development and prognosis of alcohol-induced liver disease (ALD) vary significantly with genetic background, identification of a genetic background-independent noninvasive ALD biomarker would significantly improve screening and diagnosis. This study explored the effect of genetic background on the ALD-associated urinary metabolome using the Ppara-null mouse model on two different backgrounds, C57BL/6 (B6) and 129/SvJ (129S), along with their wild-type counterparts. Reversed-phase gradient UPLC-ESI-QTOF-MS analysis revealed that urinary excretion of a number of metabolites, such as ethylsulfate, 4-hydroxyphenylacetic Acid, 4-hydroxyphenylacetic Acid sulfate, adipic Acid, Pimelic Acid, xanthurenic Acid, and taurine, were background-dependent. Elevation of ethyl-β-d-glucuronide and N-acetylglycine was found to be a common signature of the metabolomic response to alcohol exposure in wild-type as well as in Ppara-null mice of both strains. However, increased excretion of indole-3-lactic Acid and phenyllactic Acid was found to be a conserved feature exclusively associated with the alcohol-treated Ppara-null mouse on both backgrounds that develop liver pathologies similar to the early stages of human ALD. These markers reflected the biochemical events associated with early stages of ALD pathogenesis. The results suggest that indole-3-lactic Acid and phenyllactic Acid are potential candidates for conserved and pathology-specific high-throughput noninvasive biomarkers for early stages of ALD.

  • identification of noninvasive biomarkers for alcohol induced liver disease using urinary metabolomics and the ppara null mouse
    Journal of Proteome Research, 2010
    Co-Authors: Soumen K Manna, Andrew D Patterson, Qian Yang, Kristopher W Krausz, Jeffrey R Idle, Albert J Fornace, Frank J Gonzalez
    Abstract:

    Alcohol-induced liver disease (ALD) is a leading cause of nonaccident-related deaths in the United States. Although liver damage caused by ALD is reversible when discovered at the earlier stages, current risk assessment tools are relatively nonspecific. Identification of an early specific signature of ALD would aid in therapeutic intervention and recovery. In this study, the metabolic changes associated with ALD were examined using alcohol-fed male Ppara-null mouse as a model of ALD. Principal components analysis of the mass spectrometry-based urinary metabolic profile showed that alcohol-treated wild-type and Ppara-null mice could be distinguished from control animals without information on history of alcohol consumption. The urinary excretion of ethyl-sulfate, ethyl-beta-d-glucuronide, 4-hydroxyphenylacetic Acid, and 4-hydroxyphenylacetic Acid sulfate was elevated and that of the 2-hydroxyphenylacetic Acid, adipic Acid, and Pimelic Acid was depleted during alcohol treatment in both wild-type and the Ppara-null mice albeit to different extents. However, indole-3-lactic Acid was exclusively elevated by alcohol exposure in Ppara-null mice. The elevation of indole-3-lactic Acid is mechanistically related to the molecular events associated with development of ALD in alcohol-treated Ppara-null mice. This study demonstrated the ability of a metabolomics approach to identify early, noninvasive biomarkers of ALD pathogenesis in Ppara-null mouse model.