The Experts below are selected from a list of 225 Experts worldwide ranked by ideXlab platform

Eric Jauniaux - One of the best experts on this subject based on the ideXlab platform.

Shanthi Muttukrishna - One of the best experts on this subject based on the ideXlab platform.

S Gangooly - One of the best experts on this subject based on the ideXlab platform.

H S Wang - One of the best experts on this subject based on the ideXlab platform.

  • effects of glucose on Placental Hormones in the human term placenta in vitro
    Journal of the Formosan Medical Association, 1997
    Co-Authors: T T Hsieh, Kao Chin Chen, T H Chiu, C C Hsieh, H S Wang
    Abstract:

    : Glucose intake during pregnancy results in a decrease in endogenous insulin-like growth factor binding protein-1 (IGFBP-1). However, the exact role of glucose on Placental secretion of IGFBP-1 is unclear. This study was designed to investigate the direct effects of glucose on the production of IGFBP-1 and other Placental Hormones, using an isolated Placental preparation. Using the dual recirculating perfusion system for an isolated human placenta lobule, a total of 43 experiments were performed over a duration of 6 hours. Twenty placentae were perfused with a medium containing 141 +/- 10 mg/dL (7.83 +/- 0.56 mmol/L) glucose (group I) and 23 placentae with 242 +/- 12 mg/dL (13.43 +/- 0.67 mmol/L) glucose (group II). Levels of insulin, glucose, lactate, insulin-like growth factor (IGF-I), IGFBP-1, human Placental lactogen (hPL) and beta-human chorionic gonadotropin (beta-hCG) were measured at 30 minute intervals during perfusion. Insulin and IGF-I were barely detectable in the perfusates and their levels were not modulated by glucose. IGFBP-1 was predominantly detected in the maternal rather than the fetal compartment of the Placental circulation. Glucose increased the levels of IGFBP-1 in the maternal circulation in groups I and II during the first two hours of perfusion (188 +/- 58% and 193 +/- 31%, respectively). However, during the subsequent 4 hour period, the increase in IGFBP-1 concentration was significantly higher in group II (926 +/- 427%) than in group I (428 +/- 216%) (p < 0.05). There was no difference in the levels of hPL or beta-hCG between the two groups in the maternal circulation. Thus, glucose stimulates the production of IGFBP-1 in the maternal circulation of a placenta in vitro. This increase in IGFBP-1 by glucose in vitro, as opposed to the decrease of IGFBP-1 in vivo, may be due to a lack of circulatory maternal insulin in the isolated Placental preparation. These results also suggest that there may be a functional barrier within the placenta that prevents an increase in the level of IGFBP-1 in the fetal circulation.

Michael J Soares - One of the best experts on this subject based on the ideXlab platform.

  • prolactin like protein f subfamily of Placental Hormones cytokines responsiveness to maternal hypoxia
    Endocrinology, 2007
    Co-Authors: Jennifer K Hochen, Juan J Bustamante, Michael J Soares
    Abstract:

    The prolactin (PRL) family of Hormones/cytokines is involved in the maintenance of pregnancy and adaptations to physiological stressors. In this report, we identify and characterize a new member of the rat PRL family, examine the impact of maternal hypoxia on Placental PRL family gene expression, and investigate maternal adaptive responses to hypoxia. Perusal of the PRL gene family locus in the rat genome resulted in the identification of a putative new member of the rat PRL family. The new member is closely related to the previously reported PRL-like protein-F (PLP-F) and has been named PLP-Fβ and the originally characterized PLP-F, now termed PLP-Fα. The two proteins exhibit structural similarities but possess distinct cell- and temporal-specific expression profiles. In vivo hypoxia stimulates Placental PLP-Fα and PLP-E mRNA expression in the rat and mouse, respectively. Rcho-1 trophoblast cells can differentiate into trophoblast giant cells, express PLP-Fα, and exhibit enhanced PLP-Fα mRNA levels when ...